CN115251372B - Food suitable for non-dialysis nephrosis patient and preparation method thereof - Google Patents

Food suitable for non-dialysis nephrosis patient and preparation method thereof Download PDF

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CN115251372B
CN115251372B CN202210962048.5A CN202210962048A CN115251372B CN 115251372 B CN115251372 B CN 115251372B CN 202210962048 A CN202210962048 A CN 202210962048A CN 115251372 B CN115251372 B CN 115251372B
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parts
food
sea buckthorn
dialysis
food product
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CN115251372A (en
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李汉西
柳俊
黄琪评
卢韵君
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Guangzhou Enternutr Biotechnology Co ltd
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Guangzhou Enternutr Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
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Abstract

The invention discloses food suitable for non-dialysis nephrosis patients and a preparation method thereof, and relates to the technical field of food. The food comprises the following raw materials in parts by weight: 500-700 parts of maltodextrin, 170-280 parts of vegetable oil, 40-50 parts of resistant dextrin, 40-100 parts of whey protein, 15-20 parts of mineral substances, 2-3 parts of vitamins, 10-50 parts of carboxymethyl pachyman and 10-50 parts of sea buckthorn polysaccharide. The maltodextrin is used as a carbohydrate source, the vegetable oil is used as a fat source, and meanwhile, the resistant dextrin is used for increasing dietary fibers of the food, so that the protein content and nutrition of the food can be improved through whey protein, minerals and vitamins. The carboxymethyl pachyman has effects of enhancing immunity and protecting kidney. The sea buckthorn polysaccharide can be matched with carboxymethyl pachyman to realize synergistic effect, so that the immunity of organisms is obviously improved, the kidneys are protected, the blood sugar is controlled, and the incidence rate of complications and diabetes is reduced.

Description

Food suitable for non-dialysis nephrosis patient and preparation method thereof
Technical Field
The invention relates to the technical field of foods, in particular to a food suitable for non-dialysis nephrosis patients and a preparation method thereof.
Background
Chronic Kidney Disease (CKD) is a common disease worldwide with a high mortality rate associated with the progression of kidney disease and complications, and practical dietary intervention plays an important role in improving CKD outcome and preventing or delaying the onset of dialysis. Chronic renal patients have reduced renal function, which can lead to excessive sodium and volume loading, hyperkalemia, hyperphosphatemia, and accumulation of toxic metabolites of protein degradation. On the other hand, malnutrition exacerbates the risk of malnutrition and nutrient consumption. With the progression of chronic kidney disease, the need and utilization of different nutrients has changed greatly, and conventional diets are not suitable for kidney disease patients. Therefore, the kidney disease patients are required to be helped to design a nutritional food which not only can obtain sufficient nutrition, but also can effectively avoid the occurrence of bad risks.
In view of this, the present invention has been made.
Disclosure of Invention
The invention aims to provide a food suitable for non-dialysis nephrosis patients and a preparation method thereof.
The invention is realized in the following way:
in a first aspect, the invention provides a food product suitable for non-dialysis renal patients, comprising the following raw materials in parts by weight: 500-700 parts of maltodextrin, 170-280 parts of vegetable oil, 40-50 parts of resistant dextrin, 40-100 parts of whey protein, 15-20 parts of mineral substances, 2-3 parts of vitamins, 10-50 parts of carboxymethyl pachyman and 10-50 parts of sea buckthorn polysaccharide.
In a second aspect, the present invention provides a method for preparing a food product suitable for non-dialysis renal patients, comprising mixing the raw materials of the food product suitable for non-dialysis renal patients according to any one of the preceding embodiments uniformly.
The invention has the following beneficial effects: the food suitable for the non-dialysis nephrosis patient provided by the application takes maltodextrin as a main carbohydrate source, takes vegetable oil as a main fat source, and simultaneously provides resistant dextrin to increase dietary fibers of the food and increase protein content and nutrition of whey protein, minerals and vitamins. And the carboxymethyl pachyman and the seabuckthorn polysaccharide are added on the basis of the above, wherein the carboxymethyl pachyman has the effects of improving immunity and reducing the level of inflammatory factors, and can improve the immunity of a patient suffering from kidney diseases, reduce inflammation and protect the kidney. The addition of the sea buckthorn polysaccharide can be matched with the carboxymethyl pachyman to play a role in synergy, thereby remarkably improving the immunity of organisms, protecting the kidneys, controlling the blood sugar and reducing the incidence rate of complications and diabetes.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
The application provides a food suitable for non-dialysis nephrosis patients, which comprises the following raw materials in parts by weight: 500-700 parts of maltodextrin, 170-280 parts of vegetable oil, 40-50 parts of resistant dextrin, 40-100 parts of whey protein, 15-20 parts of mineral substances, 2-3 parts of vitamins, 10-50 parts of carboxymethyl pachyman and 10-50 parts of sea buckthorn polysaccharide.
In the application, maltodextrin is used as a main carbohydrate source, and is a small molecular compound subjected to pre-digestion and is easy to absorb.
Vegetable oil is used as main fat source, and comprises rapeseed oil, corn oil and coconut oil with mass ratio of 7-10:7-13:3-5. The corn oil and the rapeseed oil contain rich unsaturated fatty acid and low cholesterol content, which is beneficial to preventing the occurrence of hyperlipidemia of patients with kidney diseases; coconut oil is rich in medium-chain fatty acid, and the medium-chain fatty acid has natural comprehensive antibacterial ability and can improve the immunity of patients.
The resistant dextrin is a low-calorie soluble food raw material, and can increase the fiber content of food and provide heat for a long time.
Whey protein is a spherical protein mixture extracted from milk, has the characteristics of high nutritive value, easy digestion and absorption, various active ingredients and the like, and is one of the well-known high-quality protein supplements of human body, which is called protein king. Whey protein in this application is concentrated whey protein or hydrolyzed whey protein.
The mineral substances comprise 285-385 in mass ratio: 165-222:140-200:100-135:75-100:40-60:25-40:1-10 parts of calcium hydrophosphate, calcium carbonate, magnesium carbonate, dipotassium hydrogen phosphate, sodium chloride, ferric pyrophosphate, zinc gluconate and carrier auxiliary materials.
The vitamins comprise 500-600 mass percent: 60-100:35-60:15-30:15-30:7-15:8-13:3-7:2-6:1-5:0.1-0.8:200-300 parts of L-ascorbic acid, dl-alpha-tocopheryl acetate, nicotinic acid, riboflavin, retinyl acetate, folic acid, D-calcium pantothenate, thiamine hydrochloride, pyridoxine hydrochloride, cholecalciferol, cyanocobalamin and carrier auxiliary materials.
Poria as a traditional Chinese medicine in China contains various chemical components, wherein the main component is pachyman, and has various effects of improving immunity, resisting tumor, inducing diuresis and relieving swelling. However, pachyman extracted directly from Poria has poor solubility and is not easily absorbed by human body. The carboxymethyl pachyman obtained by carboxymethyl pachyman is easy to dissolve in water, is convenient for human body to absorb, and improves various biological activities of pachyman. The carboxymethyl pachyman can reduce the level of inflammatory factors and protect the kidney to a certain extent. The application research discovers that the carboxymethyl pachyman with specific molecular weight can improve the immunity of patients, has a certain protection effect on kidneys, has a certain control effect on blood sugar, and can reduce the incidence rate of complications and diabetes. In particular, in the present application, the molecular weight of the carboxymethyl pachyman is 50000-200000 daltons, preferably the molecular weight of the carboxymethyl pachyman is 80000-100000 daltons.
In addition, the sea buckthorn polysaccharide is added, and has the effect of proliferating probiotics. The preparation method of fructus Hippophae polysaccharide comprises oven drying fresh fructus Hippophae at 60-65deg.C for 20-30 hr to obtain dried fructus Hippophae, and breaking the dried fructus Hippophae into dry powder with wall breaking machine; weighing 1kg of sea buckthorn dry powder, adding 5000ml of petroleum ether (30-60), setting the reflux temperature to 70 ℃, refluxing for 2 hours, and carrying out petroleum ether reflux degreasing; adding 30L distilled water, and performing ultrasonic extraction at 60deg.C and power of 100w for 40-60min; filtering the extractive solution with 8 layers of gauze, cooling to room temperature, adding appropriate amount of 95% ethanol to make ethanol concentration be above 80%, sealing with preservative film, and standing for 24 hr; centrifuging (3500 r/min,15 min) with a centrifuge, and collecting the precipitate.
The research of the application finds that the compound use of the carboxymethyl pachyman and the seabuckthorn polysaccharide has the technical effect of synergy, and particularly, the mass ratio of the carboxymethyl pachyman to the seabuckthorn polysaccharide is 1-2: when the range is 1-2, the synergistic effect is more remarkable.
The food prepared from the raw materials can be prepared into different dosage forms according to different requirements, including but not limited to powder, granules, oral liquid, beverage and paste.
In addition, the application also provides a preparation method of the food suitable for the non-dialysis nephrosis patient, which comprises the step of uniformly mixing the raw materials of the food suitable for the non-dialysis nephrosis patient. The preparation method is simple, easy to operate, free of technical difficulties and easy to implement and popularize.
The features and capabilities of the present invention are described in further detail below in connection with the examples.
Example 1
The embodiment provides a food suitable for non-dialysis nephrosis patients, which comprises the following raw materials: 625g of maltodextrin, 70g of rapeseed oil, 130g of corn oil, 30g of coconut oil, 46g of resistant dextrin, 42g of concentrated whey protein powder, 17g of mineral substances, 3g of vitamins, 25g of carboxymethyl pachyman, 25g of sea buckthorn polysaccharide, 7g of essence and 5g of silicon dioxide.
Wherein the mineral substance consists of the following components in parts by weight: 338 parts of calcium hydrophosphate, 193 parts of calcium carbonate, 172 parts of magnesium carbonate, 118 parts of dipotassium hydrogen phosphate, 88 parts of sodium chloride, 52 parts of ferric pyrophosphate, 32 parts of zinc gluconate and 7 parts of carrier auxiliary materials.
The vitamin consists of the following components in parts by weight: 560 parts of L-ascorbic acid, 80 parts of dl-alpha-tocopheryl acetate, 53 parts of nicotinic acid, 23 parts of riboflavin, 21 parts of retinol acetate, 12 parts of folic acid, 12 parts of D-calcium pantothenate, 5 parts of thiamine hydrochloride, 4 parts of pyridoxine hydrochloride, 2 parts of cholecalciferol, 0.5 part of cyanocobalamin and 230 parts of carrier auxiliary materials.
The components are uniformly mixed to obtain the food suitable for patients with non-dialysis nephropathy.
Example 2
The embodiment provides a food suitable for non-dialysis nephrosis patients, which comprises the following raw materials: 625g of maltodextrin, 70g of rapeseed oil, 130g of corn oil, 30g of coconut oil, 46g of resistant dextrin, 42g of concentrated whey protein powder, 17g of mineral substances, 3g of vitamins, 30g of carboxymethyl pachyman, 50g of sea buckthorn polysaccharide, 7g of essence and 5g of silicon dioxide.
Wherein the minerals, vitamins are the same as in example 1.
The components are uniformly mixed to obtain the food suitable for patients with non-dialysis nephropathy.
Example 3
The embodiment provides a food suitable for non-dialysis nephrosis patients, which comprises the following raw materials: 625g of maltodextrin, 70g of rapeseed oil, 130g of corn oil, 30g of coconut oil, 46g of resistant dextrin, 42g of concentrated whey protein powder, 17g of mineral substances, 3g of vitamins, 50g of carboxymethyl pachyman, 50g of sea buckthorn polysaccharide, 7g of essence and 5g of silicon dioxide.
Wherein the minerals, vitamins are the same as in example 1.
The components are uniformly mixed to obtain the food suitable for patients with non-dialysis nephropathy.
Example 4
The embodiment provides a food suitable for non-dialysis nephrosis patients, which comprises the following raw materials: 500g of maltodextrin, 80g of rapeseed oil, 70g of corn oil, 40g of coconut oil, 40g of resistant dextrin, 40g of hydrolyzed whey protein powder, 15g of mineral substances, 2g of vitamins, 10g of carboxymethyl pachyman, 20g of seabuckthorn polysaccharide, 7g of essence and 5g of silicon dioxide.
Wherein the mineral substance consists of the following components in parts by weight: 285 parts of calcium hydrophosphate, 165 parts of calcium carbonate, 140 parts of magnesium carbonate, 100 parts of dipotassium hydrogen phosphate, 75 parts of sodium chloride, 40 parts of ferric pyrophosphate, 25 parts of zinc gluconate and 1 part of carrier auxiliary material.
The vitamin consists of the following components in parts by weight: 500 parts of L-ascorbic acid, 60 parts of dl-alpha-tocopheryl acetate, 35 parts of nicotinic acid, 15 parts of riboflavin, 15 parts of retinol acetate, 7 parts of folic acid, 8 parts of D-calcium pantothenate, 3 parts of thiamine hydrochloride, 2 parts of pyridoxine hydrochloride, 1 part of cholecalciferol, 0.1 part of cyanocobalamin and 200 parts of carrier auxiliary materials.
The components are uniformly mixed to obtain the food suitable for patients with non-dialysis nephropathy.
Example 5
The embodiment provides a food suitable for non-dialysis nephrosis patients, which comprises the following raw materials: 700g of maltodextrin, 100g of rapeseed oil, 120g of corn oil, 50g of coconut oil, 50g of resistant dextrin, 100g of hydrolyzed whey protein powder, 20g of minerals, 2g of vitamins, 50g of carboxymethyl pachyman, 25g of seabuckthorn polysaccharide, 7g of essence and 5g of silicon dioxide.
Wherein the mineral substance consists of the following components in parts by weight: 385 parts of calcium hydrophosphate, 222 parts of calcium carbonate, 200 parts of magnesium carbonate, 135 parts of dipotassium hydrogen phosphate, 100 parts of sodium chloride, 60 parts of ferric pyrophosphate, 40 parts of zinc gluconate and 10 parts of carrier auxiliary materials.
The vitamin consists of the following components in parts by weight: 600 parts of L-ascorbic acid, 100 parts of dl-alpha-tocopheryl acetate, 60 parts of nicotinic acid, 30 parts of riboflavin, 30 parts of retinol acetate, 15 parts of folic acid, 13 parts of D-calcium pantothenate, 7 parts of thiamine hydrochloride, 6 parts of pyridoxine hydrochloride, 5 parts of cholecalciferol, 0.8 part of cyanocobalamin and 300 parts of carrier auxiliary materials.
The components are uniformly mixed to obtain the food suitable for patients with non-dialysis nephropathy.
Comparative example 1
The components of this comparative example were identical to example 3, except that carboxymethylpachymaran and seabuckthorn polysaccharide were not added.
Comparative example 2
The components of this comparative example are identical to example 3 except that no carboxymethylpachymaran is added.
Comparative example 3
Only 50g of carboxymethyl pachyman was included in this comparative example.
Comparative example 4
The components of this comparative example were identical to example 3, except that no seabuckthorn polysaccharide was added.
Comparative example 5
Only 50g of seabuckthorn polysaccharide was included in this comparative example.
Comparative example 6
The comparative example comprises 50g of carboxymethyl pachyman and 50g of seabuckthorn polysaccharide.
Experimental example
50 male SD rats are fed under SPF level environment of experimental animal center, and are lighted for 12 hours in round-the-clock cycle, the temperature is 26 ℃, the humidity is 50%, the rats are fed with water freely, and after 1 week of adaptive feeding. Rats were randomly divided into 10 groups of 5: normal control group (normal rat, normal diet), negative control group (model rat, normal diet), test group 1 (model rat, example 2 sample), test group 2 (model rat, example 3 sample), comparative example 1 group (model rat, comparative example 1 sample), comparative example 2 group (model rat, comparative example 2 sample). Comparative example 3 group (model rat, comparative example 3 sample). Comparative example 4 group (model rat, comparative example 4 sample). Comparative example 5 group (model rat, comparative example 5 sample). Comparative example 6 group (model rat, comparative example 6 sample). In addition to the normal control group, the other 9 groups of rats were subjected to modeling.
Basal diet was administered daily to the normal control group. The building block was given a 2.5% adenine suspension daily for 14d at 250mg/kg/d followed by 14d every other day. The urine volume of the molding module is obviously greater than 50% of that of a normal control group in 24 hours, and the urine protein is obviously increased by inspection, which indicates that the molding is successful.
And after the molding is successful, starting the drug administration experiment. Both the normal and negative control groups were fed with basal feed, test group 1 was fed with an equal amount of sample food of example 2, test group 2 was fed with an equal amount of sample food of example 3, comparative example 1 was fed with an equal amount of sample of comparative example 1, comparative example 2 was fed with an equal amount of sample of comparative example 2, and feeding was continued for 2 weeks. Comparative example 3 the same amount of comparative example 3 sample was given to the group of comparative example 3 and the feeding was continued for 2 weeks. Comparative example 4 the same amount of comparative example 4 sample was given to the group of comparative example 4 and the feeding was continued for 2 weeks. Comparative example 5 the same amount of comparative example 5 sample was given to the group of comparative example 5 and the feeding was continued for 2 weeks. Comparative example 6 the same amount of comparative example 6 sample was given to the group of comparative example 6 and the feeding was continued for 2 weeks.
The conventional indexes such as blood sugar, body weight, urine volume of 24h and urine protein volume of the rats are detected once a week during the administration period, and the NK cell activity of peripheral blood is detected before and after the administration period, and the statistical data are shown in tables 1, 2, 3 and 4.
TABLE 1 statistical Table of changes in blood sugar, body weight, 24h urine volume and urine protein in rats before and after modeling
TABLE 2 statistical Table of changes in blood glucose, body weight, 24h urine volume and urine protein volume in rats after one week of administration
Table 3 statistical table of changes in blood sugar, body weight, 24h urine volume and urine protein volume of rats after two weeks of administration
Group of Body weight (g) Blood sugar (mmol/L) 24h urine volume (mL) Urine protein (mg/d)
Normal control group 435±4.34 6.02±0.22 8.3±0.63 8.04±0.50
Negative control group 318±15.08 8.84±0.65 43.8±2.39 51.2±3.63
Test group 1 329±6.19 6.34±0.18 24.8±3.56 29.6±2.70
Test group 2 324±11.52 6.16±0.27 20.2±3.77 26.8±2.86
Comparative example 1 group 293±15.39 7.00±0.41 41.4±4.83 39.8±5.36
Comparative example 2 group 300±14.29 6.60±0.16 36.6±2.97 35.2±3.03
Comparative example 3 group 313±14.33 6.42±0.23 35.0±3.54 34.2±2.59
Comparative example 4 group 299±13.01 6.74±0.21 36.4±3.97 34.4±2.51
Comparative example 5 group 295±10.81 6.66±0.29 40.2±2.49 40.0±2.55
Comparative example 6 group 295±15.41 6.48±0.15 34.2±1.79 33.6±1.67
TABLE 4 statistical table of changes in NK cell activity in rats before and after administration
According to the results of Table 1, the 24-hour urine volume and urine protein of the molding were significantly increased, indicating successful molding. The results in Table 2 and Table 3 show that the invention of example 2 and example 3 can reduce urine protein content and 24h urine volume, has a certain protective function on kidney, has a certain control function on blood sugar, and can reduce the incidence rate of complications and diabetes. As can be seen from the data of test group 2 and comparative examples 1-6, the carboxymethyl pachyman and seabuckthorn polysaccharide in the present application have synergistic lease, and the results in table 4 show that examples 2 and 3 can significantly improve the immunity of rats, and the effect of comparative examples 1-6 is significantly worse than that of example 3.
In summary, the food suitable for non-dialysis renal patients provided herein uses maltodextrin as a main carbohydrate source, vegetable oil as a main fat source, and provides resistant dextrin to increase dietary fiber of the food and increase whey protein, minerals and vitamins to increase protein content and nutrition of the food. And the carboxymethyl pachyman and the seabuckthorn polysaccharide are added on the basis of the above, wherein the carboxymethyl pachyman has the effects of improving immunity and reducing the level of inflammatory factors, and can improve the immunity of a patient suffering from kidney diseases, reduce inflammation and protect the kidney. The addition of the sea buckthorn polysaccharide can be matched with the carboxymethyl pachyman to play a role in synergy, thereby remarkably improving the immunity of organisms, protecting the kidneys, controlling the blood sugar and reducing the incidence rate of complications and diabetes.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (8)

1. The food suitable for the non-dialysis nephrosis patient is characterized by comprising the following raw materials in parts by weight: 500-700 parts of maltodextrin, 170-280 parts of vegetable oil, 40-50 parts of resistant dextrin, 40-100 parts of whey protein, 15-20 parts of mineral substances, 2-3 parts of vitamins, 10-50 parts of carboxymethyl pachyman and 10-50 parts of sea buckthorn polysaccharide;
the mass ratio of the carboxymethyl pachyman to the sea buckthorn polysaccharide is 1-2:1-2;
the molecular weight of the carboxymethyl pachyman is 80000-100000 daltons.
2. The food for non-dialysis nephrosis patient according to claim 1, wherein the sea buckthorn polysaccharide is prepared by drying fresh sea buckthorn fruit at 60-65deg.C for 20-30 hr to obtain dried sea buckthorn fruit, and pulverizing the dried sea buckthorn fruit into dry sea buckthorn powder; refluxing and degreasing the sea buckthorn dry powder by petroleum ether, setting the refluxing temperature to be 70 ℃, and refluxing for 2 hours; adding water, and ultrasonically extracting for 40-60min; filtering the extract, cooling to room temperature, adding 95% ethanol to make the ethanol concentration be above 80%, sealing with preservative film, and standing for 24 hr; centrifuging with a centrifuge, and collecting the precipitate.
3. The food product according to claim 1, wherein the vegetable oil comprises rapeseed oil, corn oil and coconut oil in a mass ratio of 7-10:7-13:3-5.
4. The food product according to claim 1, wherein the whey protein is concentrated whey protein or hydrolysed whey protein.
5. The food product according to claim 1, wherein the minerals comprise the following components in a mass ratio of 285-385:165-222:140-200:100-135:75-100:40-60:25-40:1-10 parts of calcium hydrophosphate, calcium carbonate, magnesium carbonate, dipotassium hydrogen phosphate, sodium chloride, ferric pyrophosphate, zinc gluconate and carrier auxiliary materials.
6. The food product according to claim 1, wherein the vitamins comprise a mass ratio of 500-600:60-100:35-60:15-30:15-30:7-15:8-13:3-7:2-6:1-5:0.1-0.8:200-300 parts of L-ascorbic acid, dl-alpha-tocopheryl acetate, nicotinic acid, riboflavin, retinyl acetate, folic acid, D-calcium pantothenate, thiamine hydrochloride, pyridoxine hydrochloride, cholecalciferol, cyanocobalamin and carrier auxiliary materials.
7. The food product according to any one of claims 1-6, wherein the food product is in the form of a powder, granule, oral liquid, beverage, paste.
8. A method of preparing a food product suitable for use in non-dialysis renal patients, comprising mixing the raw materials of the food product according to any one of claims 1-7 uniformly.
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CN104082739A (en) * 2014-06-24 2014-10-08 广州纽健生物科技有限公司 Comprehensive nutritional and semi-digested formulated food for special medical use, and preparation method thereof
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CN104082739A (en) * 2014-06-24 2014-10-08 广州纽健生物科技有限公司 Comprehensive nutritional and semi-digested formulated food for special medical use, and preparation method thereof
CN107223970A (en) * 2017-06-30 2017-10-03 吉林省富生食品有限公司 A kind of dialysis patient tailored version nutrient powder
CN110463989A (en) * 2019-07-24 2019-11-19 浙江禾健生营养科技有限公司 A kind of full nutrient formulation powder of nephrosis tailored version and preparation method thereof
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