CN104055975B - A kind of antitumor Chinese medicine preparation - Google Patents
A kind of antitumor Chinese medicine preparation Download PDFInfo
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Abstract
The invention discloses a kind of antitumor Chinese medicine preparation, the bulk pharmaceutical chemicals and its composition by weight of selection are respectively：10-20 grams of Semen Strychni (processed), 10-20 grams of excrementum pteropi, 5-10 grams of hairyvein agrimony, 5-10 grams of nitre, 5-10 grams of realgar, 8-12 grams of Radix Isatidis, 8-15 grams of Rhizoma Arisaematis (processed), 10-20 grams of seaweed, 8-12 grams of Fructus Forsythiae, 10-20 grams of euphorbia lunulata, 5-10 grams of pangolin, 5-10 grams of cow-bezoar, 5-10 grams of desert cistanche.The present invention has the logical analgesic of becoming silted up of qi-regulating, product of assaulting fortified position brokenly based on the principle of Chinese medicine treating both manifestation and root cause of disease, clearing heat and detoxicating, vanishing sputum and dispelling knot is promoting blood circulation and removing blood stasis, the effect of supplementing qi and nourishing yin, for having in terms of anti-curing oncoma, curative effect is fast, cure rate is high, safe ready, have no toxic side effect, the advantages such as cheap.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation that can be antitumor.
Background technology
Tumour is body tissue cell under the long term of inside and outside adverse factor, loses given birth to it at the genetic level
Neoformation made of hyperplasia and abnormal differentiation occurs for long normal regulation, clinically often occurs in the form of lump.One
Denier tumour is formed, particularly malignant tumour, and growth is independence, is entailed filial generation by cell division, is grown relatively not by machine
Body limits, and growth is vigorous, and with invasion and metastatic, causes damages to body.Tumor incidence is higher, China's case
Number is quite huge, has data to show and accounts for the 55% of whole world case load.
Modern medicine believes that, the cause of disease of tumour is extremely complex, often a kind of carcinogenic factor can induce kinds of tumors, and one
Kind tumour again may be there are many cause of disease.Caused by most tumours are the inhereditary material interaction of environmental factor and cell.
It is weary that its clinical symptoms is mainly shown as that lump, pain, pathological discharge object, ulcer, bleeding, fever, cough, body occurs in body
Power etc..Its pathogeneticing characteristic is the uncontrolled growth of abnormal cell, and is sent out from original site to other positions, this to send out as
Control will invade vital organs and cause failure, finally results in death.
Modern medicine is many in the method and drug of anti-tumor aspect, doctor trained in Western medicine Radiotherapy chemotherapy, operative treatment malignant tumour curative effect
Certainly, but toxic side effect is big, is mainly shown as bone marrow suppression, gastrointestinal reaction, hepatic and renal function damage, cardiac toxic etc., and control
Somewhat expensive is treated, many patients undertake high medical expense due to being difficult to, affect the state of an illness adversely.Though Chinese medicine toxic side effect is small, existing
Having drug, antitumor action is slow mostly, the course for the treatment of is long, it appears unable to do what one wishes.
Invention content
The present invention solves the defect existing for anti-tumor aspect at present, and it is stable, cheap to provide a kind of curative effect, can
Body's immunity is significantly improved, physical recovery is accelerated, mitigates Radiotherapy chemotherapy toxicity, improves the antitumor of long term survival rate
Chinese medicine preparation.
The technical solution adopted in the present invention is：A kind of antitumor Chinese medicine preparation, which is characterized in that the Chinese medicine preparation
Include the Chinese herb of following weight in grams：
10-20 grams of Semen Strychni (processed), 10-20 grams of excrementum pteropi, 5-10 grams of hairyvein agrimony, 5-10 grams of nitre, 5-10 grams of realgar, plate are blue
8-12 grams of root, 8-15 grams of Rhizoma Arisaematis (processed), 10-20 grams of seaweed, 8-12 grams of Fructus Forsythiae, 10-20 grams of euphorbia lunulata, 5-10 grams of pangolin, cow-bezoar
5-10 grams, 5-10 grams of desert cistanche.
As a kind of this prioritization scheme：
The Chinese medicine preparation includes the Chinese herb of following weight in grams：
10 grams of Semen Strychni (processed), 10 grams of excrementum pteropi, 5 grams of hairyvein agrimony, 5 grams of nitre, 5 grams of realgar, 8 grams of Radix Isatidis, Rhizoma Arisaematis (processed) 8
Gram, 10 grams of seaweed, 8 grams of Fructus Forsythiae, 10 grams of euphorbia lunulata, 5 grams of pangolin, 5 grams of cow-bezoar, 5 grams of desert cistanche.
As a kind of this prioritization scheme：
The Chinese medicine preparation includes the Chinese herb of following weight in grams：
15 grams of Semen Strychni (processed), 15 grams of excrementum pteropi, 8 grams of hairyvein agrimony, 8 grams of nitre, 8 grams of realgar, 10 grams of Radix Isatidis, Rhizoma Arisaematis (processed) 12
Gram, 15 grams of seaweed, 10 grams of Fructus Forsythiae, 15 grams of euphorbia lunulata, 8 grams of pangolin, 8 grams of cow-bezoar, 8 grams of desert cistanche.
As a kind of this prioritization scheme：
The Chinese medicine preparation includes the Chinese herb of following weight in grams：
20 grams of Semen Strychni (processed), 20 grams of excrementum pteropi, 10 grams of hairyvein agrimony, 10 grams of nitre, 10 grams of realgar, 12 grams of Radix Isatidis, system south
15 grams of star, 20 grams of seaweed, 12 grams of Fructus Forsythiae, 20 grams of euphorbia lunulata, 10 grams of pangolin, 10 grams of cow-bezoar, 10 grams of desert cistanche.
The instructions of taking of above-mentioned Chinese medicine preparation is：It is fried according to tradition after the raw material Chinese medicine of above-mentioned weight proportion is mixed
The method of Chinese medicine takes its concoction, daily 1 dose, divides 3~4 times and takes orally, and 30 doses are 1 course for the treatment of.It is discontinued 2~3 days between the course for the treatment of, then row lower 1
A course for the treatment of.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation：
Semen Strychni (processed), bitter are cold in nature；Return liver, the spleen channel.It radiates with promoting blood circulation, the effect of swelling and pain relieving.
Excrementum pteropi, it is sweet in flavor, it is warm-natured；Return liver warp.With dredging blood vessel, the effect of removing blood stasis and analgesics.
Hairyvein agrimony, bitter are cold in nature；Converge to heart and liver channels.With astringing to arrest bleeding, qi-restoratives disperse accumulation, stop dysentery desinsection, removing toxicity for detumescence it
Effect.
Nitre, bitter, pungent, cold nature；Return liver, gallbladder channel.It brings down a fever with inducing diaphoresis, soothing liver-qi stagnation rises the effect of lifting yang-energy.
Realgar, it is bitter, pungent, it is warm-natured, flat；The thoughts of returning home, liver, stomach, lung channel.With removing toxic substances desinsection, the effect of removing dampness and eliminating phlegm.
Radix Isatidis, bitter are cold in nature；The thoughts of returning home, stomach.With clearing heat and detoxicating, the effect of blood-stanching and blood-cooling.
Rhizoma Arisaematis (processed), it is bitter, pungent, it is warm-natured；Return lung, liver, the spleen channel.With eliminating dampness and eliminating phlegm, expel endogenous wind to relieve convulsion, the work(of mass dissipating and swelling eliminating
Effect.
Seaweed, it is bitter, salty, it is cold in nature；Return lung, stomach, the spleen channel.With softening and resolving hard mass, the effect of dissolving phlegm profit water.
Fructus Forsythiae, bitter, cold nature；Return lung, the heart, gallbladder channel.With clearing heat and detoxicating, the effect of carbuncle that disappears dissipating bind.
Euphorbia lunulata, it is bitter, pungent, it is cool in nature；Return lung, stomach, liver, the spleen channel.With kobadrin, dissipating bind is relieved oedema or abdominal distension through diuresis or purgation, detoxification desinsection it
Effect.
Pangolin, taste is salty, cold nature；Return liver, stomach.It is newborn under promoting menstruation with blood circulation promoting and dispersing pathogen accumulation, the effect of anti-stain in solid.
Cow-bezoar, it is sweet in flavor, it is cool in nature；Converge to heart and liver channels.With clearing away heart-fire and eliminating phlegm, the effect of cool liver of having one's ideas straightened out.
Desert cistanche, it is sweet in flavor, salty, it is warm-natured；Return kidney, large intestine channel.With kidney-reinforcing Yang-strengthening, the effect of relaxing bowel.
Chinese medicine thinks that the cause of disease of tumour is that exopathogen invasion, disorder of emotion, eating and drinking without temperance and labor are intended to internal injury etc..The interpretation of the cause, onset and process of an illness is weakened body resistance
The domination of pathogen, simulataneous insufficiency and excessive.The weakened body resistance predominantly deficiency of yang, the deficiency of Yin, gas yin and yang imbalance, the domination of pathogen are mainly the stagnation of the circulation of vital energy, phlegm solidifying, blood stasis, heat toxin etc..
Therefore treatment should adhere to promoting blood circulation and removing blood stasis, eliminating phlegm clearing damp, strengthening vital QI to eliminate pathogenic factors principle.In Chinese medicine preparation of the present invention, Semen Strychni (processed), five spirits
Fat can be promoting blood circulation and removing blood stasis, swelling and pain relieving；Hairyvein agrimony, Radix Isatidis, Fructus Forsythiae can be clearing heat and detoxicating, blood-stanching and blood-cooling；Realgar, cow-bezoar, Rhizoma Arisaematis (processed),
Euphorbia lunulata can be eliminating dampness and eliminating phlegm, mass dissipating and swelling eliminating, but can sensible cool liver, dissipating bind relieves oedema or abdominal distension through diuresis or purgation；Seaweed, pangolin can softening and resolving hard mass, dissolving phlegm profit
Water, invigorate blood circulation；Nitre can inducing diaphoresis bring down a fever, soothing liver-qi stagnation；Desert cistanche can kidney-reinforcing Yang-strengthening, strengthening the spleen and replenishing qi, righting reinforcing.All medicines are total
5, can recuperating qi-blood, adjustment negative and positive, training correction gas, cleaning " malicious source ", improve mesenchyma stroma of tumors cell function and reach anticancer and save one's life
Purpose.
Further to investigate the clinical efficacy of drug of the present invention, we have selected 150 patients to carry out clinical test, man 98
Example, female 52, age 28-70 Sui, average age 56 years old.It is made a definite diagnosis through cytology or pathology, KPS scorings > 60 divides, it is contemplated that
Life cycle > 3 months, wherein non-small cell lung cancer 32, breast cancer 38,24 Cases of Gastric Carcinoma, cancer of the esophagus 22, non-Hodgkin's leaching
Bar tumor 12, colorectal cancer 22 are just to control patient.It is randomly divided into treatment group and control group, every group 75.Two groups of pathological characteristics
In age, gender, behavioral aspect, tumour classification, chemotherapy regimen etc. indifference.
Criterion of therapeutical effect (treats efficacy assessment standard) according to WHO solid tumor drugs：
Complete incidence graph (CR)：Tumour is cured completely, and physical symptom restores normal.
Alleviate (PR) in part：Tumor area reduces obviously, and physical symptom is obviously improved.
Stablize (SD)：Tumor area is unchanged, and physical symptom is maintained the statusquo.
Deteriorate (PD)：Tumor area increases, and physical symptom deteriorates.
In addition, toxicity carries out toxicity assessment by WHO toxicity of anticancer agents reaction indexing (0-IV).
Therapy：
The Chinese medicine preparation of embodiment 2 is taken by treatment group, takes its concoction according to the method for the fried Chinese medicine of tradition, daily 1 dose, divides
3~4 times oral, and 30 doses are 1 course for the treatment of.It is discontinued 2~3 days between the course for the treatment of, then capable lower 1 course for the treatment of.Control group is taken according to symptom degree
Operation, chemicotherapy, embolism add the Western medicine auxiliary treatments such as cooperation brufen, rofecoxib.
Efficacy result：
Statistics patient on medication's the results are shown in Table 1.After treating three courses for the treatment of, the total effective rate 74.7% for the treatment of group；It is right
According to group total effective rate 46.7%；Two groups are compared, and treatment group's curative effect is apparently higher than control group.
Table 1：Count two groups of patient on medication's comparison tables
Adverse reaction：
Treatment group WBC reduces by 46 (61.3%)；Control group WBC reduces by 58 (77.3%), and treatment group group WBC is obviously few
In control group, significant difference (P < 0.05).Observation group's blood platelet, anaemia incidence be slightly below control group, but difference is without statistics
Learn meaning.It is shown in Table 2.
Table 2：Count the toxicity after two groups of patient's treatments
Note：* P < 0.05 compared with the control group
The result shows that Chinese medicine preparation of the invention has tumour cell significantly to resist after taking controls activity, it can be notable
Patient's body immunity is improved, tumour (cancer) cell is killed and inhibit, cure rate is high, recurrence rate is low, and pair nontoxic to human body is made
With substantially increasing patient's long term survival rate, be worth clinical application and popularization.
Specific implementation mode
Embodiment 1：A kind of antitumor Chinese medicine preparation chooses 10 grams of Semen Strychni (processed), 10 grams of excrementum pteropi, 5 grams of hairyvein agrimony, fire
5 grams of nitre, 5 grams of realgar, 8 grams of Radix Isatidis, 8 grams of Rhizoma Arisaematis (processed), 10 grams of seaweed, 8 grams of Fructus Forsythiae, 10 grams of euphorbia lunulata, 5 grams of pangolin, cow-bezoar 5
Gram, 5 grams of desert cistanche.
Embodiment 2：A kind of antitumor Chinese medicine preparation chooses 15 grams of Semen Strychni (processed), 15 grams of excrementum pteropi, 8 grams of hairyvein agrimony, fire
8 grams of nitre, 8 grams of realgar, 10 grams of Radix Isatidis, 12 grams of Rhizoma Arisaematis (processed), 15 grams of seaweed, 10 grams of Fructus Forsythiae, 15 grams of euphorbia lunulata, 8 grams of pangolin, ox
Yellow 8 grams, 8 grams of desert cistanche.
Embodiment 3：A kind of antitumor Chinese medicine preparation, choose 20 grams of Semen Strychni (processed), 20 grams of excrementum pteropi, 10 grams of hairyvein agrimony,
10 grams of nitre, 10 grams of realgar, 12 grams of Radix Isatidis, 15 grams of Rhizoma Arisaematis (processed), 20 grams of seaweed, 12 grams of Fructus Forsythiae, 20 grams of euphorbia lunulata, pangolin 10
Gram, 10 grams of cow-bezoar, 10 grams of desert cistanche.
The Chinese medicine preparation curative effect of the present invention is further verified below by specific case：
Case 1
Mr. Wang, female, 56 years old.Patient checked that prompt rumpbone single-shot tumour, patient have been run multiple hospitals, used not before 3 years
Few medicine spends a lot but also has no sign of improvement.In line with the psychology tried, takes Chinese medicine preparation embodiment 3 of the present invention and treat, one
The course for the treatment of is got off, and the state of an illness has greatly an improvement, and symptom is substantially without continuing taking the two courses and consolidated, patient is extensive at present
Multiple daily life, follow-up 2 years is without recurrence.
Case 2
Lee, female, 70 years old this year.Patient checks in March, 2010 suffers from tumor of breast, that is, performs the operation, recurred again after half a year.It examines
Worry patient age is bigger than normal, and operation risk is high again.Therefore upon somebody's introduction, start to take the treatment of Chinese medicine preparation embodiment 2 of the present invention,
After three courses for the treatment of, tumour disappears substantially, and patient body situation is greatly improved, treatment so far tumor manifestations without recurrence.
Case 3
Hu, man, 61 years old.Patient's readme is the year before because appearance is weak, dizzy, becomes thin, nervous symptom, Mr. Yu city two of going to a doctor
Institute is diagnosed as " bone fibre tumour ".It is treated using Chinese medicine preparation embodiment 1 of the present invention, the weak situation of fatigue is clearly better after 10 days,
Patient's confidence increases, it is desirable that continues to take, and adjusts each Chinese medicine dose in due course according to the state of an illness, after one and half courses for the treatment of, patient feels
There are strength, night sweat to mitigate earlier above, appetite improves.Continue after treatment, and take two courses for the treatment of, patient body is good so far
It is good, recovered normal life.Follow-up is so far without recurrence.
Case 4
Cao, man, 63 years old.Patient in 2012 start often feel left side chest pain, expiratory dyspnea, with cough,
The symptoms such as abundant expectoration check that disease is broken as malignant pleural tumour through local hospital.Patient refuses operation, is intent on treating using Chinese medicine.
After taking one course for the treatment of of Chinese medicine preparation of the present invention after being introduced, the patient feels chest pain mitigates, and complexion is also good, continues to take
With, after the treatment of 4 courses for the treatment of, check PET-CT displays left side pleura hypermetabolism tubercle and small strip lesion disappear substantially,
Patient is almost recovered.Follow-up is so far without recurrence.
Claims (4)
1. a kind of antitumor Chinese medicine preparation, which is characterized in that the Chinese medicine preparation by following weight in grams Chinese herb system
At：
10-20 grams of Semen Strychni (processed), 10-20 grams of excrementum pteropi, 5-10 grams of hairyvein agrimony, 5-10 grams of nitre, 5-10 grams of realgar, Radix Isatidis 8-
12 grams, 8-15 grams of Rhizoma Arisaematis (processed), 10-20 grams of seaweed, 8-12 grams of Fructus Forsythiae, 10-20 grams of euphorbia lunulata, 5-10 grams of pangolin, cow-bezoar 5-10
Gram, 5-10 grams of desert cistanche.
2. Chinese medicine preparation according to claim 1, which is characterized in that the Chinese medicine preparation is former by the Chinese medicine of following weight in grams
Material is made：
10 grams of Semen Strychni (processed), 10 grams of excrementum pteropi, 5 grams of hairyvein agrimony, 5 grams of nitre, 5 grams of realgar, 8 grams of Radix Isatidis, 8 grams of Rhizoma Arisaematis (processed), sea
10 grams of algae, 8 grams of Fructus Forsythiae, 10 grams of euphorbia lunulata, 5 grams of pangolin, 5 grams of cow-bezoar, 5 grams of desert cistanche.
3. Chinese medicine preparation according to claim 1, which is characterized in that the Chinese medicine preparation is former by the Chinese medicine of following weight in grams
Material is made：
15 grams of Semen Strychni (processed), 15 grams of excrementum pteropi, 8 grams of hairyvein agrimony, 8 grams of nitre, 8 grams of realgar, 10 grams of Radix Isatidis, 12 grams of Rhizoma Arisaematis (processed),
15 grams of seaweed, 10 grams of Fructus Forsythiae, 15 grams of euphorbia lunulata, 8 grams of pangolin, 8 grams of cow-bezoar, 8 grams of desert cistanche.
4. Chinese medicine preparation according to claim 1, which is characterized in that the Chinese medicine preparation is former by the Chinese medicine of following weight in grams
Material is made：
20 grams of Semen Strychni (processed), 20 grams of excrementum pteropi, 10 grams of hairyvein agrimony, 10 grams of nitre, 10 grams of realgar, 12 grams of Radix Isatidis, Rhizoma Arisaematis (processed) 15
Gram, 20 grams of seaweed, 12 grams of Fructus Forsythiae, 20 grams of euphorbia lunulata, 10 grams of pangolin, 10 grams of cow-bezoar, 10 grams of desert cistanche.
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| CN103566282A (en) * | 2012-07-27 | 2014-02-12 | 西安正大制药有限公司 | Traditional Chinese medicine composition with anti-tumor effect and preparation method thereof |
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Inventor after: Wang Yan Inventor after: Xu Bao Inventor after: Wang Guoliang Inventor after: Xu Zhaomin Inventor after: Cui Liping Inventor after: Xu Yanqing Inventor after: Wu Mingxia Inventor before: Cui Liping Inventor before: Xu Yanqing Inventor before: Wu Mingxia |
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Effective date of registration: 20200415 Address after: No. 16, Laiwu Pharmaceutical Industrial Park, Kou Town, Laiwu District, Jinan City, Shandong Province Patentee after: SHANDONG HEBAO PHARMACEUTICAL Co.,Ltd. Address before: 350200 305 units of 1 buildings in Jinjiang garden three District, Changle District, Fuzhou, Fujian, China Patentee before: The permanently happy head of district in Fuzhou City wins Information Technology Co.,Ltd. |
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Denomination of invention: An Antitumor Traditional Chinese Medicine Preparation Effective date of registration: 20230824 Granted publication date: 20181102 Pledgee: Laiwu Shandong rural commercial bank Limited by Share Ltd. Pledgor: SHANDONG HEBAO PHARMACEUTICAL Co.,Ltd. Registration number: Y2023980053684 |