CN104127550A - Medicine for treating chemoradiotherapy-induced thrombocytopenia and preparation method thereof - Google Patents

Abstract

The invention provides a medicine for treating chemoradiotherapy-induced thrombocytopenia and a preparation method thereof. The medicine is prepared from rhodiola rosea, American ginseng, deer-horn glue, herba epimedii, Semen cuscutae, pericarpium citri reticulatae, bighead atractylodes rhizome, astragalus membranaceus, angelica sinensis, longan aril, hairyvein agrimony and sarcandra glabra. The medicine provided by the invention has the effects of nourishing essence of kidney, warming yang and tonifying spleen, reinforcing qi and nourishing blood and stopping bleeding and removing stasis, can be used for realizing the effect of treating both symptoms and root causes on chemoradiotherapy-induced thrombocytopenia, eliminating clinical symptoms, and finally realizing the purpose of cure, thereby facilitating improvements on the living quality and prognosis of tumor patients. The pharmaceutical compositions in the medicine are obvious in effect and free from side effect during treatment of chemoradiotherapy-induced thrombocytopenia.

Description

Drug for treating thrombocytopenia caused by radiotherapy and chemotherapy and preparation method thereof

technical field

The invention relates to a medicine for treating thrombocytopenia, especially a medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy.

Background technique

The morbidity and mortality of malignant tumors are increasing year by year. At present, radiotherapy and chemotherapy are still an important means of comprehensive treatment of malignant tumors. Chemoradiation and chemotherapy often damage the normal bone marrow hematopoietic stem cells and the bone marrow hematopoietic microenvironment, resulting in myelosuppression and peripheral blood count reduction, especially neutrophil and thrombocytopenia, which can lead to infection or bleeding in severe cases, affecting further treatment of patients.

In recent years, with the widespread application of granulocyte colony-stimulating factor, neutropenia has been effectively controlled. For the treatment of thrombocytopenia caused by radiotherapy and chemotherapy, Western medicine mainly transfuses platelets, but there are problems such as short storage time, lack of blood supply sources, high cost, and possible blood-borne infections, blood transfusion reactions, and platelet antibody production; in recent years Although the commercially available recombinant interleukin-11 and thrombopoietin have good curative effects, they are expensive and their safety needs further study.

Traditional Chinese medicine believes that the tumor takes a long time to form, and the patient has multiple visceral qi disorders, or suffers from pathogenic toxins, resulting in stagnation of qi, blood stasis, phlegm and dampness, and the formation of tumors. Radiation and chemotherapy treatment is attacking treatment. The evil of heat and toxin can injure Qi and consume Yin, aggravate the loss of spleen and kidney, damage of Qi and blood, bone marrow suppression, thrombocytopenia, often accompanied by leukopenia and anemia. The clinical manifestations are weakness, fatigue, fatigue, dizziness, pale complexion, poor appetite, sore waist and legs, chills and fever, subcutaneous and gingival bleeding, etc. The spleen is the foundation of the acquired constitution, the source of qi and blood biochemistry, and the kidney is bound to be damaged if the spleen is deficient for a long time; Radiotherapy and chemotherapy lead to spleen and kidney damage, resulting in passive biochemistry of qi and blood, resulting in deficiency of qi and less blood, and bleeding due to inability to absorb blood due to qi deficiency. Therefore the therapeutic focus of the pharmaceutical composition of the present invention is to invigorate the kidney and essence, warm yang and invigorate the spleen, replenish qi and nourish blood, stop bleeding and remove blood stasis.

Contents of the invention

In order to obtain a new efficient and safe drug applicable to the treatment of thrombocytopenia caused by radiotherapy and chemotherapy and its preparation method, the present inventor has completed the present invention after a lot of in-depth research and sufficient creative work.

The invention relates to a medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy, which comprises rhodiola rosea, American ginseng, antler glue, epimedium, dodder, tangerine peel, atractylodes macrocephala, astragalus, angelica, longan meat, agrimony and sarcocarpus.

As an exemplary example, in the pharmaceutical composition, the content of specific components is as follows in parts by weight:

Rhodiola 5-12 parts, American ginseng 3-12 parts, antler glue 3-10 parts, epimedium 5-15 parts, dodder seed 5-20 parts, tangerine peel 3-8 parts, Atractylodes macrocephala 5-10 parts, astragalus 15- 50 parts, angelica 5-15 parts, longan meat 5-20 parts, agrimony 10-30 parts, swollen joint wind 5-15 parts.

Medicine of the present invention has preferred proportioning as:

Preferably, 6 parts of rhodiola, 5 parts of American ginseng, 4 parts of antler gum, 8 parts of epimedium, 6 parts of dodder, 4 parts of tangerine peel, 6 parts of Atractylodes macrocephala, 15 parts of astragalus, 5 parts of angelica, 12 parts of longan meat, crane 12 parts of grass, 6 parts of sarcophagus.

A kind of medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy as described above, its preparation method is: 1), according to the weight parts, take Epimedium, Cuscuta, Tangerine Peel, Atractylodes Rhizome, Radix Astragali, Angelica, Longan Meat, Agrimony , swollen joint wind, add 13 to 17 times the weight of decocting in water for 2.5 to 3.5 hours, filter and centrifuge to remove slag, and concentrate into a clear paste; 2), take the Rhodiola rosea and American ginseng in corresponding weight parts, and break into fine powder; 3 ), weighing corresponding parts by weight of deer horn gum and heating and curing with rice wine; 4), mixing the product obtained in steps 2) and 3) with the ointment described in step 1) to obtain the medicine.

Preferably, in step 1), add 15 times the weight of water and decoct for 3 hours.

The medicine can be prepared into tablets, capsules, powders, pills, granules, ointments or oral liquid preparations by adding conventional auxiliary materials and according to conventional techniques.

Among them, the main medicinal ingredients have the following effects:

Rhodiola rosea: bitter, sweet, flat, returns lung, heart meridian. Invigorating qi and activating blood circulation, dredging the pulse and relieving asthma. Tibetan medicine "Four Medical Codes" contains: flat nature, heat-clearing, nourishing vital energy, benefiting qi and nourishing blood, nourishing kidney, and treating fatigue all over the body. Modern pharmacological studies have proved that it has anti-oxidation, anti-aging, anti-radiation, anti-virus, anti-hypoxia, improvement of cardiovascular function, liver protection, etc., and it is safe and non-toxic.

American ginseng: bitter, slightly sweet, cold. Guixin, lung, kidney channel. Invigorating qi and nourishing yin, clearing fire and promoting body fluid.

Deer horn gum: sweet, salty, warm. Return liver, kidney channel. Invigorate the liver and kidney, benefit essence and blood, and stop bleeding.

Epimedium: pungent, sweet, warm. Return liver, kidney channel. Tonify kidney yang, strengthen muscles and bones, dispel wind and dampness.

Semen Cuscuta: pungent, sweet, flat. Return liver, kidney, spleen channel. Tonifying yang and benefiting yin, solidifying essence and reducing urination, nourishing liver and improving eyesight, nourishing spleen and stopping diarrhea.

Tangerine peel: pungent, bitter, warm. Return spleen, lung meridian. Regulating qi and invigorating the spleen, drying dampness and resolving phlegm.

Atractylodes macrocephala: sweet, bitter, warm. Return spleen, stomach warp. Invigorate the spleen and replenish qi, dry dampness and diuresis, solidify the surface and stop perspiration.

Radix Astragali: sweet, warm, returns spleen, lung meridian. Invigorate qi and promote yang, benefit health and solidify the exterior, detoxify and promote granulation, promote diuresis and reduce swelling.

Angelica: sweet, pungent, warm. Return liver, heart, spleen channel. Enriching blood, promoting blood circulation and relieving pain, moistening bowel and laxative.

Longan meat: sweet, warm. GUIXIN, Spleen Channel. Invigorate the heart and spleen, benefit qi and blood.

Agrimony: bitter, astringent, flat. Return lung, liver, spleen channel. Receiving astringent to stop bleeding, stop dysentery, tonic and strong.

Swollen joint wind: bitter, pungent, flat. GUIXIN, Liver Channel. Clearing away heat and cooling blood, promoting blood circulation and eliminating spots, expelling wind and dredging collaterals.

Beneficial effects of the present invention:

Combining the pharmacology and medicinal properties of the above raw materials, through a large number of studies and repeated clinical treatment trials, the drug of the present invention has been developed, which has the functions of nourishing kidney and essence, warming yang and invigorating spleen, nourishing qi and blood, and stopping bleeding and removing blood stasis. The medicine of the invention can achieve the effect of treating both symptoms and root causes of thrombocytopenia caused by radiotherapy and chemotherapy, eliminate clinical symptoms, finally achieve the purpose of curing, and help to improve the quality of life and prognosis of tumor patients. The pharmaceutical composition of the invention has remarkable effect on treating thrombocytopenia caused by radiotherapy and chemotherapy and has no side effect.

Detailed ways

The present invention will be described in detail below through specific examples, but the use and purpose of these exemplary embodiments are only used to exemplify the present invention, and do not constitute any form of any limitation to the actual protection scope of the present invention, nor will the present invention The scope of protection is limited to this.

Example 1

A medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy, in parts by weight, its specific component content is as follows:

5 parts of rhodiola rosea, 3 parts of American ginseng, 3 parts of deer horn glue, 5 parts of epimedium, 5 parts of dodder seed, 3 parts of tangerine peel, 5 parts of atractylodes rhizome, 15 parts of astragalus, 5 parts of angelica, 5 parts of longan meat, 10 parts of Agrimony , 5 parts of sarcomas.

The specific preparation method is as follows:

1), take epimedium, dodder seed, tangerine peel, Atractylodes macrocephala, astragalus, angelica, longan meat, agrimony, and sarcocarpus according to the weight parts, add 13 to 17 times the weight of water and decoct for 2.5 to 3.5 hours, filter and centrifuge Remove slag, concentrate into clear paste; 2), take the Rhodiola rosea and American ginseng of corresponding weight parts, and break into fine powder; 3), take the deer horn glue of corresponding weight parts and heat and melt with rice wine; 4), put The product obtained in steps 2), 3) is uniformly mixed with the ointment described in step 1) to obtain the drug.

Example 2

A medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy. In the pharmaceutical composition, the content of its specific components is as follows in parts by weight:

12 parts of rhodiola, 12 parts of American ginseng, 10 parts of deer horn glue, 15 parts of epimedium, 20 parts of dodder, 8 parts of tangerine peel, 10 parts of Atractylodes macrocephala, 50 parts of astragalus, 15 parts of angelica, 20 parts of longan meat, 30 parts of Agrimony , 15 parts of sarcomas.

The specific preparation method is as follows:

With embodiment 1.

Example 3

A medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy. In the pharmaceutical composition, the content of its specific components is as follows in parts by weight:

8 parts of rhodiola rosea, 6 parts of American ginseng, 6 parts of deer horn glue, 8 parts of epimedium, 8 parts of dodder seed, 4 parts of tangerine peel, 8 parts of Atractylodes macrocephala, 20 parts of astragalus, 10 parts of angelica, 8 parts of longan meat, 15 parts of Agrimony , 10 parts of sarcomas.

The specific preparation method is as follows:

With embodiment 1.

Example 4

A medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy. In the pharmaceutical composition, the content of its specific components is as follows in parts by weight:

10 parts of rhodiola rosea, 9 parts of American ginseng, 9 parts of deer horn glue, 12 parts of epimedium, 12 parts of dodder, 5 parts of tangerine peel, 10 parts of Atractylodes macrocephala, 25 parts of astragalus, 10 parts of angelica, 12 parts of longan meat, 20 parts of Agrimony , 10 parts of sarcomas.

The specific preparation method is as follows:

With embodiment 1.

Example 5

A medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy. In the pharmaceutical composition, the content of its specific components is as follows in parts by weight:

12 parts of rhodiola rosea, 10 parts of American ginseng, 10 parts of deer horn glue, 15 parts of epimedium, 15 parts of dodder, 6 parts of tangerine peel, 10 parts of Atractylodes macrocephala, 40 parts of astragalus, 15 parts of angelica, 18 parts of longan meat, 25 parts of Agrimony , 15 parts of sarcomas.

The specific preparation method is as follows:

With embodiment 1.

Example 6

A medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy. In the pharmaceutical composition, the content of its specific components is as follows in parts by weight:

6 parts of rhodiola, 5 parts of American ginseng, 4 parts of deer horn glue, 8 parts of epimedium, 6 parts of dodder, 4 parts of tangerine peel, 6 parts of Atractylodes macrocephala, 15 parts of astragalus, 5 parts of angelica, 12 parts of longan meat, 12 parts of Agrimony , 6 parts of sarcomas.

Concrete preparation method is with embodiment 1.

Cases and clinical effects:

case:

Wang, male, 72 years old. First visit on September 8, 2013.

The patient was holding his breath due to coughing and had bloody sputum for 4 months. He was diagnosed with right lung cancer and pleural effusion. The pathology was moderately differentiated adenocarcinoma. Chemotherapy (taxotere + cisplatin) has been performed for 4 cycles, and radiation therapy has been performed 10 times. Today's routine blood test showed white blood cells 2.20×10 ⁹ /L, platelet count 72×10 ⁹ /L, and hemoglobin 102g/L. The KPS score is 40 points. Symptoms include dry cough, fatigue, shortness of breath, dizziness, fear of cold, poor appetite, loose stools, yellow urine, no obvious subcutaneous and gingival bleeding. Fat tongue, pale red tongue, thin white fur, weak pulse. Thrombocytopenia was diagnosed after chemoradiotherapy for lung cancer.

Dialectical: Deficiency of the spleen and kidney, deficiency of both qi and blood.

Governing law: tonify the kidney and essence, replenish qi and nourish blood.

Prescription: Rhodiola rosea 10g, American ginseng 6g, deer horn glue 6g, epimedium 15g, dodder seed 20g, tangerine peel 6g, fried Atractylodes macrocephala 12g, astragalus 40g, angelica 10g, longan meat 20g, agrimony 20g, sarcophagus 10g. The above is the daily dosage.

Above-mentioned prescription is made granule according to embodiment 1. 3 times a day, 1 bag each time, take with boiling water.

Second visit: On September 14, after taking the medicine, the patient’s cough was relieved, fatigue and shortness of breath were significantly relieved, no dizziness and low-grade fever, diet increased, stools were normal, the tongue was light red and slightly fat, the fur was thin and white, and the pulse was weak. The blood test showed white blood cells 4.12×10 ⁹ /L, platelet count 103×10 ⁹ /L, hemoglobin 102g/L, and continued to take medicine for 7 days.

Third visit: On September 21, the patient had a slight cough and fatigue, shortness of breath during activities, normal diet and sleep, and normal bowel movements. The KPS score was 60 points, the routine blood test showed white blood cells 5.22×10 ⁹ /L, platelet count 121×10 ⁹ /L, hemoglobin 106g/L, and the blood picture returned to normal.

Zhang, male, 25 years old. First visit on April 27, 2014.

The patient suffered from pain and discomfort in the left upper abdomen and lost weight for half a year. Gastric cancer was diagnosed by gastroscopy. Postoperative diagnosis: gastric poorly differentiated adenocarcinoma stage IV (T ₃ N ₃ M ₀ ), and 4 cycles of chemotherapy (S-1 + Oxaliplatin) , still taking S-1. Routine blood test showed white blood cells 2.40×10 ⁹ /L, platelet count 68×10 ⁹ /L, hemoglobin 96g/L, KPS score 40 points, bleeding gums when brushing teeth, general fatigue, limp limbs, palpitations and nausea during activities , anorexia, belching, aversion to cold, weight loss, slightly dry stool, once every 2 days, a slightly fat tongue with tooth marks on the sides, pale red tongue with petechiae, thin white fur, thready and weak pulse. Thrombocytopenia was diagnosed after postoperative chemotherapy for gastric cancer.

Dialectical: Deficiency of spleen and kidney, deficiency of qi and blood.

Governing method: tonify the kidney and spleen, replenish qi and nourish blood.

Prescription: Rhodiola 10g, American ginseng 12g, antler gum 6g, epimedium 12g, dodder 20g, tangerine peel 8g, Atractylodes macrocephala 15g, astragalus 30g, angelica 10g, longan meat 20g, agrimony 20g, sarcophagus 10g. The above is the daily dosage.

Above-mentioned prescription is made into concentrated pill and taken according to embodiment 1, every day 3 times, each 1 bag, boiled water delivery service. After taking the medicine for 7 days, all the symptoms improved. The white blood cell count was 4.10×10 ⁹ /L, the platelet count was 103× ^{10 9} /L, and the hemoglobin was 105g/L. After taking the medicine for 14 days, the clinical symptoms disappeared. The count was 133×10 ⁹ /L, the hemoglobin was 112g/L, and the KPS score was 70 points. Continue to take the medicine in the future, and chemotherapy for 2 cycles, no obvious discomfort, reexamination blood routine is normal, no recurrence.

Lin, male, 58 years old. First visit on June 18, 2013. The patient had a chest mass-occupying lesion found in a physical examination two months ago. Chest CT and PET-CT were diagnosed as a thymic malignant tumor with metastases in both lungs, mediastinal lymph nodes, and supraclavicular lymph nodes. Squamous cell carcinoma was found in biopsy pathology. Consider primary thymic carcinoma. On May 10 and June 2, 2 cycles of chemotherapy with GP+Endostar regimen have been started. Chemotherapy response was obvious. Symptoms include dizziness, fatigue, shortness of breath during activities, lack of food, chills and warmth, weakness of the waist and knees, many subcutaneous hemorrhages in the lower limbs, some fused into flakes, and bleeding gums can be seen when brushing teeth or sucking. The tongue is fat and big with tooth marks on the sides, the tongue is pale, the tongue coating is thin and white, and the pulse is thready and weak. The blood routine white blood cell count was 2.30×10 ⁹ /L, the platelet count was 36×10 ⁹ /L, and the hemoglobin was 106g/L. The KPS score is 40 points.

Syndrome differentiation: Deficiency of spleen and kidney yang, deficiency of qi and blood, failure of qi to absorb blood

Therapeutic method: warming the yang and tonifying the kidney, replenishing qi and nourishing the blood

Prescription: Rhodiola rosea 15g, American ginseng 10g, antler glue 10g, epimedium 15g, dodder seed 12g, tangerine peel 6g, Atractylodes macrocephala 10g, astragalus 50g, angelica 10g, longan meat 20g, agrimony 30g, sarcophagus 15g. The above is the daily dosage.

Above-mentioned medicine is made capsule according to embodiment 1. 3 times a day, 4 capsules each time, take with boiled water.

Second visit: On July 5, the patient took the medicine for 7 days. The dizziness and fatigue were relieved, the shortness of breath was improved, the diet was increased, the sleep was improved, the chills were relieved, no new subcutaneous bleeding points, and a little gum bleeding was seen when brushing teeth. Recheck blood routine white blood cell 3.70×10 ⁹ /L, platelet count 62×10 ⁹ /L, hemoglobin 108g/L, KPS score 60 points, continue to take medicine.

Third visit: On July 12, the patient had no obvious dizziness, mild fatigue, shortness of breath during activities was significantly reduced compared with before, normal diet and sleep, no subcutaneous bleeding points, and no bleeding gums when brushing teeth. The KPS score is 70 points. Check blood routine white blood cell 4.2×10 ⁹ /L, platelet count 98×10 ⁹ /L, hemoglobin 113g/L. Follow up a case by regular visits to after and continue to take this medicine, continue chemotherapy for 2 cycles again, the state of an illness takes a turn for the better, and thrombocytopenia and leukopenia do not occur again.

Ma, male, 59 years old. First visit on March 13, 2014.

The patient had repeated abdominal pain and low back pain two months ago, and the CEA and CA-199 levels were significantly increased. He was diagnosed with pancreatic cancer and retroperitoneal lymph node metastasis by CT examination and PET-CT examination. GP regimen chemotherapy (gemcitabine 1000mg/m ² , intravenous infusion q1, q8; cisplatin 25mg/m ² , intravenous infusion, q1-3) has been given for 2 cycles. The present patient is fatigued, dizzy, lumbago, drowsy, nausea, poor appetite, lack of diet, loose stool, poor sleep, pinpoint-like bleeding points under the skin of the lower limbs, and bleeding gums when brushing teeth. The tongue is pale and tender, with tooth marks on the edge of the tongue, thin white fur, thready and weak pulse. The blood routine white blood cell count was 3.30×10 ⁹ /L, the platelet count was 56×10 ⁹ /L, and the hemoglobin was 108g/L. The KPS score is 50 points.

Syndrome differentiation: Deficiency of the spleen and kidney, Qi does not absorb blood

Treatment method: invigorate the spleen and kidney, replenish qi and absorb blood

Treatment: the medicine combination of Example 6 is made into tablet, and it is orally treated 3 times a day, and each dose is equivalent to crude drug 9g.

Second visit: On March 20, the patient took the medicine for 7 days, the fatigue and dizziness were relieved, the drowsiness improved, no nausea, the diet increased, the stool was slightly loose, the chills were relieved, the sleep improved, the subcutaneous bleeding spots had dissipated, and a little gum bleeding could be seen when brushing teeth. Recheck blood routine white blood cell 3.90×10 ⁹ /L, platelet count 78×10 ⁹ /L, hemoglobin 108g/L, KPS score 60 points, continue to take medicine. Third visit: On July 12, the patient had no obvious dizziness, mild fatigue, shortness of breath during activities was significantly reduced compared with before, normal diet and sleep, normal bowel movements, no subcutaneous bleeding points, and no bleeding gums when brushing teeth. The KPS score is 70 points. Check blood routine white blood cell 4.2×10 ⁹ /L, platelet count 106×10 ⁹ /L, hemoglobin 111g/L. I continued to take medication and prepared to continue chemotherapy.

clinical:

The pharmaceutical composition of the present invention has been used to clinically treat 62 patients with thrombocytopenia caused by tumor radiotherapy and chemotherapy. All patients were diagnosed as malignant tumors by cytology, histopathology or imaging examination. . Among them, there were 41 males and 21 females, aged 25-75 years, with an average of 59 years old; 21 cases of lung cancer, 12 cases of pancreatic cancer, 8 cases of breast cancer, 13 cases of gastric cancer, and 8 cases of colorectal cancer. The chemotherapeutic drugs used include gemcitabine, pemetrexed, cyclophosphamide, cisplatin, S-1, docetaxel, oxaliplatin, etc. 2 to 4 courses of chemotherapy have been given, and some patients have received radiation therapy simultaneously or successively.

Diagnosis and treatment scheme: use the medicine described in the present invention, select the medicine proportioning scheme of Embodiment 1-6 according to the patient's symptoms, and take it.

Thrombocytopenia diagnosis and curative effect standard: The thrombocytopenia caused by radiotherapy and chemotherapy is diagnosed according to the grading standard of antineoplastic drug toxicity (WHO, 1979), and the curative effect is judged by referring to the curative effect standard of relevant literature.

Significantly effective: platelets rise above 100×10 ⁹ /L;

Effective: platelets have recovered to 2 times or more but still not to 100×10 ⁹ /L;

Invalid: Those who fail to meet the markedly effective and effective evaluation standards.

Treatment results are shown in the following table (Table 1, Table 2):

Table 1. Platelet curative effect after treatment Cases (%)

Table 2. Number of cases distributed by severity of thrombocytopenia before and after treatment

The change of symptoms in patients is evaluated on a 5-point scale. After treatment, a decrease of ≥1 degree is considered improvement, an increase of ≥1 degree is defined as deterioration, and a decrease or increase of less than 1 degree is considered stable. The quality of life was evaluated with reference to the KPS score. An improvement of ≥10 points was considered improvement, a decrease of ≥10 points was considered deterioration, and an increase or decrease of less than 10 points was considered stable. The results are shown in the table below (Table 3).

Table 3 The improvement rate of patients' symptoms and KPS score after treatment Cases (%)

The above clinical research shows that: 62 cases of patients with thrombocytopenia caused by radiotherapy and chemotherapy were clinically treated with the pharmaceutical composition of the present invention. After 2 weeks of treatment, 49 cases were markedly effective, 10 cases were effective, and 3 cases were ineffective. The total effective rate reached 95.2%. After treatment, the clinical symptoms of the patients were also significantly improved, and the quality of life was improved, and no symptoms worsened.

Simultaneously, the pharmaceutical composition of the present invention has no toxic and side effects through clinical observation.

Claims (6)

1. A medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy, characterized in that: said medicine is composed of rhodiola rosea, American ginseng, antler gum, epimedium, dodder, tangerine peel, Atractylodes macrocephala, astragalus, angelica, longan meat, Agrimony , Swollen joint wind composition. 2. a kind of medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy as claimed in claim 1, is characterized in that, each component of described medicine is counted as: Rhodiola rosea 5-12 parts, American ginseng 3-12 parts , 3-10 parts of antler gum, 5-15 parts of epimedium, 5-20 parts of dodder, 3-8 parts of tangerine peel, 5-10 parts of Atractylodes macrocephala, 15-50 parts of astragalus, 5-15 parts of angelica, 5-5 parts of longan meat 20 parts, 10-30 parts of agrimony, 5-15 parts of sargassum. 3. A kind of medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy as claimed in claim 1 or 2, characterized in that, each component of the medicine is calculated in parts by weight: 6 parts of Rhodiola rosea, 5 parts of American ginseng, antler 4 parts of glue, 8 parts of epimedium, 6 parts of dodder, 4 parts of tangerine peel, 6 parts of Atractylodes macrocephala, 15 parts of astragalus, 5 parts of angelica, 12 parts of longan meat, 12 parts of agrimony, and 6 parts of sarcophagus. 4. a kind of medicine for treating thrombocytopenia caused by radiotherapy and chemotherapy as claimed in claim 1, its preparation method is: 1), take by weighing Epimedium Herba, Cuscuta Semen, Tangerine Peel, Atractylodes Rhizoma Atractylodes Rhizome, Radix Astragali, Radix Angelicae Sinensis, Add longan meat, agrimony, and swollen joints, add 13 to 17 times the weight of water and fry for 2.5 to 3.5 hours, filter and centrifuge to remove residue, and concentrate into a clear paste; 2), weigh the corresponding weight of rhodiola and American ginseng, crushed into fine powder; 3), take the deer horn glue of corresponding weight portion and heat and solidify with rice wine; 4), mix the product obtained in steps 2), 3) and the clear cream described in step 1) uniformly to obtain the medicine. 5. The medicine preparation method according to claim 4, characterized in that: said step 1) is decocting with 15 times the weight of water for 3 hours. 6. The medicine preparation method according to claim 4, characterized in that: the medicine is tablet, capsule, powder, pill, granule, ointment or oral liquid preparation.