CN103239519B - Anticancer pain-relieving traditional Chinese medicine composition - Google Patents
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Abstract
The invention relates to an anticancer pain-relieving traditional Chinese medicine composition, and in particular relates to a traditional Chinese medicine composition which is capable of preventing cancer and reliving pain. The anticancer pain-relieving traditional Chinese medicine composition comprises the following components in parts by weight: 5-20 parts of radix clematidis, 5-20 parts of radix aconiti preparata, 5-20 parts of centipede, 5-20 parts of scorpio, 5-20 parts of stiff silkworm, 5-20 parts of gecko, 5-20 parts of cockroach, 5-20 parts of Manis pentadactyla, 5-20 parts of Astragalus mongholicus, 5-20 parts of sea horse, 5-20 parts of Rhizoma Atractylodis Macrocephalae, 1-10 parts of Processed Semen Strychni, 0.1-1 part of venenum bufonis, 1-10 parts of borneol, and 0.5-5 parts of musk. The composition can enhance the immune system function and anti-cancer promotion ability, has obvious clinical effects, no side effects and low cost and is convenient to carry.
Description
Technical field
The invention belongs to technical field of Chinese medicines, especially relate to a kind of not only anticancer but also Chinese medicine composition of pain relieving.
Background technology
Disclose according to World Health Organization's data, about there are 1,400 ten thousand cancer patients in the current whole world, and wherein 30%-50% is with pain in various degree, and namely about there are 7,000,000 cancer pain patients in the whole world, and China accounts for 1,800,000 people.Recent two decades comes, and because environmental pollution increases the weight of, overworks, and mental pressure increases and chronic disease increase causes all kinds of cancer in succession to occur, cancer patient gets more and more.
The treatment of cancer patient is comparatively difficult, especially patient with advanced cancer protopathy and pain therapy are more difficult, pain degree administration is pressed in the many employings of Hospitals at Present: to mild pain person, and with non-opioid analgesic as indometacin, ibuprofen etc., its mechanism of action alleviates peripheral pain, alignment degree pain person, with weak opioid analgesic things such as codeine, to the person of having an intense pain, select strong opiates as morphine, opiates can suppress cerebral cortex pain sensation district, there is stronger analgesic activity, can add with phenytoin Sodium if desired, chlorpromazine, stable, the medicine adjuvant treatment effects such as meticorten are better, this method alleviates misery for many cancer patients really, but this kind of analgesia side effect is larger, easily cause peptic ulcer, dizzy, headache, feel sick, the symptoms such as vomiting and physiology and psychological dependence, need to strengthen dosage further, just analgesic effect can be reached, analgesic dosage increases and has increased the weight of again infringement to script weakened physical, therefore, this Analgesic techniques also needs to improve, many people have carried out in many ways exploring in pain relieving of cancers, but poor effect.
Chinese invention patent, application number 200310111522.0, name is called, and " a kind of analgesic " discloses a kind of drug regimen alleviating cancer pain; Chinese invention patent, application number 200510017543.5, name is called " medicine for treating pain of cancer ", disclose a kind of pain relieving of cancers medicine, these two kinds of pharmaceutical compositions, can only alleviate or eliminate pain, but can not be anticancer, at present, Chinese medicine and western medicine all fundamentally can not be broken through Therapeutic cancer and eliminate cancer pain and to develop simultaneously this difficult medical problem.Therefore, explore and study both Therapeutic cancer, the method that elimination cancer pain develops simultaneously again is the task of top priority of numerous medical workers.
Summary of the invention
The object of the invention is to provide that a kind of clinical efficacy is obvious, scientific formulation rationally, the not only anticancer but also anticancer pain-relieving Chinese medicine compositions of pain relieving.
The object of the present invention is achieved like this, according to Chinese medical theory, utilize the property of medicine of Chinese medicine uniqueness, adopt Radix Clematidis, Radix Aconiti Preparata, Scolopendra, Scorpio, Gekko Swinhonis, Blatta seu periplaneta, Squama Manis, Bombyx Batryticatus, the Radix Astragali, Hippocampus, the Rhizoma Atractylodis Macrocephalae, Semen Strychni processed, Venenum Bufonis, Borneolum Syntheticum, Moschus, according to certain compatibility requirement, through being processed into.
Prepare Chinese medicine composition of the present invention to be made up of following raw material medicaments: Radix Clematidis 5-20 part, Radix Aconiti Preparata 5-20 part, Scolopendra 5-20 part, Scorpio 5-20 part, Bombyx Batryticatus 5-20 part, Gekko Swinhonis 5-20 part, Blatta seu periplaneta 5-20 part, Squama Manis 5-20 part, Semen Strychni 1-10 part processed, Radix Astragali 5-20 part, Hippocampus 5-20 part, Rhizoma Atractylodis Macrocephalae 5-20 part, Venenum Bufonis 0.1-1 part, Borneolum Syntheticum 1-10 part, Moschus 0.5-5 part.
Optimum weight part of traditional Chinese medicine composite of the present invention is: Radix Clematidis 10 parts, Radix Aconiti Preparata 10 parts, Scolopendra 10 parts, Scorpio 10 parts, Bombyx Batryticatus 10 parts, Gekko Swinhonis 10 parts, Blatta seu periplaneta 10 parts, Squama Manis 10 parts, Semen Strychni processed 3 parts, the Radix Astragali 10 parts, Hippocampus 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Venenum Bufonis 0.2 part, Borneolum Syntheticum 2 parts, 1 part, Moschus.
Herbal pharmacology effect of the present invention is as follows:
Radix Clematidis: pungent, salty, warm, returns urinary bladder channel.Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, disappear a fishbone or other bone caught in the throat.For rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness.Can be used for clinically treating esophageal carcinoma.
Radix Aconiti Preparata: pungent, bitter, hot, GUIXIN, liver,spleen,kidney warp.Expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, narcotic analgesic.To hypophysis--interrenal system has excitation, and energy excited vagus maincenter, has heart tonifying, antiinflammatory, analgesia, local anaesthesia and cold resistance effect.
Scolopendra: pungent, warm, returns Liver Channel.Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Twitch for spasm, sore swollen toxin, rheumatoid arthritis stubborn, intractable headache, has antitumor, tuberculosis, antifungic action.
Scorpio: pungent, flat, returns Liver Channel.Endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation.For liver-wind stirring up internally, middle air port is oblique, hemiplegia, rheumatoid arthritis stubborn, migraine and general headache, skin infection scrofula.There are convulsion, blood pressure lowering, sedation.
Gekko Swinhonis: to expelling wind and relieving convulsion, detoxicating and resolving stagnation of pathogens.There is antitumaous effect, be used for the treatment of gastric cancer, hepatocarcinoma, pulmonary carcinoma.
Blatta seu periplaneta: salty, cold, main congestion, removing mass is poly-, throat closes.To murine sarcoma--180 have remarkable inhibitory action, and experiment in vitro is to sarcoma--180 cells have direct killing action, the phagocytic index of Turnover of Mouse Peritoneal Macrophages can be made significantly to increase, be used for the treatment of liver cancer efficacy remarkable.
Squama Manis: salty, be slightly cold, returns liver, stomach warp.Promoting blood circulation and detumescence, stimulate the menstrual flow dredging collateral.For carbuncle sore tumefacting virus, rheumatic arthralgia, paralysis due to windstroke.Put forward effect in increasing leukocyte.
Bombyx Batryticatus: salty, pungent, flat, returns liver, lung, stomach warp.Endogenous wind stopping relieving convulsion, wind-expelling pain-stopping, dissipating phlegm and resolving masses.For liver-wind folder expectorant, convulsion epilepsy is twitched, and middle air port is oblique, headache due to pathogenic wind-heat, conjunctival congestion pharyngalgia, rubella pruritus.To murine sarcoma--180 have inhibitory action.
The Radix Astragali: sweet, tepor, returns lung, spleen channel.Tonifying Qi and lifting yang, spermatogenesis nourishes blood, the stagnant blood stasis dispelling of row, expelling pus and promoting granulation.Weak for the deficiency of vital energy, sinking of QI of middle-JIAO, arthralgia pain is numb, and carbuncle difficulty is burst, and bursts for a long time and does not hold back.There is enhancing human body immunity power, diuresis, anti-aging effects.
Hippocampus: sweet, salty, warm, returns liver, kidney channel.Warming the kidney to invigorate YANG, blood circulation promoting and dispersing pathogen accumulation, reducing swelling and alleviating pain.For the sexual impotence enuresis, suffer from a deficiency of the kidney and breathe heavily, carbuncle furuncle.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, warm, returns spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels.There is antitumor, protect the liver, strengthen immunity function.
Semen Strychni processed: bitter, warm, returns liver, spleen channel.Removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating.For treating swelling and pain by traumatic injury, rheumatoid arthritis stubborn, skin sore, laryngopharynx swelling and pain.
Venenum Bufonis: pungent, warm, GUIXIN warp.Removing toxic substances, pain relieving, refreshment of having one's ideas straightened out.For carbuncle furuncle, laryngopharynx swelling and pain, stomachache is vomited and diarrhoea.There are antiinflammatory, antitumor, the effect of increase leukocyte.
Borneolum Syntheticum: pungent, bitter, be slightly cold, GUIXIN, spleen, lung meridian.To have one's ideas straightened out refreshment, clearing away heat to alleviate pain.For calentura coma, stagnation of QI sudden syncope, attacked by pestiferous factors stupor, obstruction of qi in the chest and cardialgia, laryngopharynx swelling and pain.There are antiinflammatory, antisepsis.
Moschus: pungent, warm, GUIXIN, spleen channel.Have one's ideas straightened out refreshment, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, for calentura coma, attacked by pestiferous factors stupor, obstruction of qi in the chest and cardialgia, trusted subordinate's sudden pain, fall and flutter the pain of injury, arthralgia pain is numb.There are antiinflammatory, antitumor action.
Described anticancer pain-relieving Chinese medicine compositions, the constituent content of dry product after various drug component content is and dries.
Described anticancer pain-relieving Chinese medicine compositions, weighs the medicine of each component by formula proportion, grinds, pulverizes, and after crossing 120 mesh sieves, makes required pharmaceutical dosage form.
Described pharmaceutical dosage form is powder, or is capsule, or is pill.
The present invention is according to the traditional Chinese medical science " general rule not bitterly, pain then obstructed ", " healthy energy deposit in, heresy can not be done ", the theory of " symptomatic treatment in acute condition, relieving the primary symptom in a chronic case, treating both the principal and secondary aspects of a disease ", the Chinese medicine of screening removing obstruction in the collateral to relieve pain, hard masses softening and resolving, righting QI invigorating.With Radix Clematidis, Radix Aconiti Preparata, Scolopendra, Scorpio, Bombyx Batryticatus for monarch drug; With Gekko Swinhonis, Blatta seu periplaneta, Squama Manis, Semen Strychni processed for ministerial drug; With the Radix Astragali, Hippocampus, the Rhizoma Atractylodis Macrocephalae for adjuvant drug; With Venenum Bufonis, Borneolum Syntheticum, Moschus for making medicine.Based on removing obstruction in the collateral to relieve pain, hard masses softening and resolving, righting QI invigorating is auxiliary, and the merit of existing long lasting analgesic can activate cancer patient's body immune system again, enhancing human body immunity power, thus enhancing body is to the identification of tumor cell, Scavenging activity.On the other hand, along with the raising of Abwehrkraft des Koepers, the pain territory of body and the tolerance to pain can be improved, strengthen analgesic effect.Scolopendra, Scorpio, Gekko Swinhonis also have dispersing pathogen accumulation function, can direct killing cancerous cell, enhancing body anti-cancer ability.
Chinese medicine composition clinical treatment 80 of the present invention routine cancer pain patient, clinical report is as follows:
1, physical data
80 examples all turn out to be malignant tumor patient through pathology, man 63 example, female 17 example, minimum 45 years old of age, maximum 85 years old, wherein hepatocarcinoma 16 example, esophageal carcinoma 18 example, gastric cancer 4 example, pulmonary carcinoma 14 example, nasopharyngeal carcinoma 12 example, oral cancer 1 example, bladder cancer 5 example.Slight pain 26 example, moderate pain 30 example, severe pain 24 example.
2, Therapeutic Method: to being diagnosed as cancer and taking medicine every day 2 times with pain person, each 3-6 gram, warm water is taken after mixing it with water, and 20 days is a course for the treatment of.
Moderate pain serve on 2-3 the course for the treatment of, and severe pain serve on 3-5 the course for the treatment of, routine examination liver function, kidney merit, hemogram before medication, and after medication, 2-3 week check liver function, kidney merit, hemogram are once.
3, criterion of therapeutical effect
3.1 pain calibration standards: mild pain, patient is pain slightly, does not substantially affect and has a rest and sleep; Moderate pain, patient pain is heavier, and impact is had a rest and sleep; Severe pain, patient pain is violent, is impatient at, and has a strong impact on and has a rest and sleep.
3.2 efficacy assessment standards: complete incidence graph, after administration 0.5-1 hour, pain disappears; Partial rcsponse, pain relief after administration 0.5-1 hour; Without alleviating, after administration, pain is unchanged or increase the weight of.
4, therapeutic outcome
4.1 pain relief situations: slight pain 26 example, alleviate 26 examples (100.0%); Moderate pain 30 example, complete incidence graph 15 example (50.0%), partial rcsponse 15 example (50.0%); Severe pain 24 example, partial rcsponse 20 example (83.3%), without alleviating 4 examples (16.6%), total effective rate 92.5%.
Liver function, kidney merit, White blood cell situation before and after 4.2 medications: liver function before and after medication, kidney merit, without significant change (P > 0.05), and leukocyte is all significantly improved (P < 0.05).
Patient's ordinary circumstance after 4.3 medications: after medication, patient's emotion and mental status are clearly better, appetite and food-intake obviously increase, and the length of one's sleep increases, and sleep quality improves, and along with patient pain is alleviated, quality of life improves, and strengthens beat cancer confidence.Medication has 32 examples (40.0%) patient lump to stablize after February, have 4 examples (5%) patient lump to reduce in various degree.
5. model case
5.1 men, 65 years old, are diagnosed as hepatocarcinoma through hospital, the bimester of being in hospital, every day, beginning analgesic effect was better because of hepatalgia intramuscular injection dolantin pain management, intramuscular injection every day once, its analgesic time was shorter and shorter afterwards, needed injection 3-4 time every day, changed oral anticancer pain-relieving Chinese medicine of the present invention 6 grams afterwards into, every day 2 times, good analgesic effect, takes this medicine always and does not occur hepatalgia again, until dead after a year and a half.
5.2 male, 70 years old, be diagnosed as adenocarcinoma of lung through fiberoptic bronchoscopy and pathologic finding, tumor about 3.8cm × 3.2cm × 2.6cm, start when seeking medical advice to occur pain, to its anticancer pain-relieving Chinese medicine of the present invention 3 grams, every day 2 times, after clothes, pain disappears completely, diet is normal, spirit is optimistic, checks tumor about 2.6cm × 2.1cm × 1.8cm after serveing on four courses for the treatment of, and because of cerebral hemorrhage, that all rescue measures proved ineffectual was dead afterwards.
5.3 female, 52 years old, are diagnosed as esophageal carcinoma through hospital, can not take food, dyspnea, can not put down sleeping, and pain is uncomfortable after there is breast, every day sustains life and pain relieving by transfusion, oxygen uptake, injection dolantin, takes anticancer pain-relieving Chinese medicine of the present invention 5 grams, every day 2 times, warm water slowly takes down, after second day patient's breastbone without pain and conscious dysphagia be clearly better, a little rice water can be taken, can to take food after one week medicated porridge group food, to take food after surrounding normal, and pain after there is not breastbone again.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, and this embodiment following does not only limit the present invention for illustration of the present invention.
Embodiment 1: a kind of anticancer pain-relieving Chinese medicine compositions, in units of weight portion, it is made up of following raw material medicaments: Radix Clematidis 5 parts, Radix Aconiti Preparata 5 parts, Scolopendra 5 parts, Scorpio 5 parts, Bombyx Batryticatus 5 parts, Gekko Swinhonis 5 parts, Blatta seu periplaneta 5 parts, Squama Manis 5 parts, Semen Strychni processed 5 parts, the Radix Astragali 5 parts, Hippocampus 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Venenum Bufonis 0.1 part, Borneolum Syntheticum 1 part, 0.5 part, Moschus.
Embodiment 2: a kind of anticancer pain-relieving Chinese medicine compositions, in units of weight portion, it is made up of following raw material medicaments: Radix Clematidis 10 parts, Radix Aconiti Preparata 10 parts, Scolopendra 10 parts, Scorpio 10 parts, Gekko Swinhonis 10 parts, Bombyx Batryticatus 10 parts, Blatta seu periplaneta 10 parts, Squama Manis 10 parts, Semen Strychni processed 3 parts, the Radix Astragali 10 parts, Hippocampus 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Venenum Bufonis 0.3 part, Borneolum Syntheticum 3 parts, 2 parts, Moschus.
Embodiment 3: a kind of anticancer pain-relieving Chinese medicine compositions, in units of weight portion, it is made up of following raw material medicaments: Radix Clematidis 20 parts, Radix Aconiti Preparata 20 parts, Scolopendra 20 parts, Scorpio 20 parts, Gekko Swinhonis 20 parts, Bombyx Batryticatus 20 parts, Blatta seu periplaneta 20 parts, Squama Manis 20 parts, Semen Strychni processed 10 parts, the Radix Astragali 20 parts, Hippocampus 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Venenum Bufonis 1 part, Borneolum Syntheticum 10 parts, 5 parts, Moschus.
Claims (6)
1. an anticancer pain-relieving Chinese medicine compositions, it is characterized in that: in units of weight portion, its ingredient by Radix Clematidis 5-20 part, make black river 5-20 part, Scolopendra 5-20 part, Scorpio 5-20 part, Bombyx Batryticatus 5-20 part, Gekko Swinhonis 5-20 part, Blatta seu periplaneta 5-20 part, Squama Manis 5-20 part, Radix Astragali 5-20 part, Hippocampus 5-20 part, Rhizoma Atractylodis Macrocephalae 5-20 part forms.
2. an anticancer pain-relieving Chinese medicine compositions, it is characterized in that: in units of weight portion, its ingredient by Radix Clematidis 5-20 part, make black river 5-20 part, Scolopendra 5-20 part, Scorpio 5-20 part, Bombyx Batryticatus 5-20 part, Gekko Swinhonis 5-20 part, Blatta seu periplaneta 5-20 part, Squama Manis 5-20 part, Radix Astragali 5-20 part, Hippocampus 5-20 part, Rhizoma Atractylodis Macrocephalae 5-20 part, Semen Strychni 1-10 part processed, Venenum Bufonis 0.1-1 part, Borneolum Syntheticum 1-10 part, Moschus 0.5-20 part forms.
3. anticancer pain-relieving Chinese medicine compositions according to claim 2, it is characterized in that: the constituent content of described Gekko Swinhonis is the constituent content of dry Gekko Swinhonis, described Scolopendra is the Scolopendra of drying, described Scorpio is the Scorpio of drying, described Blatta seu periplaneta is the Blatta seu periplaneta of drying, described Bombyx Batryticatus is the Bombyx Batryticatus dried, and described Hippocampus is the Hippocampus of drying.
4. anticancer pain-relieving Chinese medicine compositions according to claim 2, is characterized in that: described Radix Aconiti Preparata is the Radix Aconiti after concocting sterilization, and described Semen Strychni processed is the Semen Strychni after concocting sterilization.
5. anticancer pain-relieving Chinese medicine compositions according to claim 1 and 2, is characterized in that: weighed by formula proportion by the medicine of described each component, pulverize, cross after 120 mesh sieves, make required pharmaceutical dosage form.
6. anticancer pain-relieving Chinese medicine compositions according to claim 5, is characterized in that: described pharmaceutical dosage form is powder, or is capsule, or is pill.
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| CN107982399A (en) * | 2017-12-18 | 2018-05-04 | 青岛大学 | A kind of antitumor external application drug paste composition |
| CN118490736B (en) * | 2024-07-17 | 2024-09-24 | 长春中医药大学 | Traditional Chinese medicine composition for relieving cancer pain, external pain relieving preparation, and preparation method and application thereof |
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