CN103230562B - Traditional Chinese medicine formula for nourishing kidney and activating intestines and preparation method thereof - Google Patents
Traditional Chinese medicine formula for nourishing kidney and activating intestines and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine formula for nourishing kidney and activating intestines and a preparation method thereof. The traditional Chinese medicine formula comprises the following raw material medicines in parts by weight: 2-4 parts of rehmanniae praeparatum, 1-3 parts of fructus lycii, 1-3 parts of radix codonopsis, 1-3 parts of rhizoma dioscoreae, 1-3 parts of pericarpium arecae, 0.5-1.5 parts of cortex magnoliae officinalis, 0.5-1.5 parts of fructus amomi and 0.5-1.5 parts of radix aucklandiae. The traditional Chinese medicine formula disclosed by the invention realizes functions of nourishing kidney and strengthening spleen and regulating qi movement, and effectively improves the symptoms such as lack in desire to defecate, difficult start to defecate, reduction of defecating frequency, abdominal distension and the like caused by spleen and kidney deficiency and unsmooth qi movement.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to Chinese medicine formula of a kind of nourishing kidney fortune intestinal and preparation method thereof.
Background technology
Constipation, as a kind of sub-health state, has had a strong impact on the quality of life of people, and plays an important role in the diseases such as colon cancer, hepatic encephalopathy, presenile dementia.According to the series diagnosis standard of Rome functional gastrointestinal disorder, chronic constipation is divided into again slow-remove type (STC), Treatment of Outlet Obstruction Type (OOC) and mixed type, and wherein STC is wherein common type.
Chronic slow-transit constipation (STC) is clinical common persistent ailment, and because the cause of disease is complicated, pathogenesis is still not exclusively clear, difficult diagnosis, is the difficult problem in clinical treatment always.Modern medicine adopt Grading treatment, adopt western medicine more, but due to Western medicine curative effect how undesirable, and contraindication and complication more, finally seek help from operation, but operation genus have wound therapy, patient be generally difficult to accept.Therefore seek the slow Constipation of Chinese medicine and there is important clinical meaning.
Summary of the invention
Object of the present invention is exactly for above-mentioned defect of the prior art, provide a kind of pure Chinese drug preparation can nourishing kidney intestine moistening, effectively treatment constipation Chinese medicine formula.
To achieve these goals, technical scheme provided by the invention is: a kind of Chinese medicine formula of nourishing kidney fortune intestinal, described Chinese medicine formula comprises the crude drug according to following weight: Radix Rehmanniae 2-4 part, Fructus Lycii 1-3 part, Radix Codonopsis 1-3 part, Rhizoma Dioscoreae 1-3 part, Pericarpium Arecae 1-3 part, Cortex Magnoliae Officinalis 0.5-1.5 part, Fructus Amomi 0.5-1.5 part, Radix Aucklandiae 0.5-1.5 part.
Further, the Chinese medicine formula of above-mentioned a kind of nourishing kidney fortune intestinal, described Chinese medicine formula comprises the crude drug according to following weight: 3 parts, the Radix Rehmanniae, Fructus Lycii 2 parts, Radix Codonopsis 2 parts, Rhizoma Dioscoreae 2 parts, Pericarpium Arecae 2 parts, Cortex Magnoliae Officinalis 1 part, Fructus Amomi 1 part, the Radix Aucklandiae 1 part.
Second object of the present invention there is provided the preparation method of the Chinese medicine formula of above-mentioned nourishing kidney fortune intestinal, comprises the following steps:
1) by formula weighting raw materials, add water soaking 1-2 hour, the addition of water is for exceeding raw material powder 3-5cm;
2) the crude drug soak slow fire boiling 20-30 minute step 1) obtained;
3) by step 2) decoct after raw material medicinal liquid filter with cotton yarn, obtain nourishing kidney fortune intestinal Chinese medicine.
Further, above-mentioned preparation method, in described step 1), soak time is 5 hours, and the addition of water is for exceeding raw material powder 4cm.
Further, above-mentioned preparation method, described step 2) in, decocting time is 25 minutes.
Beneficial effect of the present invention is: the Chinese medicine formula of a kind of nourishing kidney fortune intestinal provided by the invention, can nourishing kidney spleen invigorating, regulating functional activities of qi, effective disease such as shortage awareness of defecation, defecation difficulty in starting, the minimizing of the stool frequency, abdominal distention improved caused by asthenia of both the spleen and kidney, functional activity of QI being not smooth, the property of medicine of its crude drug is as follows:
The Radix Rehmanniae: be also Radix Rehmanniae, has clearing away heat and cooling blood, effect that tonifying YIN promotes the production of body fluid;
Fructus Lycii: effect is nourishing the liver, nourishing kidney, lung moistening;
Radix Codonopsis: hinder or deficiency of both QI and blood for gas Tianjin two;
Rhizoma Dioscoreae: i.e. Rhizoma Dioscoreae, spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission;
Pericarpium Arecae: there is therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, effect of line water detumescence;
Cortex Magnoliae Officinalis: circulation of qi promoting removing food stagnancy, dampness is removed full, lowering the adverse QI to relieve asthma;
Fructus Amomi: removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive;
The Radix Aucklandiae: regulate the flow of vital energy in adjusting, drying dampness to eliminate phlegm.
Detailed directions is for can be made into oral liquid, concentrated oral liquid, powder, tablet, pill, granule, capsule.
Be below the preparation compliance test result of Chinese medicine formula provided by the invention:
1. clinical data:
MethodsThe cases enrolled 120 example, derives from the clinic case of the court's in June, 2009 in JIUYUE ,-2011, man 16 example, female 44 example; Age 20-76 year, average (51.3 ± 14.1) year; Course of disease 3.5-36, average (4.8 ± 5.2) year; Infrequent defecation time 3-6 days, average (4.8 ± 3.2) sky.All cases all meets the diagnostic criteria of chronic functional constipation in Roman II diagnosis, meet following in more than 2:
1. the defecation effort of more than 1/4;
2. be just hard more than 1/4 or bulk just;
3. the defecation of more than 1/4 is not felt to the greatest extent;
4. more than 1/4 defecation time have anal orifice and rectal intestine block sense;
5. need help by maneuver more than during 1/4 defecation;
6. 3 times are less than weekly;
7. organic constipation and constipation by outlet obstruction person is got rid of through whole body health check-up and physico-chemical examination.
Colonic transit test 72 hour-symbols thing discharges <80%, transmission index (label is at the residual number of the residual number/total colectomy of second rectum) (transitindex, TI) <0.5.All cases are by medical precedence, and by statistics random alignment table numbering, odd number group is treatment group, and even number set is matched group, wherein treatment group male 21 example, women 39 example; Matched group male 19 example, women 41 example.Through inspection, the sex of two groups, age, course of disease there was no significant difference (P>0.05), have comparability.
2. the preparation of " nourishing kidney fortune intestinal side ":
Nourishing kidney fortune intestinal side designs based on Syndrome Differentiation of Traditional Chinese Medicine, and be made up of the Chinese medicine of nourishing kidney yin, regulating qi-flowing for strengthening spleen, totally 8 tastes, dosage is followed theory of Chinese medical science " monarch " principle and determined.Prescription drug is boiled into medicinal liquid 200ml with decocting jointly, filters, packs.Medicinal liquid does not add other additive components.Preservation condition is 4 DEG C, and the pot-life is no more than 3.Every day 2 times, 200ml/ time, (medicine) being taken before meal is used sooner or later.Matched group gives mosapride, every day 3 times, 5mg/ time, bfore meals.Two groups of courses for the treatment of are January.
3. criterion of therapeutical effect:
Criterion of therapeutical effect with reference to related documents constipation is drafted in conjunction with symptom integral.
Recovery from illness: main transference cure, stool is normal, and integration 0 point, keeps more than 2 weeks.
Effective: main symptom is obviously improved, integration is comparatively treated front reduction and is reached 2/3, keeps more than 2 weeks.
Take a turn for the better: main symptom takes a turn for the better, integration reduction reaches l/2.
Invalid: symptom is not improved, integration is without reduction.
4. clinical efficacy:
Treatment group total effective rate is 85%, is obviously better than matched group (68.3%), and two groups of comparitive study differences have significant (P>0.05), and two groups of Clinical efficacy comparisons are as shown in table 1.
5. clinical symptoms change:
Before and after treatment group treatment the change of defecation cardinal symptom and somatic feature score compare (
± s) as shown in table 2.Before and after the treatment of every sings and symptoms integration comparing difference all have significant (
p<0.05).Treatment postcolon transport test check 12 example, normal 3 examples, take a turn for the better 7 examples, invalid 2 examples.Without untoward reaction such as Nausea and vomiting during patient consumes.
Compare with before treatment,
p<0.05.
6. colonic transit test result:
It is clear that made spherical radiopaque merkers develops in human body.Before treatment, experimental group and the routine patient of matched group 40 all see that mark gets rid of delay, and 48h mark slip is 20%; After treatment, visible experimental group patient 48h mark slip is 75%, and matched group 48h mark slip is 60%.
Detailed description of the invention
embodiment 1:
A Chinese medicine formula for nourishing kidney fortune intestinal, its crude drug is: 2 parts, the Radix Rehmanniae, Fructus Lycii 1 part, Radix Codonopsis 1 part, Rhizoma Dioscoreae 1 part, Pericarpium Arecae 1 part, Cortex Magnoliae Officinalis 0.5 part, Fructus Amomi 0.5 part, the Radix Aucklandiae 0.5 part
The preparation method of the Chinese medicine formula of nourishing kidney fortune intestinal, comprises the following steps:
1) by formula weighting raw materials, add water soaking 1 hour, the addition of water is for exceeding raw material powder 3cm, and formula ratio is;
2) crude drug soak slow fire boiling step 1) obtained 20 minutes;
3) by step 2) decoct after raw material medicinal liquid filter with cotton yarn, obtain nourishing kidney fortune intestinal Chinese medicine.
embodiment 2:
A Chinese medicine formula for nourishing kidney fortune intestinal, its crude drug is: 4 parts, the Radix Rehmanniae, Fructus Lycii 3 parts, Radix Codonopsis 3 parts, Rhizoma Dioscoreae 3 parts, Pericarpium Arecae 3 parts, Cortex Magnoliae Officinalis 1.5 parts, Fructus Amomi 1.5 parts, the Radix Aucklandiae 1.5 parts
The preparation method of the Chinese medicine formula of nourishing kidney fortune intestinal, comprises the following steps:
1) by formula weighting raw materials, add water soaking 2 hours, the addition of water is for exceeding raw material powder 5cm, and formula ratio is;
2) crude drug soak slow fire boiling step 1) obtained 30 minutes;
3) by step 2) decoct after raw material medicinal liquid filter with cotton yarn, obtain nourishing kidney fortune intestinal Chinese medicine.
embodiment 3:
A Chinese medicine formula for nourishing kidney fortune intestinal, its crude drug is: 3 parts, the Radix Rehmanniae, Fructus Lycii 2 parts, Radix Codonopsis 2 parts, Rhizoma Dioscoreae 2 parts, Pericarpium Arecae 2 parts, Cortex Magnoliae Officinalis 1 part, Fructus Amomi 1 part, the Radix Aucklandiae 1 part
The preparation method of the Chinese medicine formula of nourishing kidney fortune intestinal, comprises the following steps:
1) by formula weighting raw materials, add water soaking 2 hours, the addition of water is for exceeding raw material powder 4cm, and formula ratio is;
2) crude drug soak slow fire boiling step 1) obtained 25 minutes;
3) by step 2) decoct after raw material medicinal liquid filter with cotton yarn, obtain nourishing kidney fortune intestinal Chinese medicine.
Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. the Chinese medicine composition of a nourishing kidney fortune intestinal, it is characterized in that, described Chinese medicine composition is made up of the crude drug according to following weight: Radix Rehmanniae 2-4 part, Fructus Lycii 1-3 part, Radix Codonopsis 1-3 part, Rhizoma Dioscoreae 1-3 part, Pericarpium Arecae 1-3 part, Cortex Magnoliae Officinalis 0.5-1.5 part, Fructus Amomi 0.5-1.5 part, Radix Aucklandiae 0.5-1.5 part.
2. the Chinese medicine composition of a kind of nourishing kidney fortune intestinal according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the crude drug according to following weight: 3 parts, the Radix Rehmanniae, Fructus Lycii 2 parts, Radix Codonopsis 2 parts, Rhizoma Dioscoreae 2 parts, Pericarpium Arecae 2 parts, Cortex Magnoliae Officinalis 1 part, Fructus Amomi 1 part, the Radix Aucklandiae 1 part.
3. the preparation method of the Chinese medicine composition of nourishing kidney fortune intestinal according to claim 1 and 2, is characterized in that, comprise the following steps:
1) by formula weighting raw materials, add water soaking 1-2 hour, the addition of water is for exceeding raw material powder 3-5cm;
2) the crude drug soak slow fire boiling 20-30 minute step 1) obtained;
3) by step 2) decoct after raw material medicinal liquid filter with cotton yarn, obtain nourishing kidney fortune intestinal Chinese medicine.
4. preparation method according to claim 3, is characterized in that, in described step 1), soak time is 2 hours, and the addition of water is for exceeding raw material powder 4cm.
5. preparation method according to claim 3, is characterized in that, described step 2) in, decocting time is 25 minutes.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1457818A (en) * | 2002-05-16 | 2003-11-26 | 杨文志 | Poison expelling and astheniz resisting balance pill and its preparing method |
| CN101708327A (en) * | 2009-10-27 | 2010-05-19 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating diseases of weakness of spleen and stomach and indigestion and preparation method thereof |
| CN101884764A (en) * | 2009-05-15 | 2010-11-17 | 张春 | Medicament for treating chronic hepatitis splenomegaly or cirrhosis splenomegaly |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1457818A (en) * | 2002-05-16 | 2003-11-26 | 杨文志 | Poison expelling and astheniz resisting balance pill and its preparing method |
| CN101884764A (en) * | 2009-05-15 | 2010-11-17 | 张春 | Medicament for treating chronic hepatitis splenomegaly or cirrhosis splenomegaly |
| CN101708327A (en) * | 2009-10-27 | 2010-05-19 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating diseases of weakness of spleen and stomach and indigestion and preparation method thereof |
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Granted publication date: 20150415 Termination date: 20200428 |