CN104055975A - Anti-tumor traditional Chinese medicine preparation - Google Patents
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Abstract
The invention discloses an anti-tumor traditional Chinese medicine preparation which comprises the following crude drugs in parts by weight: 10-20g of processed semen strychni, 10-20g of trogopterus dung, 5-10g of hairyvein agrimony, 5-10g of potassium nitrate, 5-10g of realgar, 8-12g of radix isatidis, 8-15g of arisacma consanguineum, 10-20g of seaweed, 8-12g of fructus forsythiae, 10-20g of euphorbia lunulata, 5-10g of manis pentadactyla, 5-10g of calculus bovis and 5-10g of desert cistanche. The anti-tumor traditional Chinese medicine preparation is based on the principle of treating both symptoms and root cause of diseases of traditional Chinese medicine, has the effects of regulating vital energy and silting to relieve pain, clearing away heat and toxic materials, dissolving phlegm to remove stasis, promoting blood circulation to remove blood stasis and tonifying qi and yin, and has the advantages of rapid curative effect, high cure rate, safety, convenience, no toxic and side effects, low cost and the like in the anti-tumor aspect.
Description
Technical field
The invention belongs to the field of Chinese medicines, a kind of specifically can antineoplastic Chinese medicine preparation.
Background technology
Tumor be body tissue cell under the long term of inside and outside harmful factor, on gene level, lost the normal regulation to its growth, there is the neoplasm that hyperplasia and abnormal differentiation form, often with the form of lump, occur clinically.Once tumor forms, malignant tumor particularly, it is grown to autonomy, by cell division, entails filial generation, and growth phase, to not limited by body, is grown vigorous, and has aggressive and transitivity, and body is worked the mischief.Tumor incidence is higher, and China's case load is quite huge, has data to show and accounts for 55% of whole world case load.
Modern medicine thinks, the cause of disease of tumor is very complicated, be usually that a kind of carcinogenic factor can be brought out kinds of tumors, and a kind of tumor may have Different types of etiopathogenises.The hereditary material that most tumors are environmental factors and cell interacts and causes.Its clinical symptoms main manifestations is that body occurs that lump, pain, pathologic secretions, ulcer, hemorrhage, heating, cough, health are weak etc.Its pathogeneticing characteristic is paracytic growth out of control, and is sent out to other position by original site, and this sending out as uncontrollable exhaustion finally causes death by infringement critical organ with causing.
Modern medicine is a lot of at method and the medicine of anti-tumor aspect, doctor trained in Western medicine Radiotherapy chemotherapy, operative treatment malignant tumor curative effect are certainly, but toxic and side effects is large, main manifestations is bone marrow depression, gastrointestinal reaction, hepatic and renal function damage, cardiac toxicity etc., and medical expense is expensive, a lot of patients, owing to being difficult to bear high medical expense, affect the state of an illness adversely.Though Chinese medicine toxic and side effects is little, the most antitumor onset of existing medicine is slow, the course for the treatment of is long, seems unable to do what one wishes.
Summary of the invention
The invention solves the defect existing at anti-tumor aspect at present, a kind of stable curative effect, cheap is provided, can significantly improve body's immunity, accelerate physical recovery, alleviate Radiotherapy chemotherapy toxicity, improve the antineoplastic Chinese medicine preparation of long term survival rate.
The technical solution adopted in the present invention is: a kind of antineoplastic Chinese medicine preparation, it is characterized in that, and described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
Semen Strychni (processed) 10-20 gram, Oletum Trogopterori 10-20 gram, Herba Agrimoniae 5-10 gram, Sal Nitri 5-10 gram, Realgar 5-10 gram, Radix Isatidis 8-12 gram, Rhizoma Arisaematis (processed) 8-15 gram, Sargassum 10-20 gram, Fructus Forsythiae 8-12 gram, Herba euphorbiae lunulatae 10-20 gram, Squama Manis 5-10 gram, Calculus Bovis 5-10 gram, Herba Cistanches 5-10 gram.
As this kind of prioritization scheme:
Described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
10 grams of Semen Strychni (processed)s, 10 grams of Oletum Trogopteroris, 5 grams of Herba Agrimoniaes, 5 grams of Sal Nitri, 5 grams of Realgars, 8 grams of Radix Isatidis, 8 grams of Rhizoma Arisaematis (processed), 10 grams of Sargassums, 8 grams of Fructus Forsythiaes, 10 grams of Herba euphorbiae lunulataes, 5 grams of Squama Maniss, 5 grams of Calculus Boviss, 5 grams of Herba Cistanchess.
As this kind of prioritization scheme:
Described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
15 grams of Semen Strychni (processed)s, 15 grams of Oletum Trogopteroris, 8 grams of Herba Agrimoniaes, 8 grams of Sal Nitri, 8 grams of Realgars, 10 grams of Radix Isatidis, 12 grams of Rhizoma Arisaematis (processed), 15 grams of Sargassums, 10 grams of Fructus Forsythiaes, 15 grams of Herba euphorbiae lunulataes, 8 grams of Squama Maniss, 8 grams of Calculus Boviss, 8 grams of Herba Cistanchess.
As this kind of prioritization scheme:
Described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
20 grams of Semen Strychni (processed)s, 20 grams of Oletum Trogopteroris, 10 grams of Herba Agrimoniaes, 10 grams of Sal Nitri, 10 grams of Realgars, 12 grams of Radix Isatidis, 15 grams of Rhizoma Arisaematis (processed), 20 grams of Sargassums, 12 grams of Fructus Forsythiaes, 20 grams of Herba euphorbiae lunulataes, 10 grams of Squama Maniss, 10 grams of Calculus Boviss, 10 grams of Herba Cistanchess.
The instructions of taking of above-mentioned Chinese medicine preparation is: after the raw material Chinese medicine of above-mentioned weight proportion is mixed, according to the method for the fried Chinese medicine of tradition, get its medicine juice, 1 dose of every day, minutes 3～4 times oral, and 30 doses was 1 course for the treatment of.Between the course for the treatment of, drug withdrawal is 2～3 days, then goes lower 1 course for the treatment of.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation:
Semen Strychni (processed), bitter in the mouth, cold in nature; Return liver, spleen channel.There is the heat radiation of invigorating blood circulation, the effect of reducing swelling and alleviating pain.
Oletum Trogopterori, sweet in the mouth, warm in nature; Return Liver Channel.There is dredging blood vessel, the effect of eliminating stasis to stop pain.
Herba Agrimoniae, bitter in the mouth, cold in nature; GUIXIN, Liver Channel.There is astringing to arrest bleeding, tonify deficiency removing food stagnancy, dysentery relieving parasite killing, the effect of removing toxic substances and promoting subsidence of swelling.
Sal Nitri, bitter in the mouth, pungent, cold nature; Return liver, gallbladder meridian.Having induces sweat brings down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, the effect of elevate a turnable ladder yang-energy.
Realgar, bitter in the mouth, pungent is warm in nature, flat; GUIXIN, liver, stomach, lung meridian.There is removing toxic substances parasite killing, the effect of removing dampness and eliminating phlegm.
Radix Isatidis, bitter in the mouth, cold in nature; GUIXIN, stomach warp.There is heat-clearing and toxic substances removing, the effect of hemostasis removing heat from blood.
Rhizoma Arisaematis (processed), bitter in the mouth, pungent, warm in nature; Return lung, liver, spleen channel.There is drying dampness to eliminate phlegm, expelling wind to relieve convulsion, the effect of mass dissipating and swelling eliminating.
Sargassum, bitter in the mouth, salty, cold in nature; Return lung, stomach, spleen channel.There is hard masses softening and resolving, the effect of expectorant diuretic.
Fructus Forsythiae, bitter in the mouth, cold nature; Return lung, the heart, gallbladder meridian.There is heat-clearing and toxic substances removing, the effect of eliminating carbuncle eliminating stagnation.
Herba euphorbiae lunulatae, bitter in the mouth, pungent, cool in nature; Return lung, stomach, liver, spleen channel.Have relieving cough and expelling phlegm, eliminating stagnation is relieved oedema or abdominal distension through diuresis or purgation, the effect of the parasite killing of drawing out pus by applying a plaster to the affected part.
Squama Manis, salty in the mouth, cold nature; Return liver, stomach warp.There is blood circulation promoting and dispersing pathogen accumulation, the stimulating milk secretion of stimulating the menstrual flow, the effect of the routed heavily fortified point of eliminating carbuncle.
Calculus Bovis, sweet in the mouth, cool in nature; GUIXIN, Liver Channel.There is clearing away heart-fire and eliminating phlegm, the effect of the cool liver of having one's ideas straightened out.
Herba Cistanches, sweet in the mouth, salty, warm in nature; Return kidney, large intestine channel.There is kidney-reinforcing Yang-strengthening, the effect of loosening bowel to relieve constipation.
The traditional Chinese medical science thinks that the cause of disease of tumor is that exopathogen invasion and attack, disorder of emotion, eating and drinking without temperance and labor are wanted internal injury etc.Pathogenesis is vital QI being weakened and pathogen being violent, simulataneous insufficiency and excessive.Weakened body resistance yang deficiency, the deficiency of YIN, the gas yin and yang imbalance of being mainly, the domination of pathogen is mainly that the stagnation of QI, expectorant are solidifying, blood stasis, pyretic toxicity etc.Therefore treatment should be adhered to the principle of blood circulation promoting and blood stasis dispelling, expectorant damp eliminating, strengthening vital QI to eliminate pathogenic factors.In Chinese medicine preparation of the present invention, Semen Strychni (processed), Oletum Trogopterori can blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain; Herba Agrimoniae, Radix Isatidis, Fructus Forsythiae can heat-clearing and toxic substances removing, hemostasis removing heat from blood; Realgar, Calculus Bovis, Rhizoma Arisaematis (processed), Herba euphorbiae lunulatae can drying dampness to eliminate phlegm, and mass dissipating and swelling eliminating again can sensible cool liver, and eliminating stagnation is relieved oedema or abdominal distension through diuresis or purgation; Sargassum, Squama Manis can hard masses softening and resolving, expectorant diuretic, promoting blood circulation to restore menstrual flow; Sal Nitri can induce sweat and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI; Herba Cistanches can kidney-reinforcing Yang-strengthening, invigorating the spleen and benefiting QI, the body resistance strengthening and constitution consolidating.All medicines totally 5, can QI and blood regulating, regulating YIN and YANG, training revisal gas, cleaning " malicious source ", improves mesenchyma stroma of tumors cell function and reaches anticancer object of saving one's life.
For further investigating the clinical efficacy of medicine of the present invention, we have selected 150 routine patients to carry out clinical trial, male 98 examples, female's 52 examples, age 28-70 year, 56 years old mean age.All through cytology or pathology, make a definite diagnosis, KPS scoring > 60 minutes, expectation > life cycle 3 months, nonsmall-cell lung cancer 32 examples wherein, breast carcinoma 38 examples, 24 Cases of Gastric Carcinoma, esophageal carcinoma 22 examples, non-Hodgkin lymphoma 12 examples, colorectal cancer 22 examples, are and just control patient.Be divided at random treatment group and matched group, every group of 75 examples.Two groups of case features are at aspect zero differences such as age, sex, behavioral aspect, tumor classification, chemotherapy regimens.
Criterion of therapeutical effect (according to WHO solid tumor drugs treatment efficacy assessment standard):
Alleviate completely (CR): tumor is cured completely, it is normal that physical symptom recovers.
Partial rcsponse (PR): tumor area reducing is obvious, and physical symptom obviously improves.
Stable (SD): tumor area is unchanged, and physical symptom is maintained the statusquo.
Worsen (PD): tumor area change, physical symptom worsens.
Separately, toxicity is carried out toxicity assessment by WHO toxicity of anticancer agents reaction calibration (0-IV).
Therapeutic Method:
Treatment group is taken the Chinese medicine preparation of embodiment 2, according to the method for the fried Chinese medicine of tradition, gets its medicine juice, and 1 dose of every day, minutes 3～4 times oral, and 30 doses was 1 course for the treatment of.Between the course for the treatment of, drug withdrawal is 2～3 days, then goes lower 1 course for the treatment of.Matched group is taked operation, chemicotherapy, thromboembolism according to symptom degree, adds Western medicine auxiliary treatment such as coordinating ibuprofen, rofecoxib.
Efficacy result:
That adds up patient's drug administration the results are shown in Table 1.Treat after three courses for the treatment of the total effective rate 74.7% for the treatment of group; Matched group total effective rate 46.7%; Two groups of comparisons, treatment group curative effect is apparently higher than matched group.
Table 1: add up two groups of patient's drug administration result synopsis
Untoward reaction:
Treatment group WBC reduces 46 examples (61.3%); Matched group WBC reduces 58 examples (77.3%), and treatment group group WBC is obviously less than matched group, significant difference (P < 0.05).The incidence rate of observation group's platelet, anemia is a little less than matched group, but difference not statistically significant.In Table 2.
Table 2: add up the toxicity after two groups of patient treatments
Note: compare * P < 0.05 with matched group
Result shows, Chinese medicine preparation of the present invention is taken has the significantly anti-activity of controlling afterwards to tumor cell, can significantly improve patient's body immunity, kill and suppress tumor (cancer) cell, cure rate is high, relapse rate is low, human body is had no side effect, greatly improved patient's long term survival rate, clinic application and popularization.
The specific embodiment
Embodiment 1: a kind of antineoplastic Chinese medicine preparation, choose 10 grams of Semen Strychni (processed)s, 10 grams of Oletum Trogopteroris, 5 grams of Herba Agrimoniaes, 5 grams of Sal Nitri, 5 grams of Realgars, 8 grams of Radix Isatidis, 8 grams of Rhizoma Arisaematis (processed), 10 grams of Sargassums, 8 grams of Fructus Forsythiaes, 10 grams of Herba euphorbiae lunulataes, 5 grams of Squama Maniss, 5 grams of Calculus Boviss, 5 grams of Herba Cistanchess.
Embodiment 2: a kind of antineoplastic Chinese medicine preparation, choose 15 grams of Semen Strychni (processed)s, 15 grams of Oletum Trogopteroris, 8 grams of Herba Agrimoniaes, 8 grams of Sal Nitri, 8 grams of Realgars, 10 grams of Radix Isatidis, 12 grams of Rhizoma Arisaematis (processed), 15 grams of Sargassums, 10 grams of Fructus Forsythiaes, 15 grams of Herba euphorbiae lunulataes, 8 grams of Squama Maniss, 8 grams of Calculus Boviss, 8 grams of Herba Cistanchess.
Embodiment 3: a kind of antineoplastic Chinese medicine preparation, choose 20 grams of Semen Strychni (processed)s, 20 grams of Oletum Trogopteroris, 10 grams of Herba Agrimoniaes, 10 grams of Sal Nitri, 10 grams of Realgars, 12 grams of Radix Isatidis, 15 grams of Rhizoma Arisaematis (processed), 20 grams of Sargassums, 12 grams of Fructus Forsythiaes, 20 grams of Herba euphorbiae lunulataes, 10 grams of Squama Maniss, 10 grams of Calculus Boviss, 10 grams of Herba Cistanchess.
Below by concrete case, Chinese medicine preparation curative effect of the present invention is further verified:
Case 1
Wang, female, 56 years old.Patient checked prompting rumpbone single-shot tumor before 3 years, and patient Pao Liaoduojia hospital, has used many medicines, expensive but also have no sign of improvement.In line with the psychology of trying, take Chinese medicine preparation embodiment 3 treatments of the present invention, get off a course for the treatment of, and the state of an illness is improved greatly, and symptom has not had substantially, continues to take two courses for the treatment of and is consolidated, and patient has recovered daily life at present, follows up a case by regular visits to 2 years without recurrence.
Case 2
Lee, female, 70 years old this year.Patient checked and suffers from breast tumor in March, 2010, i.e. operation, recurrence again after half a year.Consider that patient age is bigger than normal, operation risk is high again.Therefore upon somebody's introduction, start to take Chinese medicine preparation embodiment of the present invention 2 treatments, after three courses for the treatment of, tumor disappears substantially, and patient body situation is greatly improved, and treats so far tumor symptom without recurrence.
Case 3
Hu, man, 61 years old.Patient's readme is weak because occurring, dizzy, the symptom of becoming thin, have palpitation the year before, and the medical Yu Mou city Second Academy is diagnosed as " the fine tumor of bone ".Adopt Chinese medicine preparation embodiment 1 treatment of the present invention, after 10 days, tired weak situation is clearly better, and patient's confidence increases, requirement continues to take, and adjusts each Chinese medicine dose according to the state of an illness in good time, after one and half courses for the treatment of, patient is conscious before strength, and night sweat alleviates, and appetite takes a turn for the better.Proceed after treatment, take again two courses for the treatment of, patient body is good so far, recovers orthobiosis.Follow up a case by regular visits to so far without recurrence.
Case 4
Cao, man, 63 years old.Patient started sensation left side chest pain often in 2012, dyspnea, with symptoms such as cough, abundant expectoration, breaks as malignant pleural tumor through local hospital inspection disease.Patient refuses operation, is intent on adopting treatment by Chinese herbs.Take after being introduced Chinese medicine preparation of the present invention after the course for the treatment of, patient feels that chest pain alleviates, and complexion is also good, continue to take, after the treatment of 4 courses for the treatment of, check PET-CT shows that left side pleura hypermetabolism tuberosity and little strip focus disappear substantially, and patient is almost recovered.Follow up a case by regular visits to so far without recurrence.
Claims (4)
1. an antineoplastic Chinese medicine preparation, is characterized in that, described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
Semen Strychni (processed) 10-20 gram, Oletum Trogopterori 10-20 gram, Herba Agrimoniae 5-10 gram, Sal Nitri 5-10 gram, Realgar 5-10 gram, Radix Isatidis 8-12 gram, Rhizoma Arisaematis (processed) 8-15 gram, Sargassum 10-20 gram, Fructus Forsythiae 8-12 gram, Herba euphorbiae lunulatae 10-20 gram, Squama Manis 5-10 gram, Calculus Bovis 5-10 gram, Herba Cistanches 5-10 gram.
2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is comprised of the raw material of following weight portion:
10 grams of Semen Strychni (processed)s, 10 grams of Oletum Trogopteroris, 5 grams of Herba Agrimoniaes, 5 grams of Sal Nitri, 5 grams of Realgars, 8 grams of Radix Isatidis, 8 grams of Rhizoma Arisaematis (processed), 10 grams of Sargassums, 8 grams of Fructus Forsythiaes, 10 grams of Herba euphorbiae lunulataes, 5 grams of Squama Maniss, 5 grams of Calculus Boviss, 5 grams of Herba Cistanchess.
3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is comprised of the raw material of following weight portion:
15 grams of Semen Strychni (processed)s, 15 grams of Oletum Trogopteroris, 8 grams of Herba Agrimoniaes, 8 grams of Sal Nitri, 8 grams of Realgars, 10 grams of Radix Isatidis, 12 grams of Rhizoma Arisaematis (processed), 15 grams of Sargassums, 10 grams of Fructus Forsythiaes, 15 grams of Herba euphorbiae lunulataes, 8 grams of Squama Maniss, 8 grams of Calculus Boviss, 8 grams of Herba Cistanchess.
4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is comprised of the raw material of following weight portion:
20 grams of Semen Strychni (processed)s, 20 grams of Oletum Trogopteroris, 10 grams of Herba Agrimoniaes, 10 grams of Sal Nitri, 10 grams of Realgars, 12 grams of Radix Isatidis, 15 grams of Rhizoma Arisaematis (processed), 20 grams of Sargassums, 12 grams of Fructus Forsythiaes, 20 grams of Herba euphorbiae lunulataes, 10 grams of Squama Maniss, 10 grams of Calculus Boviss, 10 grams of Herba Cistanchess.
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| CN103566282A (en) * | 2012-07-27 | 2014-02-12 | 西安正大制药有限公司 | Traditional Chinese medicine composition with anti-tumor effect and preparation method thereof |
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Denomination of invention: An Antitumor Traditional Chinese Medicine Preparation Effective date of registration: 20230824 Granted publication date: 20181102 Pledgee: Laiwu Shandong rural commercial bank Limited by Share Ltd. Pledgor: SHANDONG HEBAO PHARMACEUTICAL Co.,Ltd. Registration number: Y2023980053684 |