CN105412835A - Traditional Chinese medicine preparation for treating esophagus benign tumor - Google Patents

Traditional Chinese medicine preparation for treating esophagus benign tumor Download PDF

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CN105412835A
CN105412835A CN201510962485.7A CN201510962485A CN105412835A CN 105412835 A CN105412835 A CN 105412835A CN 201510962485 A CN201510962485 A CN 201510962485A CN 105412835 A CN105412835 A CN 105412835A
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radix
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chinese medicine
medicine preparation
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陈贵敏
韩平
韩雨霏
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Abstract

The invention discloses a traditional Chinese medicine preparation for treating an esophagus benign tumor. The traditional Chinese medicine preparation is prepared from radish seeds, seaweed, bezoar, fructus aurantii, excrementum pteropi, processed semen strychni, subprostrate sophora root, radix isatidis, indigo naturalis, agrimonia pilosa, arisacma consanguineum, salvia miltiorrhiza, pumice, arrowhead, radix paeoniae rubra, orange peel, vaccaria segetalis seed, spina gleditsiae, codonopsis pilosula, desert cistanche, rhizoma anemarrhenae, curcuma aromatica, liquorice and pangolin. The preparation has the advantages that the diagnosis, treatment and medication are performed on the basis of an overall analysis of the illness and the patient's condition in three aspects of strengthening the body resistance to tonify deficiency, dredging and dispersing blood stasis and counteracting and clearing away toxic substances; the organism immunity ability is improved; the blood microcirculation is promoted; the growth and the diffusion transferring of tumor cells are inhibited, so that the fundamental goals of regulating the human body yin and yang, the qi and blood and the internal organ physiological function balance can be achieved; the effects of relieving symptoms of the tumor, reducing the tumor body, inhibiting the tumor growth, improving the human body immunity and prolonging the life of a patient are achieved; the traditional Chinese medicine preparation is worthy of being clinically popularized and applied.

Description

A kind of Chinese medicine preparation for the treatment of esophagus benign goitre
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine preparation can treating esophagus benign goitre specifically.
Background technology
Benign tumor of esophagus is rarely found, in esophageal neoplasm, only account for 1%.Age of onset is little compared with the esophageal carcinoma, and symptom is made slow progress, and stadium is long.Modal in benign tumor of esophagus is leiomyoma, accounts for 90%, still has in addition and originates from mucous layer and submucosal polyp, lipoma, fibrolipoma, papilloma etc.Leiomyoma of esophagus is more common in middle-aged male.Leiomyoma multidigit is in distal esophagus and stage casing, and the overwhelming majority is solitary.Leiomyoma originates from esophageal wall muscle layer, slowly grows inside and outside esophageal lumen, and mucosa still keeps complete, does not thus cause hematemesis.Tumor is rounded, the oval or shape of a hoof, and have complete peplos, matter is tough and tensile, and tangent plane is canescence, has swirl shape structure tumor block, diameter 2 ~ 5cm, but can reach on 10cm if having time, hold long section esophagus.
The early treatment of benign tumor of esophagus is very important, and before not formed and blocking or shift, remove local lesion, control local pessimal stimulus well, just can reach curative effect, adopt is performed the operation and chemotherapy more at present.But because the ad-hoc location of esophagus cannot resemble Direct Surgery excision gastrointestinal tract, post-operation inflammatory also cannot be avoided to stimulate, often easily impel the transfer of tumor.And chemotherapy mainly suppresses for the explosion type division of cancer cell, because some cancerous cell is metastable, the same with normal cell certain period, such chemotherapeutics just can not react, also may be mutated into the situation of division at any time, easily repeatedly, treatment is difficult to thoroughly the state of an illness, and large to human body side effect.
Based on above-mentioned factor, increasing benign tumor of esophagus patient starts to seek help from Chinese traditional treatment.Therefore the present invention debates the principle of disease treating, treating both the principal and secondary aspects of a disease according to the traditional Chinese medical science, provide a kind of alleviation and treating primary cause combine, treat local and whole body nurse one's health the pure Chinese medicinal preparation combined, avoid carcinoid diffusion and transfer, substantially increase the life quality of patient, and extend life, improve survival rate.
Summary of the invention
Instant invention overcomes at present in the technical deficiency that the optimum swollen object space face for the treatment of esophagus exists, provide a kind of evident in efficacy, have no side effect, and can prevention of recurrence, transfer diffusion Chinese medicine preparation.
The technical solution adopted in the present invention is: a kind of Chinese medicine preparation for the treatment of esophagus benign goitre, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 10-20 gram, Sargassum 5-15 gram, Calculus Bovis 10-20 gram, Fructus Aurantii 10-20 gram, Oletum Trogopterori 10-20 gram, Semen Strychni (processed) 10-20 gram, Radix Sophorae Tonkinensis 10-20 gram, Radix Isatidis 10-20 gram, Indigo Naturalis 10-20 gram, Herba Agrimoniae 10-20 gram, Rhizoma Arisaematis (processed) 5-8 gram, Radix Salviae Miltiorrhizae 5-8 gram, Pumex 10-15 gram, arrowhead 5-8 gram, Radix Paeoniae Rubra 5-8 gram, Pericarpium Citri Reticulatae 10-15 gram, SEMEN VACCARIAE 5-8 gram, Spina Gleditsiae 5-8 gram, Radix Codonopsis 10-20 gram, Herba Cistanches 10-20 gram, Rhizoma Anemarrhenae 5-8 gram, Radix Curcumae 5-10 gram, Radix Glycyrrhizae 10-20 gram, Squama Manis 5-8 gram.
As a kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 10 grams, Sargassum 5 grams, Calculus Bovis 10 grams, Fructus Aurantii 10 grams, Oletum Trogopterori 10 grams, Semen Strychni (processed) 10 grams, Radix Sophorae Tonkinensis 10 grams, Radix Isatidis 10 grams, Indigo Naturalis 10 grams, Herba Agrimoniae 10 grams, Rhizoma Arisaematis (processed) 5 grams, Radix Salviae Miltiorrhizae 5 grams, Pumex 10 grams, arrowhead 5 grams, Radix Paeoniae Rubra 5 grams, Pericarpium Citri Reticulatae 10 grams, SEMEN VACCARIAE 5 grams, Spina Gleditsiae 5 grams, Radix Codonopsis 10 grams, Herba Cistanches 10 grams, the Rhizoma Anemarrhenae 5 grams, Radix Curcumae 5 grams, 10 grams, Radix Glycyrrhizae, Squama Manis 5 grams.
As a kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 12 grams, Sargassum 7 grams, Calculus Bovis 12 grams, Fructus Aurantii 12 grams, Oletum Trogopterori 12 grams, Semen Strychni (processed) 12 grams, Radix Sophorae Tonkinensis 12 grams, Radix Isatidis 12 grams, Indigo Naturalis 12 grams, Herba Agrimoniae 12 grams, Rhizoma Arisaematis (processed) 5 grams, Radix Salviae Miltiorrhizae 6 grams, Pumex 11 grams, arrowhead 5 grams, Radix Paeoniae Rubra 6 grams, Pericarpium Citri Reticulatae 11 grams, SEMEN VACCARIAE 5 grams, Spina Gleditsiae 6 grams, Radix Codonopsis 12 grams, Herba Cistanches 12 grams, the Rhizoma Anemarrhenae 6 grams, Radix Curcumae 6 grams, 12 grams, Radix Glycyrrhizae, Squama Manis 5 grams.
As a kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 14 grams, Sargassum 9 grams, Calculus Bovis 14 grams, Fructus Aurantii 14 grams, Oletum Trogopterori 14 grams, Semen Strychni (processed) 14 grams, Radix Sophorae Tonkinensis 14 grams, Radix Isatidis 14 grams, Indigo Naturalis 14 grams, Herba Agrimoniae 14 grams, Rhizoma Arisaematis (processed) 6 grams, Radix Salviae Miltiorrhizae 6 grams, Pumex 12 grams, arrowhead 6 grams, Radix Paeoniae Rubra 6 grams, Pericarpium Citri Reticulatae 12 grams, SEMEN VACCARIAE 6 grams, Spina Gleditsiae 6 grams, Radix Codonopsis 14 grams, Herba Cistanches 14 grams, the Rhizoma Anemarrhenae 6 grams, Radix Curcumae 7 grams, 14 grams, Radix Glycyrrhizae, Squama Manis 6 grams.
As a kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 16 grams, Sargassum 11 grams, Calculus Bovis 16 grams, Fructus Aurantii 16 grams, Oletum Trogopterori 16 grams, Semen Strychni (processed) 16 grams, Radix Sophorae Tonkinensis 16 grams, Radix Isatidis 16 grams, Indigo Naturalis 16 grams, Herba Agrimoniae 16 grams, Rhizoma Arisaematis (processed) 6 grams, Radix Salviae Miltiorrhizae 7 grams, Pumex 13 grams, arrowhead 6 grams, Radix Paeoniae Rubra 7 grams, Pericarpium Citri Reticulatae 13 grams, SEMEN VACCARIAE 7 grams, Spina Gleditsiae 6 grams, Radix Codonopsis 16 grams, Herba Cistanches 16 grams, the Rhizoma Anemarrhenae 6 grams, Radix Curcumae 8 grams, 16 grams, Radix Glycyrrhizae, Squama Manis 7 grams.
As a kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 18 grams, Sargassum 13 grams, Calculus Bovis 18 grams, Fructus Aurantii 18 grams, Oletum Trogopterori 18 grams, Semen Strychni (processed) 18 grams, Radix Sophorae Tonkinensis 18 grams, Radix Isatidis 18 grams, Indigo Naturalis 18 grams, Herba Agrimoniae 18 grams, Rhizoma Arisaematis (processed) 7 grams, Radix Salviae Miltiorrhizae 7 grams, Pumex 14 grams, arrowhead 7 grams, Radix Paeoniae Rubra 7 grams, Pericarpium Citri Reticulatae 14 grams, SEMEN VACCARIAE 7 grams, Spina Gleditsiae 7 grams, Radix Codonopsis 18 grams, Herba Cistanches 18 grams, the Rhizoma Anemarrhenae 7 grams, Radix Curcumae 9 grams, 18 grams, Radix Glycyrrhizae, Squama Manis 7 grams.
As a kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 20 grams, Sargassum 15 grams, Calculus Bovis 20 grams, Fructus Aurantii 20 grams, Oletum Trogopterori 20 grams, Semen Strychni (processed) 20 grams, Radix Sophorae Tonkinensis 20 grams, Radix Isatidis 20 grams, Indigo Naturalis 20 grams, Herba Agrimoniae 20 grams, Rhizoma Arisaematis (processed) 8 grams, Radix Salviae Miltiorrhizae 8 grams, Pumex 15 grams, arrowhead 8 grams, Radix Paeoniae Rubra 8 grams, Pericarpium Citri Reticulatae 15 grams, SEMEN VACCARIAE 8 grams, Spina Gleditsiae 8 grams, Radix Codonopsis 20 grams, Herba Cistanches 20 grams, the Rhizoma Anemarrhenae 8 grams, Radix Curcumae 10 grams, 20 grams, Radix Glycyrrhizae, Squama Manis 8 grams.
The instructions of taking of Chinese medicine preparation of the present invention is: after being mixed by the raw material Chinese medicine of above-mentioned weight proportion, 1 dose/day, every agent head decocts the 400mL that adds water, and warm fire boils 25 minutes, extracting juice 200mL; Two decoct the 300mL that adds water, and warm fire boils 20 minutes, extracting juice 150mL.Two decoct mixing, sooner or later decoction being taken hot, and 30 doses is a course for the treatment of.Drug withdrawal 2 ~ 3 days between the course for the treatment of, then go lower 1 course for the treatment of, serve on 2 ~ 3 courses for the treatment of.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation:
Semen Raphani, acrid in the mouth, sweet, property is put down; Return spleen, stomach, lung meridian.There is the de-swelling that helps digestion, effect of lowering the adverse-rising QI to resolve phlegm.Modern pharmacological research, raphanin can induce generation II phase enzyme (detoxification enzyme)-glutathione transferase (GST) and quinone reductase (QR) in each histoorgan of animal body, thus eliminate the infringement of chemical carcinogen, good active anticancer is shown to esophageal carcinoma, colon cancer, breast carcinoma etc.
Sargassum is bitter in the mouth, salty, cold in nature; Return lung, stomach, kidney channel.There is hard masses softening and resolving, effect of expectorant diuretic.Pharmaceutical research proves, seaweed extracted liquor proteoglycan can resist various virus, comprising HIV (human immunodeficiency virus) and carcinogenic RNA viruses.
Calculus Bovis, bitter in the mouth, sweet, cool in nature; GUIXIN, Liver Channel.Have removing heat from the heart to restore the consciousness, eliminating phlegm is calmed the frightened, effect of heat-clearing and toxic substances removing.Pharmacological research confirms, artificial Calculus Bovis is respectively 60% and 54.3% ~ 72.2% to sarcoma180 and sarcoma 37 suppression ratio.Virulizin has inhibitory action to a rat watt gram cancer 256, and suitable dosage can make tumor that extensive and serious necrosis occurs.
Fructus Aurantii, bitter in the mouth, pungent, sour, warm in nature; Return spleen, stomach warp.There is regulating the flow of QI to ease the stomach, effect of the stagnant relieving distension of row.Contained flavone compound has the important function such as antiinflammatory, antibacterial, antiviral, antitumor cell.
Oletum Trogopterori, sweet in the mouth, warm in nature; Return Liver Channel.There is promoting blood circulation, eliminating stasis to stop pain, effect of hemostasis by removing blood stasis, effectively can grow by inhibition tumor cell, improve body immunity.
Semen Strychni (processed), bitter in the mouth, warm in nature; Very toxic.Return liver, spleen channel.There is removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating effect.Inhibitory action is had to S180 sarcoma; Leukaemia is had to the effect of inhibit activities.
Radix Sophorae Tonkinensis, bitter in the mouth, cold; Attach to the lung and stomach meridians.There is heat-clearing and toxic substances removing, effect of relieving sore throat and diminishing swelling.DNA and the RNA synthesis of Radix Sophorae Tonkinensis to tumor cell has obvious inhibitory action, thus blocks the propagation of tumor cell, promotes lymphocyte transformation, excites or strengthen lymphocytic cytotoxicity, strengthen macrophage phagocytic function.
Radix Isatidis, bitter in the mouth, cold in nature; GUIXIN, stomach warp.There is effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, sore-throat relieving, be improved the function of immunity simultaneously.Pharmaceutical research proves, Radix Isatidis diketone can suppress the propagation of hepatoma cell line BEL-7402 and ovarian cancer A2780 cell, and has differentiation-inducing, the degraded expression of low telomerase activity and the reversing tumor cell ability to normal cell turnover.
Herba Agrimoniae, bitter in the mouth, puckery, property is put down; Return lung, liver, spleen channel.There is astringing to arrest bleeding, effect of dysentery relieving.Pharmaceutical research proves, Herba Agrimoniae almost reaches 100% to inhibition of cancer cell rate, and it is harmless to human normal cell, obvious analgesic effect is all had to various cancer, be considered to one of optimal cancer therapy drug in the world today, all tumour patients have a delicate constitution and the person that has bleeding concurrently, particularly suitable.
Indigo Naturalis, salty in the mouth, cold in nature; Return liver, lung, stomach warp.There is heat-clearing and toxic substances removing, effect of removing heat from blood detumescence.Pharmacological evaluation proves, indirubin contained in Indigo Naturalis has the inhibitory action of moderate strength to animal transplanting tumor; Be about 43% to the suppression ratio of pulmonary carcinoma; Also certain inhibitory action is had to mouse breast cancer.
Rhizoma Arisaematis (processed), bitter in the mouth, pungent, temperature; Return lung, liver, spleen channel.There is drying dampness to eliminate phlegm, effect of expelling wind to relieve convulsion.Zoopery shows, fresh Rhizoma Arisaematis aqueous extract has inhibitory action when 1:8 ~ 1:32 concentration to Hela cell, cell concentration is made to become agglomerate, destroy normal cell structure, part cell detachment, adding euphorbia egg decoctum HCA (hepatocarcinoma) solid type, U14 (for squamous epithelial cancer type cervical cancer is transplanted in mice person) etc. to mouse experiment tumor all has obvious inhibitory action.Vitro culture of human gastric cancer, pulmonary carcinoma, hepatoma carcinoma cell are are also killed and wounded and inhibitory action simultaneously.Research proves, containing the three lives pin injection of Rhizoma Arisaematis, has obvious inhibitory action, can suppress organism promote coagulate tube to the growth of murine hepatocarcinoma cell, the synthesis of DNA, RNA is suppressed to the suppression be better than protein synthesis.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.GUIXIN, pericardium, Liver Channel.There is blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, effect of nourishing blood to tranquillize the mind.Zoopery shows, Radix Salviae Miltiorrhizae obviously can extend the time-to-live of Ehrlich ascites carcinoma, and sodium tanshinon IIA silate injection can improve the effect of the anti-ehrlich carcinoma ascitic type (ECA) of hydroxy camptothecin.Radix Salviae Miltiorrhizae has Accommodation to the high microsteping albumen in the blood coagulation one fibrinolytic one platelet system disorder of tumor host without mass formed by blood stasis, cytotoxicity is had to mice S180 oncocyte, DNA can be suppressed to synthesize, act on the S phase in the tumor cell proliferation cycle, be i.e. DNA bis-times of proliferation periods.Radix Salviae Miltiorrhizae can also improve the anti-tumor activity of chemotherapeutics.
Pumex, salty, cold.Return lung, kidney channel.There is effect of removing heat from the lung and dissipating phlegm, hard masses softening and resolving.Pharmacological research proves, Pumex main component is silicate compound, has anti-cancer active matter in this type of silicate, can the growth of anticancer and transfer.
Arrowhead, bitter sweet, be slightly cold, there is clearing away heat to stop bleeding, removing toxic substances and promoting subsidence of swelling, eliminating stagnation effect.Rhizoma sagittariae sagittifoliae contains the multiple alkaloids such as colchicine, can improve the CAMP level in cancerous cell, the propagation of the mitotic cancerous cell of anticancer.There is anticancer swollen, removing toxicity for eliminating carbuncles effect, be commonly used to anti-curing oncoma.
Radix Paeoniae Rubra, bitter in the mouth, cold in nature; Return Liver Channel.There is clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, effect of reducing swelling and alleviating pain.Its water extract significantly can promote the formation of ehrlich carcinoma and W256 mouse ascites fluid, and obviously shorten the time-to-live of tumor-bearing mice, Radix Paeoniae Rubra extract significantly can promote the Lung metastases of Lewis lung cancer and euphorbia egg decoctum cell in tumor-bearing mice body.
Pericarpium Citri Reticulatae, acrid in the mouth, hardship, warm in nature; Return spleen, stomach, lung meridian.There is regulating the flow of Qi and the middle Jiao, drying dampness to eliminate phlegm, effect of diuretic relieving constipation.Pharmacology proves, in Pericarpium Citri Reticulatae contained flavone compound can inhibition tumor cell active, antioxidation prophylaxis of tumours, suppresses related enzyme activity, plays antitumor, endocrine regulation, play the generation of Tumor suppression blood vessel and the effect of growth.
SEMEN VACCARIAE, bitter in the mouth, property is put down; Return liver, kidney channel.Have promoting blood circulation to restore menstrual flow, stimulating milk secretion is subsided a swelling, effect of inducing diuresis for treating stranguria syndrome.Zoopery proves: Semen Vaccariae has obvious inhibitory action to animal tumor EC, S180.
Spina Gleditsiae, acrid in the mouth, warm in nature; Return liver, stomach warp.There is evacuation of pus of drawing out pus by applying a plaster to the affected part, effect of promoting blood circulation and detumescence.
Radix Codonopsis is put down, sweet in the mouth, there is effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, anticancer, blood pressure lowering, anti-hypoxia, defying age, body immunity can also be strengthened, improve the activity of superoxide dismutase, strengthen the ability eliminating free radical, there is the effect of Gastrointestinal motility adjustment, antiulcer, gastric acid secretion inhibiting, reduction pepsin activity.Be applicable to deficiency of the spleen and lung, the cough of cardiopalmus of breathing hard, anorexia and loose stool, ulcer, anemia, dyspnea due to deficiency, interior-heat such as to quench one's thirst at the disease.
Herba Cistanches is sweet in the mouth, salty, warm in nature; Return kidney, large intestine channel.There is kidney invigorating and YANG supporting, strong benefiting essence-blood, effect of loosening bowel to relieve constipation.Pharmacology proves, Herba Cistanches has adjustment endocrine, promote metabolism, activate the effect such as synthesis that adrenal gland discharges 17-hydroxy-11-dehydrocorticosterone, promotes salivation, promotes DNA, RNA.Can obviously strengthen human immunity regulating power after taking, improve and improve sexual function, defying age, anticancer etc.
The Rhizoma Anemarrhenae, bitter in the mouth, sweet, cold in nature; Return lung, stomach, kidney channel.There is clearing away heat-fire, nourshing Yin and drynsessmoistening prescription effect.Zhimusaponin has obvious inhibitory action to tumor cell.
Radix Curcumae is the gas medicine of blood system, both regulates the flow of vital energy, again blood stasis dispelling, dialectically commonly uses this product for qi depression to blood stasis person.Modern pharmacology proves, Radix Curcumae volatile oil injection can strengthen fibrinolytic, and passes through raising CAMP content and obvious anticoagulant, thus can play anticoagulant effect.
Radix Glycyrrhizae, sweet in the mouth, property is put down; GUIXIN, spleen, lung, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.There is removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer.Glycyrrhizic acid is topmost active component in Radix Glycyrrhizae.Glycyrrhizic acid and series of products thereof, have inhibitory action to sarcoma, growth of cancer cells, to the suppression ratio of acquired immune deficiency syndrome (AIDS) more up to 90%, has stronger increase immune function of human body effect.
Squama Manis, salty in the mouth, cold nature; Return liver, stomach warp.There is promoting blood circulation to restore menstrual flow, stimulating milk secretion, effect of detumescence and apocenosis.Squama Manis energy priming is descending, and through intralesional, attacks cancerization tumor, lump fast softening is reduced, has good antitumaous effect.
Traditional Chinese medical science medical science thinks that the esophageal carcinoma belongs to " dysphagic " category, and the generation of the esophageal carcinoma and internal organs QI and blood insufficiency of function, feel again external heresy, or raw in pathogen, causes the stagnation of QI, stagnation of phlegm, blood stasis etc. and ties in esophagus mutually, with the passing of time do not fall apart, turn to cancerous protuberance.Its disease character is deficiency in origin and excess in superficiality, and sick position, at esophagus, belongs to gastric qi and led, closely related with liver,spleen,kidney, mostly is the card of deficiency in origin and excess in superficiality.Mark is real is that the stagnation of QI, stagnation of phlegm, blood stasis etc. are held concurrently mutually; Deficiency in origin is deficiency of fluid and concentration of blood, and deficiency of YIN affecting YANG etc., form esophageal stricture jointly, and body fluid dries up, and is its crucial pathogenesis.Therefore treatment when with tonify deficiency, resolving depression, eliminate the phlegm, removing toxic substances, removing blood stasis be for principle.
This Chinese medicine preparation is empty according to the pathogeny of esophagus early lesion patients with terminal, the stasis of blood, poison, make overall plans, take righting, dredging, the large countermeasure of toxic removing three, shoot the arrow at the target, emphasis medication, by righting tonify deficiency, dredge blood stasis dispelling, the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs medication of counteracting toxic substances toxin expelling three aspect, improve body immunity, promote blood microcirculation, inhibition tumor cell growth and diffusion transfer, thus reach adjustment yin-Yang, QI and blood, the basic goal of internal organs physiological function balance, to tumor, there is certain relief of symptoms, reduce tumor body, Tumor suppression grows, improve body immunity, extend the effect of patient vitals.
Pharmacy test:
1. animal acute toxicity test
Acute toxicity test is carried out respectively with Mouse and rat, by Cmax (5g crude drug/ml) and maximum administration volume (mice 0.4ml/10g body weight, rat 2ml/100g body weight) one day twice gavage Chinese medicine preparation of the present invention, observe one week, result is none routine animal dead in experimentation, also without any toxic reaction.
2. long-term toxicity test for animals
With WISTAR rat, long term toxicity test is carried out to medicament of the present invention, divide high, normal, basic three dosage (100g crude drug/kg, 30g crude drug/kg, 10g crude drug/kg, calculate according to kg body weight, be equivalent to 40 times, 12 times, 4 times of adult's medication respectively), every day 2 times, continuous medicine-filling 3 months.Result shows except animal blood glucose slightly raises (P < 0.05), other non-evident sympton.
Result shows, Chinese medicine preparation of the present invention is without any side effects, is safe in the normal clinical scope of application.
3. Clinical Treatment Test
For investigating clinical efficacy and the safety of medicine of the present invention further, we have selected 30 routine benign esophageal tumor patients and have carried out clinical experiment, all patients be admitted to hospital after contrast examination, gastroscopy and breast CT inspection are made a definite diagnosis.The research standard included in is, tumor size at more than 2cm, single-shot or multiple smooth muscle tumor patient.In 30 routine patients male 17 example, women 13 example, age 35-80 year, average 50.9 years old, the course of disease 1 month-5 years, average 16 months; According to knub position, 8 routine breast epimeres, 10 routine Middle Thoracics, 12 routine breast hypomeres, diameter of tumor at 2-11cm, average 5.2cm.
Therapeutic Method:
All patients all take Chinese medicine preparation of the present invention, and by (with disease plus-minus) after the mixing of the raw material Chinese medicine of above-mentioned weight proportion, 1 dose/day, every agent head decocts the 400mL that adds water, and warm fire boils 25 minutes, extracting juice 200mL; Two decoct the 300mL that adds water, and warm fire boils 20 minutes, extracting juice 150mL.Two decoct mixing, sooner or later decoction being taken hot.It within 30 days, is a course for the treatment of.
Criterion of therapeutical effect:
Formulate with reference to efficacy assessment standard dysphagic in " tcm internal medicine Illnesses Diagnoses criterion of therapeutical effect ".
Cure: clinical symptom disappearance, barium meal X-ray examination, take the photograph sheet or boroscopy and recover normal, life quality Ka Shi scoring reaches 100 points.
Effective: clinical symptoms is improved, barium meal X-ray examination, take the photograph sheet or boroscopy is clearly better, life quality Ka Shi marks increase by 20 points.
Effective: clinical symptoms is improved substantially, barium meal X-ray examination, take the photograph sheet or boroscopy take a favorable turn, life quality Ka Shi increase of marking is less than 20 points
Invalid: clinical symptoms and sign are all without improvement or deterioration, and life quality Ka Shi marks without improving.
Therapeutic outcome:
After treatment, cure 13 examples in 30 routine patients, effective 11 examples, effective 5 examples, invalid 1 example, cure rate is 43.3%, and effective percentage is 96.7%.
Result shows that Chinese medicine preparation of the present invention is used for the treatment of esophagus benign goitre and has determined curative effect, has no side effect, and is a kind of good medicine for the treatment of and improving benign tumor of esophagus, clinic promotion and application.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine preparation for the treatment of esophagus benign goitre, chooses Semen Raphani 10 grams, Sargassum 5 grams, Calculus Bovis 10 grams, Fructus Aurantii 10 grams, Oletum Trogopterori 10 grams, Semen Strychni (processed) 10 grams, Radix Sophorae Tonkinensis 10 grams, Radix Isatidis 10 grams, Indigo Naturalis 10 grams, Herba Agrimoniae 10 grams, Rhizoma Arisaematis (processed) 5 grams, Radix Salviae Miltiorrhizae 5 grams, Pumex 10 grams, arrowhead 5 grams, Radix Paeoniae Rubra 5 grams, Pericarpium Citri Reticulatae 10 grams, SEMEN VACCARIAE 5 grams, Spina Gleditsiae 5 grams, Radix Codonopsis 10 grams, Herba Cistanches 10 grams, the Rhizoma Anemarrhenae 5 grams, Radix Curcumae 5 grams, 10 grams, Radix Glycyrrhizae, Squama Manis 5 grams.
Embodiment 2: a kind of Chinese medicine preparation for the treatment of esophagus benign goitre, chooses Semen Raphani 12 grams, Sargassum 7 grams, Calculus Bovis 12 grams, Fructus Aurantii 12 grams, Oletum Trogopterori 12 grams, Semen Strychni (processed) 12 grams, Radix Sophorae Tonkinensis 12 grams, Radix Isatidis 12 grams, Indigo Naturalis 12 grams, Herba Agrimoniae 12 grams, Rhizoma Arisaematis (processed) 5 grams, Radix Salviae Miltiorrhizae 6 grams, Pumex 11 grams, arrowhead 5 grams, Radix Paeoniae Rubra 6 grams, Pericarpium Citri Reticulatae 11 grams, SEMEN VACCARIAE 5 grams, Spina Gleditsiae 6 grams, Radix Codonopsis 12 grams, Herba Cistanches 12 grams, the Rhizoma Anemarrhenae 6 grams, Radix Curcumae 6 grams, 12 grams, Radix Glycyrrhizae, Squama Manis 5 grams.
Embodiment 3: a kind of Chinese medicine preparation for the treatment of esophagus benign goitre, chooses Semen Raphani 14 grams, Sargassum 9 grams, Calculus Bovis 14 grams, Fructus Aurantii 14 grams, Oletum Trogopterori 14 grams, Semen Strychni (processed) 14 grams, Radix Sophorae Tonkinensis 14 grams, Radix Isatidis 14 grams, Indigo Naturalis 14 grams, Herba Agrimoniae 14 grams, Rhizoma Arisaematis (processed) 6 grams, Radix Salviae Miltiorrhizae 6 grams, Pumex 12 grams, arrowhead 6 grams, Radix Paeoniae Rubra 6 grams, Pericarpium Citri Reticulatae 12 grams, SEMEN VACCARIAE 6 grams, Spina Gleditsiae 6 grams, Radix Codonopsis 14 grams, Herba Cistanches 14 grams, the Rhizoma Anemarrhenae 6 grams, Radix Curcumae 7 grams, 14 grams, Radix Glycyrrhizae, Squama Manis 6 grams.
Embodiment 4: a kind of Chinese medicine preparation for the treatment of esophagus benign goitre, chooses Semen Raphani 16 grams, Sargassum 11 grams, Calculus Bovis 16 grams, Fructus Aurantii 16 grams, Oletum Trogopterori 16 grams, Semen Strychni (processed) 16 grams, Radix Sophorae Tonkinensis 16 grams, Radix Isatidis 16 grams, Indigo Naturalis 16 grams, Herba Agrimoniae 16 grams, Rhizoma Arisaematis (processed) 6 grams, Radix Salviae Miltiorrhizae 7 grams, Pumex 13 grams, arrowhead 6 grams, Radix Paeoniae Rubra 7 grams, Pericarpium Citri Reticulatae 13 grams, SEMEN VACCARIAE 7 grams, Spina Gleditsiae 6 grams, Radix Codonopsis 16 grams, Herba Cistanches 16 grams, the Rhizoma Anemarrhenae 6 grams, Radix Curcumae 8 grams, 16 grams, Radix Glycyrrhizae, Squama Manis 7 grams.
Embodiment 5: a kind of Chinese medicine preparation for the treatment of esophagus benign goitre, chooses Semen Raphani 18 grams, Sargassum 13 grams, Calculus Bovis 18 grams, Fructus Aurantii 18 grams, Oletum Trogopterori 18 grams, Semen Strychni (processed) 18 grams, Radix Sophorae Tonkinensis 18 grams, Radix Isatidis 18 grams, Indigo Naturalis 18 grams, Herba Agrimoniae 18 grams, Rhizoma Arisaematis (processed) 7 grams, Radix Salviae Miltiorrhizae 7 grams, Pumex 14 grams, arrowhead 7 grams, Radix Paeoniae Rubra 7 grams, Pericarpium Citri Reticulatae 14 grams, SEMEN VACCARIAE 7 grams, Spina Gleditsiae 7 grams, Radix Codonopsis 18 grams, Herba Cistanches 18 grams, the Rhizoma Anemarrhenae 7 grams, Radix Curcumae 9 grams, 18 grams, Radix Glycyrrhizae, Squama Manis 7 grams.
Embodiment 6: a kind of Chinese medicine preparation for the treatment of esophagus benign goitre, chooses Semen Raphani 20 grams, Sargassum 15 grams, Calculus Bovis 20 grams, Fructus Aurantii 20 grams, Oletum Trogopterori 20 grams, Semen Strychni (processed) 20 grams, Radix Sophorae Tonkinensis 20 grams, Radix Isatidis 20 grams, Indigo Naturalis 20 grams, Herba Agrimoniae 20 grams, Rhizoma Arisaematis (processed) 8 grams, Radix Salviae Miltiorrhizae 8 grams, Pumex 15 grams, arrowhead 8 grams, Radix Paeoniae Rubra 8 grams, Pericarpium Citri Reticulatae 15 grams, SEMEN VACCARIAE 8 grams, Spina Gleditsiae 8 grams, Radix Codonopsis 20 grams, Herba Cistanches 20 grams, the Rhizoma Anemarrhenae 8 grams, Radix Curcumae 10 grams, 20 grams, Radix Glycyrrhizae, Squama Manis 8 grams.
Below by concrete case, Chinese medicine preparation curative effect of the present invention is verified further:
Case 1
Wang, man, 706 years old.Patient because breastbone pain when dysphagia, feed removes hospital admission, was diagnosed as benign tumor of esophagus before 2 years.Because patient body situation holds the digestive tract reaction that can't stand that chemotherapy causes, determine with Chinese traditional treatment, so under friend recommendation, take treatment by Chinese herbs of the present invention.Observe patients symptomatic, a course for the treatment of of patient consumes, milk bubble bread can be eaten gradually, and tell foam and obviously alleviate, defecate logical, spirit improvement.But retrosternal pain sense when still having xerostomia and feed.1 course for the treatment of of continual cure, patient can take food soft steamed bread and rice, takes care of oneself, in high spirits.Symptom after 2 courses for the treatment of of taking medicine takes a favorable turn, and check display tumor has obtained good control, and reduces gradually.Continue the Chinese medicine taking two courses for the treatment of, go to hospital to do CT scan, esophagogastroscope etc. and check that all recoveries of display are normal.
Case 2
Zhao, man, 60 years old.Patient usually entered food before 3 years have dysphagia sense and pain, and pain increased the weight of afterwards, through examination in hospital, was diagnosed as esophagus benign tumor.Because patient adheres to taking treatment by Chinese herbs, take medicine of the present invention upon somebody's introduction and treat, after 1 course for the treatment of of taking medicine, appetite increases, and diet is swallowed smooth and easy, few vomiting, pain deflate, from head to foot not weak, can also often do a little housework, after taking medicine 3 months, examination in hospital display is basic recovers normal.For consolidate curative effect, after continuing again to take 1 course for the treatment of, various symptom disappears completely, check display: barium agent is smooth by esophagus, expansion is good, and the smooth mucosa of tube wall is out of shape regular.Patient discontinues medication, and life is good so far.
Case 3
Song, female, 50 years old.Patient removes hospital admission because of eating difficulties before 1 year, and x-ray checks the filling defect that distal esophagus has 2cm long, and mucosal discontinuities is early stage benign tumor of esophagus through dragging in esophagus proved by pathology.Upon somebody's introduction, start to take medicine of the present invention and treat, take medicine 1 course for the treatment of, the state of an illness takes a favorable turn, and fever stops, and can eat noodles, rice water.Continue to take 2 courses for the treatment of, health is clearly better, and body weight increases by 2 kilograms, and examination in hospital indices is improved greatly, and gross tumor volume obviously reduces.After continuing to take 1 course for the treatment of, check display tumor disappearance, clinical cure.

Claims (7)

1. treat a Chinese medicine preparation for esophagus benign goitre, it is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 10-20 gram, Sargassum 5-15 gram, Calculus Bovis 10-20 gram, Fructus Aurantii 10-20 gram, Oletum Trogopterori 10-20 gram, Semen Strychni (processed) 10-20 gram, Radix Sophorae Tonkinensis 10-20 gram, Radix Isatidis 10-20 gram, Indigo Naturalis 10-20 gram, Herba Agrimoniae 10-20 gram, Rhizoma Arisaematis (processed) 5-8 gram, Radix Salviae Miltiorrhizae 5-8 gram, Pumex 10-15 gram, arrowhead 5-8 gram, Radix Paeoniae Rubra 5-8 gram, Pericarpium Citri Reticulatae 10-15 gram, SEMEN VACCARIAE 5-8 gram, Spina Gleditsiae 5-8 gram, Radix Codonopsis 10-20 gram, Herba Cistanches 10-20 gram, Rhizoma Anemarrhenae 5-8 gram, Radix Curcumae 5-10 gram, Radix Glycyrrhizae 10-20 gram, Squama Manis 5-8 gram.
2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 10 grams, Sargassum 5 grams, Calculus Bovis 10 grams, Fructus Aurantii 10 grams, Oletum Trogopterori 10 grams, Semen Strychni (processed) 10 grams, Radix Sophorae Tonkinensis 10 grams, Radix Isatidis 10 grams, Indigo Naturalis 10 grams, Herba Agrimoniae 10 grams, Rhizoma Arisaematis (processed) 5 grams, Radix Salviae Miltiorrhizae 5 grams, Pumex 10 grams, arrowhead 5 grams, Radix Paeoniae Rubra 5 grams, Pericarpium Citri Reticulatae 10 grams, SEMEN VACCARIAE 5 grams, Spina Gleditsiae 5 grams, Radix Codonopsis 10 grams, Herba Cistanches 10 grams, the Rhizoma Anemarrhenae 5 grams, Radix Curcumae 5 grams, 10 grams, Radix Glycyrrhizae, Squama Manis 5 grams.
3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 12 grams, Sargassum 7 grams, Calculus Bovis 12 grams, Fructus Aurantii 12 grams, Oletum Trogopterori 12 grams, Semen Strychni (processed) 12 grams, Radix Sophorae Tonkinensis 12 grams, Radix Isatidis 12 grams, Indigo Naturalis 12 grams, Herba Agrimoniae 12 grams, Rhizoma Arisaematis (processed) 5 grams, Radix Salviae Miltiorrhizae 6 grams, Pumex 11 grams, arrowhead 5 grams, Radix Paeoniae Rubra 6 grams, Pericarpium Citri Reticulatae 11 grams, SEMEN VACCARIAE 5 grams, Spina Gleditsiae 6 grams, Radix Codonopsis 12 grams, Herba Cistanches 12 grams, the Rhizoma Anemarrhenae 6 grams, Radix Curcumae 6 grams, 12 grams, Radix Glycyrrhizae, Squama Manis 5 grams.
4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 14 grams, Sargassum 9 grams, Calculus Bovis 14 grams, Fructus Aurantii 14 grams, Oletum Trogopterori 14 grams, Semen Strychni (processed) 14 grams, Radix Sophorae Tonkinensis 14 grams, Radix Isatidis 14 grams, Indigo Naturalis 14 grams, Herba Agrimoniae 14 grams, Rhizoma Arisaematis (processed) 6 grams, Radix Salviae Miltiorrhizae 6 grams, Pumex 12 grams, arrowhead 6 grams, Radix Paeoniae Rubra 6 grams, Pericarpium Citri Reticulatae 12 grams, SEMEN VACCARIAE 6 grams, Spina Gleditsiae 6 grams, Radix Codonopsis 14 grams, Herba Cistanches 14 grams, the Rhizoma Anemarrhenae 6 grams, Radix Curcumae 7 grams, 14 grams, Radix Glycyrrhizae, Squama Manis 6 grams.
5. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 16 grams, Sargassum 11 grams, Calculus Bovis 16 grams, Fructus Aurantii 16 grams, Oletum Trogopterori 16 grams, Semen Strychni (processed) 16 grams, Radix Sophorae Tonkinensis 16 grams, Radix Isatidis 16 grams, Indigo Naturalis 16 grams, Herba Agrimoniae 16 grams, Rhizoma Arisaematis (processed) 6 grams, Radix Salviae Miltiorrhizae 7 grams, Pumex 13 grams, arrowhead 6 grams, Radix Paeoniae Rubra 7 grams, Pericarpium Citri Reticulatae 13 grams, SEMEN VACCARIAE 7 grams, Spina Gleditsiae 6 grams, Radix Codonopsis 16 grams, Herba Cistanches 16 grams, the Rhizoma Anemarrhenae 6 grams, Radix Curcumae 8 grams, 16 grams, Radix Glycyrrhizae, Squama Manis 7 grams.
6. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 18 grams, Sargassum 13 grams, Calculus Bovis 18 grams, Fructus Aurantii 18 grams, Oletum Trogopterori 18 grams, Semen Strychni (processed) 18 grams, Radix Sophorae Tonkinensis 18 grams, Radix Isatidis 18 grams, Indigo Naturalis 18 grams, Herba Agrimoniae 18 grams, Rhizoma Arisaematis (processed) 7 grams, Radix Salviae Miltiorrhizae 7 grams, Pumex 14 grams, arrowhead 7 grams, Radix Paeoniae Rubra 7 grams, Pericarpium Citri Reticulatae 14 grams, SEMEN VACCARIAE 7 grams, Spina Gleditsiae 7 grams, Radix Codonopsis 18 grams, Herba Cistanches 18 grams, the Rhizoma Anemarrhenae 7 grams, Radix Curcumae 9 grams, 18 grams, Radix Glycyrrhizae, Squama Manis 7 grams.
7. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Semen Raphani 20 grams, Sargassum 15 grams, Calculus Bovis 20 grams, Fructus Aurantii 20 grams, Oletum Trogopterori 20 grams, Semen Strychni (processed) 20 grams, Radix Sophorae Tonkinensis 20 grams, Radix Isatidis 20 grams, Indigo Naturalis 20 grams, Herba Agrimoniae 20 grams, Rhizoma Arisaematis (processed) 8 grams, Radix Salviae Miltiorrhizae 8 grams, Pumex 15 grams, arrowhead 8 grams, Radix Paeoniae Rubra 8 grams, Pericarpium Citri Reticulatae 15 grams, SEMEN VACCARIAE 8 grams, Spina Gleditsiae 8 grams, Radix Codonopsis 20 grams, Herba Cistanches 20 grams, the Rhizoma Anemarrhenae 8 grams, Radix Curcumae 10 grams, 20 grams, Radix Glycyrrhizae, Squama Manis 8 grams.
CN201510962485.7A 2015-12-17 2015-12-17 Traditional Chinese medicine preparation for treating esophagus benign tumor Pending CN105412835A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104055975A (en) * 2014-07-01 2014-09-24 崔丽萍 Anti-tumor traditional Chinese medicine preparation
CN104173947A (en) * 2014-09-12 2014-12-03 商斌 Traditional Chinese medicine preparation for resisting esophagus cancer
CN104189484A (en) * 2014-08-25 2014-12-10 四川金堂海纳生物医药技术研究所 Medicine for treating esophageal benign tumors and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104055975A (en) * 2014-07-01 2014-09-24 崔丽萍 Anti-tumor traditional Chinese medicine preparation
CN104189484A (en) * 2014-08-25 2014-12-10 四川金堂海纳生物医药技术研究所 Medicine for treating esophageal benign tumors and preparation method thereof
CN104173947A (en) * 2014-09-12 2014-12-03 商斌 Traditional Chinese medicine preparation for resisting esophagus cancer

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