CN103735915B - A kind of medicine and preparation method for the treatment of esophageal carcinoma - Google Patents
A kind of medicine and preparation method for the treatment of esophageal carcinoma Download PDFInfo
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Abstract
The invention discloses a kind of medicine and preparation method for the treatment of esophageal carcinoma, belong to Chinese materia medica field; The raw material making described effective ingredient consists of: Fructus Chebulae, Herba Ardisiae Maculosae, Rhizoma Atractylodis, Fructus Aristolochiae Kwangsiensis, Herba Spilanthis callimorphae, Fructus Gardeniae, Fructus Psoraleae, Fructus Setariae Germinatus, Ramulus Et Folium Picrasmae, Radix Osbeckiae Crinitae, Radix Notoginseng, Folium Artemisiae Argyi, Herba Artemisiae Scopariae, Flos Caryophylli, Herba Aristolochiae and the Rhizoma Pinelliae; Selected by medicine of the present invention, medical material compatibility is suitable, there is hard masses softening and resolving, promote the production of body fluid moisturize, effect of anticancer analgetic, the treatment of the esophageal carcinoma caused for a variety of causes has significant curative effect, short treating period, safe without toxic side effect, can be widely used in the clinical treatment of esophageal carcinoma.
Description
Technical field
The present invention relates to Chinese materia medica field, particularly relate to a kind of medicine and preparation method for the treatment of esophageal carcinoma.
Background technology
The esophageal carcinoma is common digestive tract tumor, and the whole world about has 300,000 people to die from the esophageal carcinoma every year.Its M & M various countries are widely different.China is one of Esophageal Cancer area in the world, and every annual is died of illness about 150,000 people.Man is more than female, and age of onset is many more than 40 years old.The Crowds Distribute of the esophageal carcinoma and age, sex, occupation, race, region, living environment, dietary life habits, genetic predisposition etc. have certain relation.Through the disease that the existing survey data display esophageal carcinoma may be caused by many factors.Comprise the chemical cause of disease, biological agent, lack some trace element, be deficient in vitamin and esophageal cancer genetic predisposing factor etc.
The early symptom of the esophageal carcinoma is often not obvious, but may have discomfort sensation in various degree when swallowing thick and stiff food, comprises ingest food choking feeling, burns sample, acupuncture sample or tractive friction sample pain after breastbone.Food by slow, and has stagnation sense or foreign body sensation.Stalk is choked to stagnate to feel and alleviate disappearance after being swallowed water.Heavy time light during symptom, make slow progress.
Esophageal carcinoma middle and advanced stage symptom is mainly manifested in Progressive symmetric erythrokeratodermia acataposis, before this food of difficult dry pharynx, is semiliquid diet then, and last water and saliva can not be swallowed.When cancerous protuberance blocks caused inflammation edema transient remission, or after part cancerous protuberance comes off, obstruction can temporarily alleviate, and constant error thinks that sb.'s illness took a favorable turn.If cancerous protuberance invades recurrent laryngeal nerve, hoarseness can be there is; If compressing cervical sympathetic ganglia, Horner syndrome can be produced; If intrusion trachea-bronchial epithelial cell, esophagus, trachea or bronchial fistula can be formed, acutely choke when occurring swallowing water or food and cough, and respiratory system infection occurs.Finally there is cachectic states.If there is the Organ relative weight such as liver, brain, the states such as jaundice, seroperitoneum, stupor can be there is.
Treatment for esophageal carcinoma is mainly divided into surgical intervention, radiotherapy, chemotherapy and Comprehensive Treatment; Two kinds or more therapies simultaneously or successively application be called Comprehensive Treatment.Above-mentioned therapeutic outcome is better with combined therapy effect through investigation display, but Comprehensive Treatment needs the time and money of at substantial, and long-term treatment makes most of patients face huge financial difficulties.
In addition, the cured substance rate for the treatment of esophageal carcinoma is low, and toxic and side effects is large, in order to the disease alleviating patient is painful, we be badly in need of one safely and effectively medicine to treat esophageal carcinoma.
Summary of the invention
The object of this invention is to provide a kind of medicine and preparation method for the treatment of esophageal carcinoma; Selected by medicine of the present invention, medical material compatibility is suitable, there is hard masses softening and resolving, promote the production of body fluid moisturize, effect of anticancer analgetic, the treatment of the esophageal carcinoma caused for a variety of causes has significant curative effect, short treating period, safe without toxic side effect, can be widely used in the clinical treatment of esophageal carcinoma.
For achieving the above object, being implemented as follows of technical scheme of the present invention:
Treat a medicine for esophageal carcinoma, raw material composition and the parts by weight of making described effective ingredient are:
Fructus Chebulae's 40 ~ 65 parts of Herba Ardisiae Maculosaes 35 ~ 65 parts of Rhizoma Atractylodis 35 ~ 62 parts of Fructus Aristolochiae Kwangsiensiss 32 ~ 60 parts
Herba Spilanthis callimorphae's 30 ~ 60 portions of Fructus Gardeniaes 30 ~ 55 parts of Fructus Psoraleaes 27 ~ 55 parts of Fructus Setariae Germinatuss 25 ~ 50 parts
Ramulus Et Folium Picrasmae 25 ~ 50 parts of Radix Osbeckiae Crinitaes 22 ~ 50 portions of Radix Notoginseng 22 ~ 45 portions of Folium Artemisiae Argyis 20 ~ 45 parts
Herba Artemisiae Scopariae 20 ~ 42 portions of Flos Caryophyllis 15 ~ 40 parts of Herba Aristolochiaes 15 ~ 40 parts of Rhizoma Pinelliaes 10 ~ 35 parts.
Raw material composition and the parts by weight of making described effective ingredient are:
Fructus Chebulae's 44 ~ 61 parts of Herba Ardisiae Maculosaes 40 ~ 60 parts of Rhizoma Atractylodis 40 ~ 57 parts of Fructus Aristolochiae Kwangsiensiss 37 ~ 55 parts
Herba Spilanthis callimorphae's 35 ~ 55 portions of Fructus Gardeniaes 34 ~ 51 parts of Fructus Psoraleaes 32 ~ 50 parts of Fructus Setariae Germinatuss 29 ~ 46 parts
Ramulus Et Folium Picrasmae 29 ~ 46 parts of Radix Osbeckiae Crinitaes 27 ~ 45 portions of Radix Notoginseng 26 ~ 41 portions of Folium Artemisiae Argyis 24 ~ 41 parts
Herba Artemisiae Scopariae 23 ~ 38 portions of Flos Caryophyllis 19 ~ 36 parts of Herba Aristolochiaes 19 ~ 36 parts of Rhizoma Pinelliaes 14 ~ 31 parts.
Raw material composition and the parts by weight of making described effective ingredient are:
Fructus Chebulae's 48 ~ 57 parts of Herba Ardisiae Maculosaes 45 ~ 55 parts of Rhizoma Atractylodis 45 ~ 52 parts of Fructus Aristolochiae Kwangsiensiss 42 ~ 50 parts
Herba Spilanthis callimorphae's 40 ~ 50 portions of Fructus Gardeniaes 38 ~ 47 parts of Fructus Psoraleaes 37 ~ 45 parts of Fructus Setariae Germinatuss 33 ~ 42 parts
Ramulus Et Folium Picrasmae 33 ~ 42 parts of Radix Osbeckiae Crinitaes 32 ~ 40 portions of Radix Notoginseng 30 ~ 38 portions of Folium Artemisiae Argyis 28 ~ 37 parts
Herba Artemisiae Scopariae 27 ~ 34 portions of Flos Caryophyllis 23 ~ 32 parts of Herba Aristolochiaes 23 ~ 32 parts of Rhizoma Pinelliaes 18 ~ 27 parts.
Raw material composition and the parts by weight of making described effective ingredient are:
Fructus Chebulae's 52 parts of Herba Ardisiae Maculosaes 50 parts of Rhizoma Atractylodis 48 parts of Fructus Aristolochiae Kwangsiensiss 46 parts
Herba Spilanthis callimorphae's 45 portions of Fructus Gardeniaes 42 parts of Fructus Psoraleaes 41 parts of Fructus Setariae Germinatuss 38 parts
Ramulus Et Folium Picrasmae 38 parts of Radix Osbeckiae Crinitaes 36 portions of Radix Notoginseng 34 portions of Folium Artemisiae Argyis 32 parts
Herba Artemisiae Scopariae 30 portions of Flos Caryophyllis 28 parts of Herba Aristolochiaes 28 parts of Rhizoma Pinelliaes 22 parts.
Treat a preparation method for the medicine of esophageal carcinoma, comprise following processing step:
(1) by Fructus Chebulae, Rhizoma Atractylodis, Fructus Psoraleae, Radix Osbeckiae Crinitae, Radix Notoginseng, Folium Artemisiae Argyi and Flos Caryophylli and clean, put into container, add the distilled water of 8 ~ 10 times amount, soaks after 5 ~ 6 hours, boil 3 ~ 4 hours, extraction; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, for subsequent use;
(2) Herba Ardisiae Maculosae, Fructus Aristolochiae Kwangsiensis, Herba Spilanthis callimorphae, Ramulus Et Folium Picrasmae, Herba Artemisiae Scopariae and the Rhizoma Pinelliae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 75% of 2 times amount, heating extraction 3 hours, reclaim ethanol, filter, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.12, for subsequent use;
(3) get Fructus Gardeniae, Fructus Setariae Germinatus and Herba Aristolochiae decontamination, put into pot intense fire and be fried to surface in yellow, taking-up is dried in the air cool, is placed in mortar and grinds into powder, crosses 200 order fine powders for subsequent use;
(4) by the filtrate obtained by above-mentioned steps (1) ~ (3), thick paste and fine powder mixing, utilize modern advanced pharmacy science and technology, make capsule, be the medicine for the treatment of esophageal carcinoma of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Fructus Chebulae: sour in the mouth, puckery, property is put down.To astringe the lung astringing intestine to stop diarrhea, therapeutic method to keep the adverse QI flowing downwards sore-throat relieving.Cure mainly chronic diarrhea, chronic dysentery, proctoptosis, phlegmatic cough of breathing with cough, chronic cough aphonia." Japan hanako materia medica " carries: " relieving restlessness, harnesses the river for expectorant, the therapeutic method to keep the adverse QI flowing downwards, and in tune, antidiarrheal dysentery, cholera, renal mass kidney qi, lung qi dyspnea with rapid respiration, digesting and appetizing, hemorrhoidal hamorrhage rushes down blood, metrorrhagia leukorrhagia, five types of dysphagia.”
Herba Ardisiae Maculosae: acrid in the mouth, hardship, slightly warm in nature; Return liver, kidney, lung meridian.Promoting blood circulation and stopping pain, clearing throat.Cure mainly traumatic injury, fracture, rheumatic arthralgia, diphtheria, laryngopharynx swelling and pain, gastric ulcer.
Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature; Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia." Bencao Jingshu " carries: " all diseases belong to deficiency of YIN insufficiency of blood, insufficiency of essence, interior-heat hectic fever due to YIN-deficiency, dry mouth with parched lips, and cough is spat, spitted blood, and epistaxis, obstruction of the pharynx, constipation dysentery person, method is salty avoids it.Liver and kidney has the person of taking offence not take.”
Fructus Aristolochiae Kwangsiensis: bitter in the mouth, cold in nature; Return stomach warp.Heat-clearing and toxic substances removing, regulating QI to relieve pain, relaxing muscles and tendons and activating QI and blood in the collateral.For acute gastroenteritis, taste-blindness rate, pharyngolaryngitis, pulmonary tuberculosis, ulcer sore pain, stomachache, abdominalgia with intestinal abscess, rheumatic arthralgia, treating swelling and pain by traumatic injury." register planted by Guangxi medicine " carries: " refrigerantly to bring down a fever, removing toxic substances.Control dizziness, laryngalgia, gastropathy, stomachache, skin ulcer scabies, knife injury, snakebite.”
Herba Spilanthis callimorphae: acrid in the mouth, hardship, warm in nature, slightly poisonous.Expelling wind and removing dampness, eliminating stasis to stop pain.For fracture, traumatic injury, rheumatic arthritis, stimulates the menstrual flow, cold syndrome of the stomach pain, toothache, cold, traumatic hemorrhage." Yunnan Chinese herbal medicine " carries: " pain relieving, blood circulation promoting and blood stasis dispelling.Control fracture, traumatic injury, rheumatic arthritis, amenorrhea, cold syndrome of the stomach pain.”
Fructus Gardeniae: bitter in the mouth, cold in nature, nontoxic; GUIXIN, liver, lung, stomach, tri-jiao channel.Pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cooling blood for hemostasis.Cure mainly calentura vexed, liver-fire conjunctival congestion, headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprains and swells and ache.Materia Medica of Decoction carries: " also, normal lung-QI and changing, bladder is the mansion of body fluid, and urine obtains this gasification and goes out also in lung heat clearing for Fructus Gardeniae diuresis, real non-diuresis.Agitation controlled by the Decoction of Capejasmine and Fermented Soybean, tired person's gas also, hot-tempered person's blood also, the main lung of gas, the main kidney of blood, therefore tired to control lung with Fructus Gardeniae, hot-tempered to control kidney with fragrant fermented soya beans, salted or other wise.”
Fructus Psoraleae: acrid in the mouth, hardship, warm in nature; Return kidney, the heart, spleen, stomach, lung meridian.Reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha.Cure mainly insufficiency of kidney-YANG, below element deficiency and cold, chills and pain of the waist and kness, sexual impotence essence, frequent micturition, the enuresis, failure of the kidney in receiving QI, dyspnea due to deficiency is more than, asthenia of both the spleen and kidney, stool chronic diarrhea, vitiligo, alopecia areata, psoriasis." beautiful Chinese catalpa medicine solution " carry: " warm water and soil, digestion diet, rise reach taste, convergence lingering diarrhea, seminal emission, leukorrhagia, drown many, just slide all cards.”
Fructus Setariae Germinatus: sweet in the mouth, property is put down; Return spleen, stomach warp.Help digestion and in, spleen benefiting and stimulating the appetite.Do not disappear for food stagnation, abdominal distention halitosis, weakness of the spleen and stomach, not hungry lack of appetite." Bencao Jingshu " carries: " tiller rice and rice tiller also, the property of tool biochemistry, therefore be digestion-promoting spleen-invigorating, appetizing and in key medicine, taste and then in from pestilence, gas under, hotly certainly to remove also." modern medicine study, Fructus Setariae Germinatus (parched) relatively helps digestion, and can be used for not hungry lack of appetite, it is stagnant that Fructus Setariae Germinatus (parched to brown) is apt to eliminate indigestion, can be used for stagnating not disappearing.
Ramulus Et Folium Picrasmae: bitter in the mouth, cold in nature, slightly poisonous; Return lung, large intestine channel.Heat-clearing and toxic substances removing, removing dampness and killing parasites.Cure mainly upper respiratory tract infection, pneumonia, acute gastroenteritis, dysentery, biliary tract infection, furuncle, scabies, eczema, burn due to hot liquid or fire, venom.
Radix Osbeckiae Crinitae: sweet in the mouth, puckery, property is put down.Clearing away heat-damp and promoting diuresis, cough-relieving regulating menstruation.For acute gastroenteritis, bacillary dysentery, dyspepsia, chronic bronchitis, spits blood, menoxenia, tonify deficiency kidney tonifying, astringing to arrest bleeding, and the cough of consumptive disease wound is spitted blood, and lower limb are aching and limp, muscles and bones contracture, urinary incontinence, nebulousurine leucorrhea.
Radix Notoginseng: bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, benefiting stomach and stopping pain, dissipating blood stasis for subsidence of swelling.Control exogenous cough, pharyngalgia, aphtha of the mouth and tongue, vomiting and diarrhoea, dysentery, stomachache, swollen ulcer drug, traumatic injury.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " heat-clearing and toxic substances removing, eliminating stasis to stop pain.Control stomach and duodenum to burst hemorrhoid pain, treating swelling and pain by traumatic injury, neuralgia, toothache, acute gastroenteritis, bacillary dysentery, upper respiratory tract infection, pharyngalgia.”
Folium Artemisiae Argyi: acrid in the mouth, hardship, warm in nature; Return liver,spleen,kidney warp.Dispersing cold for relieving pain, warming the meridian for stopping bleeding, Li Yin gas, granulation promoting meat, wards off wind and cold.There is warming middle-JIAO, by cold, dehumidifying, ward off wind and cold alunite, regulating menstruation dissipating depression of QI, to regulate the flow of vital energy the effect of promoting the circulation of blood, all have antibacterial action to 10 kinds of Gram-positive aerophils such as anthrax bacillus, Alpha-hemolytic streptococcus, B-Streptococcus hemolyticus, diphtheria corynebacterium, bacillus pseudodiphthericus, lung diplococcoid, staphylococcus aureus, Staphylococcus citreus, white Portugal Portugal coccus, bacillus subtilis.
Herba Artemisiae Scopariae: bitter in the mouth, pungent, cold nature; Return spleen, stomach, liver, gallbladder meridian.Clearing away heat-damp and promoting diuresis, jaundice eliminating.Cure mainly jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis.Pharmaceutical research proves, Herba Artemisiae Scopariae has the effect such as function of gallbladder promoting, liver function protecting, antipyretic and anti-inflammatory, blood fat reducing, blood pressure lowering coronary dilating.
Flos Caryophylli: sweet in the mouth, pungent, extremely hot in nature; Enter stomach, kidney two warp.Warming the stomach, the kidney warming.Cure mainly cold syndrome of the stomach pain with distension, singultus, vomit and diarrhoea, arthralgia pain, colic, halitosis, toothache." Japan hanako materia medica " carries: " control implication, regurgitation, treat kidney qi, sensation of gas rushing, pain over the perineum, tonifying YANG, warm waist knee joint, killing wine Chinese medicine " Flos Caryophylli " real is Myrtaceae Flos Caryophylli poison, and disappear mass beside the umbilicus, except consumptive disease with cold nature.”
Herba Aristolochiae: bitter in the mouth, warm in nature; Enter liver,spleen,kidney three warp.Circulation of qi promoting removing dampness, promoting blood circulation and stopping pain.Cure mainly stomachache, colicky, edema during pregnancy, puerperal, vim and vigour were suffered from abdominal pain, rheumatalgia, promoting flow of QI and blood, pain relieving, diuresis, edema during pregnancy, and breast is suffered from abdominal pain, colic, rheumatalgia." book on Chinese herbal medicine is new again " carries: " removing heat from blood and promoting blood circulation, removes wind dampness removing, walk meridians, doublely controls the swollen pain of waist lower limb.”
The Rhizoma Pinelliae: acrid in the mouth, warm in nature, poisonous; Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm, and middle stomach invigorating, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Cure mainly damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness; External can reducing swelling and alleviating pain." medicine origin " carries: " control cold-phlegm and cold physique to admire cold injury lung and coughing, large easing stomach-QI, except cold syndrome of the stomach, enter diet.Control the headache of sun syncope due to accumulation of phlegm, non-this can not remove.”
The present invention compared with prior art, has following beneficial effect:
Selected by medicine of the present invention, medical material compatibility is suitable, there is hard masses softening and resolving, promote the production of body fluid moisturize, effect of anticancer analgetic, the treatment of the esophageal carcinoma caused for a variety of causes has significant curative effect, short treating period, safe without toxic side effect, can be widely used in the clinical treatment of esophageal carcinoma.
Detailed description of the invention
The present invention is done supplementary further below in conjunction with specific embodiment, but do not limit the present invention in any way.Embodiment 1
The raw material composition of effective ingredient of the present invention and weight are:
Fructus Chebulae 61g Herba Ardisiae Maculosae 60g Rhizoma Atractylodis 57g Fructus Aristolochiae Kwangsiensis 55g
Herba Spilanthis callimorphae 55g Fructus Gardeniae 51g Fructus Psoraleae 50g Fructus Setariae Germinatus 46g
Ramulus Et Folium Picrasmae 46g Radix Osbeckiae Crinitae 45g Radix Notoginseng 41g Folium Artemisiae Argyi 41g
Herba Artemisiae Scopariae 38g Flos Caryophylli 36g Herba Aristolochiae 36g Rhizoma Pinelliae 31g.
Treat a preparation method for the medicine of esophageal carcinoma, comprise following processing step:
(1) by Fructus Chebulae, Rhizoma Atractylodis, Fructus Psoraleae, Radix Osbeckiae Crinitae, Radix Notoginseng, Folium Artemisiae Argyi and Flos Caryophylli and clean, put into container, add the distilled water of 8 ~ 10 times amount, soaks after 5 ~ 6 hours, boil 3 ~ 4 hours, extraction; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, for subsequent use;
(2) Herba Ardisiae Maculosae, Fructus Aristolochiae Kwangsiensis, Herba Spilanthis callimorphae, Ramulus Et Folium Picrasmae, Herba Artemisiae Scopariae and the Rhizoma Pinelliae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 75% of 2 times amount, heating extraction 3 hours, reclaim ethanol, filter, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.12, for subsequent use;
(3) get Fructus Gardeniae, Fructus Setariae Germinatus and Herba Aristolochiae decontamination, put into pot intense fire and be fried to surface in yellow, taking-up is dried in the air cool, is placed in mortar and grinds into powder, crosses 200 order fine powders for subsequent use;
(4) by the filtrate obtained by above-mentioned steps (1) ~ (3), thick paste and fine powder mixing, make capsule, be the medicine for the treatment of esophageal carcinoma of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 3, warm water delivery service after meal; Within 8 days, be 1 course for the treatment of, 3 ~ 4 courses for the treatment of can cure, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of effective ingredient of the present invention and weight are:
Fructus Chebulae 57g Herba Ardisiae Maculosae 55g Rhizoma Atractylodis 52g Fructus Aristolochiae Kwangsiensis 50g
Herba Spilanthis callimorphae 50g Fructus Gardeniae 47g Fructus Psoraleae 45g Fructus Setariae Germinatus 42g
Ramulus Et Folium Picrasmae 42g Radix Osbeckiae Crinitae 40g Radix Notoginseng 38g Folium Artemisiae Argyi 37g
Herba Artemisiae Scopariae 34g Flos Caryophylli 32g Herba Aristolochiae 32g Rhizoma Pinelliae 27g.
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.Embodiment 3
The raw material composition of effective ingredient of the present invention and weight are:
Fructus Chebulae 52g Herba Ardisiae Maculosae 50g Rhizoma Atractylodis 48g Fructus Aristolochiae Kwangsiensis 46g
Herba Spilanthis callimorphae 45g Fructus Gardeniae 42g Fructus Psoraleae 41g Fructus Setariae Germinatus 38g
Ramulus Et Folium Picrasmae 38g Radix Osbeckiae Crinitae 36g Radix Notoginseng 34g Folium Artemisiae Argyi 32g
Herba Artemisiae Scopariae 30g Flos Caryophylli 28g Herba Aristolochiae 28g Rhizoma Pinelliae 22g.
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.Embodiment 4
The raw material composition of effective ingredient of the present invention and weight are:
Fructus Chebulae 48g Herba Ardisiae Maculosae 45g Rhizoma Atractylodis 45g Fructus Aristolochiae Kwangsiensis 42g
Herba Spilanthis callimorphae 40g Fructus Gardeniae 38g Fructus Psoraleae 37g Fructus Setariae Germinatus 33g
Ramulus Et Folium Picrasmae 33g Radix Osbeckiae Crinitae 32g Radix Notoginseng 30g Folium Artemisiae Argyi 28g
Herba Artemisiae Scopariae 27g Flos Caryophylli 23g Herba Aristolochiae 23g Rhizoma Pinelliae 18g.
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.Embodiment 5
The raw material composition of effective ingredient of the present invention and weight are:
Fructus Chebulae 44g Herba Ardisiae Maculosae 40g Rhizoma Atractylodis 40g Fructus Aristolochiae Kwangsiensis 37g
Herba Spilanthis callimorphae 35g Fructus Gardeniae 34g Fructus Psoraleae 32g Fructus Setariae Germinatus 29g
Ramulus Et Folium Picrasmae 29g Radix Osbeckiae Crinitae 27g Radix Notoginseng 26g Folium Artemisiae Argyi 24g
Herba Artemisiae Scopariae 23g Flos Caryophylli 19g Herba Aristolochiae 19g Rhizoma Pinelliae 14g.
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data
1, case selection:
As the medicine for the treatment of esophageal carcinoma, select the routine clinical observation of esophageal cancer patients 180 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 90 example, wherein male 44 example, women 46 example, 40 ~ 65 years old age, 52.4 years old mean age, the shortest person of the course of disease 6 months, most elder 10 years, average 5.5 years.Matched group 90 example, wherein male 45 example, women 45 example, 41 ~ 66 years old age, 51.7 years old mean age, the shortest person of the course of disease 5 months, most elder 11 years, average 6.1 years.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes medicine of the present invention, oral, every day 2 times, each 1 time sooner or later, each 3, warm water delivery service after meal; Within 8 days, be 1 course for the treatment of, take 3 ~ 4 courses for the treatment of continuously, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes XIAOAIPING PIAN, every day 3 times, each 8 ~ 10; Within 18 days, be 1 course for the treatment of, take 4 ~ 6 courses for the treatment of continuously, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3, efficacy determination:
(1) cure: choking feeling swallowed by food, burn the transference cures such as sample, acupuncture sample or tractive friction sample pain after breastbone, digestive function recovers normal.
(2) take a turn for the better: above-mentioned symptom takes a turn for the better to some extent, and digestive function recovers to some extent.
(3) invalid: after taking medicine, symptom is without significant change.
4, result:
Select in the treatment group of medicine of the present invention, cure 49 examples, take a turn for the better 35 examples, invalid 6 examples, cure rate 54.4%, total effective rate 93.3%.
Cure 23 examples in matched group, take a turn for the better 38 examples, invalid 29 examples, cure rate 25.6%, total effective rate 67.8%.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, certain is turned round and look at, man, 40 years old, civil servant, Heze City, Shandong Province people.The dim green grass or young crops of patient's body of the tongue, yellow fur is white, stringy and thready pulse, and slight stalk is choked, and with dysphagia.Row x-ray inspection of being admitted to hospital finds that patient belongs to early, mid-term medullary, fungoid carcinoma of esophagus.Take medicine of the present invention, after taking 1 course for the treatment of, symptom is alleviated substantially, and after taking the 2nd course for the treatment of, symptom disappears completely, Be very effective.
3, Chu, man, 61 years old, retired worker, Taian Shandong people.Patient suffers from the early stage esophageal carcinoma, and pale tongue is dim, thin white fur of tongue, stringy and thready pulse, the obvious dysphagia of main manifestations, feels when swallowing that gear in esophagus is choked, foreign body sensation or causalgia, the heavy tight sense in the gloomy discomfort of breast and back, time hidden time heavy dysphagia sense, x-ray inspection is mainly the pathological changes of the early stage esophageal carcinoma.Take medicine of the present invention, after taking 4 courses for the treatment of, esophagus digestion is normal, and symptom disappears completely, follows up a case by regular visits to without recurrence after half a year.
Claims (5)
1. treat a medicine for esophageal carcinoma, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Fructus Chebulae's 40 ~ 65 parts of Herba Ardisiae Maculosaes 35 ~ 65 parts of Rhizoma Atractylodis 35 ~ 62 parts of Fructus Aristolochiae Kwangsiensiss 32 ~ 60 parts
Herba Spilanthis callimorphae's 30 ~ 60 portions of Fructus Gardeniaes 30 ~ 55 parts of Fructus Psoraleaes 27 ~ 55 parts of Fructus Setariae Germinatuss 25 ~ 50 parts
Ramulus Et Folium Picrasmae 25 ~ 50 parts of Radix Osbeckiae Crinitaes 22 ~ 50 portions of Radix Notoginseng 22 ~ 45 portions of Folium Artemisiae Argyis 20 ~ 45 parts
Herba Artemisiae Scopariae 20 ~ 42 portions of Flos Caryophyllis 15 ~ 40 parts of Herba Aristolochiaes 15 ~ 40 parts of Rhizoma Pinelliaes 10 ~ 35 parts.
2. a kind of medicine for the treatment of esophageal carcinoma according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Fructus Chebulae's 44 ~ 61 parts of Herba Ardisiae Maculosaes 40 ~ 60 parts of Rhizoma Atractylodis 40 ~ 57 parts of Fructus Aristolochiae Kwangsiensiss 37 ~ 55 parts
Herba Spilanthis callimorphae's 35 ~ 55 portions of Fructus Gardeniaes 34 ~ 51 parts of Fructus Psoraleaes 32 ~ 50 parts of Fructus Setariae Germinatuss 29 ~ 46 parts
Ramulus Et Folium Picrasmae 29 ~ 46 parts of Radix Osbeckiae Crinitaes 27 ~ 45 portions of Radix Notoginseng 26 ~ 41 portions of Folium Artemisiae Argyis 24 ~ 41 parts
Herba Artemisiae Scopariae 23 ~ 38 portions of Flos Caryophyllis 19 ~ 36 parts of Herba Aristolochiaes 19 ~ 36 parts of Rhizoma Pinelliaes 14 ~ 31 parts.
3. a kind of medicine for the treatment of esophageal carcinoma according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Fructus Chebulae's 48 ~ 57 parts of Herba Ardisiae Maculosaes 45 ~ 55 parts of Rhizoma Atractylodis 45 ~ 52 parts of Fructus Aristolochiae Kwangsiensiss 42 ~ 50 parts
Herba Spilanthis callimorphae's 40 ~ 50 portions of Fructus Gardeniaes 38 ~ 47 parts of Fructus Psoraleaes 37 ~ 45 parts of Fructus Setariae Germinatuss 33 ~ 42 parts
Ramulus Et Folium Picrasmae 33 ~ 42 parts of Radix Osbeckiae Crinitaes 32 ~ 40 portions of Radix Notoginseng 30 ~ 38 portions of Folium Artemisiae Argyis 28 ~ 37 parts
Herba Artemisiae Scopariae 27 ~ 34 portions of Flos Caryophyllis 23 ~ 32 parts of Herba Aristolochiaes 23 ~ 32 parts of Rhizoma Pinelliaes 18 ~ 27 parts.
4. a kind of medicine for the treatment of esophageal carcinoma according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Fructus Chebulae's 52 parts of Herba Ardisiae Maculosaes 50 parts of Rhizoma Atractylodis 48 parts of Fructus Aristolochiae Kwangsiensiss 46 parts
Herba Spilanthis callimorphae's 45 portions of Fructus Gardeniaes 42 parts of Fructus Psoraleaes 41 parts of Fructus Setariae Germinatuss 38 parts
Ramulus Et Folium Picrasmae 38 parts of Radix Osbeckiae Crinitaes 36 portions of Radix Notoginseng 34 portions of Folium Artemisiae Argyis 32 parts
Herba Artemisiae Scopariae 30 portions of Flos Caryophyllis 28 parts of Herba Aristolochiaes 28 parts of Rhizoma Pinelliaes 22 parts.
5. as described in any one of Claims 1 to 4, treat a preparation method for the medicine of esophageal carcinoma, it is characterized in that: comprise following processing step:
(1) by Fructus Chebulae, Rhizoma Atractylodis, Fructus Psoraleae, Radix Osbeckiae Crinitae, Radix Notoginseng, Folium Artemisiae Argyi and Flos Caryophylli and clean, put into container, add the distilled water of 8 ~ 10 times amount, soaks after 5 ~ 6 hours, boil 3 ~ 4 hours, extraction; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, for subsequent use;
(2) Herba Ardisiae Maculosae, Fructus Aristolochiae Kwangsiensis, Herba Spilanthis callimorphae, Ramulus Et Folium Picrasmae, Herba Artemisiae Scopariae and the Rhizoma Pinelliae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 75% of 2 times amount, heating extraction 3 hours, reclaim ethanol, filter, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.12, for subsequent use;
(3) get Fructus Gardeniae, Fructus Setariae Germinatus and Herba Aristolochiae decontamination, put into pot intense fire and be fried to surface in yellow, taking-up is dried in the air cool, is placed in mortar and grinds into powder, crosses 200 order fine powders for subsequent use;
(4) by the filtrate obtained by above-mentioned steps (1) ~ (3), thick paste and fine powder mixing, make capsule, be the medicine of described treatment esophageal carcinoma.
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