CN104383466A - Traditional Chinese medicine for treating liver-kidney yin deficiency type cervical cancer and preparation method of traditional Chinese medicine - Google Patents

Traditional Chinese medicine for treating liver-kidney yin deficiency type cervical cancer and preparation method of traditional Chinese medicine Download PDF

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CN104383466A
CN104383466A CN201410777279.4A CN201410777279A CN104383466A CN 104383466 A CN104383466 A CN 104383466A CN 201410777279 A CN201410777279 A CN 201410777279A CN 104383466 A CN104383466 A CN 104383466A
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parts
chinese medicine
herba
extracting solution
traditional chinese
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胡凌云
刘玉国
韩丽
彭佐良
李玉芳
赵希义
孙笑嫚
马涛
丛竹凤
杨敏
王芳
陈海生
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SHANDONG TUMOR HOSPITAL
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SHANDONG TUMOR HOSPITAL
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention provides a traditional Chinese medicine for treating a liver-kidney yin deficiency type cervical cancer and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following raw materials: veronicastrum herb, solanum dulcamara, diversifolious patrinia root, curcuma zedoaria, air potato bulblet, herba agrimoniae, dioscorea bulbifera, barbed skullcap herb, hedyotis diffusa, euphorbia helioscopia, sea dragon, psilate catchweed bedstraw herb, solanum septemlobum, dodder, fructus lycii, pilea muscosa, lysimachia fistulosa, cortex acanthopanacis and woolly grape fern. The traditional Chinese medicine has the benefits that the liver-kidney yin deficiency type cervical cancer is highly targeted according to the syndrome differentiation principle of the traditional Chinese medicine; the traditional Chinese medicine is definite in treatment effect, takes an effect quickly, small in toxic and side effects and low in relapse rate.

Description

A kind of Chinese medicine and preparation method for the treatment of liver-kidney yin deficiency cervical cancer
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of liver-kidney yin deficiency cervical cancer.
Background technology
Cervical cancer refer to the malignant tumor occurring in utero vaginal portion and cervical canal.The transfer of cervical cancer, to adjacent tissue and organ direct extension, down to fornix vaginae and vaginal wall, upwards can invade body of uterus, can invade pelvic tissue to both sides, can invade bladder forward, can invade rectum backward.Also be transferred to by cervix uteri, in ilium by lymphatic vessel, ilium is outer, inguinal lymph nodes, even can be transferred to late period on clavicle and other lymph nodes of whole body.Hematogenous metastasis is more rare, and common metastasis site is lung, liver and bone.Cervical cancer is one of modal malignant tumor of gynecological.
Pole early stage patient can non-evident sympton, only chances on when generally investigating or other reasons does gynecologial examination.Once there is symptom, then show as more:
(1) metrorrhagia: the irregular vagina bleeding before and after menopause is the cardinal symptom of carcinoma of endometrium is often a small amount of hemorrhage to moderate, seldom for bleeding profusely.Not only younger or nearly menopause, patient easily thought menoxenia by mistake, went to a doctor not in time, even if doctor also often neglects.Also there is menstrual cycle delay person individually, but show irregular.Show as postmenopausal patients more and continue or discontinuity vaginal hemorrhage.The general contactless property of endometrial carcinoma is hemorrhage.Can to mix in monitor rotten meat sample tissue.
(2) neoplasm: because adenocarcinoma is grown in uterine cavity, infection chance is few compared with cervical cancer, therefore may only have a small amount of sanguinous leukorrhea in the early stage, but afterwards this infect, downright bad, then have the sanguinopurulent liquid of a large amount of stench to discharge.Sometimes discharge opeing can be mingled with the fractionlet of cancerous tissue.If cervical cavity empyema, cause fever, stomachache, leukocytosis.Ordinary circumstance also worsens rapidly.
(3) pain: because cancerous protuberance and the hemorrhage stasis of blood with discharge opeing thereof are amassed, stimulate the irregular contraction in uterus and cause paroxysmal pain, accounting for 10 ~ 46%.This symptom occurs in late period mostly.Penetrate serous coat as cancerous tissue or corrode the other connective tissue in palace, bladder, straight or oppress its hetero-organization and also can cause pain, often in intractable and Progressive symmetric erythrokeratodermia increase the weight of; And many from lumbosacral region, ventrad thigh and knee joint radiation.
(4) other: patients with terminal oneself can touch uterus that hypogastric region increases or and adjacent tissue's organ can cause these side lower limb and swell and ache, or compressing ureter causes this side renal pelvis ureters hydrops or causes kidney atrophy; Or there is anemia, become thin, generate heat, the cachexia performance such as dyscrasia.
The endometrium carcinogenesis age is more late, merges gestation like impossible, but document once had indivedual Case report merging gestation or tubal pregnancy.Irregular vagina bleeding, hemorrhage can in occurring any time, except row hormone therapy person.If vaginal hemorrhage appears in the postmenopausal women of row hormone replacement therapy, be similar to menstruation, then imply that cervical cancer possibility.Therefore, if having any abnormal vaginal hemorrhage or amount of bleeding many, hospital therapy should be arrived early.Vagina divides the thing that oozes, and in pink colour, brown, water sample or thick, has abnormal flavour.Find that uterus increases through pelvioscopy.Weight loss, weak, lower abdomen, back and leg pain.When this situation occurs in cancerous protuberance transfer or diffusion.
A large amount of clinical practice proves, centering end-stage patients carry out heavy dose of Radiotherapy chemotherapy, or again carries out chemotherapy to producing the patient of drug resistance can only to lead debilitant life more critically ill, accelerates death.Clinically usually can see, patient's cause of the death is not because cancer itself causes, but due to not caused by science, inappropriate lethal treatment.As hepatocarcinoma repeatedly get involved after there is the hepatic failure such as ascites, jaundice and lethal; Respiratory failure is caused and dead after cells in pleural fluids from lung cancer cases chemotherapy; Nausea and vomiting after gastric cancer, intestinal cancer chemotherapy, patient more dies of exhaustion and dies; Leukocyte declines, patient infection and death etc.The treatment of terminal cancer be the more important thing is and palliate the agonizing sufferings, improve the quality of living, symptom management, " seeking improvement in stability ", to obtain " existence of long-term band tumor ".
At present in the treatment of cervical cancer, operation and radiation and chemotherapy are the most frequently used therapeutic modalities, although have good curative effect to treatment cervical cancer, also have more side effect and untoward reaction, and the defect such as relapse rate is high.Chemotherapy is one of the most frequently used in oncotherapy in recent years Therapeutic Method.But chemotherapeutics normal " right and wrong are unclear ", " failing to differentiate between the enemy and ourselves ", while killing tumor cell, also killed and wounded human normal cell.Therefore, may there is following toxic action and untoward reaction in chemotherapy:
1, during intravenous injection chemotherapeutics, careless manipulation medicine liquid leakage can cause local tissue necrosis and angiitis obliterans.Therefore, medical personnel must be very careful, conscientiously prevented.
2, suppress medulla hematopoietic system, mainly leukocyte and platelet decline.Before each chemotherapy, all hemogram checking should be done, if if leukocytic number is lower than (2.5 ~ 3) × 10 9/ liter, platelet (50 ~ 80) × 10 9/ liter, temporarily should stop chemotherapy, the doctor's advice in accordance with doctor uses hemocytes increasing medicine.Except the treatment by Chinese herbs of original batilol, leucogen, nucleotide and vitamin B6 and vigorate qi and replenish the blood, some colony stimulating factors produced by gene recombinaton engineering in recent years, have the function significantly promoting hemocyte hypertrophy.Only after chemotherapy, using these medicines in time, leukocyte would not obviously decline.
3, can infringement liver cell in various degree, occur that glutamate pyruvate transaminase increases, bilirubin rising, hepatomegaly, hepatalgia, jaundice etc., serious meeting causes liver cirrhosis, disturbances of blood coagulation etc., so before medication and in medication process, check liver function, Timeliness coverage problem, solves in time, stops chemotherapy if desired.
4, some chemotherapeutics is to the toxic effect of cardiovascular system, serious occurred heart failure.So should check electrocardiogram before medication and in medication, note abnormalities drug withdrawal immediately, treats in time.To the patient having heart change, should avoid using the chemotherapeutics to the toxic effect of heart.
5, acute chemical pneumonia and chronic fibrosis of lung can be caused to the chemotherapeutics of the toxic effect of respiratory system and untoward reaction, even occur respiratory failure.Therefore use pulmonary toxicity medicine (namely to the virose chemotherapeutics of respiratory system), as bleomycin A5 etc., pulmonary condition should be made regular check on during medication, be also noted that after drug withdrawal and follow up a case by regular visits to.Discovery lung toxicity reacts, and stops chemotherapy immediately and uses hormone therapy.
6, the toxic action of urinary system and untoward reaction performance have albuminuria, oliguria or anuria, some generation hematurias.In order to can renal function be had a clear understanding of, all to make regular check on before medication He in medication process, pinpoint the problems, treat in time.Make every day urine volume at 2000 ~ 3000 milliliters.Empirical evidence, can reduce toxic action and the untoward reaction of urinary system like this.
7, some drugs can affect fertility, causes monster.At chemotherapeutic period, male patient answers birth control, and after female patients should stop or avoid the general drug withdrawal of chemotherapy if any gestation, reproductive function can recover.
8, alopecia and the not all patient of dermoreaction can occur, even if occur also need not too worrying, because after general patient's drug withdrawal, the hair taken off can grow again, the erythema of skin, erythra and pigmentation also can take a turn for the better or disappear.
9, in the general reaction of chemotherapy, toxic action and the untoward reaction that count digestive system make patient worried most, as Nausea and vomiting, inappetence, stomachache, diarrhoea, and stomatocace, pharyngolaryngitis etc.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of Chinese medicine and preparation method for the treatment of liver-kidney yin deficiency cervical cancer, and Chinese medicine of the present invention has definite curative effect to liver-kidney yin deficiency cervical cancer, with strong points, instant effect, toxic and side effects are little and relapse rate is low.
In order to solve the problems of the technologies described above, the invention provides a kind of treat liver-kidney yin deficiency cervical cancer Chinese medicine, each raw medicinal material of described Chinese medicine comprises: Herba veronicastri villosuli, bittersweet, Radix Patriniae heterophyllae, Rhizoma Curcumae, Bulbilus dioscoreae bulbiferae, Herba Agrimoniae, Rhizoma Dioscoreae Bulbiferae, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Herba Euphorbiae Helioscopiae, Solenognathus, Galium spurium L., Herba Solani Lyrati, Semen Cuscutae, Fructus Lycii, artillery clearweed, one, the crown flower, Cortex Acanthopancis and Botrychium lanuginosum Wall..
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba veronicastri villosuli 20 ~ 30 parts, bittersweet 15 ~ 25 parts, Radix Patriniae heterophyllae 30 ~ 40 parts, Rhizoma Curcumae 10 ~ 20 parts, Bulbilus dioscoreae bulbiferae 5 ~ 15 parts, Herba Agrimoniae 10 ~ 20 parts, Rhizoma Dioscoreae Bulbiferae 10 ~ 20 parts, Herba Scutellariae Barbatae 20 ~ 30 parts, Herba Hedyotidis Diffusae 15 ~ 25 parts, Herba Euphorbiae Helioscopiae 5 ~ 15 parts, Solenognathus 20 ~ 30 parts, Galium spurium L. 10 ~ 20 parts, Herba Solani Lyrati 5 ~ 15 parts, Semen Cuscutae 15 ~ 25 parts, Fructus Lycii 20 ~ 30 parts, artillery clearweed 10 ~ 20 parts, one, the crown spends 10 ~ 20 parts, Cortex Acanthopancis 15 ~ 25 parts and Botrychium lanuginosum Wall. 5 ~ 15 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can also be preferably as follows: Herba veronicastri villosuli 25 ~ 30 parts, bittersweet 20 ~ 25 parts, Radix Patriniae heterophyllae 35 ~ 40 parts, Rhizoma Curcumae 10 ~ 15 parts, Bulbilus dioscoreae bulbiferae 5 ~ 10 parts, Herba Agrimoniae 15 ~ 20 parts, Rhizoma Dioscoreae Bulbiferae 10 ~ 15 parts, Herba Scutellariae Barbatae 25 ~ 30 parts, Herba Hedyotidis Diffusae 15 ~ 20 parts, Herba Euphorbiae Helioscopiae 10 ~ 15 parts, Solenognathus 20 ~ 25 parts, Galium spurium L. 10 ~ 15 parts, Herba Solani Lyrati 5 ~ 10 parts, Semen Cuscutae 20 ~ 25 parts, Fructus Lycii 25 ~ 30 parts, artillery clearweed 10 ~ 15 parts, one, the crown spends 15 ~ 20 parts, Cortex Acanthopancis 20 ~ 25 parts and Botrychium lanuginosum Wall. 5 ~ 10 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine also can be preferably as follows: Herba veronicastri villosuli 28 parts, bittersweet 22 parts, Radix Patriniae heterophyllae 40 parts, Rhizoma Curcumae 12 parts, Bulbilus dioscoreae bulbiferae 8 parts, Herba Agrimoniae 15 parts, Rhizoma Dioscoreae Bulbiferae 14 parts, Herba Scutellariae Barbatae 29 parts, Herba Hedyotidis Diffusae 15 parts, Herba Euphorbiae Helioscopiae 12 parts, Solenognathus 24 parts, Galium spurium L. 11 parts, Herba Solani Lyrati 9 parts, Semen Cuscutae 21 parts, Fructus Lycii 26 parts, artillery clearweed 11 parts, one, the crown spend 17 parts, Cortex Acanthopancis 21 parts and Botrychium lanuginosum Wall. 6 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows again: Herba veronicastri villosuli 26 parts, bittersweet 24 parts, Radix Patriniae heterophyllae 37 parts, Rhizoma Curcumae 13 parts, Bulbilus dioscoreae bulbiferae 6 parts, Herba Agrimoniae 18 parts, Rhizoma Dioscoreae Bulbiferae 11 parts, Herba Scutellariae Barbatae 26 parts, Herba Hedyotidis Diffusae 19 parts, Herba Euphorbiae Helioscopiae 13 parts, Solenognathus 22 parts, Galium spurium L. 13 parts, Herba Solani Lyrati 5 parts, Semen Cuscutae 24 parts, Fructus Lycii 28 parts, artillery clearweed 12 parts, one, the crown spend 20 parts, Cortex Acanthopancis 23 parts and Botrychium lanuginosum Wall. 9 parts.
When above-mentioned the dosage form of Chinese medicine is capsule described in any one time, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80% ~ 90%, reflux 40 ~ 60 minutes, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 3 times again, reflux 30 ~ 50 minutes, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step, the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the starch of 0.1 ~ 0.3 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
When above-mentioned the dosage form of Chinese medicine is powder described in any one time, its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.
Beneficial effect of the present invention: Chinese medicine of the present invention, according to tcm treatment according to syndrome differentiation principle, with strong points to liver-kidney yin deficiency cervical cancer, have definite curative effect, instant effect, toxic and side effects is little and relapse rate is low.
Detailed description of the invention
The invention provides a kind of treat liver-kidney yin deficiency cervical cancer Chinese medicine, its raw medicinal material comprises: Herba veronicastri villosuli, bittersweet, Radix Patriniae heterophyllae, Rhizoma Curcumae, Bulbilus dioscoreae bulbiferae, Herba Agrimoniae, Rhizoma Dioscoreae Bulbiferae, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Herba Euphorbiae Helioscopiae, Solenognathus, Galium spurium L., Herba Solani Lyrati, Semen Cuscutae, Fructus Lycii, artillery clearweed, one, the crown flower, Cortex Acanthopancis and Botrychium lanuginosum Wall..
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Herba veronicastri villosuli: for goatweed climbs the herb of red rock or hair leaf Herba veronicastri villosuli.Latin plant animal mineral name: 1.Veronicastrum axillare (Sieb.Et Zucc.) Yamazaki [Paederotaaxillaris Sieb.Et Zucc.] 2.Veronicastrum uillosulum (Miq.) Yamazaki [Paederota uillosula Miq.].Bitter in the mouth; Cold nature.Return liver; Spleen; Kidney channel.Row water; Detumescence; Dissipating blood stasis; Removing toxic substances.Main cirrhotic ascites; Oedema due to nephritis; Traumatic injury; Skin ulcer swells furunculosis; Scald; Venom." China's book on Chinese herbal medicine "
Bittersweet: to be the herb of the plant of Solanaceae hair year not rotten heart.Latin plant animal mineral name: Solanum cathayanum C.Y.Wuet S.C.Huang [S.dulcamara L.var.chinenseDunal].Sweet in the mouth; Bitter; Cold in nature.Heat-clearing and toxic substances removing; Dispelling wind and relieving convulsion.Main fever of children infantile convulsion; Jaundice; Cough due to lung-heat; Acute toothache; Scrofula; Woman uterine bleeding, leukorrhagia, pelvic inflammatory disease." China's book on Chinese herbal medicine "
Radix Patriniae heterophyllae: be the root of Valerianaceae plant Radix Patriniae Scabrae or a little beans of different leaf.Latin plant animal mineral name: 1.Patrinia rupestris (Pall.) Juss.subsp.scabra (Bunge) H.J.Wang [Patriniascabra Bunge] 2.Patrinia heterophylla Bunge.Bitter in the mouth; Micro-sour and astringent; Cool in nature.GUIXIN; Liver Channel.Dampness leukorrhagia stopping; Astringing to arrest bleeding; Heat-clearing and toxic substances removing.Main leucorrhea with red and white discharge; Metrorrhagia; Dysentery; Jaundice; Malaria; Intestinal carbuncle; Sore swollen toxin; Traumatic injury; Cervical cancer; Gastric cancer." China's book on Chinese herbal medicine "
Rhizoma Curcumae: be the dry rhizome of zingiberaceous plant Rhizoma Curcumae Curcuma phaeocaulis Val., Guangxi zedoary Curcuma Kwangsiensis S.G.Lee et C.F.Liang or RADIX CURCUMAE Curcumawenyujin Y.H.Chen et C.Ling.Pungent, bitter, temperature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma." Chinese Pharmacopoeia "
Bulbilus dioscoreae bulbiferae: be the puce bulbil grown in Dioscoreaceae plant Dioscorea bulbifera L. axil.Latin plant animal mineral name: Dioscorea bulbifera L..Bitter; Pungent; Cold; Slightly poisonous.Removing heat-phlegm; Relieving cough and asthma; Powder detoxifcation.Main expectorant heat syndrome cough is breathed heavily; Pertussis; Laryngopharynx swelling and pain; Goiter; Scrofula; Sore swollen toxin; Serpentis dog flood dragon hinders." China's book on Chinese herbal medicine "
Herba Agrimoniae: be the aerial parts of rosaceous plant Agrimony.Latin plant animal mineral name: Agrimonia pilosa Ledeb. bitter in the mouth, puckery, property is put down.Return lung; Liver; Spleen channel.Astringing to arrest bleeding, dysentery relieving, parasite killing.Main spitting of blood; Spit blood; Hematuria; Have blood in stool; Dysentery; Bleeding not during menses; Impairment caused by overstrain takes off power; Carbuncle; Traumatic injury; Wound hemorrhage." China's book on Chinese herbal medicine "
Rhizoma Dioscoreae Bulbiferae: be the tuber of Dioscoreaceae plant Dioscorea bulbifera L..Latin plant animal mineral name: Dioscoreabulbifera L. is bitter; Cold; Mild toxicity.Return lung; Liver Channel.Eliminating stagnation disappears wart; Heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main goiter; Sore throat; Carbuncle sore tumefacting virus; Venom; Tumor; Spit blood; Epistaxis; Spitting of blood; Pertussis; Lung-heat cough with asthma." China's book on Chinese herbal medicine "
Herba Scutellariae Barbatae: be the herb of labiate Herba Scutellariae Barbatae.Latin plant animal mineral name: Scytekaruabarbvata D.Don (S.riu-larias Wall.) acrid in the mouth; Bitter; Cold in nature.Return lung; Liver; Kidney channel.Heat-clearing and toxic substances removing; Dissipating blood stasis stops blooding; Inducing diuresis to remove edema.Main pyretic toxicity carbuncle; Have sore throat; Lung abscess; Intestinal carbuncle; Scrofula; Venom; Traumatic injury; Spit blood; Epistaxis; Stranguria with blood; Edema; Ascites and cancer." China's book on Chinese herbal medicine "
Herba Hedyotidis Diffusae: be the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae Hedyotis diffusaWilld. [Oldenlandia diffusa (Willd.) Roxb.].Sweet, light, cool.Enter stomach, large intestine, small intestine meridian.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom." Chinese Pharmacopoeia "
Herba Euphorbiae Helioscopiae: be the herb of euphorbia plant Herba Euphorbiae Helioscopiae.Latin plant animal mineral name: Euphorbiahelioscopia L. acrid in the mouth; Bitter; Cold nature; Poisonous.Return large intestine; Small intestinal; Spleen; Lung meridian.Line water detumescence; Preventing phlegm from forming and stopping coughing; Removing toxic substances parasite killing.Cure mainly edematous asthma; Phlegm retention is breathed with cough malaria; Bacillary dysentery; Scrofula; Tuberculous fistula; Osteomyelitis." China's book on Chinese herbal medicine "
Solenognathus: be the dry body of Syngnathidae animal solenognathus hardwickii Solenognathus hardwickii (Gray), syngnathoides biaculeatus Syngn athoides biaculeatus (Bloch) or syngnathus acus Linnaeus Syngnathus acusLinnaeus.Sweet, temperature.Return liver, kidney channel.Warming the kidney to invigorate YANG, mass dissipating and swelling eliminating.For impotence and seminal emission, lump in the abdomen, scrofula sucutaneous nodule, injury from falling down; External treatment carbuncle furuncle." Chinese Pharmacopoeia "
Galium spurium L.: be the herb of Maguireothamnus speciosus Galium spurium L..Latin plant animal mineral name: Galiumspurium L. is sweet; Pungent; Micro-hardship; Flat.Heat-clearing and toxic substances removing; Promoting blood circulation to remove obstruction in the collateral; Stop blooding treating stranguria.Main stranguria; Hematuria; Appendicitis; Paronychia; Traumatic injury; Bones and muscles pain." China's book on Chinese herbal medicine "
Herba Solani Lyrati: be herb or the fruit of the blue or green Qi of plant of Solanaceae.Latin plant animal mineral name: Solanumseptemlobum Bunge.Bitter in the mouth; Cold in nature; Mild toxicity.Heat-clearing and toxic substances removing.Main laryngopharynx swelling and pain; Blurred vision is red; Mastitis; Rib adenitis; Scabies; Scabies pruritus." China's book on Chinese herbal medicine "
Semen Cuscutae: be the dry mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam..Sweet, temperature.Return liver,kidney,spleen warp.Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma." Chinese Pharmacopoeia "
Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Sweet, flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand." Chinese Pharmacopoeia "
Artillery clearweed: be the herb of contrayerva Herba Pileae microphyllae.Latin plant animal mineral name: Pileamicrophylla (L.) Liebm. [Parietaria microphylla L.].Light; Puckery; Cool in nature.Heat-clearing and toxic substances removing.Main carbuncle skin ulcer swells and ache; Erysipelas; Innominate toxic swelling; Empyrosis; Venom." China's book on Chinese herbal medicine "
One, crown flower: be the herb of Ofthe Primulaceae pipe stem Lysimachia christinae Hance.Latin plant animal mineral name: Lysimachia fistulosa Hand.-Mazz..Bitter; Cool in nature.Heat-clearing and toxic substances removing; Promoting blood circulation and detumescence.Main innominate toxic swelling; Venom; Traumatic injury." China's book on Chinese herbal medicine "
Cortex Acanthopancis: be the dry root bark of Araliaceae acanthopanax gracilistylus Acanthopanax gracilistylus W.W.Smith.Pungent, bitter, temperature.Return liver, kidney channel.Wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening.For rheumatic arthralgia, muscles and bones flaccidity is soft, children's's walking retardation in children, and body void is weak, edema, beriberi." Chinese Pharmacopoeia "
Botrychium lanuginosum Wall.: be herb or the rhizome of Botrychiaceae plant fine hair Herba Botrychii.Latin plant animal mineral name: Botrypus lanuginosus (Wall.) Holub [Botrychium lanuginosum Wall.].Micro-hardship; Sweet; Be slightly cold; Flat; Poisonous.Return liver; Kidney channel.Heat-clearing and toxic substances removing; Nourishing; Relieving cough and asthma.Main venom; Acute mastitis; Furuncle swelling toxin; Scrofula; Pharyngolaryngitis; Lung-heat cough with asthma." China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba veronicastri villosuli 20 ~ 30 parts, bittersweet 15 ~ 25 parts, Radix Patriniae heterophyllae 30 ~ 40 parts, Rhizoma Curcumae 10 ~ 20 parts, Bulbilus dioscoreae bulbiferae 5 ~ 15 parts, Herba Agrimoniae 10 ~ 20 parts, Rhizoma Dioscoreae Bulbiferae 10 ~ 20 parts, Herba Scutellariae Barbatae 20 ~ 30 parts, Herba Hedyotidis Diffusae 15 ~ 25 parts, Herba Euphorbiae Helioscopiae 5 ~ 15 parts, Solenognathus 20 ~ 30 parts, Galium spurium L. 10 ~ 20 parts, Herba Solani Lyrati 5 ~ 15 parts, Semen Cuscutae 15 ~ 25 parts, Fructus Lycii 20 ~ 30 parts, artillery clearweed 10 ~ 20 parts, one, the crown spends 10 ~ 20 parts, Cortex Acanthopancis 15 ~ 25 parts and Botrychium lanuginosum Wall. 5 ~ 15 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can also be preferably as follows: Herba veronicastri villosuli 25 ~ 30 parts, bittersweet 20 ~ 25 parts, Radix Patriniae heterophyllae 35 ~ 40 parts, Rhizoma Curcumae 10 ~ 15 parts, Bulbilus dioscoreae bulbiferae 5 ~ 10 parts, Herba Agrimoniae 15 ~ 20 parts, Rhizoma Dioscoreae Bulbiferae 10 ~ 15 parts, Herba Scutellariae Barbatae 25 ~ 30 parts, Herba Hedyotidis Diffusae 15 ~ 20 parts, Herba Euphorbiae Helioscopiae 10 ~ 15 parts, Solenognathus 20 ~ 25 parts, Galium spurium L. 10 ~ 15 parts, Herba Solani Lyrati 5 ~ 10 parts, Semen Cuscutae 20 ~ 25 parts, Fructus Lycii 25 ~ 30 parts, artillery clearweed 10 ~ 15 parts, one, the crown spends 15 ~ 20 parts, Cortex Acanthopancis 20 ~ 25 parts and Botrychium lanuginosum Wall. 5 ~ 10 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine also can be preferably as follows: Herba veronicastri villosuli 28 parts, bittersweet 22 parts, Radix Patriniae heterophyllae 40 parts, Rhizoma Curcumae 12 parts, Bulbilus dioscoreae bulbiferae 8 parts, Herba Agrimoniae 15 parts, Rhizoma Dioscoreae Bulbiferae 14 parts, Herba Scutellariae Barbatae 29 parts, Herba Hedyotidis Diffusae 15 parts, Herba Euphorbiae Helioscopiae 12 parts, Solenognathus 24 parts, Galium spurium L. 11 parts, Herba Solani Lyrati 9 parts, Semen Cuscutae 21 parts, Fructus Lycii 26 parts, artillery clearweed 11 parts, one, the crown spend 17 parts, Cortex Acanthopancis 21 parts and Botrychium lanuginosum Wall. 6 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows again: Herba veronicastri villosuli 26 parts, bittersweet 24 parts, Radix Patriniae heterophyllae 37 parts, Rhizoma Curcumae 13 parts, Bulbilus dioscoreae bulbiferae 6 parts, Herba Agrimoniae 18 parts, Rhizoma Dioscoreae Bulbiferae 11 parts, Herba Scutellariae Barbatae 26 parts, Herba Hedyotidis Diffusae 19 parts, Herba Euphorbiae Helioscopiae 13 parts, Solenognathus 22 parts, Galium spurium L. 13 parts, Herba Solani Lyrati 5 parts, Semen Cuscutae 24 parts, Fructus Lycii 28 parts, artillery clearweed 12 parts, one, the crown spend 20 parts, Cortex Acanthopancis 23 parts and Botrychium lanuginosum Wall. 9 parts.
When above-mentioned the dosage form of Chinese medicine is capsule described in any one time, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80% ~ 90%, reflux 40 ~ 60 minutes, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 3 times again, reflux 30 ~ 50 minutes, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step, the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the starch of 0.1 ~ 0.3 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
When above-mentioned the dosage form of Chinese medicine is powder described in any one time, its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: capsule
Get Herba veronicastri villosuli 260g, bittersweet 240g, Radix Patriniae heterophyllae 370g, Rhizoma Curcumae 130g, Bulbilus dioscoreae bulbiferae 60g, Herba Agrimoniae 180g, Rhizoma Dioscoreae Bulbiferae 110g, Herba Scutellariae Barbatae 260g, Herba Hedyotidis Diffusae 190g, Herba Euphorbiae Helioscopiae 130g, Solenognathus 220g, Galium spurium L. 130g, Herba Solani Lyrati 50g, Semen Cuscutae 240g, Fructus Lycii 280g, artillery clearweed 120g, the colored 200g in one, the crown, Cortex Acanthopancis 230g and Botrychium lanuginosum Wall. 90g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 80%, reflux 60 minutes, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 3 times again, reflux 40 minutes, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize and sieve acquisition 300 object micropowders;
3rd step, the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3 times, the starch of 0.2 times, the magnesium stearate of 0.035 times, carries out mixing process, namely obtains capsule 's content, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
Embodiment 2: powder
Herba veronicastri villosuli 280g, bittersweet 220g, Radix Patriniae heterophyllae 400g, Rhizoma Curcumae 120g, Bulbilus dioscoreae bulbiferae 80g, Herba Agrimoniae 150g, Rhizoma Dioscoreae Bulbiferae 140g, Herba Scutellariae Barbatae 290g, Herba Hedyotidis Diffusae 150g, Herba Euphorbiae Helioscopiae 120g, Solenognathus 240g, Galium spurium L. 110g, Herba Solani Lyrati 90g, Semen Cuscutae 210g, Fructus Lycii 260g, artillery clearweed 110g, the colored 170g in one, the crown, Cortex Acanthopancis 210g and Botrychium lanuginosum Wall. 60g.
Its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;
3rd step: add the starch relative to its quality 2.5 times in the micropowders obtained by second step, mixing, obtains powder.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 22 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 7.30g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.5 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>36.5 crude drug/kg, every day, maximum dosage-feeding was 73.0 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 6.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.107g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 26g) oral administration gavage Chinese medicine of the present invention is 682 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention presses 13.12,19.03 and 37.45g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Tumor-inhibiting action is tested:
Subjects: ICR mice 100, body weight 19-24g, male.
Test inoculation content: by subcutaneous for the dorsal part axillary fossa that the cell (U14) of mouse carcinoma of uterine cervix is inoculated in mice, when growing to 1-1.5cm etc. tumor body, select good tumor tissue, (cancerous cell number is 1 × 10 to be prepared into single cell suspension 6individual/ml).
Get ICR mice, in dorsal part axillary fossa subcutaneous traditional vaccination U14 cancer cell suspension 0.2ml, (cancerous cell number is 1 × 10 6individual cell/m1), next day is divided into 5 groups at random.Treatment group is divided into three groups, is respectively high dose group, middle dosage group and low dose group, adopts the capsule of the embodiment of the present invention 1, and after pulverizing, distilled water dissolves, and every day is gastric infusion 1.2ml, 0.8m1 and 0.4m1 respectively, continuous 10 days; Matched group is divided into two groups, is respectively normal saline group and CTX group, and normal saline group stomach every day raises 0.4m1 normal saline, continuous 10 days; CTX group to Cytoxan, daily 0.2g, distilled water dissolve after gastric infusion, continuous 10 days; 5 groups be drug withdrawal after next day put to death animal, stripping tumor is weighed, calculate tumour inhibiting rate, tumour inhibiting rate formula is: the average tumor of tumour inhibiting rate (%)=(saline control group average tumor weight-medication group average tumor weight)/saline control group heavy × 100%, result shows, medicine of the present invention has inhibitory action to U14 growth, and its tumour inhibiting rate increases with dosage and increases progressively, and has significant difference P<0.05 compared with matched group.To the inhibitory action of U14 and tumor killing effect in table 1.
Table 1: to inhibitory action and the tumor killing effect of U14
Group Average tumor heavy (g) Average mice body weight change (g) Tumour inhibiting rate (%)
High dose group 1.41±0.38 +3.95 56.88
Middle dosage group 1.56±0.62 +4.42 52.29
Low dose group 1.67±0.26 +4.84 48.93
CTX group 1.59±0.42 -1.68 51.38
Normal saline group 3.27±0.89 +5.03 0
Known by table 1: the treatment group adopting Chinese medicine preparation of the present invention, compare with normal saline group, tumor bulk-growth can be suppressed, and tumour inhibiting rate increases progressively with the increase of dosage, have significant difference P<0.05, (n=10, X ± SD); Adopt the treatment group of Chinese medicine preparation of the present invention, compare with CTX group, the body weight of the mice for the treatment of group has increase, and the Mouse Weight of CTX group alleviates, and both have compared significant difference P<0.05, (n=10, X ± SD).
Measure additionally by fluid cell instrument, result shows, Chinese medicine preparation of the present invention prevents tumor cell by S → G2 process, also have impact on the carrying out of G1 → S simultaneously, the cell of S and G1 phase is obviously increased, the cell of G2 and M phase is relatively low, disturbs the propagation activity of tumor cell, reaches antineoplastic action.
The display of above-mentioned experimental result, the tumor of Chinese medicine of the present invention to the animal model of cervical cancer has obvious inhibitory action, and then can know Chinese medicine of the present invention by inference and have effective therapeutical effect to cervical cancer.
Clinical data:
Case selection: whole 98 routine cases are my Out-patient Department or inpatient, wherein 20 ~ 30 years old woman 22 example, 31 ~ 40 years old woman 33 example, 41 ~ 50 years old woman 34 example, more than 50 years old woman 9 example.Be divided into treatment group and matched group at random, wherein treatment group 49 people, wherein 20 ~ 30 years old woman 11 example, 31 ~ 40 years old woman 16 example, 41 ~ 50 years old woman 17 example, more than 50 years old woman 5 example.Matched group 49 people, wherein 20 ~ 30 years old woman 11 example, 31 ~ 40 years old woman 17 example, 41 ~ 50 years old woman 17 example, more than 50 years old woman 4 example.Two groups of ages, diseased region, clinical manifestation and equal not statistically significants of coincident with severity degree of condition comparing difference (p>0.05).
Diagnostic criteria: with reference to diagnostic criteria and the Chinese medical discrimination diagnostic criteria of the cervical cancer in " the cervical cancer diagnosis " of Ministry of Public Health Ministry of Public Health issue in 2011.
Standards of Chinese Medical Syndrome Differentiation: liver-kidney yin deficiency: leucorrhea amount is many, has a dizzy spell, time have colporrhagia, tinnitus, the soreness of waist, susceptible to lose temper due to restlessness, insomnia and dreamful sleep, feverish sensation in the palms and soles, dry pharynx dryness of the tongue, constipation, the few tongue of red tongue or light stripping, or have crackle, stringy and thready pulse.
Therapeutic Method:
Treatment group: give the embodiment of the present invention 1 capsule every day 3 times, each 4.1 month was 1 course for the treatment of, suffered from cervical cancer time length according to patient, took 2 ~ 3 courses for the treatment of within 1 year continuously, within 1 year to 2 years, took 4 ~ 5 courses for the treatment of continuously, more than 2 years 5 ~ 6 courses for the treatment of;
Matched group: give operative treatment and Synchronous chemoradiotherapy treatment.Radiotherapy: adopt extracorporeal irradiation to combine with Esophageal cacinoma.Extracorporeal irradiation 6MV-x line linear accelerator, before and after adopting, two is large wild to wearing irradiation (upper bound is equivalent to 4th ~ 5 lumbar vertebra levels, and lower bound is 4 ~ 5cm under superior margin of pubic symphysis), 5 times weekly, DT1.8 ~ 2.0Gy/d, first irradiates 10 ~ 12 times, whole pelvic radiation DT20 ~ 25Gy, anterior posterior field center line irradiates 10 ~ 12 times with gear is plumbous again, DT20 ~ 25Gy, DT1.8 ~ 2.0Gy/d, 5 times weekly, total amount 45Gy.Intracavitary therapy Ir192 after-loading therapy during this period, once in a week, each A dose point reaches 4 ~ 6Gy, accumulated dose 36 ~ 41Gy, 6 ~ 7 weeks courses for the treatment of.Intracavitary therapy not all right extracorporeal irradiation on the same day, every day, vaginadouche was carried out in cooperation.Chemotherapy regimen: chemotherapeutics and radiotherapy synchronously carry out.DDP (cisplatin) 40mg, be used in conjunction 3d once a day, 5-FU 1.0g, be used in conjunction 3d once a day, BLM (winning enzyme element) 15mg, once a day, all be used in conjunction 3d, after getting rid of chemotherapy contraindication, each patient is each 1 course for the treatment of before radiotherapy, in radiotherapy, after radiotherapy, totally 3 courses for the treatment of.
Observation of curative effect: two groups of patient's row gynecologial examinations weekly, record cervix neoplasms is shunk back situation, record gastrointestinal reaction, colporrhagia, flow liquid, stomachache and the improvement situation such as lower abdomen is uncomfortable.2 routines of having a blood test weekly, treatment terminates rear regular outpatient service check.
Curative effect judging standard: complete incidence graph (CR): tumor disappearance, clinical symptom disappearance, the time is no less than 4 weeks; Partial rcsponse (PR): tumor mass reduction more than 1/2, clinical symptoms disappears substantially, and the time is no less than 4 weeks; Invalid (MR): tumor mass reduction less than 1/2, clinical symptoms takes a turn for the better to some extent, and occurs without new tumor focus at treatments period; Progress (PD): gross tumor volume increases and/or has new tumor focus to occur.It is effective that CR adds PR.
Therapeutic outcome: two groups treat 2 ~ 6 courses for the treatment of respectively after, statistical result is see table 1.As can be seen from Table 1, adopt treatment by Chinese herbs liver-kidney yin deficiency cervical cancer of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement.
A table 1 liang group treats two groups of comparitive study (example) after 2 ~ 6 months respectively:
Group n CR PR MR PD Effectively total
Treatment group 49 38 8 3 0 46(93.88％)
Matched group 49 27 13 5 4 40(81.63％)
Survival rate statistics: follow the tracks of all patients and follow up a case by regular visits to 5 years and periodic review, and calculate 1,3,5 year survival rate respectively, statistical result is in table 2.From table 2 statistical data, treatment group and matched group 1 year differential survival little, and the survival rate aspect of 3 years and 5 years, treatment group is obviously better than matched group, and namely Chinese medicine of the present invention obviously can extend the life span of Patients with Cervical Cancer.
A table 2 liang group follows the trail of 5 years survival rate statistics results respectively
Group 1 year 3 years 5 years
Treatment group 43(87.76％) 39(79.59％) 29(59.18％)
Matched group 41(83.67％) 30(61.22％) 17(34.69％)
Meanwhile, follow up a case by regular visits to in periodic review process in tracking, observe: in the routine CR patient for the treatment of group 38, without recurrence and transfer, in 8 routine PR patients, aggravation 1 example, total relapse rate is 2.1% (1/46); In the routine CR patient of matched group 27, recur 7 people, in 13 routine PR patients, aggravation or transferase 45 example, total relapse rate 30% (12/40).
Untoward reaction: in the routine patient for the treatment of group 49, have 4 examples to occur the symptoms such as slight Nausea and vomiting, 2 ~ 3d recovers normal; Matched group, in 49 routine patients, there are Nausea and vomiting, 22 routine loss of appetite in 34 examples, and bone marrow depression companion urgent micturition, frequent micturition and dysurea appear in 12 examples, and alopecia etc. in various degree appears in 41 examples.
Concrete case: Zhang, women, 46 years old.Because of sexual life and vagina outflow after an action of the bowels, and leucorrhea showed increased, be admitted to hospital.Check through CT and other, be diagnosed as cervical cancer.Leucorrhea amount is many, has a dizzy spell, sexual life or after an action of the bowels colporrhagia, the soreness of waist, susceptible to lose temper due to restlessness, insomnia and dreamful sleep, constipation, and the few tongue of red tongue, has crackle, stringy and thready pulse.Chinese medical discrimination is diagnosed as liver-kidney yin deficiency cervical cancer.Patient requests avoids operation as far as possible.Give Chinese medicine embodiment 1 capsule of the present invention every day 3 times, each 4, treat after 4 months, tumor disappears substantially, and continue to take and strengthen curative effect in 1 month, recovery from illness, follows up a case by regular visits to and do not recur for 5 years.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. one kind treat liver-kidney yin deficiency cervical cancer Chinese medicine, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba veronicastri villosuli, bittersweet, Radix Patriniae heterophyllae, Rhizoma Curcumae, Bulbilus dioscoreae bulbiferae, Herba Agrimoniae, Rhizoma Dioscoreae Bulbiferae, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Herba Euphorbiae Helioscopiae, Solenognathus, Galium spurium L., Herba Solani Lyrati, Semen Cuscutae, Fructus Lycii, artillery clearweed, one, the crown flower, Cortex Acanthopancis and Botrychium lanuginosum Wall..
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba veronicastri villosuli 20 ~ 30 parts, bittersweet 15 ~ 25 parts, Radix Patriniae heterophyllae 30 ~ 40 parts, Rhizoma Curcumae 10 ~ 20 parts, Bulbilus dioscoreae bulbiferae 5 ~ 15 parts, Herba Agrimoniae 10 ~ 20 parts, Rhizoma Dioscoreae Bulbiferae 10 ~ 20 parts, Herba Scutellariae Barbatae 20 ~ 30 parts, Herba Hedyotidis Diffusae 15 ~ 25 parts, Herba Euphorbiae Helioscopiae 5 ~ 15 parts, Solenognathus 20 ~ 30 parts, Galium spurium L. 10 ~ 20 parts, Herba Solani Lyrati 5 ~ 15 parts, Semen Cuscutae 15 ~ 25 parts, Fructus Lycii 20 ~ 30 parts, artillery clearweed 10 ~ 20 parts, one, the crown spends 10 ~ 20 parts, Cortex Acanthopancis 15 ~ 25 parts and Botrychium lanuginosum Wall. 5 ~ 15 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba veronicastri villosuli 25 ~ 30 parts, bittersweet 20 ~ 25 parts, Radix Patriniae heterophyllae 35 ~ 40 parts, Rhizoma Curcumae 10 ~ 15 parts, Bulbilus dioscoreae bulbiferae 5 ~ 10 parts, Herba Agrimoniae 15 ~ 20 parts, Rhizoma Dioscoreae Bulbiferae 10 ~ 15 parts, Herba Scutellariae Barbatae 25 ~ 30 parts, Herba Hedyotidis Diffusae 15 ~ 20 parts, Herba Euphorbiae Helioscopiae 10 ~ 15 parts, Solenognathus 20 ~ 25 parts, Galium spurium L. 10 ~ 15 parts, Herba Solani Lyrati 5 ~ 10 parts, Semen Cuscutae 20 ~ 25 parts, Fructus Lycii 25 ~ 30 parts, artillery clearweed 10 ~ 15 parts, one, the crown spends 15 ~ 20 parts, Cortex Acanthopancis 20 ~ 25 parts and Botrychium lanuginosum Wall. 5 ~ 10 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba veronicastri villosuli 28 parts, bittersweet 22 parts, Radix Patriniae heterophyllae 40 parts, Rhizoma Curcumae 12 parts, Bulbilus dioscoreae bulbiferae 8 parts, Herba Agrimoniae 15 parts, Rhizoma Dioscoreae Bulbiferae 14 parts, Herba Scutellariae Barbatae 29 parts, Herba Hedyotidis Diffusae 15 parts, Herba Euphorbiae Helioscopiae 12 parts, Solenognathus 24 parts, Galium spurium L. 11 parts, Herba Solani Lyrati 9 parts, Semen Cuscutae 21 parts, Fructus Lycii 26 parts, artillery clearweed 11 parts, one, the crown spend 17 parts, Cortex Acanthopancis 21 parts and Botrychium lanuginosum Wall. 6 parts.
5. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba veronicastri villosuli 26 parts, bittersweet 24 parts, Radix Patriniae heterophyllae 37 parts, Rhizoma Curcumae 13 parts, Bulbilus dioscoreae bulbiferae 6 parts, Herba Agrimoniae 18 parts, Rhizoma Dioscoreae Bulbiferae 11 parts, Herba Scutellariae Barbatae 26 parts, Herba Hedyotidis Diffusae 19 parts, Herba Euphorbiae Helioscopiae 13 parts, Solenognathus 22 parts, Galium spurium L. 13 parts, Herba Solani Lyrati 5 parts, Semen Cuscutae 24 parts, Fructus Lycii 28 parts, artillery clearweed 12 parts, one, the crown spend 20 parts, Cortex Acanthopancis 23 parts and Botrychium lanuginosum Wall. 9 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80% ~ 90%, reflux 40 ~ 60 minutes, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 3 times again, reflux 30 ~ 50 minutes, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step, the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the starch of 0.1 ~ 0.3 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80% ~ 90%, reflux 40 ~ 60 minutes, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 3 times again, reflux 30 ~ 50 minutes, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step, the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the starch of 0.1 ~ 0.3 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105012887A (en) * 2015-08-13 2015-11-04 李荣勤 Traditional Chinese medicine prescription for treating cervical cancer and preparation method thereof
CN105030997A (en) * 2015-07-22 2015-11-11 刘鹏 Traditional Chinese medicine for treating intermin-gled phlegm and blood stasis thyroid adenoma and preparing method

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1073866A (en) * 1992-08-09 1993-07-07 付耀华 Oral liquid for curing cancer and compound method thereof
CN101011559A (en) * 2007-02-01 2007-08-08 南中兴 Traditional Chinese medicine preparation for treating malignant tumor and its preparation method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1073866A (en) * 1992-08-09 1993-07-07 付耀华 Oral liquid for curing cancer and compound method thereof
CN101011559A (en) * 2007-02-01 2007-08-08 南中兴 Traditional Chinese medicine preparation for treating malignant tumor and its preparation method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105030997A (en) * 2015-07-22 2015-11-11 刘鹏 Traditional Chinese medicine for treating intermin-gled phlegm and blood stasis thyroid adenoma and preparing method
CN105012887A (en) * 2015-08-13 2015-11-04 李荣勤 Traditional Chinese medicine prescription for treating cervical cancer and preparation method thereof

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