CN105012887A - Traditional Chinese medicine prescription for treating cervical cancer and preparation method thereof - Google Patents
Traditional Chinese medicine prescription for treating cervical cancer and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine prescription for treating cervical cancer. The prescription is mainly prepared from, by mass, 10-16 parts of gentian, 8-14 parts of impatiens aquatilis, 6-13 parts of diversifolious patrinia root, 9-14 parts of black Chinese olive leaf, 8-12 parts of rhizome of peltate yam, 10-14 parts of rubia cordifolia, 8-15 parts of goldfussia psilostachys, 6-12 parts of frankincense, 9-15 parts of galium aparine, 10-13 parts of solanum lyratum thunb, 7-12 parts of rodgersia aesculifolia, 9-13 parts of bauhinia championii, 8-14 parts of rhizoma curcumae and 10-15 parts of conyza japonica. The raw materials are traditional Chinese medicine plants and are small in toxic and side effect, high in safety and capable of being easily accepted by patients; the components have the functions of relieving swelling and dispersing blood stasis, regulating qi and activating blood and the like according to the traditional Chinese medicine dialectical therapy principle; the prescription is low in cost, good in curative effect, few in adverse effect, low in recurrence rate and worthy of clinical popularization.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicinal formulae and method for making for the treatment of cervical cancer.
Background technology
Cervical cancer, refers to the malignant tumor occurring in utero vaginal portion and cervical canal, and be one of women's common cancer, sickness rate is positioned at the second of female tumor.Initial stage, without any symptom can there is remarkable vagina bleeding in the later stage.Some young patient often show as contact bleeding, occur in sexual life, gynecologial examination and hemorrhage after an action of the bowels, amount of bleeding is the amount doesn't matter, general according to size of tumor, invade and the situation of blood vessel and different in interstitial, early stage amount of bleeding is few, focus showed as more greatly and bled profusely late period, once corrode comparatively trunk may cause mortality massive hemorrhage, young patient also can show as menostaxis, cycle time, menorrhagia etc., the irregular colporrhagia of gerontal patient normal main suit post menopausal.In addition patient's neoplasm can increase, white or courageous and upright, and thin have bad smell as water sample or rice water sample, and late period, tissue necrosis, secondary infection etc., had a large amount of purulence or rice water sample fetor ex vagina to discharge because of cancerous tissue ulceration.
Publication No. CN 104001117 A(application number 201410239246.4) Chinese patent literature disclose a kind of anti-cervical cancer compositions and application thereof, comprising Radix Ginseng is 160-200 part, and Ramulus Cinnamomi is 15-30 part, and Rhizoma Curcumae is 30-80 part, and Spica Prunellae is 60-120 part.Publication No. CN 104173849 A(application number 201410419583.1) Chinese patent literature disclose the treatment Chinese medicine of cervical cancer and preparation method, it is made up of Myrrha (processed) 180g, Herba Ecliptae 150g, Rhizoma Coptidis 200g, Herba Patriniae 300g, Olibanum (processed) 180g, RHIIZOMA DIOSCOREAE fr0m Henan of China 150g, Moschus 12g, Sanguis Draxonis 60g, Fructus Hordei Germinatus 150g, Pericarpium Citri Reticulatae Viride 90g, Rhizoma Imperatae 200g, Radix Linderae 150g, PORIA from Yunnan of China 200g, Radix Astragali 300g, Colla Corii Asini 100g, Herba Artemisiae Scopariae 150g, Folium Isatidis blade root 150g, hops 120g, Semen Persicae 150g, Radix Et Rhizoma Rhei 100g, Radix Achyranthis Bidentatae 120g.Publication No. CN 104225385 A(application number 201410435184.4) Chinese patent literature disclose a kind of endo-medicine for the treatment of cervical cancer and preparation method thereof, component Radix Paeoniae Rubra, Radix Angelicae Sinensis, Rhizoma Atractylodis, Grifola umbellata, Rhizoma Smilacis Glabrae, Olibanum, Flos Lonicerae, Myrrha, Semen Coicis, Flos Sophorae, Radix Aristolochiae, Semen Benincasae, Scorpio, each 1-3 part of Scolopendra.
Current treatment cervical cancer is based on operation and radiotherapy, though effect is better, but side effect, untoward reaction and recur more, treatment for cancer patient not only will palliate the agonizing sufferings, also to improve the quality of living, symptom management, therefore, need to develop a kind of good effect, the little traditional Chinese medical science formula of side effect carrys out reduction of patient misery.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of good effect, the Chinese medicinal formulae for the treatment of cervical cancer of instant effect and method for making.
Technical scheme of the present invention is:
The Chinese medicinal formulae for the treatment of cervical cancer, is prepared from primarily of following bulk drugs, is mass parts: Radix Gentianae 10-16, water Impatientis 8-14, Radix Patriniae heterophyllae 6-13, Folium Canarii Pimelae 9-14, Dioscorea zingiberensis C. H. Wright 8-12, Radix Rubiae 10-14, Herba Goldffussiae Psilostachydis 8-15, Olibanum 6-12, Herba Galii Teneri 9-15, Herba Solani Lyrati 10-13, rodgersia aesculifolia 7-12, Caulis Bauhihiae Championii 9-13, Rhizoma Curcumae 8-14, Conyza japonica 10-15.
In preferred scheme, Radix Gentianae 12-14, water Impatientis 10-12, Radix Patriniae heterophyllae 8-11, Folium Canarii Pimelae 10-13, Dioscorea zingiberensis C. H. Wright 9-11, Radix Rubiae 11-13, Herba Goldffussiae Psilostachydis 10-13, Olibanum 8-10, Herba Galii Teneri 10-14, Herba Solani Lyrati 11-12, rodgersia aesculifolia 8-11, Caulis Bauhihiae Championii 10-12, Rhizoma Curcumae 9-13, Conyza japonica 11-14.
Be more preferably, Radix Gentianae 13, water Impatientis 11, Radix Patriniae heterophyllae 9.5, Folium Canarii Pimelae 11.5, Dioscorea zingiberensis C. H. Wright 10, Radix Rubiae 12, Herba Goldffussiae Psilostachydis 11.5, Olibanum 9, Herba Galii Teneri 12, Herba Solani Lyrati 11.5, rodgersia aesculifolia 9.5, Caulis Bauhihiae Championii 11, Rhizoma Curcumae 11, Conyza japonica 12.5.
The Chinese medicinal formulae of described treatment cervical cancer, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, and section, together puts into frying pan with the Oryza glutinosa of its quality 1.2 times, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica roguing are cleaned, dry in 60 DEG C of constant temperature ovens, pulverize and sieve together with step (1) (3) made crude drug, again with step (2) made medicamental pulverata, to sieve mixing, obtain powder.
The preparation method of the Chinese medicinal formulae powder of described treatment cervical cancer, step (4) was pulverized 200-340 mesh sieve and (preferably, was pulverized 240-300 mesh sieve; Be more preferably, pulverized 270 mesh sieves).
The Chinese medicinal formulae of described treatment cervical cancer, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, and section, together puts into frying pan with Oryza glutinosa, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica roguing are cleaned, dry in 60 DEG C of constant temperature ovens, pulverized 120-220 mesh sieve and (preferably, pulverized 140-200 mesh sieve together with step (1) (3) made crude drug; Be more preferably, pulverized 170 mesh sieves), then with step (2) made medicamental pulverata, mixing of sieving, with vinegar and ball block, generally makes ball, obtains pill.
The preparation method of the Chinese medicinal formulae pill of described treatment cervical cancer, the amount of step (3) Oryza glutinosa is 1.0-1.5 times (preferred, the amount of Oryza glutinosa is 1.2 times of Rhizoma Curcumae quality) of Rhizoma Curcumae quality.
The Chinese medicinal formulae of described treatment cervical cancer, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, and section, together puts into frying pan with the Oryza glutinosa of its quality 1.2 times, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica are cleaned, add water with boiling with step (1) (3) made crude drug, amount of water is that the 7-8 of total raw material medicine quality is doubly (preferred, amount of water is 7.5 times of total raw material medicine quality), big fire is boiled to boiling, little fire is decocted, and decocts twice altogether, merges twice gained medicinal liquid;
(5) step (2) made medicamental pulverata is joined in step (4) made medicinal liquid, stir evenly, obtain decoction.
The preparation method of the Chinese medicinal formulae decoction of described treatment cervical cancer, step (4) little fire decocts 32-48 minute, and (preferred, 36-44 minute decocted by little fire; Be more preferably, little fire decocts 40 minutes).
The Chinese medicinal formulae of described treatment cervical cancer, be made into pharmaceutically acceptable soft extract, its preparation method is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, and section, together puts into frying pan with the Oryza glutinosa of its quality 1.2 times, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica are cleaned, add water with boiling with step (1) (3) made crude drug, amount of water is that the 7-8 of total raw material medicine quality is doubly (preferred, amount of water is 7.5 times of total raw material medicine quality), big fire is boiled to boiling, little fire decocts 32-48 minute, and (preferred, 36-44 minute decocted by little fire; Be more preferably, little fire decocts 40 minutes), decoct twice altogether, merge twice gained medicinal liquid;
(5) join in step (4) made medicinal liquid by step (2) made medicamental pulverata, filter after heating mixing, filtrate decocts into clear paste, obtains soft extract.
The preparation method of the Chinese medicinal formulae soft extract of described treatment cervical cancer, the relative density of step (5) clear paste is 1.21-1.27(65 DEG C) (preferred, the relative density of clear paste is 1.23-1.25; Be more preferably, the relative density of clear paste is 1.24).
The Chinese medicinal formulae scientific formula for the treatment of cervical cancer provided by the invention, drug safety, easy to carry.In addition, excellent results of the present invention also shows:
1, raw material of the present invention is Chinese medicinal plant, and toxic and side effects is little, and safety is high, and patient easily accepts;
2, this prescription treats principle according to differential diagnosis in tcm, has the effect such as detumescence, regulating qi and activating blood;
3, cost of the present invention is low, good effect, and untoward reaction is few, and relapse rate is low.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Gentianae: base is former: be the root and rhizome of gentianaceae plant Radix Gentianae or G. triflora.Nature and flavor: bitter, cold.Gui Jing: enter liver, gallbladder meridian.Function cures mainly: eliminating pathogen in the liver gallbladder excess-fire, except damp-heat in lower-JIAO.Treating the liver is through intenseness of heat, and infantile convulsion is manic, encephalitis B, and headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.For damp and hot yellow cellulitis, swelling of the vulva pudendal pruritus, leukorrhagia, eczema pruritus, deafness, hypochondriac pain, bitter taste, convulsion with spasms.
Water Impatientis: base is former: be the herb of Balsaminaceae plant Herba Impatientis Chinensis flower.Nature and flavor: bitter in the mouth, Xin Xingping.Function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, eliminating carbuncle of drawing out the pus.Main infantile pneumonia, laryngopharynx swelling and pain, hematodiarrhoea, snake head-like infection, carbuncle pyogenic infections from tumour or sore, lung is tied.
Radix Patriniae heterophyllae: base is former: be the root of Valerianaceae plant Radix Patriniae Scabrae, Radix Patriniae Scabrae.Nature and flavor: bitter, micro-acid, puckery, cool.Function cures mainly: heat clearing and damp drying, hemostasis, leukorrhagia stopping, preventing the attack (or recurrence) of malaria.For uterine erosion, early cervical carcinoma, leucorrhea, metrorrhagia, malaria.
Folium Canarii Pimelae: base is former: the blade of olive subject plant Fructus Canarii Pimelae.Nature and flavor: micro-hardship are puckery, cool in nature.Gui Jing: Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, hemostasis.Main cold, fever, cough due to lung-heat, erysipelas, furuncle and phyma, metrorrhagia.
Dioscorea zingiberensis C. H. Wright: base is former: be the rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Zingiberensis.Nature and flavor: bitter in the mouth, micro-sweet, cool in nature, mild toxicity.Function cures mainly: clearing away lung-heat to relieve cough, and dampness removing is treating stranguria, removing obstruction in the collateral to relieve pain, removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat, damp and hot pouring pain, lumbago due to pathogenic wind-dampness, carbuncle malignant boil, osteopatia sprain, honeybee stings insect bite.
Radix Rubiae: base is former: be the root welding technology of Maguireothamnus speciosus Radix Rubiae.Nature and flavor: bitter, cold.Gui Jing: return Liver Channel.Function cures mainly: removing heat from blood, and hemostasis, blood stasis dispelling, stimulates the menstrual flow.For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.
Herba Goldffussiae Psilostachydis: base is former: be stem, the leaf of acanthaceous plant thin fringe gold foot grass.Nature and flavor: light, micro-pungent, cool.Function cures mainly: removing toxic substances and promoting subsidence of swelling, promoting the circulation of blood dissipating blood stasis.
Olibanum: base is former: be the gum resin of olive subject plant Boswellia carterii Birdw.Nature and flavor: pungent, bitter, temperature.Gui Jing: enter the heart, liver, spleen channel.Function cures mainly: regulating qi and activating blood, and analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Herba Galii Teneri: base is former: for Maguireothamnus speciosus draws the herb of rattan or thick Ye Lala rattan.Nature and flavor: toil, cold.Function cures mainly: clearing away damp-heat, dissipating blood stasis, detumescence, removing toxic substances.Control stranguria with turbid discharge, hematuria, traumatic injury, acute appendicitis, furuncle and phyma, otitis media.
Herba Solani Lyrati: base is former: be the herb of plant of Solanaceae Herba Solani Lyrati.Nature and flavor: sweetness and bitterness, cold.Function cures mainly: heat clearing away, and dampness removing dispels the wind, removing toxic substances.Treating malaria disease, jaundice, edema, gonorrhea, rheumatic arthritis, erysipelas, furuncle.
Rodgersia aesculifolia: base is former: be the rhizome of Saxifragaceae ghost lamp bark of a cork tree platymiscium RHIZOMA RODGERSIAE.Nature and flavor: bitter, puckery are flat.Slightly poisonous.Function cures mainly: cooling blood for hemostasis, subduing swelling and detoxicating.For goiter, laryngopharynx swelling and pain, epistaxis, spits blood, spitting of blood, metrorrhagia, and diarrhoea, dysentery, has blood in stool, and traumatic hemorrhage is controlled in external, uterine prolapse.
Caulis Bauhihiae Championii: base is former: be the stem of leguminous plant Caulis Bauhiniae Championii.Nature and flavor: toil are flat, nontoxic.Function cures mainly: dispel the wind, blood stasis removing, pain relieving.Dispelling the wind and dampness pathogens osteodynia, traumatic injury synthetism.
Rhizoma Curcumae: base is former: be the rhizome of zingiberaceous plant Rhizoma Curcumae.Nature and flavor: pungent, bitter, temperature.Gui Jing: return liver, spleen channel.Function cures mainly: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain, early cervical carcinoma.
Conyza japonica: base is former: be the root of feverfew Conyza japonica.Nature and flavor: pungent, micro-hardship are flat.Function cures mainly: anti-inflammatory analgesic, dispelling pathogenic wind and eliminating phlegm.Cure mainly pleuritis, infantile pneumonia, laryngitis, infantile convulsion.
embodiment 1the Chinese medicinal formulae for the treatment of cervical cancer, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Gentianae 10 parts, water Impatientis 8 parts, Radix Patriniae heterophyllae 6 parts, Folium Canarii Pimelae 9 parts, Dioscorea zingiberensis C. H. Wright 8 parts, 10 parts, Radix Rubiae, Herba Goldffussiae Psilostachydis 8 parts, Olibanum 6 parts, Herba Galii Teneri 9 parts, Herba Solani Lyrati 10 parts, rodgersia aesculifolia 7 parts, Caulis Bauhihiae Championii 9 parts, Rhizoma Curcumae 8 parts, Conyza japonica 10 parts.
The preparation method of the Chinese medicinal formulae powder of above-mentioned treatment cervical cancer is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, and section, together puts into frying pan with the Oryza glutinosa of its quality 1.2 times, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica roguing are cleaned, dry in 60 DEG C of constant temperature ovens, 270 mesh sieves were pulverized together with step (1) (3) made crude drug, again with step (2) made medicamental pulverata, to sieve mixing, obtain powder.
embodiment 2the Chinese medicinal formulae for the treatment of cervical cancer, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Gentianae 16 parts, water Impatientis 14 parts, Radix Patriniae heterophyllae 13 parts, Folium Canarii Pimelae 14 parts, Dioscorea zingiberensis C. H. Wright 12 parts, 14 parts, Radix Rubiae, Herba Goldffussiae Psilostachydis 15 parts, Olibanum 12 parts, Herba Galii Teneri 15 parts, Herba Solani Lyrati 13 parts, rodgersia aesculifolia 12 parts, Caulis Bauhihiae Championii 13 parts, Rhizoma Curcumae 14 parts, Conyza japonica 15 parts.
The preparation method of the Chinese medicinal formulae pill for the treatment of cervical cancer is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, section, and together put into frying pan with Oryza glutinosa, the amount of Oryza glutinosa is 1.2 times of Rhizoma Curcumae quality, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica roguing are cleaned, dry in 60 DEG C of constant temperature ovens, 170 mesh sieves were pulverized together with step (1) (3) made crude drug, again with step (2) made medicamental pulverata, to sieve mixing, with vinegar and ball block, generally make ball, obtain pill.
Model case: xxx, female, 41 years old.Main suit: colporrhagia half a year after sexual intercourse, with discharge opeing 3 months, originally bleeding capacity was few, dripping shape, color is fresh, few abdomen bearing down, with mild pain, rear discharge opeing increases, water from washing rice sample, free from extraneous odour, examination in hospital, has polypoid vegetation in cervical canal, diameter is 3cm, and cervical canal increases thick, smooth surface, touch blood positive, pathological examination, is finally diagnosed as the adenocarcinoma of the uterine cervix I b1 phase.
Take the Chinese medicinal formulae pill of the present embodiment gained treatment cervical cancer, every day 3 times, each 2-3 grain, warm water delivery service, 14 days courses for the treatment of.After taking a course for the treatment of, patient's complexion takes a turn for the better, and abdominal pain with tenesmus disappears, after taking two courses for the treatment of, neoplasm obviously reduces, and occasionally has hemorrhage on a small quantity, after taking four courses for the treatment of, all diseases disappear entirely, and lump obviously reduces, after adhering to having taken six courses for the treatment of, lump is eliminated completely, patient clinical is fully recovered, and follows up a case by regular visits to after 2 years, and patient is still living and in good health.
embodiment 3the Chinese medicinal formulae for the treatment of cervical cancer, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Gentianae 12 parts, water Impatientis 10 parts, Radix Patriniae heterophyllae 8 parts, Folium Canarii Pimelae 10 parts, Dioscorea zingiberensis C. H. Wright 9 parts, 11 parts, Radix Rubiae, Herba Goldffussiae Psilostachydis 10 parts, Olibanum 8 parts, Herba Galii Teneri 10 parts, Herba Solani Lyrati 11 parts, rodgersia aesculifolia 8 parts, Caulis Bauhihiae Championii 10 parts, Rhizoma Curcumae 9 parts, Conyza japonica 11 parts.
The preparation method of the Chinese medicinal formulae decoction for the treatment of cervical cancer is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, and section, together puts into frying pan with the Oryza glutinosa of its quality 1.2 times, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica are cleaned, add water with boiling with step (1) (3) made crude drug, amount of water is 7.5 times of total raw material medicine quality, big fire is boiled to boiling, little fire decocts 40 minutes, decoct twice altogether, merge twice gained medicinal liquid;
(5) step (2) made medicamental pulverata is joined in step (4) made medicinal liquid, stir evenly, obtain decoction.
Model case: xxx, female, 46 years old.Before half a year, sexual life and after an action of the bowels, vaginal hemorrhage, wherein be added with blood, the soreness of waist with leucorrhoea grow in quantity, mood is irritated, constipation, examination in hospital, red tongue tongue is few, stringy and thready pulse, the visible cauliflower-like of cervical orifice swells thing, and diameter is 4.5cm, and there is ulcer on surface, touch blood positive, be diagnosed as the cervical cancer I b2 phase through pathological examination.
Take the Chinese medicinal formulae decoction of the present embodiment gained treatment cervical cancer, adopt every day 3 times, each 200-400ml(is warm), 14 days courses for the treatment of.After taking two courses for the treatment of, leucorrhea obviously reduces, hemorrhage minimizing, and after taking seven courses for the treatment of, swollen thing disappears, and other malaise symptoms are also eliminated completely, and patient fully recovers, and follow up a case by regular visits in two years, patient body is in good condition.
embodiment 4the Chinese medicinal formulae for the treatment of cervical cancer, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Gentianae 14 parts, water Impatientis 12 parts, Radix Patriniae heterophyllae 11 parts, Folium Canarii Pimelae 13 parts, Dioscorea zingiberensis C. H. Wright 11 parts, 13 parts, Radix Rubiae, Herba Goldffussiae Psilostachydis 13 parts, Olibanum 10 parts, Herba Galii Teneri 14 parts, Herba Solani Lyrati 12 parts, rodgersia aesculifolia 11 parts, Caulis Bauhihiae Championii 12 parts, Rhizoma Curcumae 13 parts, Conyza japonica 14 parts.
The preparation method of the Chinese medicinal formulae soft extract for the treatment of cervical cancer is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, and section, together puts into frying pan with the Oryza glutinosa of its quality 1.2 times, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica are cleaned, add water with boiling with step (1) (3) made crude drug, amount of water is 7.5 times of total raw material medicine quality, big fire is boiled to boiling, little fire decocts 40 minutes, decoct twice altogether, merge twice gained medicinal liquid;
(5) step (2) made medicamental pulverata is joined in step (4) made medicinal liquid, heating mixing after filter, it is 1.24(65 DEG C that filtrate decocts into relative density) clear paste, obtain soft extract.
Model case: xxx, female, 35 years old.Contact bleeding more than a year, neoplasm two weeks, hemorrhage after having sexual intercourse the year before, pay attention to, nearly two weeks, vagina had flow liquid and with abnormal flavour, examination in hospital, and cervix uteri mouth has cauliflower like mass, diameter is about 3.4cm, contact bleeding, and through pathological examination, last diagnostic is the squamous carcinoma of the cervix I b1 phase.
Take the Chinese medicinal formulae soft extract of the present embodiment gained treatment cervical cancer, adopt every day 3 times, each 10-15g, with warm boiled water, 14 days courses for the treatment of.After taking two courses for the treatment of, lump diameter reduces, and abnormal flavour disappears, and discharge opeing is eliminated substantially, and occasionally have discharge opeing, through the treatment of six courses for the treatment of, patient's lump disappears substantially, and after continuing to take a course for the treatment of, patient clinical is cured, and follow up a case by regular visits to after 2 years, the state of an illness does not recur.
embodiment 5the Chinese medicinal formulae for the treatment of cervical cancer, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Gentianae 13 parts, water Impatientis 11 parts, Radix Patriniae heterophyllae 9.5 parts, Folium Canarii Pimelae 11.5 parts, Dioscorea zingiberensis C. H. Wright 10 parts, 12 parts, Radix Rubiae, Herba Goldffussiae Psilostachydis 11.5 parts, Olibanum 9 parts, Herba Galii Teneri 12 parts, Herba Solani Lyrati 11.5 parts, rodgersia aesculifolia 9.5 parts, Caulis Bauhihiae Championii 11 parts, Rhizoma Curcumae 11 parts, Conyza japonica 12.5 parts.
The preparation method of the Chinese medicinal formulae powder for the treatment of cervical cancer is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, and section, together puts into frying pan with the Oryza glutinosa of its quality 1.2 times, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica roguing are cleaned, dry in 60 DEG C of constant temperature ovens, 270 mesh sieves were pulverized together with step (1) (3) made crude drug, again with step (2) made medicamental pulverata, to sieve mixing, obtain powder.
test example 1the clinical practice of the Chinese medicinal formulae (embodiment 5) of gained treatment cervical cancer of the present invention:
In October ,-2014 in June, 2012, in the cervical cancer patient of 6 hospitals treatment, filter out 241 routine patients, age 34-62 year, the mean age (46.2 ± 4.3) year.All patients are all diagnosed as cervical cancer through pathological examination.Wherein I b 127 example, II a 59 example, II b 44 example, III a 11 example, histologic classification squamous cell carcinoma 166 example, adenocarcinoma 75 example.
Patient is divided into two groups at random, experimental group 141 example and matched group 100 routine, two groups in age, the course of disease, the state of an illness etc. without significant difference (
p> 0.05), there is comparability.Two groups all adopt TP scheme chemotherapy, calculate dosage, treat 2 courses for the treatment of, 21 days, interval according to body surface area, and experimental group coordinates takes products obtained therefrom of the present invention, and taken three times a day, each 5-10g(adjusts to some extent depending on concrete condition), 14 days courses for the treatment of.Treatments period carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect situation criterion: complete incidence graph: cases of complete remission, and continue more than 1 month, without recurrence or transfer; Partial rcsponse: the product of longest diameter of tumor and perpendicular diameter reduces more than 50%, other focuses, without increase or transfer, are continued above 1 month; Unchanged: focus two footpath product reduces less than 50%, increase and be no more than 25%, be continued above one month.Total effective rate=(complete incidence graph+partial rcsponse)/total number of cases × 100%
In experimental group, the patient of symptom complete incidence graph has 48 examples, the patient of partial rcsponse has 86 examples, the total effective rate of experimental group is 95.0%, in matched group, the patient of complete incidence graph has 23 examples, and the patient of partial rcsponse has 55 examples, and the total effective rate of matched group is 78.0%, compare for two groups, difference has statistical significance (P < 0.05).
Treat and follow up a case by regular visits to after 2 years, in the patient of experimental group complete incidence graph, only have an example recurrence, in the patient of partial rcsponse, have 2 routine aggravations, after 2 years, the survival rate of experimental group is 92.2%(130/141).In matched group, have 4 example recurrences in the patient of complete incidence graph, in the patient of partial rcsponse, have 8 routine patients increase the weight of or shift, the survival rate of matched group is 71.0%(71/100).
Radix Gentianae pathogenic fire purging dehumidifying in the present invention, water Impatientis heat-clearing and toxic substances removing, Radix Patriniae heterophyllae heat clearing and damp drying, Folium Canarii Pimelae clearing away heat to stop bleeding, Dioscorea zingiberensis C. H. Wright removing toxic substances and promoting subsidence of swelling, Radix Rubiae eliminating blood stasis and smoothing collaterals, Herba Goldffussiae Psilostachydis removing toxic substances and promoting subsidence of swelling, Olibanum regulating qi and activating blood, Herba Galii Teneri dissipating blood stasis for subsidence of swelling, Herba Solani Lyrati is dispeled the wind removing toxic substances, rodgersia aesculifolia subduing swelling and detoxicating, Caulis Bauhihiae Championii wind-expelling pain-stopping, Rhizoma Curcumae circulation of qi promoting removing blood stasis, Conyza japonica dispelling pathogenic wind and eliminating phlegm, multiple medical material collocation uses, and can play the effect such as detumescence, regulating qi and activating blood.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the Chinese medicinal formulae of cervical cancer, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Radix Gentianae 10-16, water Impatientis 8-14, Radix Patriniae heterophyllae 6-13, Folium Canarii Pimelae 9-14, Dioscorea zingiberensis C. H. Wright 8-12, Radix Rubiae 10-14, Herba Goldffussiae Psilostachydis 8-15, Olibanum 6-12, Herba Galii Teneri 9-15, Herba Solani Lyrati 10-13, rodgersia aesculifolia 7-12, Caulis Bauhihiae Championii 9-13, Rhizoma Curcumae 8-14, Conyza japonica 10-15.
2. the Chinese medicinal formulae for the treatment of cervical cancer as claimed in claim 1, it is characterized in that, Radix Gentianae 12-14, water Impatientis 10-12, Radix Patriniae heterophyllae 8-11, Folium Canarii Pimelae 10-13, Dioscorea zingiberensis C. H. Wright 9-11, Radix Rubiae 11-13, Herba Goldffussiae Psilostachydis 10-13, Olibanum 8-10, Herba Galii Teneri 10-14, Herba Solani Lyrati 11-12, rodgersia aesculifolia 8-11, Caulis Bauhihiae Championii 10-12, Rhizoma Curcumae 9-13, Conyza japonica 11-14 is (preferred, Radix Gentianae 13, water Impatientis 11, Radix Patriniae heterophyllae 9.5, Folium Canarii Pimelae 11.5, Dioscorea zingiberensis C. H. Wright 10, Radix Rubiae 12, Herba Goldffussiae Psilostachydis 11.5, Olibanum 9, Herba Galii Teneri 12, Herba Solani Lyrati 11.5, rodgersia aesculifolia 9.5, Caulis Bauhihiae Championii 11, Rhizoma Curcumae 11, Conyza japonica 12.5).
3. the Chinese medicinal formulae of the treatment cervical cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, and section, together puts into frying pan with the Oryza glutinosa of its quality 1.2 times, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica roguing are cleaned, dry in 60 DEG C of constant temperature ovens, pulverize and sieve together with step (1) (3) made crude drug, again with step (2) made medicamental pulverata, to sieve mixing, obtain powder.
4. the preparation method of the Chinese medicinal formulae powder for the treatment of cervical cancer as claimed in claim 3, it is characterized in that, step (4) was pulverized 200-340 mesh sieve and (preferably, was pulverized 240-300 mesh sieve; Be more preferably, pulverized 270 mesh sieves).
5. the Chinese medicinal formulae of the treatment cervical cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, and section, together puts into frying pan with Oryza glutinosa, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica roguing are cleaned, dry in 60 DEG C of constant temperature ovens, pulverized 120-220 mesh sieve and (preferably, pulverized 140-200 mesh sieve together with step (1) (3) made crude drug; Be more preferably, pulverized 170 mesh sieves), then with step (2) made medicamental pulverata, mixing of sieving, with vinegar and ball block, generally makes ball, obtains pill.
6. the preparation method of the Chinese medicinal formulae pill for the treatment of cervical cancer as claimed in claim 5, is characterized in that, the amount of step (3) Oryza glutinosa is 1.0-1.5 times (preferred, the amount of Oryza glutinosa is 1.2 times of Rhizoma Curcumae quality) of Rhizoma Curcumae quality.
7. the Chinese medicinal formulae of the treatment cervical cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, and section, together puts into frying pan with the Oryza glutinosa of its quality 1.2 times, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica are cleaned, add water with boiling with step (1) (3) made crude drug, amount of water is that the 7-8 of total raw material medicine quality is doubly (preferred, amount of water is 7.5 times of total raw material medicine quality), big fire is boiled to boiling, little fire is decocted, and decocts twice altogether, merges twice gained medicinal liquid;
(5) step (2) made medicamental pulverata is joined in step (4) made medicinal liquid, stir evenly, obtain decoction.
8. the preparation method of the Chinese medicinal formulae decoction for the treatment of cervical cancer as claimed in claim 7, is characterized in that, step (4) little fire decocts 32-48 minute, and (preferred, 36-44 minute decocted by little fire; Be more preferably, little fire decocts 40 minutes).
9. the Chinese medicinal formulae of the treatment cervical cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable soft extract, its preparation method is:
(1) get Radix Gentianae, Radix Rubiae and rodgersia aesculifolia to add yellow wine and boil, boil and exhaust to wine, take out, wrap up in four layers with wet toilet paper, be placed in when hot ash is simmered sallow to outer toilet paper and take out, remove toilet paper, cut into slices, dry;
(2) getting Olibanum is placed on refractory container, heat fused, and spray Sucus Zingberis, mixes thoroughly, and cooling, smashs to pieces, grind into powder;
(3) get clean Rhizoma Curcumae, with boiling, vinegar soaks into, and takes out, and section, together puts into frying pan with the Oryza glutinosa of its quality 1.2 times, and moderate heat heating stir-fries, and fries when becoming buff to rice, takes out, and sieve removes rice, dries;
(4) water Impatientis, Radix Patriniae heterophyllae, Folium Canarii Pimelae, Dioscorea zingiberensis C. H. Wright, Herba Goldffussiae Psilostachydis, Herba Galii Teneri, Herba Solani Lyrati, Caulis Bauhihiae Championii and Conyza japonica are cleaned, add water with boiling with step (1) (3) made crude drug, amount of water is that the 7-8 of total raw material medicine quality is doubly (preferred, amount of water is 7.5 times of total raw material medicine quality), big fire is boiled to boiling, little fire decocts 32-48 minute, and (preferred, 36-44 minute decocted by little fire; Be more preferably, little fire decocts 40 minutes), decoct twice altogether, merge twice gained medicinal liquid;
(5) join in step (4) made medicinal liquid by step (2) made medicamental pulverata, filter after heating mixing, filtrate decocts into clear paste, obtains soft extract.
10. the preparation method of the Chinese medicinal formulae soft extract for the treatment of cervical cancer as claimed in claim 9, is characterized in that, the relative density of step (5) clear paste is that 1.21-1.27(is preferred, and the relative density of clear paste is 1.23-1.25; Be more preferably, the relative density of clear paste is 1.24).
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| CN1679898A (en) * | 2005-01-13 | 2005-10-12 | 刘桂香 | Chinese medicine composition for treating hepatitis and cancers |
| CN104383466A (en) * | 2014-12-15 | 2015-03-04 | 山东省肿瘤医院 | Traditional Chinese medicine for treating liver-kidney yin deficiency type cervical cancer and preparation method of traditional Chinese medicine |
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