CN105012713A - Preparation for treating cervical cancer and preparation method thereof - Google Patents
Preparation for treating cervical cancer and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a preparation for treating cervical cancer and a preparation method thereof. The preparation is mainly prepared from, by weight, 10-16 parts of white peony root, 8-13 parts of stachys palustris L., 9-14 parts of galium aparine, 7-13 parts of medicine terminalia fruit, 10-15 parts of Balanophora dioica R.Br.ex Royle, 8-16 parts of scutellariae barbatae, 11-15 parts of bauhinia championii, 9-16 parts of conyza japonica, 7-14 parts of dendrobium, 8-14 parts of dysosma versipelis, 6-15 parts of diversifolious patrinia root, 9-13 parts of petrea volubilis, 8-12 parts of patrinia scaniosaefolia, 10-14 parts of hupeh bauhinia root and 9-15 parts of Chinese pulsatilla root. The preparation is safe and reliable, various side effects and sequelae caused by western medicine treatment can be avoided, the immunity of patients can be improved, the cancer resistant ability of the patients themselves is improved, cancer cell metastasis is restrained in time, and complications are effectively reduced.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of preparation for the treatment of cervical cancer and preparation method thereof.
Background technology
Cervical cancer is modal gynecologic malignant tumor.The cancer in situ age occurred frequently is 30 ~ 35 years old, and infiltrating carcinoma is 45 ~ 55 years old.Cervical cancer may be relevant to following factor: 1. viral infection.High-risk HPV persistent infection is the Major Risk Factors of cervical cancer.The cervical cancer of more than 90% infects with high-risk HPV.2. sexual behaviour and parturition number.Multiple sex partner, first sexual life < 16 years old, little, the how pregnant fecund of Age of first delivery etc. occur closely related with cervical cancer.3. other biological factor.The infection of the pathogen such as chlamydia trachomatis, herpes simplex virus type II, infusorian is infected at high-risk HPV and is caused there is synergism in the pathogenic process of cervical cancer.4. other behavial factors.Smoking can increase the risk of cervical cancer as the co-factor that HPV infects.In addition, malnutrition, the poor generation that also can affect disease of sanitary condition.
Clinical manifestation: the normal non-evident sympton of early cervical carcinoma and sign, cervix uteri can smoothly or difficult be distinguished with cervix uteri columnar epithelium dystopy.Neck tube type patient is because of the normally easy to cause missed diagnosis or mistaken diagnosis of cervix uteri outward appearance.With pathological development, following performance can be there is: symptom: (1) colporrhagia.Mostly be contact bleeding in early days; Middle and advanced stage is irregular colporrhagia.Amount of bleeding according to size of tumor, invade and blood vessel situation and different in interstitial, if invasion and attack trunk can cause massive hemorrhage.Young patient also can show as menostaxis, menorrhagia; Gerontal patient is often the irregular colporrhagia of post menopausal.Comparatively early there is vaginal hemorrhage symptom in general exogenic, amount of bleeding is many; Interior raw type is more late there is this symptom.(2) neoplasm.Most of patients has neoplasm, and liquid is white or courageous and upright, can be thin in water sample or water from washing rice shape, or has stench.Patients with terminal infects because of cancerous tissue necrosis companion, can have a large amount of rice water sample or purulence fetor ex vagina.(3) late period symptom.Involve scope according to cancer and occur different Secondary Symptoms.As frequent micturition, urgent micturition, constipation, lower limb swell and ache; Cancerous protuberance is oppressed or when involving ureter, can be caused ureteral obstruction, hydronephrosis and uremia; The cachexia such as anemia, cachexia symptom can be had late period.Sign: cancer in situ and micro-infiltrating carcinoma can without obvious naked eyes focuses, and cervix uteri is smooth or be only columnar epithelium dystopy.Different sign can be there is with PD.Exogenic cervical cancer visible polyps shape, cauliflower form vegetation, often accompany infection, and tumor matter is crisp easily hemorrhage; Interior raw type cervical cancer shows as that cervical hypertrophy, matter are hard, cervical canal expands; Advanced carcinoma tissue necrosis comes off, and forms ulcer or cavity companion's stench.Vaginal wall by for a long time, visible vegetative growth in vaginal wall or vaginal wall hardening; The other tissue in palace is subject to for a long time, and bimanual examination, trimanual gynecologica examination can be laid one's hand on and paracervix thickens, nodositas, matter hard or form freezing shape pelvic cavity.Histological type: common scale cancer, adenocarcinoma and adenosquamous carcinoma three types.(1) scale cancer.III grade is divided into according to histological.I grade is differentiated scale cancer, and II grade is middle differentiated squamous-cell carcinomas (non-keratosa maxicell type), and III grade is low differentiated squamous-cell carcinomas (small cell types), mostly is and does not break up minicell.(2) adenocarcinoma.Account for cervical cancer 15% ~ 20%.Major histological type has 2 kinds.1. mucinous adenocarcinoma: the most common, derive from cervical canal column mucilage cell, see gland structure under mirror, glandular epithelium hypertrophy is multilamellar, and atypia hypertrophy is obvious, and see Mitotic index, cancerous cell is that papillary charges into lumen of gland.High, medium and low differentiation adenocarcinoma can be divided into.2. malignant adenoma: also known as micro-jet device, belongs to differentiated cervical canal mucosa adenocarcinoma.Cancerous gland is many, not of uniform size, and form is changeable, and stretch into people's cervix uteri interstitial deep layer in spot-like projections, glandular epithelium, without atypia, often has lymphatic metastasis.(3) adenosquamous carcinoma.Account for 3% ~ 5% of cervical cancer.Broken up development and formed to glandular cell and squamous cell by reserve cell simultaneously.Containing adenocarcinoma and scale cancer two kinds of compositions in cancerous tissue.
Treatment: consider according to clinical stages, patient age, fertility requirement, systemic conditions, medical technique level and appointed condition etc. and formulate suitable individualized treatment scheme.Adopting based on operation and radiotherapy, chemotherapy is auxiliary comprehensive therapeutic plan.Operative treatment.Operation is mainly used in early cervical carcinoma patient.Conventional art formula has: panhysterectomy; Secondary radical hysterectomy and pelvic lymphadenectomy; Radical hysterectomy and pelvic lymphadenectomy; The other lymph excision of ventral aorta or sampling.Young patient ovary normally can retain.To requiring the young patient retaining reproductive function, belong to feasible conization early stage especially or Radical trachelectomy.Select different art formulas according to patient's difference by stages.2. radiotherapy.Be applicable to: 1. middle and advanced stage patient; 2. systemic conditions is not suitable for the early stage patient of operation; 3. the preoperation radiotherapy of cervix uteri bulk focus; 4. after operative treatment, pathologic finding finds that there is the auxiliary treatment of high risk factor.3. chemotherapy.Be mainly used in the patient of late period or relapse and metastasis, in recent years also adopt operation associating preoperative neoadjuvant chemotherapy (vein or Intraarterial Chemotherapy) to reduce tumor focus and control subclinical transfer, also for radiotherapy sensitization.Common Chemotherapy medicine has cisplatin, carboplatin, paclitaxel, bleomycin, ifosfamide, fluorouracil etc.
Application number publication No. CN 104027785 A(application number 201410302099.0) Chinese patent literature disclose a kind of Chinese medicine of cervical cancer, be made up of the crude drug of following weight: Fructus Aurantii Immaturus 8 grams, Semen Sinapis Albae 8 grams, Radix Stephaniae Tetrandrae 8 grams, 8 grams, Semen Armeniacae Amarum, 10 grams, Pericarpium Citri Reticulatae Viride, the Radix Paeoniae Alba 10 grams, Rhizoma Cyperi 10 grams, Radix Paeoniae Rubra 10 grams, Rhizoma Coptidis 10 grams, 10 grams, Semen Persicae, 15 grams, Poria, Radix Angelicae Sinensis 15 grams, Rhizoma Sparganii 15 grams, Rhizoma Curcumae 15 grams, the Rhizoma Anemarrhenae 15 grams, Endothelium Corneum Gigeriae Galli 20 grams, Cortex Phellodendri 20 grams, Radix Codonopsis 20 grams, Radix Sophorae Tonkinensis 30 grams, Herba Patriniae 30 grams, the Radix Astragali 45 grams, Scorpio 6 grams, Scolopendra 3, 3 grams, Radix Glycyrrhizae.Application number publication No. CN 104127819 A(application number 201410372223.0) Chinese patent literature disclose a kind of Chinese medicinal formulae for the treatment of cervical cancer, be made up of the raw material of Chinese medicine of following weight proportion: Oletum Trogopterori 15-40 part, Semen Persicae 10-30 part, Rhizoma Curcumae 10-30 part, Radix Curcumae 10-30 part, Rhizoma Curcumae Longae 10-30 part, Rhizoma Cyperi 10-30 part, Radix Scrophulariae 10-30 part, Radix Paeoniae Rubra 10-30 part, Arillus Longan 20-50 part, Fructus Mume 20-60 part.Application number publication No. CN 103656041A(application number 201310674302.2) Chinese patent literature disclose a kind of Chinese medicine for the treatment of cervical cancer, be made up of the crude drug of following weight: Flos Sophorae (parched) 20 grams, Spica Prunellae 20 grams, Herba Scutellariae Barbatae 20 grams, Herba Hedyotidis Diffusae 20 grams, 15 grams, Pericarpium Citri Reticulatae Viride, Cortex Moutan 15 grams, 15 grams, Semen Persicae, the Radix Paeoniae Alba 15 grams, Carapax Trionycis 15 grams, Rhizoma Cyperi 15 grams, 15 grams, Poria, Cortex Phellodendri 15 grams, Ramulus Cinnamomi 10 grams, Radix Angelicae Sinensis 10 grams, Olibanum 10 grams, Myrrha 6 grams, 5 pieces, Fructus Jujubae, Rhizoma Coptidis 10 grams, Scorpio 6 grams, Scolopendra 10g, 3 grams, Radix Glycyrrhizae.
Operation, radiation and chemotherapy treatment are the main means of current treatment of human cervical cancer.The operation of doctor trained in Western medicine, chemicotherapy have very large toxic and side effects and sequela.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of preparation for the treatment of cervical cancer and preparation method thereof.The present invention is safe and reliable, not only can avoid many side effect and the sequela of western medical treatment, and can improve patient immune function, improves patient self anti-tumor capacity, the transfer of timely anticancer, and the effective generation reducing complication.
Technical scheme of the present invention is:
The preparation for the treatment of cervical cancer, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Paeoniae Alba 10-16, the blue or green 8-13 in Wangjiang, Herba Galii Teneri 9-14, Fructus Chebulae 7-13, Cor Cervi grass 10-15, Herba Scutellariae Barbatae 8-16, Caulis Bauhihiae Championii 11-15, Conyza japonica 9-16, Herba Dendrobii 7-14, Radix et Rhizoma Dysosmatis 8-14, Radix Patriniae heterophyllae 6-15, Radix seu Folium Tetracerae asiaticae 9-13, Herba Patriniae 8-12, Bauhinia purpurea 10-14, Radix Pulsatillae 9-15.
The preparation for the treatment of cervical cancer, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Paeoniae Alba 12-14, Wangjiang blue or green 9-12, Herba Galii Teneri 10-13, Fructus Chebulae 8-12, Cor Cervi grass 11-14, Herba Scutellariae Barbatae 10-14, Caulis Bauhihiae Championii 12-14, Conyza japonica 11-15, Herba Dendrobii 9-12, Radix et Rhizoma Dysosmatis 10-13, Radix Patriniae heterophyllae 8-13, Radix seu Folium Tetracerae asiaticae 10-12, Herba Patriniae 9-11, Bauhinia purpurea 11-13, Radix Pulsatillae 12-14.
The preparation for the treatment of cervical cancer, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: the Radix Paeoniae Alba 13, Wangjiang green grass or young crops 11, Herba Galii Teneri 12, Fructus Chebulae 10, Cor Cervi grass 12, Herba Scutellariae Barbatae 13, Caulis Bauhihiae Championii 13, Conyza japonica 14, Herba Dendrobii 10, Radix et Rhizoma Dysosmatis 11, Radix Patriniae heterophyllae 11, Radix seu Folium Tetracerae asiaticae 11, Herba Patriniae 10, Bauhinia purpurea 12, the Radix Pulsatillae 13.
Present invention also offers the preparation method preparation of aforementioned therapies cervical cancer being made pharmaceutically acceptable powder, decoction, pill and tablet.
The preparation method of described powder is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. eight sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1-2 hour (preferably vexed 1.5 hours), and then steam 3-5 hour (preferably and then steam 4 hours), take out, dry, pulverize, cross No. eight sieves;
(3) put by Bauhinia purpurea in 55 DEG C of vacuum drying ovens, dry 10-15 hour (preferably dry 13 hours), pulverize, cross No. eight sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, decoct with water twice, amount of water is the 5.8-7.6 of 12 taste crude drug gross weights doubly (preferred amount of water is 6.7 times of 12 taste crude drug gross weights), each decoction 1.4 hours, merges twice medicinal liquid, is concentrated into the thick paste (being preferably concentrated into the thick paste that relative density is 1.35) that relative density is 1.32-1.36, put into 55 DEG C of vacuum drying ovens, dry 12 hours, pulverize, cross No. eight sieves;
(5) step (1), step (2) step (3) and step (4) gained are mixed, add cane sugar powder, the weight of cane sugar powder is the weight of the 1/14-1/9(preferably sucrose powder of all crude drug gross weights is 1/12 of all crude drug gross weights), stir, often to wrap 5g subpackage, sterile packaged, to obtain final product.
The preparation method of described decoction is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. eight sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1-2 hour (preferably vexed 1.5 hours), and then steam 3-5 hour (preferably and then steam 4 hours), take out, dry, pulverize, cross No. eight sieves;
(3) put by Bauhinia purpurea in 55 DEG C of vacuum drying ovens, dry 10-15 hour (preferably dry 13 hours), pulverize, cross No. eight sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, add the water (preferably adding the water of 12 taste crude drug 5.6 times amount) of 12 taste crude drug 4.6-6.5 times amount, after big fire is boiled, turn little fire to boil 24-38 minute (preferably turn little fire and boil 32 minutes), leach medicinal liquid;
(5) step (1), step (2) and step (3) gained are mixed;
(6) joined in step (4) gained medicinal liquid by step (5) gained, add crystal sugar, the weight of crystal sugar is the weight of the preferred crystal sugar of 1/13-1/9(of all crude drug gross weights is 1/10 of all crude drug gross weights), stir, to obtain final product.
The preparation method of described pill is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. six sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1-2 hour (preferably vexed 1.5 hours), and then steam 3-5 hour (preferably and then steam 4 hours), take out, dry, pulverize, cross No. six sieves;
(3) put by Bauhinia purpurea in 55 DEG C of vacuum drying ovens, dry 10-15 hour (preferably dry 13 hours), pulverize, cross No. six sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, decoct with water twice, amount of water is the 5.8-7.6 of 12 taste crude drug gross weights doubly (preferred amount of water is 6.7 times of 12 taste crude drug gross weights), each decoction 1.4 hours, merge twice medicinal liquid, be concentrated into the thick paste (being preferably concentrated into the thick paste that relative density is 1.35) that relative density is 1.32-1.36;
(5) step (1), step (2) and step (3) gained are joined in step (4) gained thick paste, with water pill, make the pill that particle diameter is 4mm, dry, to obtain final product.
The preparation method of described tablet is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. seven sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1-2 hour (preferably vexed 1.5 hours), and then steam 3-5 hour (preferably and then steam 4 hours), take out, dry, pulverize, cross No. seven sieves;
(3) put by Bauhinia purpurea in 55 DEG C of vacuum drying ovens, dry 10-15 hour (preferably dry 13 hours), pulverize, cross No. seven sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, decoct with water twice, amount of water is the 5.8-7.6 of 12 taste crude drug gross weights doubly (preferred amount of water is 6.7 times of 12 taste crude drug gross weights), each decoction 1.4 hours, merges twice medicinal liquid, is concentrated into the thick paste (being preferably concentrated into the thick paste that relative density is 1.35) that relative density is 1.32-1.36, put into 55 DEG C of vacuum drying ovens, dry 12 hours, pulverize, cross No. seven sieves;
(5) step (1), step (2) step (3) and step (4) gained are mixed, add cane sugar powder, the weight of cane sugar powder is the weight of the 1/14-1/9(preferably sucrose powder of all crude drug gross weights is 1/12 of all crude drug gross weights), stir, tabletting, the heavy 0.5g of every sheet, to obtain final product.
The preparation recipe science for the treatment of cervical cancer provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience.In addition, excellent results of the present invention also shows:
1, safe and reliable, many side effect and the sequela of western medical treatment can be avoided;
2, can patient suffering be alleviated, extending life, improve life quality;
3, easy to patients;
4, there is removing toxic substances heat clearing away, eliminating stasis and resolving masses, dampness leukorrhagia stopping, astringing to arrest bleeding, spleen invigorating regulated the flow of vital energy, effect of kidney invigorating and YANG supporting, patient immune function can be improved, improve patient self anti-tumor capacity, the transfer of timely anticancer, and the effective generation reducing complication.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the preparation for the treatment of cervical cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 700g): the Radix Paeoniae Alba 10 parts, blue or green 8 parts of Wangjiang, Herba Galii Teneri 9 parts, Fructus Chebulae 7 parts, Cor Cervi grass 10 parts, Herba Scutellariae Barbatae 8 parts, Caulis Bauhihiae Championii 11 parts, Conyza japonica 9 parts, Herba Dendrobii 7 parts, Radix et Rhizoma Dysosmatis 8 parts, Radix Patriniae heterophyllae 6 parts, Radix seu Folium Tetracerae asiaticae 9 parts, Herba Patriniae 8 parts, Bauhinia purpurea 10 parts, the Radix Pulsatillae 9 parts.
The preparation method of the preparation decoction of above-mentioned treatment cervical cancer is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. eight sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1 hour, and then steams 3 hours, takes out, dries, and pulverizes, and crosses No. eight sieves;
(3) Bauhinia purpurea is put in 55 DEG C of vacuum drying ovens, dry 10 hours, pulverize, cross No. eight sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, add the water of 12 taste crude drug 4.6 times amount, after big fire is boiled, turn little fire and boil 24 minutes, leach medicinal liquid;
(5) step (1), step (2) and step (3) gained are mixed;
(6) joined in step (4) gained medicinal liquid by step (5) gained, add crystal sugar, the weight of crystal sugar is 1/13 of all crude drug gross weights, stirs, to obtain final product.
The instructions of taking of the preparation decoction of gained treatment cervical cancer of the present invention is: oral, one day twice, each 180mL(was warm).
embodiment 2the preparation for the treatment of cervical cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 700g): the Radix Paeoniae Alba 16 parts, blue or green 13 parts of Wangjiang, Herba Galii Teneri 14 parts, Fructus Chebulae 13 parts, Cor Cervi grass 15 parts, Herba Scutellariae Barbatae 16 parts, Caulis Bauhihiae Championii 15 parts, Conyza japonica 16 parts, Herba Dendrobii 14 parts, Radix et Rhizoma Dysosmatis 14 parts, Radix Patriniae heterophyllae 15 parts, Radix seu Folium Tetracerae asiaticae 13 parts, Herba Patriniae 12 parts, Bauhinia purpurea 14 parts, the Radix Pulsatillae 15 parts.
The preparation method of the preparation powder of above-mentioned treatment cervical cancer is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. eight sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1.5 hours, and then steams 4 hours, takes out, dries, and pulverizes, and crosses No. eight sieves;
(3) Bauhinia purpurea is put in 55 DEG C of vacuum drying ovens, dry 13 hours, pulverize, cross No. eight sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, decoct with water twice, amount of water is 6.7 times of 12 taste crude drug gross weights, each decoction 1.4 hours, merges twice medicinal liquid, is concentrated into the thick paste that relative density is 1.35, put into 55 DEG C of vacuum drying ovens, dry 12 hours, pulverize, cross No. eight sieves;
(5) step (1), step (2) step (3) and step (4) gained are mixed, add cane sugar powder, the weight of cane sugar powder is 1/12 of all crude drug gross weights, stirs, and often to wrap 5g subpackage, sterile packaged, to obtain final product.
model case one:grandson XX, female, 47 years old.Main suit: suffer from more than cervical cancer 2 year.Before 2 years, there is abnormal vaginal bleeding in patient, leucorrhoea grow in quantity symptom, is diagnosed as cervical cancer to local hospital inspection.After accepting treatment, the state of an illness has no and is clearly better.Then to our hospital.Patient's abnormal vaginal bleeding, profuse leukorrhea, matter is thin, dirtyly smellyly not weigh, and aversion to cold and cold limbs, pale tongue, while be shown in that tooth prints, thin fur, deep,thready and forceless pulse.Through pathological examination, be diagnosed as cervical cancer.Take the preparation powder of the present embodiment gained treatment cervical cancer, one day twice, each 5g, boiled water was taken after mixing it with water.After taking 1 month, bleeding is eliminated substantially, and leucorrhea is normal.Continue to take 1 month, on inspection tumor disappearance, recover normal.Follow up a case by regular visits to and do not recur.
embodiment 3the preparation for the treatment of cervical cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 700g): the Radix Paeoniae Alba 12 parts, blue or green 9 parts of Wangjiang, Herba Galii Teneri 10 parts, Fructus Chebulae 8 parts, Cor Cervi grass 11 parts, Herba Scutellariae Barbatae 10 parts, Caulis Bauhihiae Championii 12 parts, Conyza japonica 11 parts, Herba Dendrobii 9 parts, Radix et Rhizoma Dysosmatis 10 parts, Radix Patriniae heterophyllae 8 parts, Radix seu Folium Tetracerae asiaticae 10 parts, Herba Patriniae 9 parts, Bauhinia purpurea 11 parts, the Radix Pulsatillae 12 parts.
The preparation method of the preparation pill of above-mentioned treatment cervical cancer is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. six sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1.5 hours, and then steams 4 hours, takes out, dries, and pulverizes, and crosses No. six sieves;
(3) Bauhinia purpurea is put in 55 DEG C of vacuum drying ovens, dry 13 hours, pulverize, cross No. six sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, decoct with water twice, amount of water is 6.7 times of 12 taste crude drug gross weights, each decoction 1.4 hours, merge twice medicinal liquid, be concentrated into the thick paste that relative density is 1.35;
(5) step (1), step (2) and step (3) gained are joined in step (4) gained thick paste, with water pill, make the pill that particle diameter is 4mm, dry, to obtain final product.
model case two:yellow XX, female, 39 years old.Main suit: abnormal vaginal bleeding, leucorrhea half a year on the high side.The symptoms such as before half a year, abnormal vaginal bleeding appears in patient, and leucorrhea is on the high side, once attempted taking Chinese and western medicine Drug therapy, therapeutic effect is not good, then medical.The a small amount of irregular bleeding of patient's vagina, accompany stasis of blood block, leucorrhea is on the high side, susceptible to lose temper due to restlessness, lower abdominal distention pain, bitter taste in the mouth and dry throat, and tongue is dark, micro-Huang, stringy pulse.Cervix uteri cut sections for microscopic examination, are diagnosed as squamous carcinoma of the cervix early infiltrate type.Take the preparation pill of the present embodiment gained treatment cervical cancer, three times on the one, each 3 balls, warm water takes.After taking two weeks, abnormal vaginal bleeding reduces, and leucorrhea is normal.Continue to take 1 month, all diseases disappear, tumor disappearance on inspection, recover normal.Follow up a case by regular visits to and do not recur.
embodiment 4the preparation for the treatment of cervical cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 700g): the Radix Paeoniae Alba 14 parts, blue or green 12 parts of Wangjiang, Herba Galii Teneri 13 parts, Fructus Chebulae 12 parts, Cor Cervi grass 14 parts, Herba Scutellariae Barbatae 14 parts, Caulis Bauhihiae Championii 14 parts, Conyza japonica 15 parts, Herba Dendrobii 12 parts, Radix et Rhizoma Dysosmatis 13 parts, Radix Patriniae heterophyllae 13 parts, Radix seu Folium Tetracerae asiaticae 12 parts, Herba Patriniae 11 parts, Bauhinia purpurea 13 parts, the Radix Pulsatillae 14 parts.
The preparation method of the formulation tablet of above-mentioned treatment cervical cancer is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. seven sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1.5 hours, and then steams 4 hours, takes out, dries, and pulverizes, and crosses No. seven sieves;
(3) Bauhinia purpurea is put in 55 DEG C of vacuum drying ovens, dry 13 hours, pulverize, cross No. seven sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, decoct with water twice, amount of water is 6.7 times of 12 taste crude drug gross weights, each decoction 1.4 hours, merges twice medicinal liquid, is concentrated into the thick paste that relative density is 1.35, put into 55 DEG C of vacuum drying ovens, dry 12 hours, pulverize, cross No. seven sieves;
(5) step (1), step (2) step (3) and step (4) gained are mixed, add cane sugar powder, the weight of cane sugar powder is 1/12 of all crude drug gross weights, stirs, tabletting, and the heavy 0.5g of every sheet, to obtain final product.
model case three:king XX, female, 32 years old.Main suit: unregular vaginal bleeding more than 1 year.Before 1 year, there is intermenstruum unregular vaginal bleeding without obvious inducement in patient, leucorrhea is on the high side.Once treated at local hospital, less effective.Then to our hospital.Patient's unregular vaginal bleeding, amount is few, and color is comparatively dark, bitter taste and dryness in the mouth, and leucorrhea is on the high side, yellow skin, time have stench, red tongue, yellow and greasy fur, slippery and rapid pulse.Under row colposcope, cervical biopsy shows: cervix uteri Squamous Cell Carcinoma.Training checks: the married presentation of pudendum, and vagina is unobstructed, and inside see a small amount of kermesinus bloody fluid, cervical erosion, quality is hard, anteversion of uterus, normal in size, in matter, activity can, without tenderness, palace is other, and without thickening sense, right adnexa thickens sense, without tenderness, left adnexa without tenderness, not and obvious enclosed mass.Auxiliary examination: cervical tissue biopsy pathology is reported: low differentiation Squamous Cell Carcinoma in cervix uteri.Take the formulation tablet of the present embodiment gained treatment cervical cancer, three times on the one, each 2, warm water takes.After taking 1 month, unregular vaginal bleeding is eliminated substantially, and leucorrhea is normal.Continue to take 1 month, all diseases disappear, tumor disappearance on inspection, recover normal.Follow up a case by regular visits to and do not recur.
embodiment 5the preparation for the treatment of cervical cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 700g): the Radix Paeoniae Alba 13 parts, blue or green 11 parts of Wangjiang, Herba Galii Teneri 12 parts, Fructus Chebulae 10 parts, Cor Cervi grass 12 parts, Herba Scutellariae Barbatae 13 parts, Caulis Bauhihiae Championii 13 parts, Conyza japonica 14 parts, Herba Dendrobii 10 parts, Radix et Rhizoma Dysosmatis 11 parts, Radix Patriniae heterophyllae 11 parts, Radix seu Folium Tetracerae asiaticae 11 parts, Herba Patriniae 10 parts, Bauhinia purpurea 12 parts, the Radix Pulsatillae 13 parts.
The preparation method of the preparation decoction of above-mentioned treatment cervical cancer is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. eight sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1.5 hours, and then steams 4 hours, takes out, dries, and pulverizes, and crosses No. eight sieves;
(3) Bauhinia purpurea is put in 55 DEG C of vacuum drying ovens, dry 13 hours, pulverize, cross No. eight sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, add the water of 12 taste crude drug 5.6 times amount, after big fire is boiled, turn little fire and boil 32 minutes, leach medicinal liquid;
(5) step (1), step (2) and step (3) gained are mixed;
(6) joined in step (4) gained medicinal liquid by step (5) gained, add crystal sugar, the weight of crystal sugar is 1/10 of all crude drug gross weights, stirs, to obtain final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
The Radix Paeoniae Alba: base is former: be the dry root of ranunculaceae plant Radix Paeoniae.The property of medicine: bitter, sour, is slightly cold.Return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Wangjiang is blue or green: base is former: be root or the herb of labiate Stachys palustris L..The property of medicine: sweet in the mouth; Bitter; Cool in nature.Return lung meridian.Function cures mainly: heat-clearing and toxic substances removing; Removing heat from blood and promoting blood circulation.Main laryngopharynx swelling and pain; Lung abscess; Pertussis; Dysentery; Acute mastitis; Herpes zoster; The raw cataracta of order; Spitting of blood; Treating swelling and pain by traumatic injury.
Herba Galii Teneri: base is former: for Maguireothamnus speciosus draws the herb of rattan or thick Ye Lala rattan.The property of medicine: herb is very thin, easily broken, the grayish green or green and brown color in surface, feeble QI, acrid in the mouth, bitter in the mouth, cold nature.Composition: Herba Galii Teneri aerial parts is containing alkaloid, and fruit contains Fructus Hordei Germinatus amine, jaligonic acid etc.; Thick Ye Lala rattan aerial parts contains asperuloside, vitamin C.Find according to modern pharmacological research, this medical instrument has antibacterial, anticancer, heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, reducing swelling and alleviating pain effect, for swollen ulcer drug, and appendicitis, cold, fever, hematuria etc.
Fructus Chebulae: base is former: be the fruit of Combretum Racemosum plant Fructus Chebulae.Composition: fruit is containing tannin 23.60 ~ 37.36%, and its composition is chebulinic acid, Chebulagic acid, 1,3,6-trigalloylglucose and 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose, corilagin, terchebin, glucogallin, benzoaric acid and gallic acid etc.Again containing shikimic acid, dehydroshikimis acid, quininic acid, arabinose, fructose, glucose, sucrose, rhamnose and aminoacid.Also containing Sennoside A, terchebin, tannase, polyphenol oxidase, peroxidase, ascorbic acid oxidase etc.Bark is containing cupreol, tannin, benzoaric acid, gallic acid and Jiao's property catechol.Function cures mainly: astringe the lung, astringing intestine to stop diarrhea, the therapeutic method to keep the adverse QI flowing downwards.Control chronic cough aphonia, chronic diarrhea, chronic dysentery, proctoptosis, have blood in stool, metrorrhagia, leukorrhagia, seminal emission, frequent micturition.
Cor Cervi grass: base is former: be the herb of the thick fringe Balaenoptera borealis Lesson of Balanophoraceae plant.The property of medicine: bitter; Puckery; Warm in nature.Function cures mainly: kidney invigorating and YANG supporting; Spleen invigorating is regulated the flow of vital energy; Hemostasis.Main sexual impotence; Dysentery; Stomachache is spitted blood; Menorrhagia; Traumatic hemorrhage.
Herba Scutellariae Barbatae: base is former: be the herb of labiate Herba Scutellariae Barbatae.The property of medicine: pungent, bitter, cold.Return lung, liver, kidney channel.Function cures mainly: heat-clearing and toxic substances removing, and dissipating blood stasis stops blooding, inducing diuresis to remove edema.Main pyretic toxicity carbuncle, has sore throat, lung abscess, acute appendicitis, scrofula, venom, traumatic injury, spits blood, epistaxis, stranguria with blood, edema, ascites and cancer.
Caulis Bauhihiae Championii: base is former: be root or the stem of leguminous plant Caulis Bauhiniae Championii.The property of medicine: bitter; Flat; Nontoxic.Return liver, kidney channel.Function cures mainly: expelling wind and removing dampness, promoting flow of QI and blood.Main air pain of dampness syndrome, traumatic injury, hemiplegia, gastric abscess, infantile malnutrition, dysentery.
Conyza japonica: base is former: be the root of feverfew Conyza japonica.The property of medicine: bitter in the mouth; Pungent; Cold in nature.Function cures mainly: clearing away heat to alleviate pain; Dispelling pathogenic wind and eliminating phlegm.Main pleuritis; Pneumonia; Laryngopharynx swelling and pain; Infantile convulsion.
Herba Dendrobii: base is former: be the stem of orchid Dendrobium nobile or its multiple congener.Chemical analysis: Dendrobium nobile contains dendrobine, dendramine, Herba Dendrobii time alkali, dendroxine, dendrine, 6-hydroxydendroxine, still mucous matter, starch.Dendrobium moniliformeSweet is containing dendrobine, dendramine and N-methyl dendrobine (quaternary ammonium salt).Sieve river Herba Dendrobii is containing shihunine.The property of medicine: sweet, light, micro-salty, cold.Return stomach, lung, kidney channel.Function cures mainly: promote the production of body fluid stomach reinforcing, clearing away heat and nourishing YIN.Control consumption of body fluid caused by febrile disease, xerostomia excessive thirst, after being ill deficiency-heat, it is dark that the moon hinders order.
Radix et Rhizoma Dysosmatis: base is former: be the root and rhizome of Berberidaceae plant Radix et Rhizoma Dysosmatis, Dysosma Pleiantha and dysosma veitchii Fu.The property of medicine: bitter in the mouth; Pungent; Cool in nature; Poisonous.Return lung, Liver Channel.Function cures mainly: dissipating phlegm and resolving masses; Stasis-dispelling and pain-killing; Heat-clearing and toxic substances removing.Main cough; Laryngopharynx swelling and pain; Scrofula; Goiter; Carbuncle; Furuncle; Venom; Traumatic injury; Arthromyodynia.
Radix Patriniae heterophyllae: base is former: be the root of Valerianaceae plant Radix Patriniae Scabrae, Radix Patriniae Scabrae.The property of medicine: " Guangxi Chinese medicinal herbal ": " acrid in the mouth, warm in nature." " Guangxi Chinese medicinal herbal ": " enter the heart, liver two warp." function cures mainly: dampness leukorrhagia stopping, astringing to arrest bleeding, heat-clearing and toxic substances removing.Main leucorrhea with red and white discharge, metrorrhagia, dysentery, jaundice, malaria, acute appendicitis, sore swollen toxin, traumatic injury, cervical cancer, gastric cancer.For uterine erosion, early cervical carcinoma, leucorrhea, metrorrhagia, malaria.
Radix seu Folium Tetracerae asiaticae: base is former: be root or the stem and leaf of rattan when Dilleniaceae plant Radix seu Folium Tetracerae asiaticae and row leaf stannum.The property of medicine: acid; Puckery; Flat.Return liver, large intestine channel.Function cures mainly: arresting collape syndrome by astringents; Reducing swelling and alleviating pain.Main chronic diarrhea chronic dysentery; Have blood in stool; Proctoptosis; Seminal emission; Leucorrhea; Uterine prolapse; Treating swelling and pain by traumatic injury.
Herba Patriniae: base is former: be the herb of Valerianaceae plant Patrinia scabiosaefolia Fisch and patrima villosa.The property of medicine: acrid in the mouth; Bitter; Cold nature.Function cures mainly: heat-clearing and toxic substances removing; To invigorate blood circulation evacuation of pus.Main intestinal carbuncle; Lung abscess; Carbuncle; Dysentery; The stagnant stomachache of the stasis of blood in puerperal.
Bauhinia purpurea: base is former: be the root of pulse family bauhinia Bauhinia purpurea.The property of medicine: bitter, puckery, flat.Function cures mainly: invigorating the spleen to clear away damp pathogen, hemostasis.Cure mainly dyspepsia, acute gastroenteritis, hepatitis, cough spitting of blood, arthralgia, traumatic injury.
The Radix Pulsatillae: base is former: this product is the dry root of the ranunculaceae plant Radix Pulsatillae.The property of medicine: bitter, cold.Return stomach, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.For toxic-heat and blood stasis, pudendal pruritus leukorrhagia, amebic dysentery.
test example 1the clinical practice of the preparation (embodiment 5) of gained treatment cervical cancer of the present invention: in June ,-2010 in July, 2007, screen 284 routine cervical cancer patients in 4 hospitals and carry out clinical observation.Be divided into two groups at random, experimental group and matched group (often organizing 142 people).Two groups of patients compare in the physical data such as age, the state of an illness, and there was no significant difference, has comparability.Experimental group uses gained of the present invention to treat the preparation of cervical cancer, using method: oral, and one day twice, each 180mL(was warm), within 4 weeks, be a course for the treatment of.Matched group takes the Drug therapys such as methotrexate, XIAOAIPING PIAN, doxifluridine capsule.Two groups of patients all treat after two months, carry out Comparison of therapeutic.
Curative effect situation criterion: complete incidence graph (CR): lump disappears completely, maintains more than 4 weeks; Partial rcsponse (PR): mass reduction more than 50%, and maintain more than 4 weeks; Take a turn for the better (MR): mass reduction 25% ~ 50%, and maintain more than 4 weeks; Stable (SD): local mass reduction or increase equal < 25%; Progress (PD): tumor increases > 25% or occurs new pathological changes.Effectively total=CR+PR+MR.Result is as shown in table 1.
Table 1: the preparation compliance test result [example (%)] of gained treatment cervical cancer of the present invention
Therapeutic effect: in 142 routine patients of experimental group, complete incidence graph 88 example, accounts for 61.97%; Partial rcsponse 49 example, accounts for 34.51%; Take a turn for the better 3 examples, accounts for 2.11%; Stablize 2 examples, account for 1.41%; Total effective rate reaches 98.59%.In 142 routine patients of matched group, complete incidence graph 40 example, accounts for 28.17%; Partial rcsponse 44 example, accounts for 30.99%; Take a turn for the better 24 examples, accounts for 16.9%; Stablize 26 examples, account for 18.31%; Progress 8 example, accounts for 5.63%; Total effective rate is 76.06%.Experimental group total effective rate is obviously better than matched group, and two groups of comparing differences have significance.
The present invention is primary raw material medicine with the Radix Paeoniae Alba, Wangjiang green grass or young crops, Herba Galii Teneri and Fructus Chebulae etc., makes the preparation for the treatment of cervical cancer.Radix Paeoniae Alba suppressing the hyperactive liver pain relieving in side, nourishing blood for regulating menstruation, astringing YIN to stop sweating.The blue or green heat-clearing and toxic substances removing in Wangjiang; Removing heat from blood and promoting blood circulation.Herba Galii Teneri has antibacterial, anticancer, heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, reducing swelling and alleviating pain effect.Fructus Chebulae astringes the lung, astringing intestine to stop diarrhea, the therapeutic method to keep the adverse QI flowing downwards.Cor Cervi grass kidney invigorating and YANG supporting; Spleen invigorating is regulated the flow of vital energy; Hemostasis.Herba Scutellariae Barbatae heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, inducing diuresis to remove edema.Caulis Bauhihiae Championii expelling wind and removing dampness, promoting flow of QI and blood.Conyza japonica clearing away heat to alleviate pain; Dispelling pathogenic wind and eliminating phlegm.Herba Dendrobii promotes the production of body fluid stomach reinforcing, clearing away heat and nourishing YIN.Radix et Rhizoma Dysosmatis dissipating phlegm and resolving masses; Stasis-dispelling and pain-killing; Heat-clearing and toxic substances removing.Radix Patriniae heterophyllae dampness leukorrhagia stopping, astringing to arrest bleeding, heat-clearing and toxic substances removing.Radix seu Folium Tetracerae asiaticae arresting collape syndrome by astringents; Reducing swelling and alleviating pain.Herba Patriniae heat-clearing and toxic substances removing; To invigorate blood circulation evacuation of pus.Bauhinia purpurea invigorating the spleen to clear away damp pathogen, hemostasis.Radix Pulsatillae heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.Many medicines share, and mutually coordinate, and play removing toxic substances heat clearing away altogether, eliminating stasis and resolving masses, dampness leukorrhagia stopping, astringing to arrest bleeding, spleen invigorating are regulated the flow of vital energy, the effect of kidney invigorating and YANG supporting, patient immune function can be improved, improve patient self anti-tumor capacity, the transfer of timely anticancer, and the effective generation reducing complication.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat the preparation of cervical cancer, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Paeoniae Alba 10-16, Wangjiang blue or green 8-13, Herba Galii Teneri 9-14, Fructus Chebulae 7-13, Cor Cervi grass 10-15, Herba Scutellariae Barbatae 8-16, Caulis Bauhihiae Championii 11-15, Conyza japonica 9-16, Herba Dendrobii 7-14, Radix et Rhizoma Dysosmatis 8-14, Radix Patriniae heterophyllae 6-15, Radix seu Folium Tetracerae asiaticae 9-13, Herba Patriniae 8-12, Bauhinia purpurea 10-14, Radix Pulsatillae 9-15.
2. the preparation for the treatment of cervical cancer as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Paeoniae Alba 12-14, Wangjiang blue or green 9-12, Herba Galii Teneri 10-13, Fructus Chebulae 8-12, Cor Cervi grass 11-14, Herba Scutellariae Barbatae 10-14, Caulis Bauhihiae Championii 12-14, Conyza japonica 11-15, Herba Dendrobii 9-12, Radix et Rhizoma Dysosmatis 10-13, Radix Patriniae heterophyllae 8-13, Radix seu Folium Tetracerae asiaticae 10-12, Herba Patriniae 9-11, Bauhinia purpurea 11-13, Radix Pulsatillae 12-14.
3. the preparation for the treatment of cervical cancer as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: the Radix Paeoniae Alba 13, Wangjiang green grass or young crops 11, Herba Galii Teneri 12, Fructus Chebulae 10, Cor Cervi grass 12, Herba Scutellariae Barbatae 13, Caulis Bauhihiae Championii 13, Conyza japonica 14, Herba Dendrobii 10, Radix et Rhizoma Dysosmatis 11, Radix Patriniae heterophyllae 11, Radix seu Folium Tetracerae asiaticae 11, Herba Patriniae 10, Bauhinia purpurea 12, the Radix Pulsatillae 13.
4. the preparation of the treatment cervical cancer as described in as arbitrary in claims 1 to 3, it is characterized in that, the preparation of this treatment cervical cancer is made pharmaceutically acceptable powder, and the preparation method of described powder is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. eight sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1-2 hour (preferably vexed 1.5 hours), and then steam 3-5 hour (preferably and then steam 4 hours), take out, dry, pulverize, cross No. eight sieves;
(3) put by Bauhinia purpurea in 55 DEG C of vacuum drying ovens, dry 10-15 hour (preferably dry 13 hours), pulverize, cross No. eight sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, decoct with water twice, amount of water is the 5.8-7.6 of 12 taste crude drug gross weights doubly (preferred amount of water is 6.7 times of 12 taste crude drug gross weights), each decoction 1.4 hours, merges twice medicinal liquid, is concentrated into the thick paste (being preferably concentrated into the thick paste that relative density is 1.35) that relative density is 1.32-1.36, put into 55 DEG C of vacuum drying ovens, dry 12 hours, pulverize, cross No. eight sieves;
(5) step (1), step (2) step (3) and step (4) gained are mixed, add cane sugar powder, the weight of cane sugar powder is the weight of the 1/14-1/9(preferably sucrose powder of all crude drug gross weights is 1/12 of all crude drug gross weights), stir, often to wrap 5g subpackage, sterile packaged, to obtain final product.
5. the preparation of the treatment cervical cancer as described in as arbitrary in claims 1 to 3, it is characterized in that, the preparation of this treatment cervical cancer is made pharmaceutically acceptable decoction, and the preparation method of described decoction is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. eight sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1-2 hour, and then steams 3-5 hour, takes out, dries, and pulverizes, and crosses No. eight sieves;
(3) Bauhinia purpurea is put in 55 DEG C of vacuum drying ovens, dry 10-15 hour, pulverize, cross No. eight sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, add the water (preferably adding the water of 12 taste crude drug 5.6 times amount) of 12 taste crude drug 4.6-6.5 times amount, after big fire is boiled, turn little fire to boil 24-38 minute (preferably turn little fire and boil 32 minutes), leach medicinal liquid;
(5) step (1), step (2) and step (3) gained are mixed;
(6) joined in step (4) gained medicinal liquid by step (5) gained, add crystal sugar, the weight of crystal sugar is the weight of the preferred crystal sugar of 1/13-1/9(of all crude drug gross weights is 1/10 of all crude drug gross weights), stir, to obtain final product.
6. the preparation of the treatment cervical cancer as described in as arbitrary in claims 1 to 3, it is characterized in that, the preparation of this treatment cervical cancer is made pharmaceutically acceptable pill, and the preparation method of described pill is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. six sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1-2 hour (preferably vexed 1.5 hours), and then steam 3-5 hour (preferably and then steam 4 hours), take out, dry, pulverize, cross No. six sieves;
(3) put by Bauhinia purpurea in 55 DEG C of vacuum drying ovens, dry 10-15 hour (preferably dry 13 hours), pulverize, cross No. six sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, decoct with water twice, amount of water is the 5.8-7.6 of 12 taste crude drug gross weights doubly (preferred amount of water is 6.7 times of 12 taste crude drug gross weights), each decoction 1.4 hours, merge twice medicinal liquid, be concentrated into the thick paste (being preferably concentrated into the thick paste that relative density is 1.35) that relative density is 1.32-1.36;
(5) step (1), step (2) and step (3) gained are joined in step (4) gained thick paste, with water pill, make the pill that particle diameter is 4mm, dry, to obtain final product.
7. the preparation of the treatment cervical cancer as described in as arbitrary in claims 1 to 3, it is characterized in that, the preparation of this treatment cervical cancer is made pharmaceutically acceptable tablet, and the preparation method of described tablet is:
(1) Fructus Chebulae is put into put pot, with slow fire heating, fry to buff, take out, cool, pulverize, cross No. seven sieves;
(2) Sal is dissolved in water, and joins in Radix seu Folium Tetracerae asiaticae and mixes thoroughly, the weight ratio 100:6:12 of Radix seu Folium Tetracerae asiaticae, Sal and water, vexed 1-2 hour (preferably vexed 1.5 hours), and then steam 3-5 hour (preferably and then steam 4 hours), take out, dry, pulverize, cross No. seven sieves;
(3) put by Bauhinia purpurea in 55 DEG C of vacuum drying ovens, dry 10-15 hour (preferably dry 13 hours), pulverize, cross No. seven sieves;
(4) all the other the 12 taste crude drug except Fructus Chebulae, Radix seu Folium Tetracerae asiaticae and Bauhinia purpurea are put into pot, decoct with water twice, amount of water is the 5.8-7.6 of 12 taste crude drug gross weights doubly (preferred amount of water is 6.7 times of 12 taste crude drug gross weights), each decoction 1.4 hours, merges twice medicinal liquid, is concentrated into the thick paste (being preferably concentrated into the thick paste that relative density is 1.35) that relative density is 1.32-1.36, put into 55 DEG C of vacuum drying ovens, dry 12 hours, pulverize, cross No. seven sieves;
(5) step (1), step (2) step (3) and step (4) gained are mixed, add cane sugar powder, the weight of cane sugar powder is the weight of the 1/14-1/9(preferably sucrose powder of all crude drug gross weights is 1/12 of all crude drug gross weights), stir, tabletting, the heavy 0.5g of every sheet, to obtain final product.
8. the preparation method of the preparation decoction for the treatment of cervical cancer as claimed in claim 5, is characterized in that, in step (2) vexed 1.5 hours.
9. the preparation method of the preparation decoction for the treatment of cervical cancer as claimed in claim 5, is characterized in that, in step (2) and then steam 4 hours.
10. the preparation method of the preparation decoction for the treatment of cervical cancer as claimed in claim 5, is characterized in that, drying 13 hours in step (3).
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107982292A (en) * | 2018-01-11 | 2018-05-04 | 广西中医药大学 | The application of asian tetracera root or leaf and its extract in terms for the treatment of and/or the medicine that prevents liver cancer is prepared |
| CN108143754A (en) * | 2018-01-11 | 2018-06-12 | 广西中医药大学 | The application of asian tetracera root or leaf and its extract in terms for the treatment of and/or prevention tumour medicine is prepared |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172672A (en) * | 1997-08-29 | 1998-02-11 | 刘进成 | Chinese medicinal herb composition for treating cancer |
| CN104383514A (en) * | 2014-12-09 | 2015-03-04 | 袁国防 | Traditional Chinese medicine for treating cervical cancer |
-
2015
- 2015-08-13 CN CN201510495244.6A patent/CN105012713A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172672A (en) * | 1997-08-29 | 1998-02-11 | 刘进成 | Chinese medicinal herb composition for treating cancer |
| CN104383514A (en) * | 2014-12-09 | 2015-03-04 | 袁国防 | Traditional Chinese medicine for treating cervical cancer |
Non-Patent Citations (4)
| Title |
|---|
| 司富春等: "治疗子宫颈癌中医方药分析", 《中医研究》 * |
| 周维顺等: "略论宫颈癌的诊治原则", 《浙江中医学院学报》 * |
| 杨建宇等主编: "《一本书读懂中草药抗癌》", 31 August 2014, 中原农民出版社 * |
| 王昃睿等主编: "《名老中医王治强临床经验荟萃》", 30 June 2015, 科学技术文献出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107982292A (en) * | 2018-01-11 | 2018-05-04 | 广西中医药大学 | The application of asian tetracera root or leaf and its extract in terms for the treatment of and/or the medicine that prevents liver cancer is prepared |
| CN108143754A (en) * | 2018-01-11 | 2018-06-12 | 广西中医药大学 | The application of asian tetracera root or leaf and its extract in terms for the treatment of and/or prevention tumour medicine is prepared |
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Address after: 744300, Gansu Province, Dingxi District, Liberty Street, No. 54 Wen Yuan District, building 2, 1-202 Applicant after: Li Rongqin Address before: Kang Hong Lu 250000 Shandong province Ji'nan city high tech Development Zone No. 758 Applicant before: Li Rongqin |
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Application publication date: 20151104 |