CN104096172A - Traditional Chinese medicine preparation capable of resisting malignant tumors - Google Patents
Traditional Chinese medicine preparation capable of resisting malignant tumors Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation capable of resisting malignant tumors. The preparation comprises selected bulk drugs by weight as follows: 10-20 g of ginger processed pinellia, 10-20 g of red ginseng, 20-30 g of poria, 8-12 g of liquorice, 5-10 g of trogopterus dung, 8-12 g of turmeric root-tuber, 8-15 g of alumen, 10-20 g of stir-fried resina toxicodendri, 8-12 g of giant knotweed rhizome, 5-10 g of red paeony root, 10-20 g of fructus gardeniae preparatus and 5-10 g of honeysuckle. The selected medicinal materials have effects of clearing heat and toxic materials, promoting blood circulation, removing blood stasis, benefiting qi, nourishing yin, strengthening the body resistance, removing stagnation, relieving swellings, resisting cancers and the like together. According to clinical applications, the preparation is stable in curative effect, low in price, capable of significantly improving the body immune function, accelerating body rehabilitation, relieving toxic and side effects caused by radiotherapy and chemotherapy, increasing the complete elimination rate of the malignant tumors, decreasing the tumor recurrence rate and increasing the long-term survival rate and worthy of clinical popularization and applications.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation that can anti-malignant tumor.
Background technology
Malignant tumor is cancer, and it is the general designation of more than 100 kind of relevant disease.This disease is main forms cancerous cell because health inner cell is undergone mutation, and the feature of cancerous cell be unrestrictedly, hypertrophy without end, the nutrient substance in patient body is consumed in a large number; Cancerous cell discharges multiple toxin, and transfers to whole body growth and breeding everywhere, causes that becoming thin appears in human body, unable, anemia, inappetence, heating and the series of symptoms such as serious organ function is impaired.Can disorganize when serious, the 26S Proteasome Structure and Function of organ, cause downright bad hemorrhage concurrent infection, patient is finally dead due to organ failure.
Malignant tumor is serious threat people ' s health, jeopardizes the serious disease of people's life.In some developed country, tumor has come first of the cause of the death.It is reported, the whole world has 6,000,000 people that tumor occurs every year, and 5,000,000 people die from tumor above.China approximately has 1,200,000 people that tumor occurs every year, approximately 900,000 people's death.In recent years, tumor patient number is increases trend generally, and the age is rejuvenation trend, also sharply rises clinically for the demand of antineoplastic agent.
Method and the medicine of modern medicine aspect anti-malignant tumor is a lot, doctor trained in Western medicine Radiotherapy chemotherapy, operative treatment malignant tumor curative effect are certainly, but toxic and side effects is large, main manifestations is bone marrow depression, gastrointestinal reaction, hepatic and renal function damage, cardiac toxicity etc., and medical expense costliness, a lot of patients, owing to being difficult to bear high medical expense, affect the state of an illness adversely.Though Chinese medicine toxic and side effects is little, the most anti-malignant tumor onset of existing medicine is slow, the course for the treatment of is long, seems unable to do what one wishes.
Summary of the invention
The invention solves the defect existing at present aspect anti-malignant tumor, a kind of stable curative effect, cheap is provided, can significantly improve body's immunity, accelerate physical recovery, alleviate Radiotherapy chemotherapy toxicity, reduce tumor recurrence rate, improve the rate that entirely disappears of malignant tumor and the Chinese medicine preparation of long term survival rate.
The technical solution adopted in the present invention is: a kind of Chinese medicine preparation of anti-malignant tumor, it is characterized in that, and described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10-20 gram, Radix Ginseng Rubra 10-20 gram, Poria 20-30 gram, Radix Glycyrrhizae 8-12 gram, Oletum Trogopterori 5-10 gram, Radix Curcumae 8-12 gram, Alumen 8-15 gram, 10-20 gram, fried dry paint, Rhizoma Polygoni Cuspidati 8-12 gram, Radix Paeoniae Rubra 5-10 gram, Fructus Gardeniae Preparatus 10-20 gram, Flos Lonicerae 5-10 gram.
As this kind of prioritization scheme:
Described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
10 grams of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 10 grams of Radix Ginseng Rubras, 20 grams of Poria, 8 grams, Radix Glycyrrhizae, 5 grams of Oletum Trogopteroris, 8 grams of Radix Curcumaes, 8 grams of Alumens, 10 grams, fried dry paint, 8 grams of Rhizoma Polygoni Cuspidati, 5 grams of Radix Paeoniae Rubra, 10 grams of Fructus Gardeniae Preparatuss, 5 grams of Flos Loniceraes.
As this kind of prioritization scheme:
Described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
15 grams of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 15 grams of Radix Ginseng Rubras, 25 grams of Poria, 10 grams, Radix Glycyrrhizae, 8 grams of Oletum Trogopteroris, 10 grams of Radix Curcumaes, 12 grams of Alumens, 15 grams, fried dry paint, 10 grams of Rhizoma Polygoni Cuspidati, 8 grams of Radix Paeoniae Rubra, 15 grams of Fructus Gardeniae Preparatuss, 8 grams of Flos Loniceraes.
As this kind of prioritization scheme:
Described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
20 grams of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 20 grams of Radix Ginseng Rubras, 30 grams of Poria, 12 grams, Radix Glycyrrhizae, 10 grams of Oletum Trogopteroris, 12 grams of Radix Curcumaes, 15 grams of Alumens, 20 grams, fried dry paint, 12 grams of Rhizoma Polygoni Cuspidati, 10 grams of Radix Paeoniae Rubra, 20 grams of Fructus Gardeniae Preparatuss, 10 grams of Flos Loniceraes.
The instructions of taking of above-mentioned Chinese medicine preparation is: after the raw material Chinese medicine of above-mentioned weight proportion is mixed, get its medicine juice according to the method for the fried Chinese medicine of tradition, 1 dose of every day, points 3～4 times oral.30 doses was 1 course for the treatment of.Drug withdrawal 2～3 days between the course for the treatment of, then go lower 1 course for the treatment of.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation:
Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), pungent, warm; Return spleen, stomach, lung meridian.There is stopping nausea and vomiting by lowering the adverse flow of QI, damp eliminating clears phlegm.
Radix Ginseng Rubra, sweet in the mouth, micro-hardship, slightly warm in nature; Return spleen, lung, the heart, kidney channel.Have invigorating YANG and consolidate, multiple arteries and veins is admittedly de-, effect of nourishing qi to stop.
Poria, slightly sweet flavor is flat; GUIXIN, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.
Radix Glycyrrhizae, sweet in the mouth is flat; GUIXIN, spleen, lung, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription
Oletum Trogopterori, bitter, sweet, temperature; Return Liver Channel.There is promoting blood circulation and stopping pain, effect of removing stasis to stop bleeding.
Radix Curcumae, acrid in the mouth, hardship, cold; GUIXIN, liver, gallbladder meridian.There is promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clearing away heat and cooling blood, removing heat from the heart to restore the consciousness, effect of dampness removing jaundice eliminating.
Alumen, sour in the mouth, puckery, cold; Return lung, spleen, liver, large intestine channel.There is blood antidiarrheal, dispel effect of wind-phlegm.
Fried dry paint, acrid in the mouth, temperature; Return liver, spleen channel.There is blood circulation promoting and blood stasis dispelling, effect of righting removing food stagnancy.
Rhizoma Polygoni Cuspidati, bitter in the mouth, cold; Return liver, gallbladder, lung meridian.There is promoting blood circulation and stopping pain, heat-clearing and toxic substances removing, effect of preventing phlegm from forming and stopping coughing.
Radix Paeoniae Rubra, micro-hardship, cold; Return Liver Channel.There is clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, effect of reducing swelling and alleviating pain.
Fructus Gardeniae Preparatus, bitter in the mouth, cold; GUIXIN, lung, tri-jiao channel.There is effect of cooling blood for hemostasis.
Flos Lonicerae, cold in nature, sweet in the mouth; Attach to the lung and stomach meridians.There is heat-clearing and toxic substances removing, effect of dispelling wind and heat pathogens.
The traditional Chinese medical science thinks that the cause of disease of malignant tumor is that exopathogen invasion and attack, disorder of emotion, eating and drinking without temperance and labor are wanted internal injury etc.Pathogenesis is vital QI being weakened and pathogen being violent, simulataneous insufficiency and excessive.Weakened body resistance gas (sun) void, cloudy (blood) void, gas cloudy (blood) two void of being mainly, the domination of pathogen is mainly that the stagnation of QI, expectorant are solidifying, blood stasis, pyretic toxicity etc., and therefore treatment should be taking blood circulation promoting and blood stasis dispelling, expectorant damp eliminating, strengthening vital QI to eliminate pathogenic factors (anticancer) as basic principle.
Chinese medicine preparation of the present invention, Radix Ginseng Rubra can vigorate qi and replenish the blood, strengthening the body resistance, multiple arteries and veins are admittedly de-, improves body immunity; Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Alumen, Rhizoma Polygoni Cuspidati three medicines are associated with and can damp eliminating be reduced phlegm, promoting blood circulation and stopping pain; Poria, Radix Curcumae can promoting QI circulation for relieving depression, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming; Oletum Trogopterori, fried dry paint, Radix Paeoniae Rubra three medicine collocation are blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, and the good medicine of righting removing food stagnancy, is equipped with Fructus Gardeniae Preparatus, the merit of the cooling blood for hemostasis of holding concurrently again; Flos Lonicerae, Radix Glycyrrhizae are heat-clearing and toxic substances removing, and dispelling wind and heat pathogens again can coordinating the actions of various ingredients in a prescription.All medicines gather heat-clearing and toxic substances removing altogether, blood circulation promoting and blood stasis dispelling, supplementing QI and nourishing YIN, righting removing food stagnancy, the effect such as subside a swelling anticancer, can have efficient recovery body equilibrium between yin and yang, improves immunologic function, suppress and contact element in cancerous cell, reach the rate that entirely disappears that improves malignant tumor, reduce tumor recurrence rate, improve the object of long term survival rate.
For further investigating the clinical efficacy of medicine of the present invention, we have selected 150 routine patients to carry out clinical trial, male 98 examples, female's 52 examples, age 28-70 year, 56 years old mean age.All make a definite diagnosis through cytology or pathology, 60 points of KPS scoring >, expectation > life cycle 3 months, wherein nonsmall-cell lung cancer 32 examples, breast carcinoma 38 examples, 24 Cases of Gastric Carcinoma, esophageal carcinoma 22 examples, non-Hodgkin lymphoma 12 examples, colorectal cancer 22 examples, are and just control patient.Be divided at random treatment group and matched group, every group of 75 examples, take the Chinese medicine preparation in the embodiment of the present invention 2 after Chemotherapy in Patients; Matched group 50 examples, alone chemotherapy.Two groups of case features are at aspect zero differences such as age, sex, behavioral aspect, tumor classification, chemotherapy regimens.
Criterion of therapeutical effect (according to WHO solid tumor drugs treatment efficacy assessment standard):
Alleviate completely (CR): tumor is cured completely, it is normal that physical symptom recovers.
Partial rcsponse (PR): tumor area reducing is obvious, and physical symptom obviously improves.
Stable (SD): tumor area is unchanged, and physical symptom is maintained the statusquo.
Worsen (PD): tumor area change, physical symptom worsens.
Separately, toxicity is carried out toxicity assessment by WHO toxicity of anticancer agents reaction calibration (O-IV).
Therapeutic Method:
Treatment group is taken the Chinese medicine preparation of embodiment 2, gets its medicine juice according to the method for the fried Chinese medicine of tradition, and 1 dose of every day, points 3～4 times oral.30 doses was 1 course for the treatment of.Drug withdrawal 2～3 days between the course for the treatment of, then go lower 1 course for the treatment of.Matched group only gives chemotherapy.
Be specially: nonsmall-cell lung cancer, breast carcinoma NP scheme (cisplatin 25mg/m2 1-5 days, vinorelbine 25mg/m2 1-7 days), gastric cancer, esophageal carcinoma PF scheme (cisplatin 25mg/m2 1-5 days, fluorouracil (5-Fu) 500mg/m2 1-8 days), non-Hodgkin lymphoma CHOP scheme (ring phosphorus phthalein amine 750mg/m2 the 1st day, doxorubicin 40mg/m2 the 1st day, vincristine 2mg the 1st day, prednisone 100mg 1-5 days), colorectal cancer FOLFOX scheme (JM-216 130mg/m2 the 1st day, 5-Fu500mg 1-5 days, calcium folinate 200mg/m2 1-7 days), emesis all gives granisetron, 15min before dexamethasone chemotherapy, ivd, 2 cycles post-evaluation curative effect.Before and after recording untoward reaction, KPS scoring, oral Chinese medicine preparation of the present invention, application flow cytometer detects Immunological Markers for Cell-Mediated Immunity.
Efficacy result:
That adds up patient's drug administration the results are shown in Table 1.Treat after three courses for the treatment of the total effective rate 65.3% for the treatment of group; Matched group total effective rate 46.7%; Two groups of comparisons, treatment group curative effect is apparently higher than matched group.
Table 1: add up two groups of patient's drug administration result synopsis
Untoward reaction:
Treatment group WBC reduces 46 examples (61.3%); Matched group WBC reduces 58 examples (77.3%), and treatment group group WBC is obviously less than matched group, significant difference (P < 0.05).The incidence rate of observation group's platelet, anemia is a little less than matched group, but difference not statistically significant.In table 2.
Table 2: the toxicity of two groups of patient's drug administrations of statistics
Note: with relatively * P < 0.05 of matched group
The KPS variation of marking:
10 points of KPS scoring changes are decided to be and are changed.Scoring ascensionist 29 examples after observation group's treatment, constant person's 36 examples, descender's 10 examples; Matched group ascensionist 17 examples, constant person's 32 examples, descender's 26 examples; The KPS of observation group scoring climbing (38.7%) is higher than matched group (22.7%), and through inspection, difference has significance (P < 0.05).
4. cellular immune function changes:
Index CD4/CD8 ratio and the NK positive percentage of observation group's reflection cellular immunity are all significantly improved after treatment.Through t inspection, after the CD4/CD8 of observation group ratio and NK positive percentage are treated and before treatment, compare, difference has significance (t=-2.193, P=0.031 and t=-2.523, P=0.013), in table 3.
Table 3: after adding up two groups of patient treatments, cellular immunization changes
Note: relatively front with treatment, * 1P < 0.05, * 2P < 0.01
Result shows, Chinese medicine preparation of the present invention has obvious active anticancer after taking, can improve patient's body immunity comprehensively, cancer cell is had to stronger killing and inhibition ability, and human body is had no side effect, and strengthen Chemotherapy, and reduce chemical therapy toxic side effect, improve patient's long term survival rate.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine preparation of anti-malignant tumor, choose 10 grams of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 10 grams of Radix Ginseng Rubras, 20 grams of Poria, 8 grams, Radix Glycyrrhizae, 5 grams of Oletum Trogopteroris, 8 grams of Radix Curcumaes, 8 grams of Alumens, 10 grams, fried dry paint, 8 grams of Rhizoma Polygoni Cuspidati, 5 grams of Radix Paeoniae Rubra, 10 grams of Fructus Gardeniae Preparatuss, 5 grams of Flos Loniceraes.
Embodiment 2: a kind of Chinese medicine preparation of anti-malignant tumor, choose 15 grams of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 15 grams of Radix Ginseng Rubras, 25 grams of Poria, 10 grams, Radix Glycyrrhizae, 8 grams of Oletum Trogopteroris, 10 grams of Radix Curcumaes, 12 grams of Alumens, 15 grams, fried dry paint, 10 grams of Rhizoma Polygoni Cuspidati, 8 grams of Radix Paeoniae Rubra, 15 grams of Fructus Gardeniae Preparatuss, 8 grams of Flos Loniceraes.
Embodiment 3: a kind of Chinese medicine preparation of anti-malignant tumor, choose 20 grams of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 20 grams of Radix Ginseng Rubras, 30 grams of Poria, 12 grams, Radix Glycyrrhizae, 10 grams of Oletum Trogopteroris, 12 grams of Radix Curcumaes, 15 grams of Alumens, 20 grams, fried dry paint, 12 grams of Rhizoma Polygoni Cuspidati, 10 grams of Radix Paeoniae Rubra, 20 grams of Fructus Gardeniae Preparatuss, 10 grams of Flos Loniceraes.
Below by concrete case, Chinese medicine preparation curative effect of the present invention is further verified:
Case 1
Zhao × ×, female, 47 years old.Patient be lymphocyst secondary infection with heating, body temperature 37.4-39 DEG C, average 38 DEG C, local pain aggravation, touches a tender spot obviously, cyst can obviously increase in the short time.CF antibacterial culturing can be positive, gets rid of other site infections.Patient's general immunity hypofunction, after chemotherapy, neutrophilic granulocyte reduces or lacks, and is the Susceptible population of hospital infection.Upon somebody's introduction, chemotherapy starts to take Chinese medicine preparation of the present invention after three days, according to the real-time regulating drug dosage of physical symptom.Take continuously two courses for the treatment of, physical symptom is alleviated obviously, and immunity of organisms significantly improves, and holds on and takes later, and postoperative 6 years so far, health did not hinder.
Case 2
King × ×, man, 65 years old.Patient's right shoulder of prominent sense and chest pain before six months, medical after CT prompting have lung occupy-place, after be diagnosed as pulmonary carcinoma, and have the many places such as bottom right lung, pleura, liver to shift, after carry out chemotherapy operation.Start to take Chinese medicine preparation of the present invention, further to strengthen the organism ability of antitumor cell.Patient took after the course for the treatment of of the present invention, and conscious ambition is no longer stuffy, and hydrothorax reduces, and appetite is cumulative, and spirit is comparatively improved.Advise by household, adhere to taking Chinese medicine preparation of the present invention so far, health is good.
Case 3
Du × ×, female, 56 years old.2013, there is unregular vaginal bleeding without inducement, made a definite diagnosis and suffered from cervical cancer afterwards, after radiotherapy in the treatment, fail fine control tumor growth, disease relapse, starts to shift toward pulmonary, lymph and rectum place, simultaneously with heating and cough symptom.Upon somebody's introduction, start hair Chinese medicine preparation of the present invention, after the course for the treatment of, patient's readme limbs take a turn for the better obviously, and cough obviously reduces, and body temperature is tending towards normally, and sleep quality has had large increase, and appetite is cumulative, and patient's mood is good greatly, and the mental status is greatly improved; Adhere to taking Chinese medicine preparation of the present invention and have a surplus for 1 year, fecal and urinary functions recovers normally substantially, and the symptom of having blood in stool is effectively controlled, and therapeutic effect is very obvious, and patient is healthy living so far.
Claims (4)
1. a Chinese medicine preparation for anti-malignant tumor, is characterized in that, described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10-20 gram, Radix Ginseng Rubra 10-20 gram, Poria 20-30 gram, Radix Glycyrrhizae 8-12 gram, Oletum Trogopterori 5-10 gram, Radix Curcumae 8-12 gram, Alumen 8-15 gram, 10-20 gram, fried dry paint, Rhizoma Polygoni Cuspidati 8-12 gram, Radix Paeoniae Rubra 5-10 gram, Fructus Gardeniae Preparatus 10-20 gram, Flos Lonicerae 5-10 gram.
2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
10 grams of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 10 grams of Radix Ginseng Rubras, 20 grams of Poria, 8 grams, Radix Glycyrrhizae, 5 grams of Oletum Trogopteroris, 8 grams of Radix Curcumaes, 8 grams of Alumens, 10 grams, fried dry paint, 8 grams of Rhizoma Polygoni Cuspidati, 5 grams of Radix Paeoniae Rubra, 10 grams of Fructus Gardeniae Preparatuss, 5 grams of Flos Loniceraes.
3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
15 grams of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 15 grams of Radix Ginseng Rubras, 25 grams of Poria, 10 grams, Radix Glycyrrhizae, 8 grams of Oletum Trogopteroris, 10 grams of Radix Curcumaes, 12 grams of Alumens, 15 grams, fried dry paint, 10 grams of Rhizoma Polygoni Cuspidati, 8 grams of Radix Paeoniae Rubra, 15 grams of Fructus Gardeniae Preparatuss, 8 grams of Flos Loniceraes.
4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
20 grams of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 20 grams of Radix Ginseng Rubras, 30 grams of Poria, 12 grams, Radix Glycyrrhizae, 10 grams of Oletum Trogopteroris, 12 grams of Radix Curcumaes, 15 grams of Alumens, 20 grams, fried dry paint, 12 grams of Rhizoma Polygoni Cuspidati, 10 grams of Radix Paeoniae Rubra, 20 grams of Fructus Gardeniae Preparatuss, 10 grams of Flos Loniceraes.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110946941A (en) * | 2020-01-09 | 2020-04-03 | 靳祥红 | Traditional Chinese medicine for treating tumor |
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| CN102772745A (en) * | 2012-08-21 | 2012-11-14 | 卢速江 | Chinese medicinal preparation for treating cancer and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102772745A (en) * | 2012-08-21 | 2012-11-14 | 卢速江 | Chinese medicinal preparation for treating cancer and preparation method thereof |
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| 李艳: "扶正祛邪化毒法在肿瘤治疗中的应用", 《中医药临床杂志》 * |
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Application publication date: 20141015 |