CN109010704A - It is a kind of for controlling the Chinese medicine composition and preparation method of tumour growth - Google Patents
It is a kind of for controlling the Chinese medicine composition and preparation method of tumour growth Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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- A61K35/60—Fish, e.g. seahorses; Fish eggs
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- A61K35/56—Materials from animals other than mammals
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Abstract
The embodiment of the invention discloses a kind of for controlling the Chinese medicine composition of tumour growth, and the Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of bittersweet, 15-25 parts of ganoderma lucidum, 15-20 parts of vinegar rhizoma corydalis, 12-20 parts of vinegar endothelium corneum gigeriae galli, 15-20 parts of edible tulip, 10-20 parts of root of kirilow rhodiola, 10-15 parts of bear gall powder, 10-15 parts of Radix Notoginseng powder, 10-15 parts of curcuma zedoary, 8-15 parts of hippocampus, 6-15 parts of American Ginseng, 8-12 parts of roasted SQUAMA MANITIS into puffy with sand, 6-10 parts of calculus bovis factitius, 5-8 parts of pearl powder.The invention also discloses a kind of for controlling the preparation method of the Chinese medicine composition of tumour growth.The Chinese medicine composition of the embodiment of the present invention is capable of the dynamic equilibrium of conditioning engine body, enhances body's immunity, improves the microenvironment of cancer cell, inhibit or directly kill cancer cell, effectively control growth of tumour cell, improves the symptom of clinical patients, it palliates the agonizing sufferings, improves life quality；While killing cancer cell, damaging normal tissue cells, do not realize the purpose for a long time with tumor existence.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and preparation for controlling tumour growth
Method.
Background technique
Tumour is body under the effect of various carcinogenic factors, some cell of local organization loses pair at the genetic level
Its normal regulation grown leads to its clonal abnormality hyperplasia and the neoformation that is formed.It is generally believed that tumour cell is monoclonal
Property, i.e. all oncocytes in a tumour are the offsprings of the cell of a mutation.According to neoplastic cell characteristics and
It is divided into benign tumour and malignant tumour two major classes to the harmfulness degree of body, and by tumour, and cancer is malignant tumour
General name.
With the development of economy, environmental pollution yet more and more severe and human lives' habit change, daily life system is not
Rule, sub-health population significantly increase, and immunity is lower, while fat, and high fat diet does not move, and Smoking And Drinking, feed salts down
The factors such as food processed, so that the disease incidence of cancer rises year by year.
Tumour is to lead to one of primary disease of human death, currently, treatment tumour mainly has surgical treatment (operation), changes
Learn therapy (chemotherapy), radiotherapy (radiotherapy), traditional traditional Chinese medicine treatment.Surgical excision is the side for the treating cancer applied earliest
Method, and the preferred therapy of many early-stage cancer treatments at present, but excision primary tumor of performing the operation can promote neoplasm metastasis quick
Development.Chemotherapy prevents the proliferation of cancer cell, infiltration, transfer using chemicals, until final one kind for killing cancer cell
The mode for the treatment of such as inhibits bone the disadvantage is that normal tissue organ can generate some adverse reactions because chemotherapeutics specificity is weak
Marrow, diminishing blood platelet reduce immune function, damage urinary system, damage to heart, liver and nervous system.Radiation is controlled
Treat as radiotherapy acts on increasing, the nearly half that cancer is cured in patient is attributed to the fact that radiotherapy, but radioactive ray can treating cancer,
Cancer can be induced.
Traditional Chinese medicine is treated based on Chinese medicine entirety dialectical theory, is a kind of anticancer, saving one's life combines and treat with effecting a permanent cure
Method.But the disadvantages of tumour Chinese medicine clinically used at present has uncertain therapeutic efficacy mostly and cuts, and side effect is big, therefore, research
Chinese medicine significant in efficacy and that safety is without side-effects is developed to be of great significance.
Summary of the invention
Of the existing technology in order to solve the problems, such as, being designed to provide for the embodiment of the present invention is a kind of for controlling tumour
The Chinese medicine composition and preparation method of growth.
To achieve the above object, the first aspect of the embodiment of the present invention provides a kind of for controlling the Chinese medicine of tumour growth
Composition, the Chinese medicine composition are prepared from the following raw materials in parts by weight: 20-30 parts of bittersweet, 15-25 parts of ganoderma lucidum, vinegar prolong recklessly
15-20 parts of rope, 12-20 parts of vinegar endothelium corneum gigeriae galli, 15-20 parts of edible tulip, 10-20 parts of root of kirilow rhodiola, 10-15 parts of bear gall powder, Radix Notoginseng powder 10-
15 parts, 10-15 parts of curcuma zedoary, 8-15 parts of hippocampus, 6-15 parts of American Ginseng, 8-12 parts of roasted SQUAMA MANITIS into puffy with sand, 6-10 parts of calculus bovis factitius, pearl powder 5-
8 parts.
Preferably, the Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 parts of bittersweet, 20 parts of ganoderma lucidum, vinegar
18 parts of rhizoma corydalis, 16 parts of vinegar endothelium corneum gigeriae galli, 18 parts of edible tulip, 15 parts of root of kirilow rhodiola, 12 parts of bear gall powder, 12 parts of Radix Notoginseng powder, 12 parts of curcuma zedoary,
11 parts of hippocampus, 10 parts of American Ginseng, 10 parts of roasted SQUAMA MANITIS into puffy with sand, 8 parts of calculus bovis factitius, 6 parts of pearl powder.
The second aspect of the embodiment of the present invention provides a kind of above-mentioned for controlling the system of the Chinese medicine composition of tumour growth
Preparation Method the described method comprises the following steps:
(1) calculus bovis factitius, pearl powder, Radix Notoginseng powder, bear gall powder are ground into fine powder respectively；
(2) hippocampus, vinegar endothelium corneum gigeriae galli, the roasted SQUAMA MANITIS into puffy with sand drying at 60-80 DEG C is ground into moisture content less than 8%, 80 DEG C or less
Fine powder；
(3) American Ginseng, root of kirilow rhodiola, ganoderma lucidum, vinegar rhizoma corydalis, bittersweet, edible tulip, curcuma zedoary are dried at 80-100 DEG C to aqueous
Rate is ground into fine powder less than 8%, 100 DEG C or less；
(4) fine powder that step (1)-(3) obtain uniformly is mixed using equal increments mixing method.
Preferably, in step (1)-(3), the partial size of the fine powder is 80-120 mesh.
The third aspect of the embodiment of the present invention provides a kind of containing any of the above-described Chinese traditional medicine composition for being used to control tumour growth
The preparation of object, the preparation are made of Chinese medicine composition and pharmaceutically acceptable carrier.The preparation be capsule, tablet,
Any one of granule, pill.
The effect of each raw material in the present invention, is described below:
Bittersweet: it is cold in nature for the herb of plant of Solanaceae bittersweet Solanum lyratum Thunb., it is sweet in flavor, bitter, return liver warp,
Gallbladder channel, kidney channel have effects that clearing heat and detoxicating, dispelling pathogenic wind and eliminating phlegm, removing dampness through diuresis and removing jaundice, anticancer.For treating malaria, jaundice, oedema, leaching
Disease, rheumatic arthritis, erysipelas, furunculosis.
Ganoderma lucidum: also known as Lin Zhongling, fine jade are precious, are the fructifications of On Polyporaceae ganoderma lucidum.It is sweet-bitter flavor, mild-natured, return heart, lung,
Liver, the spleen channel have mental-tranquilization, support lung QI invigorating, and the effect of Qi management and blood stasis, nourishing liver and spleen, it is weak to cure mainly consumptive disease, spiritlessness and weakness,
Palpitation and insomnia, the head swoon, and chronic cough asthma, loss of appetite is slow in reacting, short of breath to wait diseases.Studies have shown that more in ganoderma lucidum
Sugar has bidirectional modulation immunity of organisms, antitumor and protect liver effect；Alkaloid in ganoderma lucidum can be with anti-inflammatory and antalgic；Ganoderma lucidum spore
Sub- powder can stop blooding, toxin expelling, antioxygen.
Rhizoma corydalis: for the dry tuber of papaveraceae plant corydalis.Acrid flavour, hardship, it is warm-natured, return liver, the spleen channel, there is promoting blood circulation,
The effect of promoting the circulation of qi, analgesic, cures mainly stagnation of QI-blood pain and demonstrate,proves.The present invention uses vinegar rhizoma corydalis, takes net rhizoma corydalis, is mixed thoroughly with vinegar, infiltrates,
It is exhausted to vinegar, sets micro- dry with being fried with slow fire in pot, taking-up cools；Or net rhizoma corydalis is taken, add vinegar to set in pot and boils altogether, until vinegar exhausts,
Drying is taken out, is cooled.The effect of analgesic can be enhanced after vinegar system.
Endothelium corneum gigeriae galli: referring to the gizzard inner wall of family chicken, be digestive organs, sweet in flavor, flat for grinding food, returns spleen, stomach, small
Intestines, bladder meridian.For diseases such as indigestion, spermatorrhea night sweat.Appropriate digested bad, sallow complexion, do not think Na Gu, infantile malnutrition,
The condition subjects such as body syntexis, the big abdominal distension of abdomen, weakness of the spleen and the stomach, dyspepsia turgor, intestinal tuberculosis, bone tuberculosis are edible, studies have shown that in chicken
Gold can inhibit the growth of tumour cell.Vinegar endothelium corneum gigeriae galli of the invention is will to spray into rice after endothelium corneum gigeriae galli drying by baking oven high temperature
Vinegar, for increasing the activity of endothelium corneum gigeriae galli protease.
Edible tulip: also known as Mao aunt, aunt Zhu, PSEUDOBULBUS CREMASTRAE APPENDICULATAE, it is the drying of orchid Cremastra appendiculata, pleione bulbocodioides or Pleione yunnanensis
Pseudobulb.Its nature and flavor is pungent, trembles with fear, and has the effect of clearing heat and detoxicating, carbuncle that disappears dissipating bind, cures mainly ulcer serious case of furuncle, scrofula subcutaneous nodule , Disorder lump in the abdomen ruffian
Block.
Root of kirilow rhodiola: alias Rhodiola rosea sweeps sieve Ma boolean (hiding name) etc., is herbaceos perennial, cold in nature, sweet in flavor,
It is puckery, it is distributed in lung channel.Have effects that tonifying Qi clearing lung-heat, intelligence development nourishing heart, controlling of bleeding with astringents, eliminating stasis to subdue swelling.It cures mainly deficiency of vital energy and physically weak, fear after being ill
Cold, shortness of breath and fatigue, cough with lung heat, hemoptysis, leukorrhea diarrhea, traumatic injury etc..
Bear gall powder: it is translucent for powder, irregular fragment or particle, brown color, green-yellow or dark-brown, there is hyaloid
Gloss.Matter is crisp, the easy moisture absorption, the micro- raw meat of gas faint scent, and the extremely bitter micro- Hui Tian of taste has refrigerant sense.Bear gall powder has heat-clearing, calming the liver, improving eyesight
Effect；It can be used to treat red eye, swell pain, the symptoms such as abscess of throat.
Radix Notoginseng powder: warm-natured for the dry root of Araliaceae herbaceos perennial Radix Notoginseng powder, sweet in flavor, slight bitter enters liver, stomach meridian,
Have effects that hemostasia and dissipation blood stasis, detumescence hemostasis, for wound swelling and pain bleeding, hematemesis blood, bloody flux, metrorrhagia and metrostaxis, postpartum blood stasis abdominal pain, carbuncle
Swollen sore
Curcuma zedoary: You Ming Shu medicine, Curcuma Shu, green ginger, evil mind ginger, turmeric, are the rhizome of zingiberaceous plant curcuma zedoary.Acrid flavour, hardship, property
Temperature returns liver, the spleen channel.There are breaking blood and promoting the circulation of qi, clearing stagnation and killing pain, product dissipating bind, dissipating blood stasis with potent drugs, promoting digestion and removing indigestion.Cure mainly qi and blood stagnation,
Trusted subordinate's distending pain, abdominal mass, place food do not disappear.
Hippocampus: also known as river dog, water horse etc. are a kind of rare Chinese medicines, be known as " northern ginseng, southern hippocampus " it
Reputation.Its pharmacological property temperature, it is sweet in flavor, salty, it is nontoxic, return liver and kidney channel, have keep fit and healthy, tonifying kidney and strengthening yang, relaxing tendons and activating collaterals, anti-inflammatory analgetic, town
Jing'an mind, relieving cough and asthma effect, are used for impotence defective ejaculation, uterus cold infertile, the soreness and weakness of waist and knees, frequent micturition of decline of kidney-YANG, kidney deficiency characterized by dyspnea；
External application can treat negative subcutaneous ulcer sore swells, traumatic hemorrhage.
American Ginseng: for the root of Panax quinquefolium L. of araliaceae.It is cool in nature, sweet in flavor, slight bitter, returns spleen, lung, the heart, kidney channel.Suitable for gas
The patient of Yin bivacuity, disturbance of deficiency-heat inside the body has the effect of boosting qi and nourishing yin, clearing heat and promoting fluid.For deficiency of vital energy yin deficiency, interior heat, cough and asthma phlegm blood,
Abnormal heat is tired of tired, is quenched one's thirst, and the dry larynx of mouth is dry.Studies have shown that American Ginseng can not only improve cancer patient's operation and chemicotherapy is later
Various discomforts enhance immunity of organisms, and there are also direct killings and inhibiting effect to tumour.
Roasted SQUAMA MANITIS into puffy with sand: for the scale and shell of Manidae animal pangolin, taste is salty, cool in nature, slightly cold, returns liver, stomach meridian.With under promoting menstruation
Cream, detumescence and apocenosis, are used for the mass amenorrhea due to blood stasis dredging, alactation, carbuncle sore tumefacting virus, arthralgia, numbness contracture etc. the effect of searching wind and removing obstruction in channels
Disease.
Calculus bovis factitius: it is processed by bilein, cholic acid, hyodesoxycholic acid, taurine, bilirubin, cholesterol, microelement etc.
It is made.With clearing away heart-fire, the effect of slit phlegm is had one's ideas straightened out, cool liver, relieve the wind syndrome, removing toxic substances, it to be used for pyreticosis coma, stroke and phlegm confusing heart, twitch,
Epilepsy is gone mad, abscess of throat, aphthae, carbuncle swells furunculosis.
Pearl powder: belonging to transquilization with heavy material class drug, sweet in flavor, salty, cold in nature, return heart, and Liver Channel has arresting convulsion of calming the nerves, calming the liver bright
Mesh, clearing heat and detoxicating and constitutional function.
We are control tumour growth side, are mainly used for the band tumor patient of stable disease after chemicotherapy, prevent its progress.It is suitable
For Chinese medicine maintenance therapy patient.Band tumor patient cancer poison is not clear, and healthy tendency virtual loss, therefore strengthening vital QI to eliminate pathogenic factors is answered to be used in combination, and increases eliminating evil
Drug is to ensure to control its not developing deeply.The real evil predominantly phlegm wet condensation, qi depression to blood stasis, scorchingly hot interior knot of tumour, therefore use more
Dispelling phlegm and eliminating dampness, activating microcirculation and removing stasis medicinal dissipating bind, the treatment of clearing heat and detoxicating drug are subject to building up healthful vital energy drug, and reach " eliminating evil helps tumor to disappear ",
" support positive product from remove ", " healthy tendency deposit in, heresy can not be done ", to achieve the purpose that control tumour growth.
The embodiment of the present invention has the advantages that
1, Chinese medicine composition disclosed by the invention by bittersweet, ganoderma lucidum, vinegar rhizoma corydalis, vinegar endothelium corneum gigeriae galli, edible tulip, root of kirilow rhodiola,
Bear gall powder, Radix Notoginseng powder, curcuma zedoary, hippocampus, American Ginseng, roasted SQUAMA MANITIS into puffy with sand, calculus bovis factitius, pearl powder are prepared as a raw material, Ben Fangzhong, and three
Seven powder can invigorate blood circulation dissipating blood stasis and reducing the stagnation, but can stagnation resolvation without hurting just；American Ginseng boosting qi and nourishing yin, root of kirilow rhodiola enters lung, spleen two passes through, and QI invigorating is strong
Spleen, vinegar endothelium corneum gigeriae galli invigorating the spleen and stomach, ganoderma lucidum invigorating qi for tranquilization, share can building up healthful vital energy, prevent eliminating evil too；Hippocampus promoting blood circulation regulating the qi flowing in the channels stops
Bitterly, mass dissipating and swelling eliminating, can treat qi depression to blood stasis a lump in the abdomen causing distension and pain, the analgesic of vinegar rhizoma corydalis blood-activating and qi-promoting, curcuma zedoary breaking blood and promoting the circulation of qi, disperse accumulation stops
Bitterly, three medicines can reduce pain caused by cancer；Roasted SQUAMA MANITIS into puffy with sand promoting blood circulation disappears Cheng；Bear gall powder, pearl powder, bittersweet, edible tulip are clearing heat and detoxicating；Calculus bovis factitius
Clearing heat and detoxicating slit phlegm.Modern pharmacological research shows that Radix Notoginseng powder, endothelium corneum gigeriae galli, mother-of-pearl can inhibit tumour cell, and curcuma zedoary can inhibit swollen
Tumor metastasis, ganoderma lucidum can be improved immune, antitumor, and rhizoma corydalis, bittersweet, edible tulip have antineoplastic action.All medicines share is played altogether
Consolidate radically reform, be clearing heat and detoxicating, phencyclidine, dispersing swelling and dissipating binds, strengthening the spleen and stomach the effect of.The present invention uses the raw material of different properties,
Scientific compatibility is carried out, Chinese medicine composition obtained is capable of the dynamic equilibrium of conditioning engine body, enhances body's immunity, and it is thin to improve cancer
The microenvironment of born of the same parents inhibits or directly kills cancer cell, effectively control growth of tumour cell, improves the symptom of clinical patients, mitigate
Pain improves life quality；While killing cancer cell, damaging normal tissue cells, are not realized for a long time with tumor existence
Purpose.
2, the preparation method of Chinese medicine composition of the present invention is easy to operate, is suitble to industrialization production.
Specific embodiment
Present invention will be further explained by specific examples below, it should be understood, however, that, these embodiments are only
It is used, is but should not be understood as present invention is limited in any form for specifically describing in more detail.
This part carries out general description to the material and test method that arrive used in present invention test.Although being
It realizes many materials used in the object of the invention and operating method is it is known in the art that still the present invention still uses up herein
It may detailed description.It will be apparent to those skilled in the art that within a context, if not specified, material therefor of the present invention and behaviour
It is well known in the art as method.Without specified otherwise, " part " in following embodiment refers both to " parts by weight ".
Embodiment 1
The Chinese medicine composition for controlling tumour growth of the present embodiment is prepared from the following raw materials in parts by weight: bittersweet 26
Part, 18 parts of ganoderma lucidum, 15 parts of vinegar rhizoma corydalis, 12 parts of vinegar endothelium corneum gigeriae galli, 15 parts of edible tulip, 18 parts of root of kirilow rhodiola, 10 parts of bear gall powder, Radix Notoginseng powder
15 parts, 15 parts of curcuma zedoary, 8 parts of hippocampus, 7 parts of American Ginseng, 8 parts of roasted SQUAMA MANITIS into puffy with sand, 6 parts of calculus bovis factitius, 7 parts of pearl powder.
The preparation method of the Chinese medicine composition of the present embodiment the following steps are included:
(1) calculus bovis factitius, pearl powder, Radix Notoginseng powder, bear gall powder are ground into partial size respectively is 80-120 targeted fine powder；
(2) hippocampus, vinegar endothelium corneum gigeriae galli, the roasted SQUAMA MANITIS into puffy with sand drying at 60-80 DEG C is ground into moisture content less than 8%, 80 DEG C or less
Partial size is 80-120 targeted fine powder；
(3) American Ginseng, root of kirilow rhodiola, ganoderma lucidum, vinegar rhizoma corydalis, bittersweet, edible tulip, curcuma zedoary are dried at 80-100 DEG C to aqueous
It is 80-120 targeted fine powder that rate, which is ground into partial size less than 8%, 100 DEG C or less,；
(4) fine powder that step (1)-(3) obtain uniformly is mixed using equal increments mixing method.
Embodiment 2
The Chinese medicine composition for controlling tumour growth of the present embodiment is prepared from the following raw materials in parts by weight: bittersweet 25
Part, 20 parts of ganoderma lucidum, 18 parts of vinegar rhizoma corydalis, 16 parts of vinegar endothelium corneum gigeriae galli, 18 parts of edible tulip, 15 parts of root of kirilow rhodiola, 12 parts of bear gall powder, Radix Notoginseng powder
12 parts, 12 parts of curcuma zedoary, 11 parts of hippocampus, 10 parts of American Ginseng, 10 parts of roasted SQUAMA MANITIS into puffy with sand, 8 parts of calculus bovis factitius, 6 parts of pearl powder.
The preparation method is the same as that of Example 1 for the Chinese medicine composition of the present embodiment.
Embodiment 3
The Chinese medicine composition for controlling tumour growth of the present embodiment is prepared from the following raw materials in parts by weight: bittersweet 20
Part, 25 parts of ganoderma lucidum, 18 parts of vinegar rhizoma corydalis, 14 parts of vinegar endothelium corneum gigeriae galli, 15 parts of edible tulip, 10 parts of root of kirilow rhodiola, 15 parts of bear gall powder, Radix Notoginseng powder
14 parts, 10 parts of curcuma zedoary, 15 parts of hippocampus, 12 parts of American Ginseng, 11 parts of roasted SQUAMA MANITIS into puffy with sand, 9 parts of calculus bovis factitius, 5 parts of pearl powder.
The preparation method is the same as that of Example 1 for the Chinese medicine composition of the present embodiment.
Embodiment 4
The Chinese medicine composition for controlling tumour growth of the present embodiment is prepared from the following raw materials in parts by weight: bittersweet 22
Part, 15 parts of ganoderma lucidum, 20 parts of vinegar rhizoma corydalis, 15 parts of vinegar endothelium corneum gigeriae galli, 20 parts of edible tulip, 20 parts of root of kirilow rhodiola, 12 parts of bear gall powder, Radix Notoginseng powder
10 parts, 10 parts of curcuma zedoary, 13 parts of hippocampus, 6 parts of American Ginseng, 12 parts of roasted SQUAMA MANITIS into puffy with sand, 7 parts of calculus bovis factitius, 8 parts of pearl powder.
The preparation method is the same as that of Example 1 for the Chinese medicine composition of the present embodiment.
Embodiment 5
The Chinese medicine composition for controlling tumour growth of the present embodiment is prepared from the following raw materials in parts by weight: bittersweet 30
Part, 22 parts of ganoderma lucidum, 16 parts of vinegar rhizoma corydalis, 20 parts of vinegar endothelium corneum gigeriae galli, 18 parts of edible tulip, 15 parts of root of kirilow rhodiola, 10 parts of bear gall powder, Radix Notoginseng powder
12 parts, 12 parts of curcuma zedoary, 10 parts of hippocampus, 15 parts of American Ginseng, 9 parts of roasted SQUAMA MANITIS into puffy with sand, 10 parts of calculus bovis factitius, 5 parts of pearl powder.
The preparation method is the same as that of Example 1 for the Chinese medicine composition of the present embodiment.
Embodiment 6
Any obtained powder of Example 1-5, directly pours into capsule, that is, capsule is made.
Embodiment 7
Tablet is made in any obtained powder of Example 1-5, tabletting.
Embodiment 8
Any obtained powder of Example 1-5, granulation, that is, be made granule.
Embodiment 9
Any obtained powder of Example 1-5 is added honey, adds water pill, dry, that is, pill is made.
Comparative example 1
The Chinese medicine composition for controlling tumour growth of this comparative example is prepared from the following raw materials in parts by weight: bittersweet 26
Part, 18 parts of ganoderma lucidum, 15 parts of vinegar rhizoma corydalis, 12 parts of vinegar endothelium corneum gigeriae galli, 15 parts of edible tulip, 18 parts of Radix Astragali, 10 parts of bear gall powder, Radix Notoginseng powder 15
Part, 15 parts of curcuma zedoary, 8 parts of hippocampus, 7 parts of American Ginseng, 8 parts of roasted SQUAMA MANITIS into puffy with sand, 6 parts of calculus bovis factitius, 7 parts of pearl powder.(the area with embodiment 1
It is not: replaces root of kirilow rhodiola with Radix Astragali)
The preparation method is the same as that of Example 1 for the Chinese medicine composition of this comparative example.
Comparative example 2
The Chinese medicine composition for controlling tumour growth of this comparative example is prepared from the following raw materials in parts by weight: bittersweet 26
Part, 6 parts of ganoderma lucidum, 15 parts of vinegar rhizoma corydalis, 12 parts of vinegar endothelium corneum gigeriae galli, 15 parts of edible tulip, 6 parts of root of kirilow rhodiola, 10 parts of bear gall powder, Radix Notoginseng powder 15
Part, 15 parts of curcuma zedoary, 8 parts of hippocampus, 30 parts of American Ginseng, 8 parts of roasted SQUAMA MANITIS into puffy with sand, 6 parts of calculus bovis factitius, 7 parts of pearl powder.(the area with embodiment 1
Be not: proportion is different)
The preparation method is the same as that of Example 1 for the Chinese medicine composition of this comparative example.
Pharmacological toxicity test
1 test material
1.1 drugs: Chinese medicine composition made from embodiment 1 (before gastric infusion, is mixed well) with water.
1.2 animals: BALB/c mouse, female, fifty-fifty, the weight 18-22g of hero, by Chinese Academy of Medical Sciences's Animal Experimental Study
It is provided.Raising was in indoor adaptation environment 3 days, 18-25 DEG C of room temperature before experiment, relative humidity 45-65%.
2 test methods
2.1 acute toxicity test
Healthy mice 20 are taken, 12h is deprived of food but not water before medication, and gastric infusion amount is 20g/kgbw, is equivalent to adult
Clinical consumption per day 800 times (quantity be 60kg adult 2 times a day, each 0.75g).Conventinal breeding is carried out after administration, is seen
Dead mouse situation in 3d is examined, LD is calculated50。
If having death in 3d, should perform an autopsy on sb. immediately；It should also perform an autopsy on sb. when off-test, observe the change of its internal organs
Change situation.
2.2 cumulative toxicity test
Healthy mice 30 are taken, is randomly divided into 3 groups, 12h is deprived of food but not water before being administered, and gastric infusion amount is respectively: the 1st group
10g/kgbw, the 2nd group of 5g/kgbw, the 3rd group of 2.5g/kgbw (be respectively relative to adult clinical daily dosage 400,200,
100 times).It sets simultaneously and control group is not administered.Conventinal breeding is carried out after administration, successive administration 20d is observed small daily during administration
The physiological status and activity condition (including mental status and diet etc.) of mouse.It is observed again after administration 1 week, and cuts open and kill corpse
Inspection, observe its viscera tissue organ have it is without exception.
3 results
There is slight discomfort after the administration of 3.1 intragastric administration on mice in 2h, appetite stimulator, amount of drinking water is normal；After 4-6h, mouse activity is extensive
It is multiple normal, do not show any abnormalities reaction；Without dead mouse in 7d.Mice viscera is dissected and observed after putting to death in disconnected neck, without exception.It says
The Chinese medicine composition of the bright embodiment of the present invention belongs to nontoxic substance.
For 3.2 every groups of mouse during administration and after being discontinued in 7d, mouse is also no different paradoxical reaction without the phenomena of mortality.Administration knot
Shu Houzai is observed 1 week, and is cutd open and killed weighing postmortem, and there was no significant difference with control group for each test group mouse weight, observes its internal organ
Histoorgan health is without exception.Illustrate the Chinese medicine composition of the embodiment of the present invention substantially without cumulative toxicity.
Pharmacodynamics test
1 test material
1.1 knurl sources: lotus ehrlich ascites cancer (EAC) original seed mouse is provided by institute of oncology of the Chinese Academy of Sciences.
1.2 drugs: Chinese medicine composition made from embodiment 1 and comparative example 1-2 uses normal saline before use.
1.3 animals: BALB/c mouse, half male and half female, weight 18-22g, by Institute of Experimental Animals, Chinese Academy of Medical Sciences
It provides, raising was in indoor adaptation environment 3 days, 18-25 DEG C of room temperature before testing, relative humidity 45-65%.
2 test methods
Former tumor-bearing mice ascites fluid is extracted, is placed in triangular flask, suspension is configured to 1:3 with physiological saline, adjustment is thin
Born of the same parents' number is 5 × 106/ ml takes 0.2ml tumor cell suspension to be subcutaneously injected in mouse right fore oxter row, and whole process is sterile
Under the conditions of operate complete.Tumor-bearing mice is randomly divided into model group, example 1 group, comparative example 1-2 group, every group 20, male and female are each
Half.
Wherein, model group: physiological saline stomach-filling；Example 1 group: the Chinese medicine composition stomach-filling of embodiment 1；Comparative example 1-2
Group: the Chinese medicine composition stomach-filling of comparative example 1-2.One time a day, continuous 7 times, embodiment 1 and the dosage of comparative example 1-2 group are
1.25g/kg·bw。
Mouse is put to death after 7 days, removes tumor tissues, weighing, and calculate tumour inhibiting rate according to the following formula.
Tumour inhibiting rate=(control group knurl weight-experimental group knurl weight)/control group knurl weight × 100%
3 results
Suppression cancer situation is shown in Table 1 in each group Mice Body.
Table 1
| Group | Knurl weight/g | Tumour inhibiting rate/% |
| Model group | 2.28±0.35 | 0 |
| Embodiment 1 | 1.54±0.28 | 32.5 |
| Comparative example 1 | 1.74±0.46 | 23.6 |
| Comparative example 2 | 1.89±0.32 | 17.2 |
The result shows that: the Chinese medicine composition of the embodiment of the present invention 1 control and inhibit the effect of growth of tumour cell better than pair
Ratio 1-2 group.
Clinical test
1 clinical data
Select to be diagnosed as middle and terminal cancer totally 63 patients as research object, male 36, female 39；Age 35-68 years old,
Average (55 ± 7.35) year.In 63 patients, the cancer of the esophagus 9, gastric cancer 7, colorectal cancer 10, liver cancer 13,12 Cases of Lung Cancer, cream
Gland cancer 4, cervical carcinoma 3, ascites carcinoma 5.All patients are the voluntary Chinese medicine composition for requiring to use the embodiment of the present invention.
Using random, balanced principle, 63 clinical cases are randomly divided into treatment 1-5 group, carry out pretherapy and post-treatment observation of curative effect.
Through statistical analysis, treatment group's case compares in terms of gender, age, the course of disease and the state of an illness before treating, and difference is equal
Not statistically significant (P > 0.05), is comparable.
2 curative effect determinate standards
Referring to " traditional Chinese and western medicine tumour diagnosis and treatment complete works of " Zheng Yuzhen chief editor, China Traditional Chinese Medicine Publishing House 1996 the 1st edition.
Effective: symptom makes moderate progress, and lesion is basicly stable, observes in one month or more person.
Effective: symptom disappears substantially, and lesion reduces more than half, and other objective determinations take an evident turn for the better, observe 2 months with
On not developing deeply person.
Invalid: symptom and objective determination are without improvement, or only short-term improvement, and rapid deterioration person.
(3) treatment method
It treats 1-5 group: taking orally Chinese medicine composition made from 1-5 of the embodiment of the present invention respectively, 2 times a day, 1 0.75g is used
Decoction of medicinal ingredients (warm water) takes, 30 days as one therapeutic course.
4 results
After taking a course for the treatment of, the clinical test results of each treatment group are shown in Table 2.
Table 2
The total effective rate of the Chinese medicine composition of the embodiment of the present invention reaches 66% or more, shows Chinese medicine composition of the invention
Tumour growth can be effectively controlled, and by adhering to the Chinese medicine group for taking the embodiment of the present invention to patient's long-term follow follow-up
Close object, it can be achieved that " band tumor existence " target, the service life of most Advanced cancers patients all extended, and 5 annual survival rates reach
To 70% or more.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention are fallen within the scope of the claimed invention.
Claims (6)
1. a kind of for controlling the Chinese medicine composition of tumour growth, which is characterized in that the Chinese medicine composition is by following parts by weight
Several raw materials are made: 20-30 parts of bittersweet, 15-25 parts of ganoderma lucidum, 15-20 parts of vinegar rhizoma corydalis, 12-20 parts of vinegar endothelium corneum gigeriae galli, edible tulip
15-20 parts, 10-20 parts of root of kirilow rhodiola, 10-15 parts of bear gall powder, 10-15 parts of Radix Notoginseng powder, 10-15 parts of curcuma zedoary, 8-15 parts of hippocampus, the West
Join 6-15 parts, 8-12 parts of roasted SQUAMA MANITIS into puffy with sand, 6-10 parts of calculus bovis factitius, 5-8 parts of pearl powder.
2. according to claim 1 for controlling the Chinese medicine composition of tumour growth, which is characterized in that the Chinese traditional medicine composition
Object is prepared from the following raw materials in parts by weight: 25 parts of bittersweet, 20 parts of ganoderma lucidum, 18 parts of vinegar rhizoma corydalis, 16 parts of vinegar endothelium corneum gigeriae galli, edible tulip
18 parts, 15 parts of root of kirilow rhodiola, 12 parts of bear gall powder, 12 parts of Radix Notoginseng powder, 12 parts of curcuma zedoary, 11 parts of hippocampus, 10 parts of American Ginseng, roasted SQUAMA MANITIS into puffy with sand 10
Part, 8 parts of calculus bovis factitius, 6 parts of pearl powder.
3. a kind of of any of claims 1 or 2 for controlling the preparation method of the Chinese medicine composition of tumour growth, feature exists
In the described method comprises the following steps:
(1) calculus bovis factitius, pearl powder, Radix Notoginseng powder, bear gall powder are ground into fine powder respectively；
(2) hippocampus, vinegar endothelium corneum gigeriae galli, roasted SQUAMA MANITIS into puffy with sand are dried to moisture content at 60-80 DEG C and are ground into fine powder less than 8%, 80 DEG C or less；
(3) drying at 80-100 DEG C of American Ginseng, root of kirilow rhodiola, ganoderma lucidum, vinegar rhizoma corydalis, bittersweet, edible tulip, curcuma zedoary is small to moisture content
Fine powder is ground into 8%, 100 DEG C or less；
(4) fine powder that step (1)-(3) obtain uniformly is mixed using equal increments mixing method.
4. according to claim 3 for controlling the preparation method of the Chinese medicine composition of tumour growth, which is characterized in that step
Suddenly in (1)-(3), the partial size of the fine powder is 80-120 mesh.
5. a kind of 1-4 containing claim is described in any item for controlling the preparation of the Chinese medicine composition of tumour growth, feature
It is, the preparation is made of Chinese medicine composition and pharmaceutically acceptable carrier.
6. according to claim 5 for controlling the preparation of the Chinese medicine composition of tumour growth, which is characterized in that the system
Agent is any one of capsule, tablet, granule, pill.
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Citations (1)
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| CN101181529A (en) * | 2007-12-14 | 2008-05-21 | 吕宝俊 | Chinese medicine composition for curing tumor and preparation method thereof |
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| Title |
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| 南新记，等: "扶正化积丸联合化疗治疗晚期老年肺癌", 《中国民间疗法》 * |
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