CN103861079A - Traditional Chinese medicine composition with effects of clearing heat, relieving pain and eliminating tumors - Google Patents

Traditional Chinese medicine composition with effects of clearing heat, relieving pain and eliminating tumors Download PDF

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CN103861079A
CN103861079A CN201410095759.2A CN201410095759A CN103861079A CN 103861079 A CN103861079 A CN 103861079A CN 201410095759 A CN201410095759 A CN 201410095759A CN 103861079 A CN103861079 A CN 103861079A
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chinese medicine
medicine composition
clearing away
away heat
alleviate pain
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CN103861079B (en
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杨峻峻
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Abstract

The invention relates to the technical field of medicines and in particular relates to a traditional Chinese medicine composition with effects of clearing heat, relieving pain and eliminating tumors. The formula consists of the following main components in parts by weight: 3-5 parts of alga, 2-4 parts of albumen powder, 1-3 parts of pseudo-ginseng and 0.05-1.5 parts of musk. A product prepared from the medicine composition has the functions that pain of cancer patients can be relieved, injuries on human body, physiological functions and immune systems of patients are avoided, the possibility of diffusion and metastasis caused by cancer cell infiltrated muscular layer, blood vessels and lymph-vessels is eliminated, the drug resistance and tolerance of cancer cells are avoided, the toxic and side effects of the medicine are reduced, the processes of generating body hormones, subsequently maintaining the immunity, realizing aerobic transfer of nutrient substances and generating and intensifying hemoglobin and blood platelets in the treatment process and after healing are ensured, and the cancer cure rate and remission rate are further increased.

Description

A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition
Technical field
The present invention relates to medical technical field, relate in particular to a kind of Chinese medicine composition of clearing away heat to alleviate pain dispersing tumor.
Background technology
Epithelial Malignant Tumors, i.e. cancer, is the Tough questions that the current whole mankind faces, and the prognosis for the treatment of is poor, and mortality rate almost reaches absolutely.Along with the development of social economy and industrial and mineral industry, cause severe contamination to environment, come at recent two decades, cancer patient's sickness rate presents ascendant trend, and sickness rate is shifted to rejuvenation personnel by senescence personnel.
But for the treatment of cancer, the means that adopt at present mainly contain surgical excision operation, radiation cure, chemotherapy and four kinds of methods of Biotherapeutics, wherein, the early stage patient that surgical excision operation is higher mainly for Carcinoma cell differentiation degree, grade malignancy is low, and can not be by some small tumor focus and the special tumor resection of residual cancer cell and position, and then after operation, because immunity degradation, operation cause when injected organism tissue damage, cause cancer patient's disease recurrence or transfer and the diffusion of cancerous cell, increased cancer patient's mortality rate, radiation cure is to adopt X ray, electric wire, proton beam and other particle beam to treat the method for cancer, anticancer, be mainly used in cancer patient's topical therapeutic, compare surgical operation and chemotherapy, degree of injury to human body is lower, but still can cause that bone marrow depression, hemogram are too low, tumor focus position with and surrounding tissue fibrosis, lonizing radiation pericarditicly increase, whole body physiological function disorderly with imbalance with skin and mucosa injury, further reduce body immunity, cause continual cure difficulty, chemotherapy is to adopt the mode of " treating the poisonous disease with poisonous drugs " that cancerous cell is treated, but the chemicals adopting is to be all with virose medicine, after it is brought to health whole body, just can cause the good bad cell in health be all affected and destroy, and then can cause damage to human body, and then cause toxic and side effects and the untoward reaction such as physical weakness, bone marrow depression, gastricism, inflammation outbreak, heart failure, kidney discomfort, pulmonary fibrosis, and then cause immunologic function degression, Biotherapeutics is by human intervention immunocyte, transfer the immunologic function of health self, and then the therapeutic process of inhibition or removing cancerous cell, itself and surgical operation, radiotherapy and chemotherapy are compared, there is efficiency high, better tolerance, high specificity, promote the anti-cancer function of systemic immune system, and patient suffering is reduced, but, cultivation and the hypertrophy of the external artificial immunocyte of mainly taking due to Biotherapeutics, after feeding back to human body again, easily suffer the repulsion of autoimmune cell, and after a while, the artificial immunocyte of cultivating also can apoptosis, need to be every treatment in several days once, and then cause patient's treatment cost high, the more important thing is, avoid the contaminated risk of external cell very difficult, and then the infection risk that causes cancer patient to be brought by the external world is larger, meanwhile, cultivate in vitro immunocyte out, also fail precision accurately to kill and wound cancerous cell, most importantly Biotherapeutics is also difficult to the treatment having no adverse reaction to the cancer cell of all internal organs, and then guarantees cancer patient's quality of life and quality of life.
For this reason, in prior art, there is researcher from alleviating patient's misery, strengthen cancer patient's autoimmunity, carry out the treatment of kinds cancer Herba indigoferae Pseudotinctoriae, improve cancer patient's quality of life and the angle of quality of life is set out, enriching substance and preparation method to treatment by Chinese herbs cancer have been made research, as the patent No. of Xu Shangxun be 00136001.9 " a kind of formula of enriching substance and production technology ", the formula that discloses a kind of enriching substance is Herba Hedyotidis Diffusae, Radix Codonopsis, the Radix Astragali, Poria, Rhizoma Atractylodis Macrocephalae (parched), Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Radix Notoginseng, Moschus moschiferous perfume (or spice), Sargassum, Herba Taraxaci, 47 Chinese herbal medicine such as Rhizoma Corydalis, by pulverizing, mix, refine, absorb, clear paste, strengthen molding, closing quotation, dry, upper garment, air-dry, check, the operations such as packing, make good effect, short treating period, can effect a radical cure the Chinese medicine of kinds cancer tumor disease, and the anti-inflammation effect having by multi-medicament is carried out comprehensive function, improve therapeutic effect, but, this enriching substance for human body hormone produce, have oxygen transport and the hemoglobin and hematoblastic generation and strengthening aspect of follow-uply the maintaining of immunity, nutrient substance be but difficult to be protected, and, the medical knowledge of well known " being three points of poison of medicine ", the combination of 47 taste medicines, has not only strengthened the production cost of enriching substance, and has strengthened patient's treatment cost, has brought great economic pressures to patient.
Therefore, we need to adopt treatment by Chinese herbs to cancer patient, alleviating patient's misery, strengthen patient's autoimmunity, when improving patients ' life quality and quality of life, should consider the cost of drug manufacture, reduce kind and the taste number of medicine material, and then alleviate patient's financial burden and the toxic and side effects to health, and consider that the human body hormone after patient treatment process and healing produces, the follow-up of immunity maintains, nutrient substance have oxygen transport and hemoglobin and hematoblastic generation and a strengthening aspect, Chinese medicine formula and production to treatment cancer provide a kind of new approaches.
Summary of the invention
In order to solve the above-mentioned technical problem existing in prior art, the invention provides a kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, said composition can alleviate cancer patient's misery, avoid the body injury to patient, avoid patient physiological function and immune system to cause damage, get rid of cancer cell infiltration flesh layer, the diffusion that blood vessel and lymphatic vessel cause and the probability of transfer, avoid Drug resistance and the drug resistance of cancerous cell, reduce poisonous side effect of medicine, guarantee that the human body hormone after therapeutic process and healing produces, the follow-up of immunity maintains, nutrient substance have oxygen transport and hemoglobin and hematoblastic generation and a strengthening, further improve cancer cure rate and remission rate.
Specifically be achieved by the following technical programs:
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, the Main Ingredients and Appearance of its formula is made up of following weight portion: Sargassum 3-5 part, egg albumen powder 2-4 part, Radix Notoginseng 1-3 part, Moschus 0.05-1.5 part.
Further, the Main Ingredients and Appearance of described formula is made up of following weight portion: Sargassum 3.5-4.5 part, egg albumen powder 2.5-3.5 part, Radix Notoginseng 1.5-2.5 part, Moschus 0.1-1 part.
Further, the Main Ingredients and Appearance of described formula is made up of following weight portion: 4 parts of Sargassums, 3 parts of egg albumen powders, 2 parts of Radix Notoginseng, 0.5 part, Moschus.
The main component of described formula also comprises Radix Glycyrrhizae, and wherein the consumption of Radix Glycyrrhizae is to be less than 1/2 part of Sargassum consumption.
Wherein, described egg albumen powder is to adopt the one or more combination in the soybean protein, casein, lactalbumin of purifying to form.
Further, described Chinese medicine composition can, according to the conventional method of pharmacy, add adjuvant, makes required preparation; Described preparation comprises tablet, capsule, injection with small volume, high-capacity injection, freeze-dried powder.
Further, described preparation can also be made up of Sargassum extract, Radix Notoginseng extractive substance, egg albumen powder solution and Moschus extract, and wherein the content of Moschus extract is 100-200mg/ml.
Further, the content of described Moschus extract is 120-180mg/ml.
Further, the content of described Moschus extract is 140-160mg/ml.
Further, the content of described Moschus extract is 150mg/ml
Compared with prior art there is following technique effect:
1. study by the main component to Sargassum, and its effect and pharmacological action are explored, the main component that draws Sargassum is algin acid and crude protein, there is effect of vanishing sputum and dispelling knot, inducing diuresis to remove edema, and it is hyperfunction to have the thyroid of inhibition, the temporary transient basal metabolism that suppresses cancer patient, suppresses the effect of breast carcinoma; And combine in conjunction with the Radix Notoginseng that there is the Moschus of effect swollen in the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, elimination abdomen and there is effect of anti-inflammatory analgetic, blood circulation promoting and blood stasis dispelling, hemostasia and detumescence, make to form synergism between three, promote the therapeutic effect to cancer patient; And conjugated protein physiological function that tissue is repaired, the physiological function strengthening with immune protein to human immunocyte, can provide for organism the specially good effect of heat energy, impel predictability and the universality of Chinese medicine to treatment of cancer.
2. by the Main Ingredients and Appearance of Chinese medicine composition is carried out to research and discussion, choose Sargassum, Moschus moschiferous perfume (or spice), three kinds of genuine Chinese crude drugs of Radix Notoginseng combine with protein, and control inhibition and the therapeutical effect of Chinese medicine composition to cancer cell by the content of four kinds of main components, alleviate cancer patient's misery, avoid the body injury to patient, avoid patient physiological function and immune system to cause damage, get rid of cancer cell infiltration flesh layer, the diffusion that blood vessel and lymphatic vessel cause and the probability of transfer, avoid Drug resistance and the drug resistance of cancerous cell, reduce poisonous side effect of medicine.
3. study and inquire into by the synergism to Sargassum and Radix Glycyrrhizae or inhibitory action, the amount of locating accurately Radix Glycyrrhizae is controlled at below 1/2nd of Sargassum consumption, can promote the feature of the drug effect of Sargassum treatment, guarantee cure rate and the suppression ratio of Chinese medicine composition to cancer patient, further alleviate cancer patient's misery, and poisonous side effect of medicine, further guarantee that the human body hormone after therapeutic process and healing produces, the follow-up of immunity maintains, nutrient substance have oxygen transport and hemoglobin and hematoblastic generation and a strengthening, improve body immunity.
4. by the number to Moschus dosage, the effect situation of hepatomicrosome medicine invertase is studied and inquired into, control accurately the number of Moschus dosage, accelerate nembutal metabolism inactivation in liver, impelled central nervous excitation, and then improve patient's mental attitude, and then improve cancer patient's quality of life and quality of life, improve cancer patient's cure rate.
5. carry out research and discussion by the content of the taste number to pharmaceutical compositions and each herbal medicine, draw the Chinese medicine that can treat kinds cancer disease, uncertainty and the limitation for the treatment of of cancer are reduced, also not intellectual, limitation and the one-sidedness of single Sargassum treatment cancer have been overcome, also reduce patient treatment cancer and purchased medicine cost, alleviated cancer patient's financial burden.
6. by the combination of Sargassum, egg albumen powder, Radix Notoginseng, Moschus, weak, the easy heating fever in cancer disease, hemorrhage, lump, cancerous pain have been reached to effective alleviation and control, improve the cure rate of cancer, alleviate cancer patient's slight illness.
The specific embodiment
Below in conjunction with concrete embodiment, technical scheme of the present invention is done to further restriction and set forth, but claimed scope is not only confined to done description.
Medicine explanation:
Sargassum main component is algin acid and crude protein, and bitter in the mouth, salty is returned Liver Channel, stomach warp, kidney channel, has vanishing sputum and dispelling knot, inducing diuresis to remove edema effect; There is inhibition hyperthyroidism, suppress the effect of basal metabolism, hepatosplenomegaly person is had to good therapeutic effect, can suppress tubercule bacillus and epidemic virus, its extract is being processed, while making its sulfur content reach 9.2-12.3%, its anticoagulation has 1/2nd times of anticoagulant heparin effect; And research by experiment, has the function that reduces cholesterol and suppress white mice breast carcinoma; Can treat the diseases such as cardiopalmus, inappetence, tuberculosis, breast carcinoma initial stage, angina pectoris.
The main component of Moschus is muscone, acrid in the mouth, GUIXIN warp, spleen channel, there is the effects such as the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, Moschus can directly act on central nervous system by blood brain barrier, after deliberation, its low dose can activate the effect of hepatomicrosome medicine invertase, accelerates nembutal metabolism inactivation in liver, makes central nervous excitation; Heavy dose plays inhibitory action; And can improve the tolerance of nervus centralis under anaerobic environment state, promote separation and the growth of hemocyte, accelerate heart rate and blood pressure drops, increase respiratory frequency and the degree of depth, strengthen heart contraction amplitude, promote smooth muscle loosening, prevention and treatment burst disease, strengthen humoral immunization and cellular immunity, can destroy in vitro cancerous cell, suppress tumor cell breathing and venom and the antfhistamine pharmacology of animal; Can treat the diseases such as liver cirrhosis and hepatitis, prostatitis, asthma, coronary heart disease.
Radix Notoginseng has another name called Radix Notoginseng, main component is arasaponin, flavonoid glycoside, sweet in the mouth, return stomach through, Liver Channel, there is hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, the antiviral effect of antiinflammatory heart tonifying, can treat the diseases such as abdominal distention, haematemesis, dysentery, bloody dysentery, external haemorrhage, too fat to move, cerebral thrombosis and cerebral hemorrhage.
Protein has and maintains body fluid acid-base balance, maintains osmotic pressure and body fluid balance in human body, forms the various regulatory enzymes of human body, strengthens the formation of immunocyte and immune protein, guarantees that the metabolism of human body can normally maintain.
Embodiment:
Embodiment 1
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, adopts traditional process of preparing Chinese medicine, oven dry, porphyrize compatibility to obtain by the raw material of following weight portion: 3 parts of Sargassums, 4 parts of soybean protein powders, 1 part of Radix Notoginseng, 1.5 parts, Moschus.
Embodiment 2
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, adopts traditional process of preparing Chinese medicine, oven dry, porphyrize compatibility to obtain by the raw material of following weight portion: 5 parts of Sargassums, 2 parts of casoid flours, 3 parts of Radix Notoginseng, 0.05 part, Moschus.
Embodiment 3
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, adopts traditional process of preparing Chinese medicine, oven dry, porphyrize compatibility to obtain by the raw material of following weight portion: 4.5 parts of Sargassums, 2.5 parts of lactalbumin powders, 2.5 parts of Radix Notoginseng, 0.1 part, Moschus.
Embodiment 4
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, adopts traditional process of preparing Chinese medicine, oven dry, porphyrize compatibility to obtain by the raw material of following weight portion: 3.5 parts of Sargassums, 2 parts of soybean protein powders, 1.5 parts of lactalbumin powders, 1.5 parts of Radix Notoginseng, 1 part, Moschus.
Embodiment 5
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, adopts traditional process of preparing Chinese medicine, oven dry, porphyrize compatibility to obtain by the raw material of following weight portion: 4 parts of Sargassums, 1.5 parts of casoid flours, 1.5 parts of lactalbumin powders, 2 parts of Radix Notoginseng, 1 part, Moschus.
Embodiment 6
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, adopts traditional process of preparing Chinese medicine, oven dry, porphyrize compatibility to obtain by the raw material of following weight portion: 4 parts of Sargassums, 1 part of soybean protein powder, 2 parts of casoid flours, 2 parts of Radix Notoginseng, 0.1 part, Moschus.
Embodiment 7
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, adopts traditional process of preparing Chinese medicine, oven dry, porphyrize compatibility to obtain by the raw material of following weight portion: 4 parts of Sargassums, 1 part of soybean protein powder, 1 part of lactalbumin powder, 1 part of casoid flour, 2 parts of Radix Notoginseng, 0.5 part, Moschus.
Embodiment 8
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, on the basis of embodiment 1-7, adds the Radix Glycyrrhizae of Sargassum consumption 1/2nd, adopts traditional process of preparing Chinese medicine, oven dry, porphyrize compatibility to obtain.
Embodiment 9
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, on the basis of embodiment 1-7, adds the Radix Glycyrrhizae of Sargassum consumption 1/5th, adopts traditional process of preparing Chinese medicine, oven dry, porphyrize compatibility to obtain.
Embodiment 10
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, on the basis of embodiment 1-7, adds the Radix Glycyrrhizae of Sargassum consumption 1/4th, adopts traditional process of preparing Chinese medicine, oven dry, porphyrize compatibility to obtain.
Embodiment 11
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, on the basis of embodiment 1-7, adds the Radix Glycyrrhizae of Sargassum consumption 1/3rd, adopts traditional process of preparing Chinese medicine, oven dry, porphyrize compatibility to obtain.
Embodiment 12
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, on the basis of embodiment 1-7, adds the Radix Glycyrrhizae of Sargassum consumption 1/6th, adopts traditional process of preparing Chinese medicine, oven dry, porphyrize compatibility to obtain.
Embodiment 13
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, adds adjuvant, makes clearing away heat to alleviate pain XIAOLIU WAN.Wherein the weight portion of Moschus is 0.6-1 part, makes clearing away heat to alleviate pain XIAOLIU WAN No. 1, for the cancer patient of the cancer patient without other diseases and corresponding disease, Deficiency and coldness of spleen and stomach and humidity hysteresis; The weight portion of Moschus is 0.1-0.3 part, makes clearing away heat to alleviate pain XIAOLIU WAN No. 2, for weakly cancer patient; The weight portion of Moschus is 0.3-0.6 part, makes clearing away heat to alleviate pain XIAOLIU WAN No. 3, for there being the cancer patient of bile duct class disease.
Embodiment 14
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, adds adjuvant, makes clearing away heat to alleviate pain lumor eliminating powder.Wherein the weight portion of Moschus is 0.6-1 part, makes clearing away heat to alleviate pain lumor eliminating powder No. 1, for the cancer patient of the cancer patient without other diseases and corresponding disease, Deficiency and coldness of spleen and stomach and humidity hysteresis; The weight portion of Moschus is 0.1-0.3 part, makes clearing away heat to alleviate pain lumor eliminating powder No. 2, for weakly cancer patient; The weight portion of Moschus is 0.3-0.6 part, makes clearing away heat to alleviate pain lumor eliminating powder No. 3, for there being the cancer patient of bile duct class disease.
Embodiment 15
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first makes extract, then adds conventional adjuvant, makes clearing away heat to alleviate pain dispersing tumor ejection preparation, and wherein the content of Moschus extract is 100mg/ml.
Embodiment 16
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first makes extract, then adds conventional adjuvant, makes clearing away heat to alleviate pain dispersing tumor ejection preparation, and wherein the content of Moschus extract is 200mg/ml.
Embodiment 17
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first makes extract, then adds conventional adjuvant, makes clearing away heat to alleviate pain dispersing tumor ejection preparation, and wherein the content of Moschus extract is 150mg/ml.
Embodiment 18
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first makes extract, then adds conventional adjuvant, makes clearing away heat to alleviate pain dispersing tumor ejection preparation, and wherein the content of Moschus extract is 120mg/ml.
Embodiment 19
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first makes extract, then adds conventional adjuvant, makes clearing away heat to alleviate pain dispersing tumor ejection preparation, and wherein the content of Moschus extract is 140mg/ml.
Embodiment 20
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first makes extract, then adds conventional adjuvant, makes clearing away heat to alleviate pain dispersing tumor ejection preparation, and wherein the content of Moschus extract is 160mg/ml.
Embodiment 21
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first makes extract, then adds conventional adjuvant, makes clearing away heat to alleviate pain dispersing tumor ejection preparation, and wherein the content of Moschus extract is 180mg/ml.
Embodiment 22
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-21, according to the conventional method of pharmacy, first make extract, then add conventional adjuvant, make clearing away heat to alleviate pain dispersing tumor injection with small volume, the total amount take dry powder metering of the each main component wherein containing in this injection with small volume is as 3 grams.
Embodiment 23
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-21, according to the conventional method of pharmacy, first make extract, then add conventional adjuvant, make clearing away heat to alleviate pain dispersing tumor high-capacity injection, the total amount take dry powder metering of the each main component wherein containing in this high-capacity injection is as 6 grams.
Embodiment 24
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first make extract, then add conventional adjuvant, make clearing away heat to alleviate pain dispersing tumor freeze-dried powder, the total amount of the dry powder metering of the each main component wherein containing in this freeze-dried powder is 3 grams, and the content of Moschus extract is 150mg.
Embodiment 25
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first make extract, then add conventional adjuvant, make clearing away heat to alleviate pain dispersing tumor freeze-dried powder, the total amount of the dry powder metering of the each main component wherein containing in this freeze-dried powder is 6 grams, and the content of Moschus extract is 180mg.
Embodiment 26
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first make extract, then add conventional adjuvant, make clearing away heat to alleviate pain dispersing tumor freeze-dried powder, the total amount of the dry powder metering of the each main component wherein containing in this freeze-dried powder is 3 grams, and the content of Moschus extract is 130mg.
Embodiment 27
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first make extract, then add conventional adjuvant, make clearing away heat to alleviate pain dispersing tumor freeze-dried powder, the total amount of the dry powder metering of the each main component wherein containing in this freeze-dried powder is 9 grams, and the content of Moschus extract is 200mg.
Embodiment 28
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first make extract, then add conventional adjuvant, make clearing away heat to alleviate pain dispersing tumor freeze-dried powder, the total amount of the dry powder metering of the each main component wherein containing in this freeze-dried powder is 6 grams, and the content of Moschus extract is 150mg.
Embodiment 29
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first make extract, then add conventional adjuvant, make clearing away heat to alleviate pain dispersing tumor freeze-dried powder, the total amount of the dry powder metering of the each main component wherein containing in this freeze-dried powder is 9 grams, and the content of Moschus extract is 180mg.
Embodiment 30
A kind of clearing away heat to alleviate pain dispersing tumor Chinese medicinal composition preparation, on the basis of embodiment 1-12, according to the conventional method of pharmacy, first make extract, then add conventional adjuvant, make clearing away heat to alleviate pain dispersing tumor freeze-dried powder, the total amount of the dry powder metering of the each main component wherein containing in this freeze-dried powder is 6 grams, and the content of Moschus extract is 120mg.
Drug usage consumption:
For disease, patient is lighter, and the dosage of every day is 3 grams, is divided into three medications, each 1 gram; For disease, patient is more serious, and the dosage of every day is 6 grams, is divided into three medications, each 2 grams; For disease patient especially severe, the maximum dosage of every day is 9 grams, is divided into three medications, each 3 grams; Can alleviate and control the various cancer diseases that patient occurs, after various cancer patient's medications for early stage, mid-term, late period, can reach corresponding therapeutic effect, effective percentage has reached more than 95%, cancer patient's life quality and quality of life are improved, extend patient's band tumor life span, increase patient's curability.
Test example:
Below in conjunction with zoopery and clinical experiment, come that further instruction the present invention has beyond thought technique effect and pharmacological effect effect and toxic and side effects.
Test example one, mouse toxicity experiment
Get 20 of mices, weight is at 12-18 gram, and male and female all have, according to 30 times of feeding administrations of maximum survival dose, before administration, mice is weighed, successive administration feeding 15 days, and in the process of administration feeding, observe mice diet, activity and fur situation of change, found that mice is not abnormal, and claimed mice weight at the 15th day, the weight of 20 mices maintains 19-25 gram, visible, the weight of mice all increases to some extent, therefore, can learn, this medicine does not have obvious toxic and side effects.
Test example two, rabbit immune function experiment
Get 10 of white rabbits, body weight is in 1.5kg left and right, be divided into two groups, one group is matched group, one group is experimental group, experimental group was according to 15 times of administration feedings of people's oral dose 30 days, the normal saline feeding of equivalent for matched group, until the 31st day time, put to death white rabbit, get the section statining of white rabbit internal organs, and carry out microscopy, two groups contrast and draw: the white pulp in the spleen in administration group is significantly increased, and the phagocyte in red pulp also has significant increase, and function is active, visible the present invention has the effect of high immunologic function.
Test example three, TWO cell carcinogenesis suppress experiment
Get 3 of TWOs, body weight 1kg left and right, stop the feeding to TWO simultaneously, observe upgrowth situation and the inspection of TWO, detect the health of TWO, after three days, put to death TWO, take out respectively the mammary gland of a TWO, a TWO liver, the spleen of a TWO, and with the ray mammary gland to TWO respectively, liver, spleen carries out after cancerization processing, and by the mammary gland of TWO, liver, the cancerization parts such as spleen are divided into three groups, and be placed in respectively and be added with enriching substance, in the culture dish of Sargassum and Chinese medicine composition of the present invention, cultivate, after cultivating 20 days, and respectively to three groups of mammary gland, liver, cancerous cell in spleen enlivens situation, the differentiation fragmentation condition of cancerous cell, the survival rate of cancerous cell is analyzed as shown in the table:
Figure BDA0000477460200000131
From table, draw, enriching substance group and Sargassum group all have good inhibitory action to breast carcinoma, and a little less than comparing for the inhibitory action of other histiocytic cancerous cell of human body organ, its successful is bad; And of the present invention group not only have good inhibitory action to breast cancer cell, and the inhibitory action of cancerous cell to other when injected organism tissue cells is also fine; And of the present invention group contrasts with enriching substance group and Sargassum group, can draw, no matter, for the cancerous cell of any when injected organism tissue, the inhibition of cancer cell effect of of the present invention group all has good advantage; Therefore, can draw, the present invention has anticancer Differentiation, and then kills the effect of cancerous cell.
Test example four, the experiment of mice anti-inflammation hemostasia
Get 8 mices, be divided into two large groups, a large group adopts Oleum Tiglii to process after mice, causes mice auricle swelling, is divided into 2 groups, and a small group is physiology saline control group, and a small group is processed group of the present invention; Two groups contrast, and show that the present invention has obvious inhibitory action to mice auricle swelling, and the present invention has anti-inflammation detumescence effect; The shank of other one large group mice hurts processing, and be divided into 2 groups after extracting some blood, a small group is matched group, a small group is processed group of the present invention, wound to mice: matched group adopts enriching substance to process, and processed group of the present invention adopts medicine of the present invention to process according to people's taking dose; Blood to taking out: matched group adopts enriching substance and its mixed processing, and processed group of the present invention adopts the injection of this medicine to carry out mixed processing; From mice wound healing degree, of the present invention group to compare matched group healing better, and healing rate is very fast; From blood coagulating time, the setting time of the mouse blood of of the present invention group of processing is shorter, and the setting time of the blood of enriching substance processing is longer; As fully visible, the present invention has anti-inflammation hemostasia, promotes Epithelial cell Differentiation effect.
Test example five, clinical experiment
1, experimental data:
Sum up by the patient that treats for many years, have 23 routine patients, wherein male 19 examples, female's 4 examples, the age, the mean age was 57.9 years old in 31-76 year.
23 routine patients' clinical manifestation is: 2 routine gastralgias; 1 routine blurred vision; 2 routine constipation; Pain of joint muscle 1 example; Edema of lower limbs 2 examples; 8 examples of generating heat; Weak 9 examples; Ascites 5 examples; 8 examples of coughing; Cough sputum with blood streaks 6 examples; Sacrum bone pain 1 example; Abdominal distention 2 examples; Nasal cavity and right side face and right temporal bone pain 1 example; Left Upper abdominal pain diffuses to full abdomen and back pain 1 example; Chest and shoulder and back ache 7 examples; Upper right abdomen and shoulder and back ache 5 examples.
Diagnosis before 23 routine patient's medicines: chest X-ray, CT scan, blood test, biopsy etc., make a definite diagnosis 23 examples, wherein pulmonary carcinoma 8 examples, primary hepatocarcinoma 7 examples, esophageal cancer cell 2 examples, rhinitis cancer 1 example, sigmoid colon cancer 1 example, cancer of pancreas 1 example, rectal cancer 1 example, cervical cancer 1 example, gastric cancer 1 example, wherein have 7 examples not adopt operative treatment, radiation and chemotherapy.After all the other 16 examples adopt operative treatment, radiation and chemotherapy, check that finding that there is 9 examples shifts to other organs and tissue.
2, experimental technique and explanation:
Give QI invigorating, enrich blood and function of spleen and stomach regulating for weak patient, abdominal distention patient gives catharsis irritability, and ascites, edema of lower limbs patient give diuresis, with the course for the treatment of application method treat.And whether according to, operative treatment, radiation and chemotherapy are divided into two groups by the patient in this experiment, do not perform the operation and a group of chemicotherapy is 6 people; Perform the operation and one group of 16 people of chemicotherapy; Wherein there is 1 routine patient there is no medication treatment.
In 22 routine patients of above-mentioned medication, there are complication 8 examples, there is blurred vision for pulmonary carcinoma intracranial shifts in 1 example; 4 routine pulmonary carcinoma intracranial shift and occur occipital bone pain; There is ascites in 2 routine primary hepatocarcinoma; There is upper abdomen distending pain in 1 routine esophageal carcinoma hepatic metastasis; 1 routine cervical cancer patient pelvic cavity shifts and occurs rumpbone pain and edema of lower limbs; There is upper abdomen distending pain in 1 routine pulmonary carcinoma hepatitis B patient; 1 routine rhinitis cancer intracranial shifts and occurs temporal bone pain.
3, clinical efficacy:
In two groups of above-mentioned clinical experiments, do not give in operative treatment, radiation and chemotherapy one group, after medication, there is 50% patient all can control the symptoms such as heating, hemoptysis, pain, after 6 courses for the treatment of of medication, the survival rate of 1 year is 100%, the survival rate of 5 years is 66%, the survival rate of 20 years is 33%.In operation and one group of chemicotherapy, more than 1 year survival rate 100%, more than 3 years survival rate 12%, more than 10 years survival rate 6.3%; In the 8 routine patients that have complication, 7 routine patients all can control the symptom of complication after medication or after direction of medication usage.
4, conclusion:
With observation post administration and diagnosis: in 23 routine patients, except 1 routine gastric cancer patient, because other causes of disease do not continue medication, no matter whether all the other 22 routine patients, carry out operating excision or chemicotherapy, reach after 6 courses for the treatment of in medication, all obtained good curative effect; Reach 10 more than the course for the treatment of in medication, all obtained good recovery; For diffusion transfer of cancerous cell and patient beyond cure, all can control the symptoms such as weak, heating, hemorrhage, hemoptysis, constipation, abdominal distention, diarrhoea, cough, cancerous pain, and the tumor of primary lesion also reduces greatly.

Claims (10)

1. a clearing away heat to alleviate pain dispersing tumor Chinese medicine composition, is characterized in that: the Main Ingredients and Appearance of its formula is made up of following weight portion: Sargassum 3-5 part, egg albumen powder 2-4 part, Radix Notoginseng 1-3 part, Moschus 0.05-1.5 part.
2. clearing away heat to alleviate pain dispersing tumor Chinese medicine composition as claimed in claim 1, is characterized in that: the Main Ingredients and Appearance of described formula is made up of following weight portion: Sargassum 3.5-4.5 part, egg albumen powder 2.5-3.5 part, Radix Notoginseng 1.5-2.5 part, Moschus 0.1-1 part.
3. clearing away heat to alleviate pain dispersing tumor Chinese medicine composition as claimed in claim 1, is characterized in that: the Main Ingredients and Appearance of described formula is made up of following weight portion: 4 parts of Sargassums, 3 parts of egg albumen powders, 2 parts of Radix Notoginseng, 0.5 part, Moschus.
4. clearing away heat to alleviate pain dispersing tumor Chinese medicine composition as claimed in claim 1, is characterized in that: the main component of described formula also comprises Radix Glycyrrhizae, and wherein the consumption of Radix Glycyrrhizae is less than 1/2 part of Sargassum consumption.
5. the clearing away heat to alleviate pain dispersing tumor Chinese medicine composition as described in as arbitrary in claim 1-4, is characterized in that: described egg albumen powder is to adopt the one or more combination in the soybean protein of purifying, casein, lactalbumin to form.
6. the clearing away heat to alleviate pain dispersing tumor Chinese medicine composition as described in as arbitrary in claim 1-4, is characterized in that, described Chinese medicine composition can, according to the conventional method of pharmacy, add adjuvant, makes required preparation; Described preparation comprises tablet, capsule, injection with small volume, high-capacity injection, freeze-dried powder.
7. clearing away heat to alleviate pain dispersing tumor Chinese medicine composition as claimed in claim 6, is characterized in that, described preparation can also be made up of Sargassum extract, Radix Notoginseng extractive substance, egg albumen powder solution and Moschus extract, and wherein the content of Moschus extract is 100-200mg/ml.
8. clearing away heat to alleviate pain dispersing tumor Chinese medicine composition as claimed in claim 7, is characterized in that, the content of described Moschus extract is 120-180mg/ml.
9. clearing away heat to alleviate pain dispersing tumor Chinese medicine composition as claimed in claim 7, is characterized in that, the content of described Moschus extract is 140-160mg/ml.
10. clearing away heat to alleviate pain dispersing tumor Chinese medicine composition as claimed in claim 7, is characterized in that, the content of described Moschus extract is 150mg/ml.
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