CN1040539C - 3-脱氧低聚糖,其制备方法和含有它们的药物组合物 - Google Patents

3-脱氧低聚糖,其制备方法和含有它们的药物组合物 Download PDF

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Publication number
CN1040539C
CN1040539C CN94104961A CN94104961A CN1040539C CN 1040539 C CN1040539 C CN 1040539C CN 94104961 A CN94104961 A CN 94104961A CN 94104961 A CN94104961 A CN 94104961A CN 1040539 C CN1040539 C CN 1040539C
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CN
China
Prior art keywords
formula
compound
group
deoxy
sulfo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN94104961A
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English (en)
Chinese (zh)
Other versions
CN1099038A (zh
Inventor
M·琵缇托
G·F·B·朱伦德
C·A·A·万博克尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Elf Sanofi SA
Akzo Nobel NV
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Application filed by Elf Sanofi SA, Akzo Nobel NV filed Critical Elf Sanofi SA
Publication of CN1099038A publication Critical patent/CN1099038A/zh
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Publication of CN1040539C publication Critical patent/CN1040539C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN94104961A 1993-04-22 1994-04-21 3-脱氧低聚糖,其制备方法和含有它们的药物组合物 Expired - Lifetime CN1040539C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9304769A FR2704226B1 (fr) 1993-04-22 1993-04-22 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR9304769 1993-04-22

Publications (2)

Publication Number Publication Date
CN1099038A CN1099038A (zh) 1995-02-22
CN1040539C true CN1040539C (zh) 1998-11-04

Family

ID=9446334

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94104961A Expired - Lifetime CN1040539C (zh) 1993-04-22 1994-04-21 3-脱氧低聚糖,其制备方法和含有它们的药物组合物

Country Status (18)

Country Link
US (1) US5514659A (https=)
EP (1) EP0621282B1 (https=)
JP (1) JP3594990B2 (https=)
KR (1) KR100324583B1 (https=)
CN (1) CN1040539C (https=)
AT (1) ATE155140T1 (https=)
AU (1) AU665901B2 (https=)
CA (1) CA2121997C (https=)
DE (1) DE69404071T2 (https=)
ES (1) ES2106463T3 (https=)
FI (1) FI111725B (https=)
FR (1) FR2704226B1 (https=)
HU (1) HU226807B1 (https=)
NO (1) NO300137B1 (https=)
NZ (1) NZ260357A (https=)
RU (1) RU2133752C1 (https=)
TW (1) TW318183B (https=)
ZA (1) ZA942767B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
FR2751334B1 (fr) * 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
AUPO888497A0 (en) * 1997-09-01 1997-09-25 Australian National University, The Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
AUPO976897A0 (en) * 1997-10-14 1997-11-06 Australian National University, The Use of sulfated oligosaccharides in lowering blood triglyceride levels
FR2773804B1 (fr) * 1998-01-19 2000-02-18 Sanofi Sa Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
TWI289566B (en) * 1999-12-07 2007-11-11 N.V.Organon Antithrombotic compound
UA81657C2 (ru) * 2003-03-04 2008-01-25 Орто-Макнейл Фармасьютикел, Инк. Способ получения противосудорожных производных топирамата
CN103788141B (zh) * 2004-03-04 2016-08-17 普罗吉恩制药有限公司 硫酸化寡聚糖衍生物
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
US8147126B2 (en) * 2009-01-26 2012-04-03 Spar Food Machinery Mfg. Co., Ltd. Covering structure of a mixer
EP2464668B1 (en) 2009-07-31 2022-12-07 Reliable Biopharmaceutical Corporation Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
WO2012042123A1 (fr) 2010-09-10 2012-04-05 Sanofi Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
JP5883453B2 (ja) * 2010-10-05 2016-03-15 シノファーム シンガポール ピーティーイー，リミテッドＳｃｉｎｏｐｈａｒｍ Ｓｉｎｇａｐｏｒｅ Ｐｔｅ，Ｌｔｄ． ヘパリンのペンタサッカライドに適用されるジサッカライドの調製のための方法
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
WO2014205115A2 (en) 2013-06-19 2014-12-24 The Regents Of The University Of California Regioselective silyl exchange of per-silylated oligosaccharides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
EP0454220A1 (en) * 1990-04-23 1991-10-30 Akzo Nobel N.V. Carbohydrate derivatives comprising a trisaccharide unit

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
HU177887B (en) * 1979-03-21 1982-01-28 Richter Gedeon Vegyeszet Process for preparing a raw material containing heparin
US4451858A (en) * 1981-02-10 1984-05-29 Vertimag Systems Corporation Analog recording system
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
SU1694065A3 (ru) * 1982-02-01 1991-11-23 Шоай С.А. (Фирма) Способ получени пентасахарида
CA1192545A (en) * 1982-02-16 1985-08-27 Glaxo Group Limited Heterocyclic derivatives as histamine h.sub.2- antagonists
US4788307A (en) * 1986-04-30 1988-11-29 Choay S.A. Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
DE4140117C1 (https=) * 1991-12-05 1993-01-28 Bayer Ag, 5090 Leverkusen, De

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
EP0454220A1 (en) * 1990-04-23 1991-10-30 Akzo Nobel N.V. Carbohydrate derivatives comprising a trisaccharide unit

Also Published As

Publication number Publication date
NO941461L (no) 1994-10-24
ES2106463T3 (es) 1997-11-01
DE69404071D1 (de) 1997-08-14
FI111725B (fi) 2003-09-15
DE69404071T2 (de) 1998-02-19
NO941461D0 (no) 1994-04-21
HUT67572A (en) 1995-04-28
CN1099038A (zh) 1995-02-22
CA2121997C (en) 2005-09-27
NO300137B1 (no) 1997-04-14
HU9401150D0 (en) 1994-07-28
KR100324583B1 (ko) 2002-11-13
FR2704226A1 (fr) 1994-10-28
TW318183B (https=) 1997-10-21
RU2133752C1 (ru) 1999-07-27
FR2704226B1 (fr) 1995-07-21
JPH0789977A (ja) 1995-04-04
EP0621282A1 (fr) 1994-10-26
NZ260357A (en) 1995-12-21
ZA942767B (en) 1995-10-23
ATE155140T1 (de) 1997-07-15
JP3594990B2 (ja) 2004-12-02
AU665901B2 (en) 1996-01-18
AU6052494A (en) 1994-10-27
FI941836A7 (fi) 1994-10-23
CA2121997A1 (en) 1994-10-23
EP0621282B1 (fr) 1997-07-09
HU226807B1 (en) 2009-10-28
US5514659A (en) 1996-05-07
FI941836A0 (fi) 1994-04-20

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C53 Correction of patent of invention or patent application
COR Change of bibliographic data

Free format text: CORRECT: PATENTEE; FROM: OSSIE SIDE BRANCHES SERGEI BOLISUOWEIQI; AKZO NOVEL N.V. CORP. TO: SANOFI-SANOFI-SYNTHELABO SA; AKZO NOVEL N.V. CORP.

CP01 Change in the name or title of a patent holder

Patentee after: Sanofi-Sandra Castle Co.,Ltd.

Patentee after: AKZO NOBEL N.V.

Patentee before: SANOFI ELF

Patentee before: AKZO NOBEL N.V.

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20040924

Address after: Paris France

Patentee after: Sanofi-Sandra Castle Co.,Ltd.

Address before: France Paris Akzo Nobel company

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Owner name: SANOFI. AVENTIS CO., LTD.

Free format text: FORMER NAME OR ADDRESS: SANOFI-SANOFI-SYNTHELABO SA

CP01 Change in the name or title of a patent holder

Address after: Paris France

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Patentee before: Sanofi-Sandra Castle Co.,Ltd.

C17 Cessation of patent right
CX01 Expiry of patent term

Expiration termination date: 20140421

Granted publication date: 19981104