ES2106463T3 - 3-desoxi-oligosacaridos, procedimientos para su obtencion y composiciones farmaceuticas que los contienen. - Google Patents

3-desoxi-oligosacaridos, procedimientos para su obtencion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2106463T3
ES2106463T3 ES94400879T ES94400879T ES2106463T3 ES 2106463 T3 ES2106463 T3 ES 2106463T3 ES 94400879 T ES94400879 T ES 94400879T ES 94400879 T ES94400879 T ES 94400879T ES 2106463 T3 ES2106463 T3 ES 2106463T3
Authority
ES
Spain
Prior art keywords
radical
formula
oligosacarides
desoxi
procedures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94400879T
Other languages
English (en)
Inventor
Maurice Petitou
Guy Francois Bernard Jaurand
Boeckel Constant Adriaan A Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Akzo Nobel NV
Original Assignee
Sanofi SA
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA, Akzo Nobel NV filed Critical Sanofi SA
Application granted granted Critical
Publication of ES2106463T3 publication Critical patent/ES2106463T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

LA INVENCION SE REFIERE A 3-DESOXIOLIGOSACARIDOS DE FORMULA I EN LA QUE , DE FORMULA R_O, UN RADICAL DE FORMULA, O UN RADICAL DE FORMULA, Y REPRESENTA UN RADICAL DE FORMULA: ALKILO, ICAL HIDROXI, UN RADICAL ALCOXI O UN RADICAL -OSO3-, -R2, R4, R6, R9, R11 REPRESENTAN UN ATOMO DE HIDROGENO, UN RADICAL HIDROCI, UN RADICAL ALCOXI O UN RADICAL -OSO3-, SIEMPRE QUE AL MENOS R2 O R4 O R9 O R11 REPRESENTE UN ATOMO DE HIDROGENO, Y SUS SALES CON UNA BASE, FARMACEUTICAMENTE ACEPTABLES.
ES94400879T 1993-04-22 1994-04-22 3-desoxi-oligosacaridos, procedimientos para su obtencion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2106463T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9304769A FR2704226B1 (fr) 1993-04-22 1993-04-22 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2106463T3 true ES2106463T3 (es) 1997-11-01

Family

ID=9446334

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94400879T Expired - Lifetime ES2106463T3 (es) 1993-04-22 1994-04-22 3-desoxi-oligosacaridos, procedimientos para su obtencion y composiciones farmaceuticas que los contienen.

Country Status (18)

Country Link
US (1) US5514659A (es)
EP (1) EP0621282B1 (es)
JP (1) JP3594990B2 (es)
KR (1) KR100324583B1 (es)
CN (1) CN1040539C (es)
AT (1) ATE155140T1 (es)
AU (1) AU665901B2 (es)
CA (1) CA2121997C (es)
DE (1) DE69404071T2 (es)
ES (1) ES2106463T3 (es)
FI (1) FI111725B (es)
FR (1) FR2704226B1 (es)
HU (1) HU226807B1 (es)
NO (1) NO300137B1 (es)
NZ (1) NZ260357A (es)
RU (1) RU2133752C1 (es)
TW (1) TW318183B (es)
ZA (1) ZA942767B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
AUPO888497A0 (en) * 1997-09-01 1997-09-25 Australian National University, The Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
AUPO976897A0 (en) 1997-10-14 1997-11-06 Australian National University, The Use of sulfated oligosaccharides in lowering blood triglyceride levels
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
FR2773804B1 (fr) * 1998-01-19 2000-02-18 Sanofi Sa Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant
TWI289566B (en) * 1999-12-07 2007-11-11 N.V.Organon Antithrombotic compound
UA81657C2 (ru) * 2003-03-04 2008-01-25 Орто-Макнейл Фармасьютикел, Инк. Способ получения противосудорожных производных топирамата
RU2392281C2 (ru) * 2004-03-04 2010-06-20 Проджен Фармасьютикалз Лимитед Сульфатированные производные олигосахаридов
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
US8147126B2 (en) * 2009-01-26 2012-04-03 Spar Food Machinery Mfg. Co., Ltd. Covering structure of a mixer
US8288515B2 (en) * 2009-07-31 2012-10-16 Reliable Biopharmaceutical Corporation Process for preparing Fondaparinux sodium and intermediates useful in the synthesis thereof
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
JP2013537181A (ja) 2010-09-10 2013-09-30 サノフイ 抗血栓活性及び改善された代謝安定性を有するビオチン化多糖類
ES2608960T3 (es) * 2010-10-05 2017-04-17 Scinopharm Singapore Pte Ltd. Procedimiento para la preparación de disacáridos aplicado a pentasacáridos de heparina
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
WO2014205115A2 (en) 2013-06-19 2014-12-24 The Regents Of The University Of California Regioselective silyl exchange of per-silylated oligosaccharides

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
HU177887B (en) * 1979-03-21 1982-01-28 Richter Gedeon Vegyeszet Process for preparing a raw material containing heparin
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
US4451858A (en) * 1981-02-10 1984-05-29 Vertimag Systems Corporation Analog recording system
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
SU1694065A3 (ru) * 1982-02-01 1991-11-23 Шоай С.А. (Фирма) Способ получени пентасахарида
CA1192545A (en) * 1982-02-16 1985-08-27 Glaxo Group Limited Heterocyclic derivatives as histamine h.sub.2- antagonists
US4788307A (en) * 1986-04-30 1988-11-29 Choay S.A. Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
DK0454220T3 (da) * 1990-04-23 1993-11-22 Sanofi Elf Carbohydratderivater omfattende en trisaccharidenhed
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
DE4140117C1 (es) * 1991-12-05 1993-01-28 Bayer Ag, 5090 Leverkusen, De

Also Published As

Publication number Publication date
EP0621282A1 (fr) 1994-10-26
NO941461D0 (no) 1994-04-21
HUT67572A (en) 1995-04-28
EP0621282B1 (fr) 1997-07-09
CN1040539C (zh) 1998-11-04
NO300137B1 (no) 1997-04-14
NO941461L (no) 1994-10-24
TW318183B (es) 1997-10-21
JPH0789977A (ja) 1995-04-04
CN1099038A (zh) 1995-02-22
HU9401150D0 (en) 1994-07-28
DE69404071D1 (de) 1997-08-14
FI941836A7 (fi) 1994-10-23
FR2704226B1 (fr) 1995-07-21
ATE155140T1 (de) 1997-07-15
CA2121997A1 (en) 1994-10-23
AU6052494A (en) 1994-10-27
FI111725B (fi) 2003-09-15
FI941836A0 (fi) 1994-04-20
RU2133752C1 (ru) 1999-07-27
CA2121997C (en) 2005-09-27
KR100324583B1 (ko) 2002-11-13
AU665901B2 (en) 1996-01-18
HU226807B1 (en) 2009-10-28
ZA942767B (en) 1995-10-23
JP3594990B2 (ja) 2004-12-02
FR2704226A1 (fr) 1994-10-28
NZ260357A (en) 1995-12-21
DE69404071T2 (de) 1998-02-19
US5514659A (en) 1996-05-07

Similar Documents

Publication Publication Date Title
ES2106463T3 (es) 3-desoxi-oligosacaridos, procedimientos para su obtencion y composiciones farmaceuticas que los contienen.
ES2054860T5 (es) Derivados de 9-halogeno-(z)-prostaglandinas, procedimiento para su preparacion y su utilizacion como medicamentos.
ES2076935T3 (es) Compuesto de pirazolopiridina y procedimientos para su preparacion.
ES2185711T3 (es) 1,4-benzotiazepina-1,1-dioxidoshipolipimemicos.
HN2003000407A (es) Nuevos derivados de fluoroglicosisdos aromaticos, medicamentos que contienen estos compuestos y sus usos.
AR001440A1 (es) Nuevos taxoides, su preparación y composiciones farmacéuticas que los contienen.
SE9504661D0 (sv) New compounds
CO5160257A1 (es) La n-piperidino-5-(4-bromofenil)-1-(2,4-diclorofenil)-4-etilpirazol-3-carboxamida, sus sales, su preparacion y las composiciones farmaceuticas que la contienen
ES2076147T3 (es) Nuevos derivados de amina ciclicos, medicamento que contiene estos compuestos y procedimiento para su preparacion.
ES2142030T3 (es) Nuevos compuestos espiro-heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2084831T3 (es) Nuevo procedimiento para preparar formoterol y compuestos relacionados.
AR012504A1 (es) Utilizacion de derivados de tetrahidropiridina, para la preparacion de medicamentos para el tratamiento de las enfermedades que provocan unadesmielinizacion.
ES2176296T3 (es) Composiciones farmaceuticas que permiten la liberacion prolongada de trimetacidina despues de la administracion por via oral.
ES2184304T3 (es) Procedimiento de preparacion de un perhidro-isoindol sustituido.
ES2043863T3 (es) Procedimiento para preparar derivados de la 1,2,5,6-tetrahidropiridina.
ES2020171T3 (es) Eteres de 1-bencil-3-hidroximetilindazol con 2-hidroxiacidos alifaticos.
ES2045484T3 (es) Nuevos derivados de la vitamina d: aplicaciones terapeuticas y a las dosificaciones de los metabolitos de la vitamina d.
CO4940448A1 (es) Modificacion a cristal de una sustancia de medicamento
ES2143833T3 (es) Acidos y esteres de la diosmetina y composiciones farmaceuticas que los contienen.
ES2172023T3 (es) Nuevos derivados tetrahidro-piridinicos sustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2182090T3 (es) Nuevos derivados de pirrol.
ES2125963T3 (es) Nuevos derivados espiranicos del 3-amino-cromano, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.
AR050260A1 (es) Derivados de diarilmetilpiperazinas, su preparacion y su utilizacion
MX9300306A (es) Bencimidazoles medicamentos que contienen estos compuestos y procedimiento para su preparacion.
ES2043943T3 (es) Procedimiento para la preparacion de compuestos con actividad analgesica central.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 621282

Country of ref document: ES