CN104039807B - 甾醇衍生物的制备方法 - Google Patents

甾醇衍生物的制备方法 Download PDF

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Publication number
CN104039807B
CN104039807B CN201280065737.0A CN201280065737A CN104039807B CN 104039807 B CN104039807 B CN 104039807B CN 201280065737 A CN201280065737 A CN 201280065737A CN 104039807 B CN104039807 B CN 104039807B
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CN
China
Prior art keywords
hydroxy
alpha
amino
beta
aminopropyl
Prior art date
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Active
Application number
CN201280065737.0A
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English (en)
Chinese (zh)
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CN104039807A (zh
Inventor
M·普瓦罗
M·帕亚尔斯
P·德梅迪纳
S·普瓦罗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dendro Rogernicks Co
Original Assignee
Ai Feichemu
National Medical And Health Research Institute
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Publication of CN104039807A publication Critical patent/CN104039807A/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201280065737.0A 2011-11-24 2012-11-23 甾醇衍生物的制备方法 Active CN104039807B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11306548.6 2011-11-24
EP11306548 2011-11-24
PCT/EP2012/073489 WO2013076257A1 (en) 2011-11-24 2012-11-23 Process for the preparation of sterol derivatives

Publications (2)

Publication Number Publication Date
CN104039807A CN104039807A (zh) 2014-09-10
CN104039807B true CN104039807B (zh) 2018-02-13

Family

ID=47216329

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280065737.0A Active CN104039807B (zh) 2011-11-24 2012-11-23 甾醇衍生物的制备方法

Country Status (14)

Country Link
US (1) US9447141B2 (enExample)
EP (1) EP2782923B1 (enExample)
JP (1) JP6157492B2 (enExample)
KR (1) KR20140098131A (enExample)
CN (1) CN104039807B (enExample)
AU (1) AU2012342460B2 (enExample)
BR (1) BR112014012458A2 (enExample)
CA (1) CA2856609C (enExample)
ES (1) ES2613753T3 (enExample)
IN (1) IN2014MN00976A (enExample)
MX (1) MX343787B (enExample)
RU (1) RU2014125435A (enExample)
WO (1) WO2013076257A1 (enExample)
ZA (1) ZA201403736B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3091970B1 (en) 2014-01-10 2020-10-28 Rgenix, Inc. Lxr agonists and uses thereof
CN109069461A (zh) 2016-01-11 2018-12-21 洛克菲勒大学 与髓源性抑制细胞相关的病症的治疗方法
FR3064470A1 (fr) * 2017-03-31 2018-10-05 Lessonia Masque ou patch prepare a partir d’une composition d’alginate
EP3713575A4 (en) 2017-11-21 2021-08-25 Rgenix, Inc. POLYMORPHS AND THEIR USES
JP2022501371A (ja) * 2018-09-19 2022-01-06 モデルナティエックス インコーポレイテッドModernaTX, Inc. ステロールの精製
BE1027157B9 (fr) * 2019-08-01 2020-11-03 Dendrogenix Composition de dérivés de stérols pour son utilisationdans le traitement d’une pathologie neuronale liée à une hypoxie et/ou à une hypoglycémie et composition correspondante
HUE067466T2 (hu) 2019-12-13 2024-10-28 Inspirna Inc Fémsók és alkalmazásuk
BE1028852B1 (fr) 2020-12-03 2022-07-05 Dendrogenix PRODROGUE DU 5α-hydroxy-6β-[2-(1H-imidazol-4-yl) éthylamino]cholestan-3β-ol ET COMPOSITIONS PHARMACEUTIQUES LE COMPRENANT POUR UTILISATION DANS LE TRAITEMENT DU CANCER
US20230391817A1 (en) * 2020-10-29 2023-12-07 Dendrogenix 5alpha-hydroxy-6beta-[2-(1-h-imidazol-4-yl)-ethylamino]-cholestan-3beta-ol analogues and pharmaceutical compositions comprising same for use in the treatment of cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003262422A1 (en) * 2002-04-19 2003-11-03 Institut National De La Sante Et De La Recherche Medicale Aminoalkyl sterol compounds having an anti-tumoral and neuroprotective activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003262422A1 (en) * 2002-04-19 2003-11-03 Institut National De La Sante Et De La Recherche Medicale Aminoalkyl sterol compounds having an anti-tumoral and neuroprotective activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthesis of New Alkylaminooxysterols with Potent Cell Differentiating Activities: Identification of Leads for the Treatment of Cancer and Neurodegenerative Diseases;Philippe de Medina et al;《J. Med. Chem.》;20090922;第52卷;7765–7777 *

Also Published As

Publication number Publication date
KR20140098131A (ko) 2014-08-07
AU2012342460B2 (en) 2017-06-29
EP2782923B1 (en) 2016-11-23
AU2012342460A1 (en) 2014-06-12
ES2613753T3 (es) 2017-05-25
CA2856609A1 (en) 2013-05-30
WO2013076257A1 (en) 2013-05-30
RU2014125435A (ru) 2015-12-27
JP6157492B2 (ja) 2017-07-05
JP2015502934A (ja) 2015-01-29
IN2014MN00976A (enExample) 2015-04-24
US9447141B2 (en) 2016-09-20
CA2856609C (en) 2021-01-12
BR112014012458A2 (pt) 2017-06-06
EP2782923A1 (en) 2014-10-01
US20140309417A1 (en) 2014-10-16
MX343787B (es) 2016-10-31
CN104039807A (zh) 2014-09-10
ZA201403736B (en) 2015-11-25
MX2014006303A (es) 2014-09-08

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Effective date of registration: 20250715

Address after: Liege, Belgium

Patentee after: Dendro Rogernicks Co.

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Address before: Paris France

Patentee before: INSERM (INSTITUT NATIONAL DE LA SANTe ET DE LA RECHERCHE MeDICALE)

Country or region before: France

Patentee before: Efitcham

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