CN104039148A - 组合als疗法 - Google Patents

组合als疗法 Download PDF

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Publication number
CN104039148A
CN104039148A CN201280034661.5A CN201280034661A CN104039148A CN 104039148 A CN104039148 A CN 104039148A CN 201280034661 A CN201280034661 A CN 201280034661A CN 104039148 A CN104039148 A CN 104039148A
Authority
CN
China
Prior art keywords
riluzole
dose
administration
experimenter
effective dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280034661.5A
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English (en)
Chinese (zh)
Inventor
杰西.锡达鲍姆
约翰.毛
法迪.马利克
安德鲁.A.沃尔夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytokinetics Inc
Original Assignee
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc filed Critical Cytokinetics Inc
Priority to CN201811116043.0A priority Critical patent/CN109316480A/zh
Publication of CN104039148A publication Critical patent/CN104039148A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280034661.5A 2011-07-13 2012-07-12 组合als疗法 Pending CN104039148A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811116043.0A CN109316480A (zh) 2011-07-13 2012-07-12 组合als疗法

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201161507381P 2011-07-13 2011-07-13
US61/507,381 2011-07-13
US201161544533P 2011-10-07 2011-10-07
US61/544,533 2011-10-07
US201261637770P 2012-04-24 2012-04-24
US201261637759P 2012-04-24 2012-04-24
US61/637,770 2012-04-24
US61/637,759 2012-04-24
US201261646699P 2012-05-14 2012-05-14
US61/646,699 2012-05-14
PCT/US2012/046523 WO2013010015A2 (en) 2011-07-13 2012-07-12 Combination als therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811116043.0A Division CN109316480A (zh) 2011-07-13 2012-07-12 组合als疗法

Publications (1)

Publication Number Publication Date
CN104039148A true CN104039148A (zh) 2014-09-10

Family

ID=47506929

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201280034661.5A Pending CN104039148A (zh) 2011-07-13 2012-07-12 组合als疗法
CN201811116043.0A Pending CN109316480A (zh) 2011-07-13 2012-07-12 组合als疗法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201811116043.0A Pending CN109316480A (zh) 2011-07-13 2012-07-12 组合als疗法

Country Status (16)

Country Link
US (1) US10272082B2 (https=)
EP (1) EP2731611B1 (https=)
JP (2) JP6145946B2 (https=)
KR (1) KR101951220B1 (https=)
CN (2) CN104039148A (https=)
AU (2) AU2012281042B2 (https=)
BR (1) BR112014000742A2 (https=)
CA (1) CA2849213A1 (https=)
EA (2) EA028060B1 (https=)
HK (1) HK1197178A1 (https=)
IL (1) IL230391B (https=)
IN (1) IN2014DN00200A (https=)
PH (1) PH12014500094A1 (https=)
SG (1) SG10201605707UA (https=)
WO (1) WO2013010015A2 (https=)
ZA (1) ZA201400236B (https=)

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US20160263110A1 (en) * 2013-11-04 2016-09-15 Ab Science Use of masitinib for treatment of amyotrophic lateral sclerosis
SI3137622T1 (sl) * 2014-04-29 2022-05-31 Cytokinetics, Inc. Postopki za zmanjšanje upada vitalne kapacitete
CN107735077A (zh) * 2014-11-21 2018-02-23 拜尔哈文制药股份有限公司 利鲁唑的舌下给药
WO2016081472A1 (en) * 2014-11-21 2016-05-26 Biohaven Pharmaceutical Holding Company Ltd. Sublingual formulation of riluzole
EP3072513A1 (en) * 2015-03-26 2016-09-28 Medday Biotin for treating Amyotrophic lateral sclerosis
SG11201808106YA (en) 2016-03-25 2018-10-30 Ab Science Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation
US11439626B2 (en) 2019-09-20 2022-09-13 Icahn School Of Medicine At Mount Sinai Controlled release formulations of riluzole and their uses

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Also Published As

Publication number Publication date
US20140243344A1 (en) 2014-08-28
AU2012281042A1 (en) 2014-01-30
EP2731611B1 (en) 2019-09-18
EA201791043A1 (ru) 2017-09-29
EP2731611A4 (en) 2015-02-18
JP6145946B2 (ja) 2017-06-14
US10272082B2 (en) 2019-04-30
EA028060B1 (ru) 2017-10-31
CN109316480A (zh) 2019-02-12
WO2013010015A2 (en) 2013-01-17
SG10201605707UA (en) 2016-09-29
KR20140074270A (ko) 2014-06-17
PH12014500094A1 (en) 2014-03-17
JP2017128610A (ja) 2017-07-27
BR112014000742A2 (pt) 2016-08-23
HK1197178A1 (en) 2015-01-09
CA2849213A1 (en) 2013-01-17
ZA201400236B (en) 2014-10-29
IL230391B (en) 2019-03-31
KR101951220B1 (ko) 2019-02-22
WO2013010015A3 (en) 2014-05-15
IN2014DN00200A (https=) 2015-06-05
EP2731611A2 (en) 2014-05-21
NZ619924A (en) 2016-02-26
AU2012281042B2 (en) 2016-07-14
EA201490011A1 (ru) 2014-08-29
AU2016244263A1 (en) 2016-11-03
JP2014520856A (ja) 2014-08-25

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Address after: American California

Applicant after: Cytokinetics Inc.

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Application publication date: 20140910