CN104023699B - 溶解的厚朴酚类似物 - Google Patents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
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Abstract
含有溶解的厚朴酚类似物的组合物，所述组合物包含至少一种选自丙基厚朴酚、异丙基厚朴酚、丁基厚朴酚和异丁基厚朴酚的厚朴酚类似物和异山梨醇二甲醚。这些溶解的类似物用于个人护理、口腔护理与家庭护理组合物中以提供抗菌活性并减少促炎介质表达。
Description
技术领域
本发明公开了一种溶解的厚朴酚类似物。
背景技术
已知例如丙基厚朴酚、异丙基厚朴酚、丁基厚朴酚和异丁基厚朴酚等厚朴酚类似物具有抗菌活性，它们还显示出能够降低在口腔组织中促炎介质的表达。使用这些厚朴酚类似物的问题是它们在典型的个人护理、口腔护理或家庭护理组合物中的溶解度。它们的使用受限于它们的溶解度。需要溶解这些类似物以增加它们在个人、口腔或家庭护理组合物中的用途。问题是寻找可以溶解这些类似物的材料。即便在某一类给定的材料中，也并不是该类材料中的所有成分都能有效溶解这些类似物。
发明简述
本发明提供一种含有溶解的厚朴酚类似物的组合物，所述组合物包含至少一种选自丙基厚朴酚、异丙基厚朴酚、丁基厚朴酚、异丁基厚朴酚的厚朴酚类似物和异山梨醇二甲醚。
本发明的其他应用领域将通过下文提供的详细描述而变得显而易见。但应当理解的是，虽然详细描述和具体实施例给出了本发明的优选实施方案，但它们仅用于举例说明的目的，而非用于限制本发明的范围。
发明详述
下面描述的优选实施方案仅仅用于示例说明，而决无意于限制本发明、其应用或用途。
本发明公开了含有溶解的厚朴酚类似物的组合物，所述组合物包含至少一种选自丙基厚朴酚、异丙基厚朴酚、丁基厚朴酚、异丁基厚朴酚的厚朴酚类似物和异山梨醇二甲醚。
丙基厚朴酚是5，5′-二正丙基联苯-2，2′-二酚，丁基厚朴酚是5，5′-二正丁基联苯-2，2′-二酚，异丙基厚朴酚是5，5′-二异丙基联苯-2，2′-二酚，异丁基厚朴酚是5，5′-二异丁基联苯-2，2′-二酚。
异山梨醇二甲醚能溶解最多每升200克纯的丙基厚朴酚或异丙基厚朴酚，或最多每升100克异丁基厚朴酚，或最多每升50克丁基厚朴酚。在某些实施方案中，所述组合物中异山梨醇二甲醚的量为丙基厚朴酚或异丙基厚朴酚重量的至少5倍。在某些实施方案中，所述组合物中异山梨醇二甲醚的量为异丁基厚朴酚重量的至少10倍。在某些实施方案中，所述组合物中异山梨醇二甲醚的量为丁基厚朴酚重量的至少20倍。
异山梨醇二甲醚可使用Croda的ArlasoveTM DMI。
异山梨醇二甲醚可以溶解这些类似物是令人感到意外的。很多其它增溶剂，例如PEG-7椰油酸甘油酯，泊洛沙姆124，PPG-2羟乙基椰油酰胺，PPG-5月桂醇聚醚-5(EumulginTMES)，PEG-8/SMDI共聚物，肉豆蔻酸异丙酯，或C12-15烷基苯甲酸酯不能够溶解异丁基厚朴酚。
在所述组合物中厚朴酚类似物的量可以是任意所需的量。在某些实施方案中，厚朴酚类似物的量为组合物的0.01至5重量％。在其它实施方案中，厚朴酚类似物的量为组合物的至少0.05、至少0.1、至少0.2、至少0.3、至少0.4、至少0.5或至少1重量％，最高可达5重量％。在其它实施方案中，厚朴酚类似物的量为组合物的前述最小量至最高达4、3、2、1重量％。异山梨醇二甲醚的重量为溶解所述类似物的量，异山梨醇二甲醚的最少用量基于所述类似物在异山梨醇二甲醚中的最大溶解度计。在某些实施方案中，厚朴酚类似物的量为0.1％重量，0.2％重量，0.3％重量，0.4％重量，或0.5％重量。
这些溶解的类似物可用于个人护理、口腔护理和家庭护理组合物中。个人护理组合物的例子包括但不限于，沐浴露/沐浴凝胶、液体洗手液、条皂、香波、调理剂、止汗剂/除臭剂和化妆品。口腔护理组合物的例子包括但不限于，洁齿剂、牙膏、牙粉、预防性糊剂、漱口液、锭剂、树胶、凝胶、涂料、糖果和假牙清洁剂。可包含所述溶解的厚朴酚类似物的口腔护理组合物的例子可参见WO2011/106492。家庭护理组合物的例子包括但不限于，洗盘洗洁精、洗盘糊剂、硬表面清洁剂、织物调理剂和洗衣剂。
在某些实施方案中，所述厚朴酚类似物可存在于沐浴露/沐浴凝胶、液体洗手液或香波中，其中这些组合物中的每一种包括表面活性剂。所述厚朴酚类似物还可包含在皂(脂肪酸皂)中，其可以是条皂的形状。
实施例
下面为可包括溶解的厚朴酚类似物的组合物的非限定性实施例。
液体清洁剂(沐浴露或洗手液)
皂条
口腔护理组合物
贯穿本发明整篇说明书和权利要求书所提及的范围用于描述在该范围内的每一个值。所述范围内的任意值可被选作该范围的端点。此外，本文引用的所有参考文献均通过全文引用结合到本文中。在本发明公开的定义和所引用的参考有冲突时，以本发明的公开为准。
除非另有说明，在本发明书中各处所表示的所有百分数和量应理解是指重量百分比。给出的量是基于物质的活性重量计。
Claims (7)
1.含有溶解的厚朴酚类似物的组合物，所述组合物包含：
至少一种选自丙基厚朴酚、异丙基厚朴酚和异丁基厚朴酚的厚朴酚类似物；和
异山梨醇二甲醚，
其中所述异山梨醇二甲醚的存在量为所述异丙基厚朴酚或丙基厚朴酚重量的至少5倍，所述异山梨醇二甲醚的存在量为所述异丁基厚朴酚重量的至少10倍。
2.权利要求1所述的组合物，其中所述厚朴酚类似物在所述组合物中的存在量为0.01%-5 %重量。
3.权利要求1-2中任一项所述的组合物，所述组合物进一步含有表面活性剂。
4.权利要求1-2中任一项所述的组合物，所述组合物进一步含有皂。
5.权利要求4所述的组合物，所述组合物是皂条的形式。
6.权利要求1-2中任一项所述的组合物，所述组合物是液体清洁剂的形式。
7.权利要求1-2中任一项所述的组合物，所述组合物是口腔护理组合物的形式。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2011/065016 WO2013089716A1 (en) | 2011-12-15 | 2011-12-15 | Solubilized magnolol analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104023699A CN104023699A (zh) | 2014-09-03 |
| CN104023699B true CN104023699B (zh) | 2016-10-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180075555.7A Expired - Fee Related CN104023699B (zh) | 2011-12-15 | 2011-12-15 | 溶解的厚朴酚类似物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20140341818A1 (zh) |
| EP (1) | EP2790650B1 (zh) |
| KR (1) | KR20140109380A (zh) |
| CN (1) | CN104023699B (zh) |
| AU (1) | AU2011383308B2 (zh) |
| BR (1) | BR112014014207B1 (zh) |
| CA (1) | CA2858032A1 (zh) |
| MX (1) | MX346800B (zh) |
| PH (1) | PH12014501265A1 (zh) |
| RU (1) | RU2014128838A (zh) |
| WO (1) | WO2013089716A1 (zh) |
| ZA (1) | ZA201404191B (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10517808B2 (en) | 2015-12-15 | 2019-12-31 | Tartarend, Llc | Oral care formulation and method for the removal of tartar and plaque from teeth |
| CN106581159B (zh) * | 2017-01-24 | 2020-05-12 | 广州薇美姿实业有限公司 | 一种儿童口腔护理组合物及一种益早益晚组合儿童牙膏 |
| CN107440926A (zh) * | 2017-07-05 | 2017-12-08 | 张严 | 一种油水共溶入肤和透皮溶剂及其应用 |
| FR3074423B1 (fr) * | 2017-12-01 | 2020-03-06 | Roquette Freres | Utilisation de dinahydrohexitol en hygiene bucco dentaire pour reduire le developpement de souches bacteriennes |
| CN111096932B (zh) * | 2018-10-29 | 2022-07-15 | 好维股份有限公司 | 一种口腔护理组合物 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011055139A2 (en) * | 2009-11-03 | 2011-05-12 | Syntopix Group Plc | Formulations |
| FR2953406A1 (fr) * | 2009-12-08 | 2011-06-10 | Oreal | Nouvelle composition cosmetique destinee a ameliorer la couleur de la peau et utilisation d'agents anti-glycation pour eclaircir la carnation d'un sujet |
| WO2011106492A1 (en) * | 2010-02-24 | 2011-09-01 | Colgate-Palmolive Company | Oral care compositions |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4514385A (en) * | 1981-10-05 | 1985-04-30 | Alcon Laboratories, Inc. | Anti-acne compositions |
| JPH0733649A (ja) * | 1993-07-19 | 1995-02-03 | Kanebo Ltd | 抗う蝕剤 |
| JP2719301B2 (ja) * | 1993-07-19 | 1998-02-25 | 鐘紡株式会社 | ニキビ治療及び予防剤 |
| AU5764800A (en) * | 1999-07-01 | 2001-01-22 | Johnson & Johnson Consumer Companies, Inc. | Cleansing compositions |
| DE60215148T2 (de) * | 2001-05-15 | 2007-08-16 | The Procter & Gamble Company, Cincinnati | Mundpflegezusammensetzungen |
| US20030194385A1 (en) * | 2002-01-29 | 2003-10-16 | Lila Gruber Research Foundation | Pharmaceutical formulations containing solubilized hydroquinone, salicylic acid and hydrocortisone for the treatment of melasma and related dermatological problems |
| US8071077B2 (en) * | 2004-12-29 | 2011-12-06 | Colgate-Palmolive Company | Oral compositions containing biphenol antibacterial compounds |
| US20080025926A1 (en) * | 2006-07-24 | 2008-01-31 | Dr. Nick's White & Healthy, Llc | Oral care formulations with hydrogen peroxide and lycopene |
| JP5746035B2 (ja) * | 2008-10-08 | 2015-07-08 | ダウ テクノロジー インベストメンツ リミティド ライアビリティー カンパニー | ビスホスファイトの合成のためのスラリープロセス |
| TWI459957B (zh) * | 2010-02-24 | 2014-11-11 | Colgate Palmolive Co | 口腔保健組成物 |
| DE102010015789A1 (de) * | 2010-04-20 | 2011-10-20 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen enthaltend Kombinationen aus Magnolienrindenextrakt und Alkylsulfaten |
-
2011
- 2011-12-15 KR KR1020147016046A patent/KR20140109380A/ko not_active Application Discontinuation
- 2011-12-15 CN CN201180075555.7A patent/CN104023699B/zh not_active Expired - Fee Related
- 2011-12-15 WO PCT/US2011/065016 patent/WO2013089716A1/en active Application Filing
- 2011-12-15 MX MX2014007139A patent/MX346800B/es active IP Right Grant
- 2011-12-15 AU AU2011383308A patent/AU2011383308B2/en not_active Ceased
- 2011-12-15 BR BR112014014207-6A patent/BR112014014207B1/pt not_active IP Right Cessation
- 2011-12-15 CA CA2858032A patent/CA2858032A1/en not_active Abandoned
- 2011-12-15 RU RU2014128838A patent/RU2014128838A/ru not_active Application Discontinuation
- 2011-12-15 US US14/362,885 patent/US20140341818A1/en not_active Abandoned
- 2011-12-15 EP EP11811220.0A patent/EP2790650B1/en active Active
-
2014
- 2014-06-05 PH PH12014501265A patent/PH12014501265A1/en unknown
- 2014-06-06 ZA ZA2014/04191A patent/ZA201404191B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011055139A2 (en) * | 2009-11-03 | 2011-05-12 | Syntopix Group Plc | Formulations |
| FR2953406A1 (fr) * | 2009-12-08 | 2011-06-10 | Oreal | Nouvelle composition cosmetique destinee a ameliorer la couleur de la peau et utilisation d'agents anti-glycation pour eclaircir la carnation d'un sujet |
| WO2011106492A1 (en) * | 2010-02-24 | 2011-09-01 | Colgate-Palmolive Company | Oral care compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014014207B1 (pt) | 2018-02-14 |
| EP2790650B1 (en) | 2017-05-24 |
| ZA201404191B (en) | 2016-10-26 |
| PH12014501265A1 (en) | 2014-09-15 |
| WO2013089716A1 (en) | 2013-06-20 |
| MX2014007139A (es) | 2014-09-04 |
| CN104023699A (zh) | 2014-09-03 |
| RU2014128838A (ru) | 2016-02-10 |
| KR20140109380A (ko) | 2014-09-15 |
| AU2011383308A1 (en) | 2014-05-22 |
| US20140341818A1 (en) | 2014-11-20 |
| EP2790650A1 (en) | 2014-10-22 |
| BR112014014207A2 (pt) | 2017-06-13 |
| CA2858032A1 (en) | 2013-06-20 |
| MX346800B (es) | 2017-03-31 |
| AU2011383308B2 (en) | 2015-07-02 |
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