CN104016902B - 沙格列汀的结晶形式 - Google Patents
沙格列汀的结晶形式 Download PDFInfo
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- CN104016902B CN104016902B CN201410283458.2A CN201410283458A CN104016902B CN 104016902 B CN104016902 B CN 104016902B CN 201410283458 A CN201410283458 A CN 201410283458A CN 104016902 B CN104016902 B CN 104016902B
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- saxagliptin
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- saxagliptin hydrochloride
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- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000005051 trimethylchlorosilane Substances 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16791809P | 2009-04-09 | 2009-04-09 | |
| EP09157723.9 | 2009-04-09 | ||
| US61/167,918 | 2009-04-09 | ||
| EP09157723 | 2009-04-09 | ||
| EP09175259.2 | 2009-11-06 | ||
| EP09175259 | 2009-11-06 | ||
| CN201080025360.7A CN102459170B (zh) | 2009-04-09 | 2010-04-09 | 沙格列汀的结晶形式 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201080025360.7A Division CN102459170B (zh) | 2009-04-09 | 2010-04-09 | 沙格列汀的结晶形式 |
Publications (2)
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|---|---|
| CN104016902A CN104016902A (zh) | 2014-09-03 |
| CN104016902B true CN104016902B (zh) | 2017-10-20 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| CN201080025360.7A Expired - Fee Related CN102459170B (zh) | 2009-04-09 | 2010-04-09 | 沙格列汀的结晶形式 |
| CN201410283458.2A Expired - Fee Related CN104016902B (zh) | 2009-04-09 | 2010-04-09 | 沙格列汀的结晶形式 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080025360.7A Expired - Fee Related CN102459170B (zh) | 2009-04-09 | 2010-04-09 | 沙格列汀的结晶形式 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20120088808A1 (enExample) |
| EP (1) | EP2417107B1 (enExample) |
| JP (2) | JP6088245B2 (enExample) |
| KR (1) | KR20120006047A (enExample) |
| CN (2) | CN102459170B (enExample) |
| AU (1) | AU2010233718B2 (enExample) |
| BR (1) | BRPI1006547A2 (enExample) |
| CA (1) | CA2757934C (enExample) |
| ES (1) | ES2548386T3 (enExample) |
| PL (1) | PL2417107T3 (enExample) |
| RU (1) | RU2539590C2 (enExample) |
| WO (1) | WO2010115974A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0487425A (ja) * | 1990-07-31 | 1992-03-19 | Fujitsu Ltd | 回線切り替え装置 |
| CA2757934C (en) * | 2009-04-09 | 2017-12-19 | Sandoz Ag | Crystal forms of saxagliptin |
| US20110313035A1 (en) * | 2009-12-16 | 2011-12-22 | Hetero Research Foundation | Polymorphs of darunavir |
| US8853430B2 (en) | 2010-05-20 | 2014-10-07 | Hetero Research Foundation | Crystalline hydrochloride salt of darunavir |
| US8410288B2 (en) | 2010-10-04 | 2013-04-02 | Teva Pharmaceutical Industries Ltd. | Polymorphs of Saxagliptin hydrochloride and processes for preparing them |
| US20140302150A1 (en) | 2011-09-07 | 2014-10-09 | Umit Cifter | Dpp-iv inhibitor formulations |
| EP2578208B1 (en) | 2011-10-06 | 2014-05-21 | Sanovel Ilac Sanayi ve Ticaret A.S. | DPP-IV inhibitor solid dosage formulations |
| WO2013136343A1 (en) | 2012-03-12 | 2013-09-19 | Mylan Laboratories Ltd. | Amorphous saxagliptin hydrochloride |
| US20150087686A1 (en) * | 2012-04-25 | 2015-03-26 | Enantia, S.L. | Crystalline forms of saxagliptin |
| CA2885957C (en) | 2012-05-24 | 2019-10-22 | Apotex Pharmachem India Pvt. Ltd | Salts of saxagliptin with organic acids |
| SG11201408619WA (en) | 2012-07-02 | 2015-01-29 | Ranbaxy Lab Ltd | Saxagliptin salts |
| WO2015067223A1 (en) | 2013-11-06 | 2015-05-14 | Zentiva, K., S. | L-tartrate salt of (1s,3s,5s)-2-[(2s)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl) acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile and process for preparation thereof |
| JP2022182181A (ja) * | 2021-05-27 | 2022-12-08 | キョーリンリメディオ株式会社 | ビルダグリプチン含有医薬品 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1213028C (zh) * | 2000-03-10 | 2005-08-03 | 布里斯托尔-迈尔斯斯奎布公司 | 基于环丙基稠合的吡咯烷二肽基肽酶iv抑制剂、它们的制备方法及用途 |
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| JPS6032616B2 (ja) * | 1976-08-24 | 1985-07-29 | アレクサンダ− ガラツト | 高い貯蔵安定性の無水アセチルサリチル酸ナトリウム |
| US7420079B2 (en) * | 2002-12-09 | 2008-09-02 | Bristol-Myers Squibb Company | Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof |
| US6995183B2 (en) * | 2003-08-01 | 2006-02-07 | Bristol Myers Squibb Company | Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods |
| TWI415635B (zh) * | 2004-05-28 | 2013-11-21 | 必治妥施貴寶公司 | 加衣錠片調製物及製備彼之方法 |
| MX2007000625A (es) * | 2004-07-16 | 2007-03-07 | Warner Lambert Co | Agentes activadores del crecimiento capilar. |
| US20060035954A1 (en) * | 2004-08-11 | 2006-02-16 | Sharma Padam N | Ammonolysis process for the preparation of intermediates for DPP IV inhibitors |
| PE20090696A1 (es) * | 2007-04-20 | 2009-06-20 | Bristol Myers Squibb Co | Formas cristalinas de saxagliptina y procesos para preparar las mismas |
| CA2757934C (en) * | 2009-04-09 | 2017-12-19 | Sandoz Ag | Crystal forms of saxagliptin |
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2010
- 2010-04-09 CA CA2757934A patent/CA2757934C/en not_active Expired - Fee Related
- 2010-04-09 US US13/262,652 patent/US20120088808A1/en not_active Abandoned
- 2010-04-09 AU AU2010233718A patent/AU2010233718B2/en not_active Ceased
- 2010-04-09 RU RU2011145054/04A patent/RU2539590C2/ru not_active IP Right Cessation
- 2010-04-09 WO PCT/EP2010/054692 patent/WO2010115974A1/en not_active Ceased
- 2010-04-09 KR KR1020117026595A patent/KR20120006047A/ko not_active Abandoned
- 2010-04-09 BR BRPI1006547A patent/BRPI1006547A2/pt not_active Application Discontinuation
- 2010-04-09 CN CN201080025360.7A patent/CN102459170B/zh not_active Expired - Fee Related
- 2010-04-09 EP EP10713211.0A patent/EP2417107B1/en not_active Not-in-force
- 2010-04-09 PL PL10713211T patent/PL2417107T3/pl unknown
- 2010-04-09 ES ES10713211.0T patent/ES2548386T3/es active Active
- 2010-04-09 JP JP2012504028A patent/JP6088245B2/ja not_active Expired - Fee Related
- 2010-04-09 CN CN201410283458.2A patent/CN104016902B/zh not_active Expired - Fee Related
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2013
- 2013-10-02 US US14/044,204 patent/US9260389B2/en active Active
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2015
- 2015-07-16 JP JP2015141890A patent/JP2016006063A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1213028C (zh) * | 2000-03-10 | 2005-08-03 | 布里斯托尔-迈尔斯斯奎布公司 | 基于环丙基稠合的吡咯烷二肽基肽酶iv抑制剂、它们的制备方法及用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102459170B (zh) | 2014-07-23 |
| BRPI1006547A2 (pt) | 2016-10-18 |
| RU2011145054A (ru) | 2013-05-20 |
| EP2417107A1 (en) | 2012-02-15 |
| WO2010115974A1 (en) | 2010-10-14 |
| EP2417107B1 (en) | 2015-08-26 |
| JP2012523395A (ja) | 2012-10-04 |
| RU2539590C2 (ru) | 2015-01-20 |
| JP2016006063A (ja) | 2016-01-14 |
| CN104016902A (zh) | 2014-09-03 |
| US20120088808A1 (en) | 2012-04-12 |
| US9260389B2 (en) | 2016-02-16 |
| US20140200252A1 (en) | 2014-07-17 |
| ES2548386T3 (es) | 2015-10-16 |
| JP6088245B2 (ja) | 2017-03-01 |
| CA2757934C (en) | 2017-12-19 |
| AU2010233718B2 (en) | 2015-11-05 |
| AU2010233718A1 (en) | 2011-10-27 |
| PL2417107T3 (pl) | 2016-02-29 |
| CA2757934A1 (en) | 2010-10-14 |
| CN102459170A (zh) | 2012-05-16 |
| KR20120006047A (ko) | 2012-01-17 |
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