CN103998470A - 运铁蛋白-肿瘤抑素融合蛋白质及其生成和使用方法 - Google Patents

运铁蛋白-肿瘤抑素融合蛋白质及其生成和使用方法 Download PDF

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Publication number
CN103998470A
CN103998470A CN201280051256.4A CN201280051256A CN103998470A CN 103998470 A CN103998470 A CN 103998470A CN 201280051256 A CN201280051256 A CN 201280051256A CN 103998470 A CN103998470 A CN 103998470A
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CN
China
Prior art keywords
transferrin
tumorstatin
protein
recombinant
recombinant protein
Prior art date
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Pending
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CN201280051256.4A
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English (en)
Chinese (zh)
Inventor
U·B·科姆佩拉
R·I·沙因曼
P·泰亚吉
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University of Colorado Denver
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University of Colorado Denver
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Application filed by University of Colorado Denver filed Critical University of Colorado Denver
Priority to CN201910156923.9A priority Critical patent/CN110105453A/zh
Publication of CN103998470A publication Critical patent/CN103998470A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201280051256.4A 2011-08-17 2012-08-15 运铁蛋白-肿瘤抑素融合蛋白质及其生成和使用方法 Pending CN103998470A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910156923.9A CN110105453A (zh) 2011-08-17 2012-08-15 运铁蛋白-肿瘤抑素融合蛋白质及其生成和使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161524508P 2011-08-17 2011-08-17
US61/524,508 2011-08-17
PCT/US2012/051013 WO2013025846A2 (en) 2011-08-17 2012-08-15 Transferrin-tumstatin fusion protein and methods for producing and using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201910156923.9A Division CN110105453A (zh) 2011-08-17 2012-08-15 运铁蛋白-肿瘤抑素融合蛋白质及其生成和使用方法

Publications (1)

Publication Number Publication Date
CN103998470A true CN103998470A (zh) 2014-08-20

Family

ID=47715692

Family Applications (2)

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CN201280051256.4A Pending CN103998470A (zh) 2011-08-17 2012-08-15 运铁蛋白-肿瘤抑素融合蛋白质及其生成和使用方法
CN201910156923.9A Pending CN110105453A (zh) 2011-08-17 2012-08-15 运铁蛋白-肿瘤抑素融合蛋白质及其生成和使用方法

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Country Status (15)

Country Link
US (1) US9290562B2 (cg-RX-API-DMAC7.html)
EP (1) EP2744831B1 (cg-RX-API-DMAC7.html)
JP (1) JP6073888B2 (cg-RX-API-DMAC7.html)
CN (2) CN103998470A (cg-RX-API-DMAC7.html)
AU (1) AU2012296588B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014008680A2 (cg-RX-API-DMAC7.html)
CA (1) CA2849015C (cg-RX-API-DMAC7.html)
DK (1) DK2744831T3 (cg-RX-API-DMAC7.html)
ES (1) ES2659161T3 (cg-RX-API-DMAC7.html)
NO (1) NO2820418T3 (cg-RX-API-DMAC7.html)
PL (1) PL2744831T3 (cg-RX-API-DMAC7.html)
PT (1) PT2744831T (cg-RX-API-DMAC7.html)
SI (1) SI2744831T1 (cg-RX-API-DMAC7.html)
TR (1) TR201802686T4 (cg-RX-API-DMAC7.html)
WO (1) WO2013025846A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109053899A (zh) * 2017-12-22 2018-12-21 湖南远泰生物技术有限公司 一种含人转铁蛋白抗原表位序列的嵌合体抗原受体

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014180288A1 (zh) * 2013-05-06 2014-11-13 中国药科大学 具有抑制肿瘤微环境血管再生和激活适应性免疫应答双功能的融合蛋白及其基因和应用
WO2014203182A1 (en) * 2013-06-20 2014-12-24 Novartis Ag Use of a vegf antagonist in treating choroidal neovascularisation
US11058750B2 (en) 2015-12-03 2021-07-13 Mor Research Applications Ltd. Compositions and methods for treatment of ocular diseases
KR101818151B1 (ko) 2016-03-25 2018-01-16 한국과학기술원 트렌스페린을 포함하는 허혈성망막병증 예방 및 치료용 조성물

Citations (1)

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US20060172941A1 (en) * 2004-10-14 2006-08-03 Luca Rastelli Anti-angiogenic peptides and methods of use thereof

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US5672683A (en) 1989-09-07 1997-09-30 Alkermes, Inc. Transferrin neuropharmaceutical agent fusion protein
US20050192242A1 (en) 1995-10-11 2005-09-01 Neal Zane C. Therapeutic fusion protein transgenes
CA2331332A1 (en) * 1998-06-17 1999-12-23 Raghuram Kalluri Anti-angiogenic proteins and methods of use thereof
JP2003517847A (ja) 1999-12-23 2003-06-03 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド トランスフェリンポリヌクレオチド、ポリペプチド、および抗体
WO2003020746A1 (en) 2001-08-30 2003-03-13 Biorexis Pharmaceutical Corporation Modified transferrin fusion proteins
US8129504B2 (en) * 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
NZ534310A (en) * 2002-02-07 2008-03-28 Novozymes Delta Ltd Albumin-fused anti-angiogenesis peptides
EP1670428A4 (en) 2003-10-10 2008-03-12 Univ Southern California HYBRID PROTEINS G-CSF-TRANSFERRIN
EP1722762A2 (en) * 2004-03-02 2006-11-22 Massachusetts Institute of Technology Nanocell drug delivery system
WO2006049983A2 (en) 2004-10-27 2006-05-11 Biorexis Pharmaceutical Corporation Peptide yy modified transferrin fusion proteins
WO2006119128A2 (en) * 2005-04-29 2006-11-09 Research Development Foundation Vascular targeting of ocular neovascularization
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CN101092452A (zh) * 2007-05-23 2007-12-26 哈尔滨医科大学 肿瘤抑素抗血管生成小分子多肽、融合蛋白及两者制备方法
WO2009086132A2 (en) * 2007-12-20 2009-07-09 University Of Southern California Design of spacers to increase the expression of recombinant fusion proteins
JP6101638B2 (ja) 2011-03-03 2017-03-22 ザイムワークス，インコーポレイテッド 多価ヘテロマルチマー足場設計及び構築物

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CHOWERS ITAY等: "The iron carrier transferring is upregulated in retinas from patients with age-related macular degeneration", 《INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE》, vol. 47, no. 5, 1 May 2006 (2006-05-01), pages 2135 - 2140 *
FARJO, KRYSTEN .M等: "The potential of nanomedicine therapies to treat neovascular disease in the retina,art21", 《J ANGIOGENES RES》, vol. 2, 31 October 2010 (2010-10-31), pages 1 - 14 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109053899A (zh) * 2017-12-22 2018-12-21 湖南远泰生物技术有限公司 一种含人转铁蛋白抗原表位序列的嵌合体抗原受体
CN109053899B (zh) * 2017-12-22 2021-11-16 湖南远泰生物技术有限公司 一种含人转铁蛋白抗原表位序列的嵌合体抗原受体

Also Published As

Publication number Publication date
WO2013025846A2 (en) 2013-02-21
TR201802686T4 (tr) 2018-03-21
JP2014526890A (ja) 2014-10-09
CA2849015C (en) 2017-08-08
NO2820418T3 (cg-RX-API-DMAC7.html) 2018-05-05
EP2744831A2 (en) 2014-06-25
PL2744831T3 (pl) 2018-05-30
JP6073888B2 (ja) 2017-02-01
SI2744831T1 (en) 2018-04-30
US9290562B2 (en) 2016-03-22
PT2744831T (pt) 2018-03-05
DK2744831T3 (en) 2018-03-05
US20140179612A1 (en) 2014-06-26
AU2012296588B2 (en) 2017-07-27
AU2012296588A1 (en) 2014-04-03
CA2849015A1 (en) 2013-02-21
EP2744831A4 (en) 2015-03-11
EP2744831B1 (en) 2017-12-06
BR112014008680A2 (pt) 2017-06-13
ES2659161T3 (es) 2018-03-14
CN110105453A (zh) 2019-08-09
WO2013025846A3 (en) 2013-05-02

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Application publication date: 20140820