BR112014008680A2 - proteína de fusão de transferrina-tumstatina e métodos para produzir e usar a mesma - Google Patents
proteína de fusão de transferrina-tumstatina e métodos para produzir e usar a mesmaInfo
- Publication number
- BR112014008680A2 BR112014008680A2 BR112014008680A BR112014008680A BR112014008680A2 BR 112014008680 A2 BR112014008680 A2 BR 112014008680A2 BR 112014008680 A BR112014008680 A BR 112014008680A BR 112014008680 A BR112014008680 A BR 112014008680A BR 112014008680 A2 BR112014008680 A2 BR 112014008680A2
- Authority
- BR
- Brazil
- Prior art keywords
- producing
- methods
- transferrin
- same
- tumstatin
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 2
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 4
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 4
- 102100033780 Collagen alpha-3(IV) chain Human genes 0.000 abstract 2
- 102000004338 Transferrin Human genes 0.000 abstract 2
- 108090000901 Transferrin Proteins 0.000 abstract 2
- 239000013612 plasmid Substances 0.000 abstract 2
- 239000012581 transferrin Substances 0.000 abstract 2
- 108010012374 type IV collagen alpha3 chain Proteins 0.000 abstract 2
- 102000008076 Angiogenic Proteins Human genes 0.000 abstract 1
- 108010074415 Angiogenic Proteins Proteins 0.000 abstract 1
- 230000001772 anti-angiogenic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
abstract: the present invention provides recombinant proteins comprising transferrin that is linked to tumstatin or other antiangiogenic protein and methods for producing and using the same. the present invention also provides an expression system, a plasmid, and a cell that is capable of expressing such recombinant proteins and methods for producing and using the same. tradução do resumo resumo patente de invenção: "proteína de fusão de transferrina-tumstatina e métodos para produzir e usar a mesma". a presente invenção provê proteínas recombinantes com-preendendo transferrina que é ligada à tumstatina ou outra proteína angiogênica, e métodos para produzir e usar a mesma. a presente in-venção também provê um sistema de expressão, um plasmídeo, e uma célula que é capaz de expressar tais proteínas recombinantes e métodos para produzir e usar as mesmas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161524508P | 2011-08-17 | 2011-08-17 | |
| PCT/US2012/051013 WO2013025846A2 (en) | 2011-08-17 | 2012-08-15 | Transferrin-tumstatin fusion protein and methods for producing and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014008680A2 true BR112014008680A2 (pt) | 2017-06-13 |
Family
ID=47715692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014008680A BR112014008680A2 (pt) | 2011-08-17 | 2012-08-15 | proteína de fusão de transferrina-tumstatina e métodos para produzir e usar a mesma |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9290562B2 (pt) |
| EP (1) | EP2744831B1 (pt) |
| JP (1) | JP6073888B2 (pt) |
| CN (2) | CN103998470A (pt) |
| AU (1) | AU2012296588B2 (pt) |
| BR (1) | BR112014008680A2 (pt) |
| CA (1) | CA2849015C (pt) |
| DK (1) | DK2744831T3 (pt) |
| ES (1) | ES2659161T3 (pt) |
| NO (1) | NO2820418T3 (pt) |
| PL (1) | PL2744831T3 (pt) |
| PT (1) | PT2744831T (pt) |
| SI (1) | SI2744831T1 (pt) |
| TR (1) | TR201802686T4 (pt) |
| WO (1) | WO2013025846A2 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2995626T3 (en) * | 2013-05-06 | 2018-10-29 | Univ China Pharma | BIFUNCTIONAL FUSION PROTEINS TO INHIBIT ANGIOGENESIS IN TUMOR ENVIRONMENTS AND ACTIVATE ADAPTIVE IMMUNE RESPONSE, AND THE GENES AND APPLICATIONS THEREOF |
| EP3010525A1 (en) * | 2013-06-20 | 2016-04-27 | Novartis AG | Use of a vegf antagonist in treating choroidal neovascularisation |
| US11058750B2 (en) | 2015-12-03 | 2021-07-13 | Mor Research Applications Ltd. | Compositions and methods for treatment of ocular diseases |
| KR101818151B1 (ko) | 2016-03-25 | 2018-01-16 | 한국과학기술원 | 트렌스페린을 포함하는 허혈성망막병증 예방 및 치료용 조성물 |
| CN109053899B (zh) * | 2017-12-22 | 2021-11-16 | 湖南远泰生物技术有限公司 | 一种含人转铁蛋白抗原表位序列的嵌合体抗原受体 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5672683A (en) | 1989-09-07 | 1997-09-30 | Alkermes, Inc. | Transferrin neuropharmaceutical agent fusion protein |
| US20050192242A1 (en) | 1995-10-11 | 2005-09-01 | Neal Zane C. | Therapeutic fusion protein transgenes |
| CN1309663A (zh) * | 1998-06-17 | 2001-08-22 | 贝斯以色列护理医疗中心 | 抗血管生成蛋白及其应用 |
| AU3075801A (en) | 1999-12-23 | 2001-07-03 | Human Genome Sciences, Inc. | Transferrin polynucleotides, polypeptides, and antibodies |
| US8129504B2 (en) * | 2001-08-30 | 2012-03-06 | Biorexis Technology, Inc. | Oral delivery of modified transferrin fusion proteins |
| ATE490969T1 (de) | 2001-08-30 | 2010-12-15 | Biorexis Pharmaceutical Corp | Modifizierte transferrin-fusionsproteine |
| EP2277910A1 (en) | 2001-12-21 | 2011-01-26 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| KR20110014661A (ko) * | 2002-02-07 | 2011-02-11 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민-융합 쿠니츠 도메인 펩타이드 |
| US8188032B2 (en) | 2003-10-10 | 2012-05-29 | National Institutes Of Health (Nih) | G-CSF transferrin fusion proteins |
| CN101031287A (zh) * | 2004-03-02 | 2007-09-05 | 麻省理工学院 | 纳米细胞药物递送系统 |
| EP1812030A4 (en) * | 2004-10-14 | 2009-01-14 | Sopherion Therapeutics Inc | ANTI-ANGIOGENIC PEPTIDES AND METHODS OF USE THEREOF |
| WO2006049983A2 (en) | 2004-10-27 | 2006-05-11 | Biorexis Pharmaceutical Corporation | Peptide yy modified transferrin fusion proteins |
| JP2008540342A (ja) * | 2005-04-29 | 2008-11-20 | リサーチ ディベロップメント ファウンデーション | 眼の新生血管形成の血管標的化 |
| ATE551067T1 (de) | 2006-02-03 | 2012-04-15 | Crc For Asthma And Airways Ltd | Tumstatin zur behandlung von erkrankungen die mit der neumodellierung von atemwegsgewebe zusammenhängen |
| CN101070349B (zh) * | 2007-05-22 | 2010-10-13 | 山西康宝生物制品股份有限公司 | 具有选择性杀伤肿瘤新生血管内皮细胞作用的融合蛋白与应用 |
| CN101092452A (zh) * | 2007-05-23 | 2007-12-26 | 哈尔滨医科大学 | 肿瘤抑素抗血管生成小分子多肽、融合蛋白及两者制备方法 |
| US7943733B2 (en) * | 2007-12-20 | 2011-05-17 | University Of Southern California | Spacers to increase the expression of recombinant fusion proteins |
| AU2012222833B2 (en) | 2011-03-03 | 2017-03-16 | Zymeworks Inc. | Multivalent heteromultimer scaffold design and constructs |
-
2012
- 2012-08-15 TR TR2018/02686T patent/TR201802686T4/tr unknown
- 2012-08-15 BR BR112014008680A patent/BR112014008680A2/pt unknown
- 2012-08-15 JP JP2014526189A patent/JP6073888B2/ja active Active
- 2012-08-15 DK DK12824616.2T patent/DK2744831T3/en active
- 2012-08-15 EP EP12824616.2A patent/EP2744831B1/en active Active
- 2012-08-15 PT PT128246162T patent/PT2744831T/pt unknown
- 2012-08-15 WO PCT/US2012/051013 patent/WO2013025846A2/en active Application Filing
- 2012-08-15 AU AU2012296588A patent/AU2012296588B2/en active Active
- 2012-08-15 SI SI201231232T patent/SI2744831T1/en unknown
- 2012-08-15 CN CN201280051256.4A patent/CN103998470A/zh active Pending
- 2012-08-15 PL PL12824616T patent/PL2744831T3/pl unknown
- 2012-08-15 CN CN201910156923.9A patent/CN110105453A/zh active Pending
- 2012-08-15 CA CA2849015A patent/CA2849015C/en active Active
- 2012-08-15 US US14/239,176 patent/US9290562B2/en active Active
- 2012-08-15 ES ES12824616.2T patent/ES2659161T3/es active Active
-
2013
- 2013-07-22 NO NO13745268A patent/NO2820418T3/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2744831T (pt) | 2018-03-05 |
| WO2013025846A2 (en) | 2013-02-21 |
| NO2820418T3 (pt) | 2018-05-05 |
| CN110105453A (zh) | 2019-08-09 |
| EP2744831A4 (en) | 2015-03-11 |
| CA2849015A1 (en) | 2013-02-21 |
| EP2744831A2 (en) | 2014-06-25 |
| WO2013025846A3 (en) | 2013-05-02 |
| AU2012296588B2 (en) | 2017-07-27 |
| US9290562B2 (en) | 2016-03-22 |
| PL2744831T3 (pl) | 2018-05-30 |
| EP2744831B1 (en) | 2017-12-06 |
| US20140179612A1 (en) | 2014-06-26 |
| TR201802686T4 (tr) | 2018-03-21 |
| CA2849015C (en) | 2017-08-08 |
| JP2014526890A (ja) | 2014-10-09 |
| DK2744831T3 (en) | 2018-03-05 |
| ES2659161T3 (es) | 2018-03-14 |
| JP6073888B2 (ja) | 2017-02-01 |
| SI2744831T1 (en) | 2018-04-30 |
| CN103998470A (zh) | 2014-08-20 |
| AU2012296588A1 (en) | 2014-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B12F | Appeal: other appeals |