CN103989618A - 用于治疗牙龈炎的牙膏及其制备方法 - Google Patents
用于治疗牙龈炎的牙膏及其制备方法 Download PDFInfo
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- CN103989618A CN103989618A CN201410201583.4A CN201410201583A CN103989618A CN 103989618 A CN103989618 A CN 103989618A CN 201410201583 A CN201410201583 A CN 201410201583A CN 103989618 A CN103989618 A CN 103989618A
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Abstract
Description
组别 | n | 治愈率 | 好转率 | 无效率 | 总有效率 |
治疗1组 | 100 | 53(53.0%) | 36(36.0%) | 11(11.0%) | 89(89.0%) |
治疗2组 | 100 | 65(65.0%) | 31(31.0%) | 4(4.0%) | 96(96.0%) |
对照组 | 100 | 25(25.0%) | 35(35.0%) | 40(40.0%) | 40(40.0%) |
组别 | 红肿、疼痛消失天数 | 牙龈停止出血天数 |
治疗1组 | 7.2±0.9 | 6.5±0.7 |
5.8±0.6 | 4.9±0.8 | |
对照组 | 11.9±1.3 | 12.7±2.1 |
Claims (10)
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106063776A (zh) * | 2016-05-31 | 2016-11-02 | 安徽皖斛堂生物科技有限公司 | 一种铁皮石斛牙膏及其制备方法 |
CN106265384A (zh) * | 2016-10-14 | 2017-01-04 | 柳州环山科技有限公司 | 一种孕妇用漱口水及其制备方法 |
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CN107875048A (zh) * | 2017-06-21 | 2018-04-06 | 苏州雅致堂草本科技有限公司 | 一种用于治疗牙龈炎牙周炎纯中药配方牙膏及其制备方法 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101690706A (zh) * | 2009-09-22 | 2010-04-07 | 河南省济源市济世药业有限公司 | 一种中药牙膏及其制备方法 |
CN103156984A (zh) * | 2013-04-03 | 2013-06-19 | 刘冰甜 | 用于治疗牙龈炎的中药组合物及其制备方法 |
CN103536451A (zh) * | 2013-11-01 | 2014-01-29 | 广州市倩采化妆品有限公司 | 一种中药牙膏及其制备方法 |
CN104127363A (zh) * | 2014-08-08 | 2014-11-05 | 侨健新能源科技(苏州)有限公司 | 一种消炎去肿杀菌成人牙膏 |
-
2014
- 2014-05-13 CN CN201410201583.4A patent/CN103989618B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101690706A (zh) * | 2009-09-22 | 2010-04-07 | 河南省济源市济世药业有限公司 | 一种中药牙膏及其制备方法 |
CN103156984A (zh) * | 2013-04-03 | 2013-06-19 | 刘冰甜 | 用于治疗牙龈炎的中药组合物及其制备方法 |
CN103536451A (zh) * | 2013-11-01 | 2014-01-29 | 广州市倩采化妆品有限公司 | 一种中药牙膏及其制备方法 |
CN104127363A (zh) * | 2014-08-08 | 2014-11-05 | 侨健新能源科技(苏州)有限公司 | 一种消炎去肿杀菌成人牙膏 |
Cited By (6)
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---|---|---|---|---|
CN106063776A (zh) * | 2016-05-31 | 2016-11-02 | 安徽皖斛堂生物科技有限公司 | 一种铁皮石斛牙膏及其制备方法 |
CN106333900A (zh) * | 2016-10-13 | 2017-01-18 | 常州创索新材料科技有限公司 | 一种利用褐藻胶制备抗菌消炎牙膏的方法 |
CN106265384A (zh) * | 2016-10-14 | 2017-01-04 | 柳州环山科技有限公司 | 一种孕妇用漱口水及其制备方法 |
CN107875048A (zh) * | 2017-06-21 | 2018-04-06 | 苏州雅致堂草本科技有限公司 | 一种用于治疗牙龈炎牙周炎纯中药配方牙膏及其制备方法 |
CN107320390A (zh) * | 2017-08-09 | 2017-11-07 | 何家平 | 一种含有中草药的牙膏 |
WO2021060962A1 (ru) * | 2019-09-26 | 2021-04-01 | Зайнулла Фаритович ИБРАГИМОВ | Лечебно-профилактическая композиция для стоматологии |
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