CN103957910A - 增加先天免疫反应的化合物和方法 - Google Patents

增加先天免疫反应的化合物和方法 Download PDF

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Publication number
CN103957910A
CN103957910A CN201280051347.8A CN201280051347A CN103957910A CN 103957910 A CN103957910 A CN 103957910A CN 201280051347 A CN201280051347 A CN 201280051347A CN 103957910 A CN103957910 A CN 103957910A
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CN
China
Prior art keywords
trifluoromethyl
hydrogen
imidazo
methyl
naphthyridin
Prior art date
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Pending
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CN201280051347.8A
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English (en)
Chinese (zh)
Inventor
A.L.班卡
J.博特延什基
E.G.伯勒斯
J.G.卡塔拉诺
W.H.切尔恩
H.D.迪克森
M.J.加特兰德
R.哈马泰克
H.霍夫兰德
J.D.凯彻尔
C.B.摩尔
J.B.肖特维尔
M.D.塔兰特
J-P.瑟里恩
S.尤
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GlaxoSmithKline China Investment Co Ltd
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GlaxoSmithKline China Investment Co Ltd
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Application filed by GlaxoSmithKline China Investment Co Ltd filed Critical GlaxoSmithKline China Investment Co Ltd
Publication of CN103957910A publication Critical patent/CN103957910A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN201280051347.8A 2011-10-21 2012-10-19 增加先天免疫反应的化合物和方法 Pending CN103957910A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161549784P 2011-10-21 2011-10-21
US61/549784 2011-10-21
US201261692431P 2012-08-23 2012-08-23
US61/692431 2012-08-23
PCT/US2012/060971 WO2013059559A2 (en) 2011-10-21 2012-10-19 Compounds and methods for enhancing innate immune responses

Publications (1)

Publication Number Publication Date
CN103957910A true CN103957910A (zh) 2014-07-30

Family

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CN201280051347.8A Pending CN103957910A (zh) 2011-10-21 2012-10-19 增加先天免疫反应的化合物和方法

Country Status (23)

Country Link
US (1) US20140249143A1 (enExample)
EP (1) EP2768506A4 (enExample)
JP (1) JP2014532626A (enExample)
KR (1) KR20140094559A (enExample)
CN (1) CN103957910A (enExample)
AR (1) AR088793A1 (enExample)
AU (1) AU2012325971B2 (enExample)
BR (1) BR112014008727A2 (enExample)
CA (1) CA2851801A1 (enExample)
CL (1) CL2014001016A1 (enExample)
CO (1) CO6910198A2 (enExample)
CR (1) CR20140175A (enExample)
DO (1) DOP2014000081A (enExample)
EA (1) EA201490610A1 (enExample)
IL (1) IL231894A0 (enExample)
MX (1) MX2014004814A (enExample)
PE (1) PE20141359A1 (enExample)
PH (1) PH12014500865A1 (enExample)
SG (2) SG11201400988SA (enExample)
TW (2) TW201542567A (enExample)
UY (1) UY34406A (enExample)
WO (1) WO2013059559A2 (enExample)
ZA (1) ZA201402392B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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CN104529893A (zh) * 2014-12-30 2015-04-22 中国科学技术大学 一类可以作为高尔基体细胞器探针的新型喹啉染料
CN105175277A (zh) * 2015-05-18 2015-12-23 中山大学肿瘤防治中心 一种3-磷酸甘油醛脱氢酶的抑制剂及其制备方法和应用

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CN103333168B (zh) * 2013-07-23 2015-08-05 清华大学 一种酰胺类化合物及其制备方法与应用
US9758518B2 (en) 2015-03-04 2017-09-12 Pimera, Inc. Compositions, uses and methods for making them
EP3200778A4 (en) * 2014-09-29 2018-05-23 The Trustees Of The University Of Pennsylvania Antivirals against molluscum contagiosum virus
WO2018043747A1 (ja) * 2016-09-05 2018-03-08 国立大学法人京都大学 抗ｂ型肝炎ウイルス剤
CN110709400A (zh) 2017-03-28 2020-01-17 皮梅拉股份有限公司 Pol1抑制剂的新型晶体形式
EP3870581B1 (en) 2018-10-23 2023-06-14 Basf Se Tricyclic pesticidal compounds
CN114681472B (zh) * 2019-03-13 2023-06-30 中国人民解放军军事科学院军事医学研究院 氨基葡萄糖及其衍生物作为抗病毒药物的应用
KR20230002396A (ko) 2020-04-14 2023-01-05 바스프 에스이 트리시클릭 살충 화합물
WO2022049521A1 (en) * 2020-09-03 2022-03-10 Glaxosmithkline Intellectual Property Development Limited Imidazonaphthyridines and imidazopyridopyrimidines as ifnar2 agonists for treating sars-cov-2 infections
WO2022175425A1 (en) 2021-02-22 2022-08-25 Glaxosmithkline Intellectual Property Development Limited Inhaled mtor kinase inhibitors for use in the treatment or the prevention of a respiratory rna virus infection
US12030883B2 (en) 2021-09-21 2024-07-09 Incyte Corporation Hetero-tricyclic compounds as inhibitors of KRAS
CA3234375A1 (en) 2021-10-01 2023-04-06 Incyte Corporation Pyrazoloquinoline kras inhibitors
PE20242113A1 (es) 2021-10-14 2024-10-28 Incyte Corp Compuestos de quinolina como inhibidores de kras
WO2023244672A1 (en) 2022-06-14 2023-12-21 Assembly Biosciences, Inc. 2-(imidazo[1, 2-a]1,8-naphthyridin-8-yl)-1,3,4-oxadiazole derivatives as enhancers of innate immune response for the treatment of viral infections
CN120916763A (zh) * 2023-04-14 2025-11-07 人福医药美国公司 用于治疗疼痛和相关医学病症的单酰甘油脂肪酶（magl）抑制剂
WO2025089372A1 (ja) * 2023-10-26 2025-05-01 国立研究開発法人理化学研究所 イソインドリン誘導体
WO2025128898A1 (en) 2023-12-13 2025-06-19 Assembly Biosciences, Inc. Imidazo[1,2-a][1,8]naphthyridine derivatives as enhancers of innate immune response for the treatment of viral infections

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CN1320126A (zh) * 1998-07-28 2001-10-31 3M创新有限公司 噁唑并、噻唑并和硒唑并[4,5－c]喹啉－4－胺及其类似物
US20050159385A1 (en) * 2003-12-19 2005-07-21 Mohapatra Shyam S. JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection
CN1646529A (zh) * 2002-04-03 2005-07-27 霍夫曼-拉罗奇有限公司 咪唑并稠合化合物
WO2010113416A1 (ja) * 2009-03-31 2010-10-07 ダイキン工業株式会社 高分子アクチュエータ素子用電極膜及びそれを有する高分子アクチュエータ素子

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IL59104A (en) * 1979-02-09 1984-02-29 Roussel Uclaf Heterotricyclic derivatives,process for their preparation and pharmaceutical compositions incorporating them
US4492697A (en) * 1983-08-16 1985-01-08 Ayerst, Mckenna & Harrison, Inc. 4H-Imidazo[2,3-c]pyrido[2,3-e][1,4]oxazine derivatives
DE102005019181A1 (de) * 2005-04-25 2006-10-26 Novartis Ag Peptid-Deformylase (PDF) Inhibitoren 1
CL2009001884A1 (es) * 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
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GB201002409D0 (en) * 2010-02-12 2010-03-31 Univ Nottingham Methods

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WO2010113416A1 (ja) * 2009-03-31 2010-10-07 ダイキン工業株式会社 高分子アクチュエータ素子用電極膜及びそれを有する高分子アクチュエータ素子

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104529893A (zh) * 2014-12-30 2015-04-22 中国科学技术大学 一类可以作为高尔基体细胞器探针的新型喹啉染料
CN104529893B (zh) * 2014-12-30 2016-08-24 中国科学技术大学 一类可以作为高尔基体细胞器探针的喹啉染料
CN105175277A (zh) * 2015-05-18 2015-12-23 中山大学肿瘤防治中心 一种3-磷酸甘油醛脱氢酶的抑制剂及其制备方法和应用
CN105175277B (zh) * 2015-05-18 2018-04-03 中山大学肿瘤防治中心 一种3‑磷酸甘油醛脱氢酶的抑制剂及其制备方法和应用

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Publication number Publication date
TW201333003A (zh) 2013-08-16
AR088793A1 (es) 2014-07-10
CA2851801A1 (en) 2013-04-25
DOP2014000081A (es) 2014-07-15
PE20141359A1 (es) 2014-10-13
EP2768506A4 (en) 2015-08-19
BR112014008727A2 (pt) 2017-04-25
KR20140094559A (ko) 2014-07-30
SG10201505664WA (en) 2015-09-29
JP2014532626A (ja) 2014-12-08
EP2768506A2 (en) 2014-08-27
ZA201402392B (en) 2017-09-27
CO6910198A2 (es) 2014-03-31
IL231894A0 (en) 2014-05-28
PH12014500865A1 (en) 2014-05-26
MX2014004814A (es) 2014-05-27
AU2012325971A1 (en) 2014-04-17
CL2014001016A1 (es) 2015-01-16
US20140249143A1 (en) 2014-09-04
EA201490610A1 (ru) 2014-09-30
AU2012325971B2 (en) 2016-03-31
TW201542567A (zh) 2015-11-16
CR20140175A (es) 2014-06-03
WO2013059559A3 (en) 2013-11-14
SG11201400988SA (en) 2014-07-30
WO2013059559A2 (en) 2013-04-25
UY34406A (es) 2013-05-31

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