CN103948626A - Organosilicon quaternary ammonium salt antibacterial agent for synergism of skin and application of antibacterial agent - Google Patents
Organosilicon quaternary ammonium salt antibacterial agent for synergism of skin and application of antibacterial agent Download PDFInfo
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- CN103948626A CN103948626A CN201410167261.2A CN201410167261A CN103948626A CN 103948626 A CN103948626 A CN 103948626A CN 201410167261 A CN201410167261 A CN 201410167261A CN 103948626 A CN103948626 A CN 103948626A
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- quaternary ammonium
- ammonium salt
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Abstract
The invention relates to an organosilicon quaternary ammonium salt antibacterial agent for synergism of skin, and the organosilicon quaternary ammonium salt antibacterial agent comprises organosilicon quaternary ammonium salt. The organosilicon quaternary ammonium salt is matched with citric acid, acetic acid and boric acid synergists and deionized water is used as a dispersion medium so that organosilicon quaternary ammonium salt antibacterial agent water solution is prepared. The organosilicon quaternary ammonium salt antibacterial agent for synergism of skin has the characteristics of strong stability and low cost, and has safety to human body and tenderness to skin at the same time.
Description
Technical field
The present invention relates to a kind of potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent and application thereof that is exclusively used in skin.
Background technology
Organosilicon quaternary ammonium salt is that 3-(tri-alkoxy is silica-based)-propyl group octadecyl alkyl dimethyl ammonium chloride is the durable washable fabric bacterium finishing agent of being invented by Dow corning company nineteen seventies.Because having divided, it has quaternary ammonium salt cationic gene, various antibacterials are had to the bacteriostasis and sterilization effect of wide spectrum as gram positive bacteria and gram negative bacteria and fungus etc., again because containing three methoxyl groups (or ethyoxyl) in its molecule, in water, facile hydrolysis is three silicon hydroxyls, and easily polycondensation is water-fast netted polysiloxanes.So can not take water as solvent storage, can only be stored in alcohols solvent or other nonaqueous solvent.
The individual of company that this area research is engaged in the whole world for many years is also being devoted to head it off.As US Patent No. 6613755, proposition be take ultra-pure water as medium, require more than the purity resistivity of water reaches 18 megaohms centimetre, stable silane quaternary ammonium salt aqueous solution can be made, various stable disinfection hand cleansers can be made, cleansing milk etc., but the preparation of ultra-pure water is very high to equipment requirements, the electronics industry pure water of domestic production also difficulty to reach resistivity be 18 megaohms centimetre, and ultra-pure water to packing container, surrounding is all required very high, be difficult to practical.US6087319 adopts and in water, to add a large amount of propylene glycols, alkyl quaternary ammonium salts and the third surfacant, can obtain stable aqueous solution, but cost increases relatively, and antibacterial effect and washability be there is no to guarantee.And for example US662172 employing Allyl carbonate and butyl glycol ether are solvent, are then added to the water and can obtain stable, aqueous solution, but how long can store on earth, do not indicate, and Allyl carbonate, the consumption of butyl glycol ether is large, and cost is high.
Summary of the invention
For overcoming above-mentioned technical disadvantages, the invention provides and a kind ofly with organosilicon quaternary ammonium salt and citric acid, acetic acid, boric acid synergist, coordinate, take deionized water as disperse medium, be made into potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent and application thereof for skin stable storage, that antibacterial effect improves greatly.
The present invention solves the technical method that its technical problem adopts: a kind of antibacterial potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent for skin, its ingredient comprises organosilicon quaternary ammonium salt, and and citric acid, acetic acid, boric acid synergist coordinate, the deionized water of take makes silicone Quaternary Ammonium Salt Antimicrobial Agent aqueous solution as disperse medium.
Described organosilicon quaternary ammonium salt comprises that 3-(trimethoxy is silica-based) propyl group octadecyl alkyl dimethyl ammonium chloride, 3-(triethoxy is silica-based) propyl group octadecyl alkyl dimethyl ammonium chlorides, 3-(trimethoxy is silica-based) propyl group 18-hexadecyldimethyl benzyl ammonium ammonium chloride and 3-(triethoxy silica-based) propyl group 18 hexadecyldimethyl benzyl ammonium ammonium chloride, when organosilicon quaternary ammonium salt is synthetic, solvent used can be used isopropyl alcohol, ethylene glycol monomethyl ether, propylene glycol monomethyl ether, butyl glycol ether, also can use ethanol, methanol, can also use Allyl carbonate, or the mixed solvent of above-mentioned solvent.
Use the above-mentioned potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent for skin, can be applied in skin degerming pruritus.
Above-mentioned its component of skin degerming pruritus and weight ratio are organosilicon quaternary ammonium salt (60%) 2%, the essence of boric acid 3.0%, 3.0%
,all the other are the deionized water of electrical conductivity≤5MS/CM, can be used in skin degerming, antipruritic, and to skin without any zest.
Use the above-mentioned potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent for skin, can be applied in disinfection hand cleanser.
A disinfection hand cleanser, its component and weight ratio thereof are: 70% dodecyl polyoxyethylene sodium sulfate 8%, 30% cocamido propyl betaine 5%, cocoanut fatty acid diethanolamide 2%, sodium chloride 1%, 60% silane quaternary ammonium salt 1.0%, citric acid is adjusted PH6.0-7.0 in right amount, is left for deionized water.
Use the above-mentioned potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent for skin, can be applied in anti-bacterial, anti-itching anti-dandruff transparent hair shampoo.
A kind of anti-bacterial, anti-itching anti-dandruff transparent hair shampoo, its component and weight ratio thereof are: 70% dodecyl polyoxyethylene sodium sulfate 12%, 30% cocamido propyl betaine 5%, cocoanut fatty acid diethanolamide 3%, sodium chloride 1%, boric acid 1%, 60% diethoxy silane quaternary ammonium salt 1%, deionized water 77%, water-soluble essence 0.3%.
The invention has the beneficial effects as follows: organosilicon quaternary ammonium salt is as silica-based in 3-(tri-alkoxy) Mlc of propyl group octadecyl alkyl dimethyl ammonium chloride is higher, because the shielding action minimum inhibitory concentration of siloxanes is large usage quantity more than 200PPM, the minimum inhibitory concentration of general non-silicon class antibacterial is several to tens PPM, this is the shortcoming of organosilicon antibacterial agent, also be its advantage on the other hand, because it is non-stimulated to skin to human-body safety.The present invention adds acid, as citric acid, acetic acid, boric acid synergist improve the antibacterial effect of organosilicon quaternary ammonium salt, does not affect it to the safety of human body and the mildness to skin, and the present invention has stability feature strong, with low cost.
the specific embodiment
Below in conjunction with embodiment, the present invention is further described.
For a potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent for skin, its ingredient comprises organosilicon quaternary ammonium salt, and and citric acid, acetic acid, boric acid synergist coordinate, the deionized water of take makes silicone Quaternary Ammonium Salt Antimicrobial Agent aqueous solution as disperse medium.
Described organosilicon quaternary ammonium salt comprises that 3-(trimethoxy is silica-based) propyl group octadecyl alkyl dimethyl ammonium chloride, 3-(triethoxy is silica-based) propyl group octadecanes, alkyl dimethyl ammonium chloride, 3-(trimethoxy is silica-based) propyl group 18-hexadecyldimethyl benzyl ammonium ammonium chloride and 3-(triethoxy silica-based) propyl group octadecane cetyl base alkyl dimethyl ammonium chloride, the solvent of using when organosilicon quaternary ammonium salt is synthetic can be used isopropyl alcohol, ethylene glycol monomethyl ether, propylene glycol monomethyl ether, butyl glycol ether, also can use ethanol, methanol, can also use Allyl carbonate, the mixed solvent of ethylene carbonate or above-mentioned solvent.
Use the above-mentioned potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent for skin, can be applied in skin degerming pruritus.
Above-mentioned its component of skin degerming pruritus and weight ratio are organosilicon quaternary ammonium salt (60%) 2%, the essence of boric acid 3.0%, 0.3%
,all the other are the deionized water of electrical conductivity≤5MS/CM, can be used in skin degerming, antipruritic, and to skin without any zest.
Use the above-mentioned potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent for skin, can be applied in disinfection hand cleanser.
A disinfection hand cleanser, its component and weight ratio thereof are: 70% dodecyl polyoxyethylene sodium sulfate 8%, 30% cocamido propyl betaine 5%, cocoanut fatty acid diethanolamide 2%, sodium chloride 1%, 60% silane quaternary ammonium salt 1.0%, citric acid is adjusted PH6.0-7.0 in right amount, is left for deionized water.
Use the above-mentioned potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent for skin, can be applied in anti-bacterial, anti-itching anti-dandruff transparent hair shampoo.
A kind of anti-bacterial, anti-itching anti-dandruff transparent hair shampoo, its component and weight ratio thereof are: 70% dodecyl polyoxyethylene sodium sulfate 12%, 30% cocamido propyl betaine 5%, cocoanut fatty acid diethanolamide 3%, sodium chloride 1%, boric acid 1%, 60% diethoxy silane quaternary ammonium salt 1%, deionized water 77%, water-soluble essence 0.3%.
Organosilicon quaternary ammonium salt is as silica-based in 3-(tri-alkoxy) Mlc of propyl group octadecyl alkyl dimethyl ammonium chloride is higher, because the shielding action minimum inhibitory concentration of siloxanes is large usage quantity more than 200PPM, the minimum inhibitory concentration of general non-silicon class antibacterial is several to tens PPM, this is the shortcoming of organosilicon antibacterial agent, also be its advantage on the other hand, because it is non-stimulated to skin to human-body safety.The present invention adds acid, as citric acid, acetic acid, boric acid synergist improve the antibacterial effect of organosilicon quaternary ammonium salt, does not affect it to the safety of human body and the mildness to skin, and the present invention has stability feature strong, with low cost.
Claims (8)
1. the antibacterial potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent for skin, it is characterized in that ingredient comprises organosilicon quaternary ammonium salt, and and citric acid, acetic acid, boric acid synergist coordinate, the deionized water of take makes silicone Quaternary Ammonium Salt Antimicrobial Agent aqueous solution as disperse medium.
2. as claimed in claim 1 for the antibacterial potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent of skin, it is characterized in that described organosilicon quaternary ammonium salt comprises that 3-(trimethoxy is silica-based) propyl group octadecyl alkyl dimethyl ammonium chloride, 3-(triethoxy is silica-based) propyl group octadecyl alkyl dimethyl ammonium chlorides, 3-(trimethoxy is silica-based) propyl group 18-hexadecyldimethyl benzyl ammonium ammonium chloride and 3-(triethoxy silica-based) propyl group 18 hexadecyldimethyl benzyl ammonium ammonium chloride, when organosilicon quaternary ammonium salt is synthetic, solvent used can be used isopropyl alcohol, ethylene glycol monomethyl ether, propylene glycol monomethyl ether, butyl glycol ether, also can use ethanol, methanol, can also use Allyl carbonate, or the mixed solvent of above-mentioned solvent.
3. as claimed in claim 1 for the antibacterial potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent of skin, it is characterized in that using the above-mentioned potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent for skin, can be applied in skin degerming pruritus.
4. a skin degerming pruritus is characterized in that component and weight ratio are organosilicon quaternary ammonium salt (60%) 2%, the essence of boric acid 3.0%, 3.0%
,all the other are the deionized water of electrical conductivity≤5MS/CM, can be used in skin degerming, antipruritic, and to skin without any zest.
5. for the antibacterial potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent of skin, it is characterized in that using the above-mentioned potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent for skin as claimed in claim 1, can be applied in disinfection hand cleanser.
6. a disinfection hand cleanser, it is characterized in that component and weight ratio thereof are: 70% dodecyl polyoxyethylene sodium sulfate 8%, 30% cocamido propyl betaine 5%, cocoanut fatty acid diethanolamide 2%, sodium chloride 1%, 60% silane quaternary ammonium salt 1.0%, citric acid is adjusted PH6.0-7.0 in right amount, is left for deionized water.
7. for the antibacterial potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent of skin, it is characterized in that using the above-mentioned potentiation silicone Quaternary Ammonium Salt Antimicrobial Agent for skin as claimed in claim 1, can be applied in anti-bacterial, anti-itching anti-dandruff transparent hair shampoo.
8. an anti-bacterial, anti-itching anti-dandruff transparent hair shampoo, it is characterized in that component and weight ratio thereof are: 70% dodecyl polyoxyethylene sodium sulfate 12%, 30% cocamido propyl betaine 5%, cocoanut fatty acid diethanolamide 3%, sodium chloride 1%, boric acid 1%, 60% diethoxy silane quaternary ammonium salt 1%, deionized water 77%, water-soluble essence 0.3%.
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| CN201410167261.2A CN103948626A (en) | 2014-04-24 | 2014-04-24 | Organosilicon quaternary ammonium salt antibacterial agent for synergism of skin and application of antibacterial agent |
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| CN201410167261.2A CN103948626A (en) | 2014-04-24 | 2014-04-24 | Organosilicon quaternary ammonium salt antibacterial agent for synergism of skin and application of antibacterial agent |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104179010A (en) * | 2014-08-11 | 2014-12-03 | 李济锋 | Preparation method of antibacterial antifouling agent for cloth |
| CN104472530A (en) * | 2014-12-07 | 2015-04-01 | 南雄鼎成化工有限公司 | Solid powdery organosilicon quaternary ammonium salt antibacterial agent and preparation method thereof |
| CN105696323A (en) * | 2016-03-04 | 2016-06-22 | 湖南利洁生物股份有限公司 | Concentrated continuous antibacterial bedding article care solution and using method thereof |
| CN107056830A (en) * | 2017-06-07 | 2017-08-18 | 南雄鼎成新材料科技有限公司 | A kind of organosilicon amphoteric ion antibacterial agent and preparation method thereof |
| CN107114396A (en) * | 2017-06-07 | 2017-09-01 | 南雄鼎成新材料科技有限公司 | A kind of stabilizer for being used to stablize the trialkoxy silane quaternary ammonium salt antiseptic aqueous solution |
| CN107334653A (en) * | 2017-07-12 | 2017-11-10 | 南雄鼎成新材料科技有限公司 | A kind of antibacterial anti-dandruff and itching-relieving shampoo with treatment containing organosilicon quaternary ammonium salt |
| CN108524315A (en) * | 2018-06-29 | 2018-09-14 | 广州市润研基因科技有限公司 | A kind of novel anti-pollution moisturizing skin makeup liquid and preparation method thereof |
| CN108912162A (en) * | 2018-07-27 | 2018-11-30 | 江苏康普生物医药科技有限公司 | A kind of production method of New-type long-acting anti-biotic material |
| CN108948069A (en) * | 2018-07-27 | 2018-12-07 | 江苏康普生物医药科技有限公司 | A kind of new preparation method of long acting antibiotic material |
| CN109549544A (en) * | 2018-12-03 | 2019-04-02 | 铜陵麟安生物科技有限公司 | A kind of manufacture craft and its addition equipment of wet tissue annex solution |
| CN111592946A (en) * | 2020-06-05 | 2020-08-28 | 上海和黄白猫有限公司 | Antibacterial laundry detergent and preparation method thereof |
| CN111903704A (en) * | 2020-08-06 | 2020-11-10 | 江苏海云花新材料有限公司 | Organosilicon cation quaternary ammonium salt antibacterial agent |
-
2014
- 2014-04-24 CN CN201410167261.2A patent/CN103948626A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104179010A (en) * | 2014-08-11 | 2014-12-03 | 李济锋 | Preparation method of antibacterial antifouling agent for cloth |
| CN104472530A (en) * | 2014-12-07 | 2015-04-01 | 南雄鼎成化工有限公司 | Solid powdery organosilicon quaternary ammonium salt antibacterial agent and preparation method thereof |
| CN105696323A (en) * | 2016-03-04 | 2016-06-22 | 湖南利洁生物股份有限公司 | Concentrated continuous antibacterial bedding article care solution and using method thereof |
| CN107056830A (en) * | 2017-06-07 | 2017-08-18 | 南雄鼎成新材料科技有限公司 | A kind of organosilicon amphoteric ion antibacterial agent and preparation method thereof |
| CN107114396A (en) * | 2017-06-07 | 2017-09-01 | 南雄鼎成新材料科技有限公司 | A kind of stabilizer for being used to stablize the trialkoxy silane quaternary ammonium salt antiseptic aqueous solution |
| CN107334653A (en) * | 2017-07-12 | 2017-11-10 | 南雄鼎成新材料科技有限公司 | A kind of antibacterial anti-dandruff and itching-relieving shampoo with treatment containing organosilicon quaternary ammonium salt |
| CN108524315A (en) * | 2018-06-29 | 2018-09-14 | 广州市润研基因科技有限公司 | A kind of novel anti-pollution moisturizing skin makeup liquid and preparation method thereof |
| CN108912162A (en) * | 2018-07-27 | 2018-11-30 | 江苏康普生物医药科技有限公司 | A kind of production method of New-type long-acting anti-biotic material |
| CN108948069A (en) * | 2018-07-27 | 2018-12-07 | 江苏康普生物医药科技有限公司 | A kind of new preparation method of long acting antibiotic material |
| CN109549544A (en) * | 2018-12-03 | 2019-04-02 | 铜陵麟安生物科技有限公司 | A kind of manufacture craft and its addition equipment of wet tissue annex solution |
| CN111592946A (en) * | 2020-06-05 | 2020-08-28 | 上海和黄白猫有限公司 | Antibacterial laundry detergent and preparation method thereof |
| CN111903704A (en) * | 2020-08-06 | 2020-11-10 | 江苏海云花新材料有限公司 | Organosilicon cation quaternary ammonium salt antibacterial agent |
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Application publication date: 20140730 |