CN103933392A - Pharmaceutical composition for treating xerostomia and application thereof - Google Patents
Pharmaceutical composition for treating xerostomia and application thereof Download PDFInfo
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- CN103933392A CN103933392A CN201410142639.3A CN201410142639A CN103933392A CN 103933392 A CN103933392 A CN 103933392A CN 201410142639 A CN201410142639 A CN 201410142639A CN 103933392 A CN103933392 A CN 103933392A
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Abstract
The invention relates to a pharmaceutical composition for treating xerostomia and application thereof. The pharmaceutical composition is prepared from the following Chinese herbal medicine raw materials in parts by weight: 30-45 parts of eclipta alba, 8-16 parts of radix sophorae flavescentis, 7-15 parts of chrysanthemum, 20-32 parts of rhizoma phragmitis, 7-15 parts of radix ophiopogonis and 13-21 parts of radix polygonati officinalis. The pharmaceutical composition disclosed by the invention is significant in effective effect on the xerostomia, and is especially applicable to young and old patients with physiological xerostomia, the xerostomia of the patient can be removed, and salivary secretion and gestation return to normal.
Description
Technical field
The invention belongs to Chinese medicine technical field, be specifically related to a kind of pharmaceutical composition for the treatment of xerostomia, relate in particular to a kind of pharmaceutical composition and application thereof of the person in middle and old age's for the treatment of physiological xerostomia.
Background technology
Xerostomia is clinical comparatively common Oral symptoms, and wherein the highest with the mid-aged population sickness rate of 40～70 years old, Women’s climacteric patient is more common.The reason that causes person in middle and old age's xerostomia has two kinds of physiological xerostomia and pathologic xerostomias, and physiological xerostomia is the atrophy due to old people oral cavity body of gland, due to salivation reduces; Pathologic xerostomia is due to due to various diseases, wherein the modal patient who has diabetes, pulmonary tuberculosis, anemia, hyperthyroidism, chronic pharyngolaryngitis, climacteric syndrome and hypovitaminosis C.Modern medicine, for the treatment of person in middle and old age's physiological xerostomia, is main mainly with anti symptom treatment, there is no so far specific short.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of xerostomia, a kind of pharmaceutical composition and application thereof of the person in middle and old age's for the treatment of physiological xerostomia are especially provided.
The object of the present invention is achieved like this:
Treat a pharmaceutical composition for xerostomia, it is formed by the traditional Chinese medicinal material raw materials decocting that comprises following weight portion: Herba Ecliptae 30-45 part, Radix Sophorae Flavescentis 8-16 part, Flos Chrysanthemi 7-15 part, Rhizoma Phragmitis 20-32 part, Radix Ophiopogonis 7-15 part, Rhizoma Polygonati Odorati 13-21 part.
Preferably, the pharmaceutical composition for the treatment of xerostomia as above, it is formed by the traditional Chinese medicinal material raw materials decocting of following weight portion: Herba Ecliptae 34-40 part, Radix Sophorae Flavescentis 10-13 part, Flos Chrysanthemi 9-12 part, Rhizoma Phragmitis 24-27 part, Radix Ophiopogonis 9-12 part, Rhizoma Polygonati Odorati 15-18 part.
In a most preferred embodiment of the present invention, the pharmaceutical composition for the treatment of xerostomia as above is formed by the traditional Chinese medicinal material raw materials decocting of following weight portion: 36 parts of Herba Ecliptaes, 12 parts of Radix Sophorae Flavescentiss, 10 parts of Flos Chrysanthemis, 25 parts of Rhizoma Phragmitiss, 10 parts of Radix Ophiopogonis, 16 parts of Rhizoma Polygonati Odorati.
By experimental study, find, pharmaceutical composition of the present invention is for the therapeutic effect highly significant of person in middle and old age's physiological xerostomia, therefore, second object of the present invention is to provide a kind of pharmaceutical applications, i.e. the application of aforementioned pharmaceutical compositions in the medicine of preparation treatment person in middle and old age physiological xerostomia.
The preparation method of the pharmaceutical composition the present invention relates to comprises the steps: to get Herba Ecliptae 30-45 part, Radix Sophorae Flavescentis 8-16 part, Flos Chrysanthemi 7-15 part, Rhizoma Phragmitis 20-32 part, Radix Ophiopogonis 7-15 part and Rhizoma Polygonati Odorati 13-21 part, clean roguing, dry, merge, add water and cover powder 2cm, soak 1-1.2h, pulling medical material out puts multi-functional extraction and decocts with water secondary in filling with, add up for the first time the water that medical material 8-10 doubly measures, decoct 2h, get decocting liquid, filter, add up for the second time the water that medical material 6-8 doubly measures, decoct 1h, getting twice decocting liquid merges, filter, be concentrated into every milliliter containing 2-3g crude drug amount, set to 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered, obtain medicinal liquid.
By a large amount of clinical application practice, show that medicine composite for curing xerostomia of the present invention evident in efficacy is especially applicable to person in middle and old age's physiological xerostomia patient, can make patient's xerostomia transference cure, salivation, the sense of taste recover normal, follow up a case by regular visits to and do not recur half a year, and part clinical practice example gathers as follows:
Physiological xerostomia patient 83 examples through making a definite diagnosis, clinical manifestation is that saliva is few, conscious dry mouth and parching tongue, pain, poor appetite or loss of appetite, often accompany vexed insomnia, being irritable and getting angry easily; Dim or the dark complexion around the eyes of lip, tongue is dim red or have an ecchymosis, thready pulse or unsmooth.In all patients, women's 72 examples, male's 11 examples; The oldest 75 years old, minimum 43 years old, 53.6 ± 2.0 years old mean age; The course of disease 3 months～8 years.All patients are divided into test group (42 example) and matched group (41 example) at random.Two groups of sexes, age, the state of an illness etc. are there was no significant difference relatively, has comparability.
Test group patient takes Chinese medicinal formulae, writes out a prescription to be: Herba Ecliptae 36g, Radix Sophorae Flavescentis 12g, Flos Chrysanthemi 10g, Rhizoma Phragmitis 25g, Radix Ophiopogonis 10g, Rhizoma Polygonati Odorati 16g.1 dose of every day, decoct into the about 300mL of decoction, be divided into 3 parts, early, middle and late respectively clothes 1 time.It should be noted that when Chinese medicine decoction is preferably in 40-45 ℃ and take, swallow again after can making medicine stop for 10～15 seconds in the process of taking in oral cavity, medicinal liquid is fully contacted to each position in oral cavity and throat, keep every day amount of drinking water at 3000mL, continue 2 weeks.Matched group gives oral vitamin C (0.2g/ time, 3 times/day), vitamin B (10mg/ time, 3 times/day), drinks common white boiled water simultaneously, and every day, amount of drinking water was no less than 3000mL.All take 7 days as 1 course for the treatment of, treat altogether 2 courses for the treatment of for two groups.
Observe xerostomia, the sense of taste and the salivation degree of two groups of patients after treatment and change, by following criterion, carry out therapeutic evaluation.
Cure: xerostomia transference cure, salivation, the sense of taste recover normal, follow up a case by regular visits to and do not recur half a year;
Effective: xerostomia transference cure, salivation, the sense of taste have remarkable improvement;
Take a turn for the better: xerostomia symptom has obviously and alleviates, and salivation, the sense of taste take an evident turn for the better;
Invalid: after 2 courses for the treatment of, xerostomia symptom is without obvious change.
By observing and find after clinical treatment, in test group 42 examples, cure 17 examples, effective 20 examples, 3 examples that take a turn for the better, invalid 2 examples, total effective rate is 95.2%; In matched group 41 examples, cure 0 example, effective 2 examples, 9 examples that take a turn for the better, invalid 30 examples, total effective rate 26.8%.The invalid patient of matched group is xerostomia transference cure after Chinese medicinal formulae continual cure of the present invention, and salivation, the sense of taste have remarkable improvement.
The specific embodiment
The source of the traditional Chinese medicinal material raw materials that various embodiments of the present invention adopt is as follows: Herba Ecliptae is selected the dry aerial parts of feverfew Eclipta prostrata EcliptaprostrataL..Radix Sophorae Flavescentis is selected the dry root of the perennial semishrub plant's Radix Sophorae Flavescentis of falling leaves.Flos Chrysanthemi is selected the dry capitulum of feverfew Flos Chrysanthemi ChrysanthemummorifoliumRamat.Rhizoma Phragmitis is selected the dry rhizome of grass phragmites communis PhragmitescommunisTrin..Be selected from Liliaceae Ophiopogon plant OphiopogonJaponicus(Thunb. Radix Ophiopogonis Radix Ophiopogonis) dried root of Ker-Gawl..Rhizoma Polygonati Odorati is selected the dry rhizome of liliaceous plant (Polygonatumodoratum (Mill.) Druce) Rhizoma Polygonati Odorati.
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment 1
Crude drug prescription: Herba Ecliptae 36kg, Radix Sophorae Flavescentis 12kg, Flos Chrysanthemi 10kg, Rhizoma Phragmitis 25kg, Radix Ophiopogonis 10kg, Rhizoma Polygonati Odorati 16kg.
Preparation method: take the above-mentioned traditional Chinese medicinal material raw materials of recipe quantity, clean roguing, dry, merge, add water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 10 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 8 times of amounts of medical material, decoct 1h, get twice decocting liquid and merge, filter, be concentrated into every milliliter containing 3g crude drug amount, set to 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered, obtain medicinal liquid.
Embodiment 2
Crude drug prescription: Herba Ecliptae 30kg, Radix Sophorae Flavescentis 10kg, Flos Chrysanthemi 8kg, Rhizoma Phragmitis 20kg, Radix Ophiopogonis 15kg, Rhizoma Polygonati Odorati 21kg.
Preparation method: take the above-mentioned traditional Chinese medicinal material raw materials of recipe quantity, clean roguing, dry, merge, add water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 8 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 8 times of amounts of medical material, decoct 1h, get twice decocting liquid and merge, filter, be concentrated into every milliliter containing 2g crude drug amount, set to 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered, obtain medicinal liquid.
Embodiment 3
Crude drug prescription: Herba Ecliptae 42kg, Radix Sophorae Flavescentis 15kg, Flos Chrysanthemi 15kg, Rhizoma Phragmitis 30kg, Radix Ophiopogonis 7kg, Rhizoma Polygonati Odorati 13kg.
Preparation method: take the above-mentioned traditional Chinese medicinal material raw materials of recipe quantity, clean roguing, dry, merge, add water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 8 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 6 times of amounts of medical material, decoct 1h, get twice decocting liquid and merge, filter, be concentrated into every milliliter containing 3g crude drug amount, set to 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered, obtain medicinal liquid.
Claims (5)
1. a pharmaceutical composition for the treatment of xerostomia, is characterized in that: described pharmaceutical composition is formed by the traditional Chinese medicinal material raw materials decocting that comprises following weight portion: Herba Ecliptae 30-45 part, Radix Sophorae Flavescentis 8-16 part, Flos Chrysanthemi 7-15 part, Rhizoma Phragmitis 20-32 part, Radix Ophiopogonis 7-15 part, Rhizoma Polygonati Odorati 13-21 part.
2. the pharmaceutical composition for the treatment of xerostomia according to claim 1, is characterized in that: described pharmaceutical composition is formed by the traditional Chinese medicinal material raw materials decocting of following weight portion: Herba Ecliptae 34-40 part, Radix Sophorae Flavescentis 10-13 part, Flos Chrysanthemi 9-12 part, Rhizoma Phragmitis 24-27 part, Radix Ophiopogonis 9-12 part, Rhizoma Polygonati Odorati 15-18 part.
3. the pharmaceutical composition for the treatment of xerostomia according to claim 2, is characterized in that: described pharmaceutical composition is formed by the traditional Chinese medicinal material raw materials decocting of following weight portion: 36 parts of Herba Ecliptaes, 12 parts of Radix Sophorae Flavescentiss, 10 parts of Flos Chrysanthemis, 25 parts of Rhizoma Phragmitiss, 10 parts of Radix Ophiopogonis, 16 parts of Rhizoma Polygonati Odorati.
4. according to the pharmaceutical composition of the treatment xerostomia described in claim 1-3 any one, it is characterized in that: described xerostomia is person in middle and old age's physiological xerostomia.
5. the application of the pharmaceutical composition described in claim 1-3 any one in the medicine of preparation treatment person in middle and old age physiological xerostomia.
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| CN201410142639.3A CN103933392B (en) | 2014-04-10 | 2014-04-10 | A kind of pharmaceutical composition treating xerostomia and application thereof |
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| CN201410142639.3A CN103933392B (en) | 2014-04-10 | 2014-04-10 | A kind of pharmaceutical composition treating xerostomia and application thereof |
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| CN103933392A true CN103933392A (en) | 2014-07-23 |
| CN103933392B CN103933392B (en) | 2016-08-17 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102872346A (en) * | 2012-09-07 | 2013-01-16 | 王先忠 | Traditional Chinese medicine composition for treating xerostomia |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872346A (en) * | 2012-09-07 | 2013-01-16 | 王先忠 | Traditional Chinese medicine composition for treating xerostomia |
Non-Patent Citations (2)
| Title |
|---|
| 于志谋: "路志正教授益气养阴法论治原发性干燥综合征口干疗效研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
| 王宜健: "治疗老年性口干症临床研究近况", 《光明中医》 * |
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