CN103933467A - Traditional Chinese medicine composition for treating gall stone - Google Patents

Traditional Chinese medicine composition for treating gall stone Download PDF

Info

Publication number
CN103933467A
CN103933467A CN201410111342.0A CN201410111342A CN103933467A CN 103933467 A CN103933467 A CN 103933467A CN 201410111342 A CN201410111342 A CN 201410111342A CN 103933467 A CN103933467 A CN 103933467A
Authority
CN
China
Prior art keywords
parts
chinese medicine
radix
composition
cholelithiasis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410111342.0A
Other languages
Chinese (zh)
Inventor
李子虎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201410111342.0A priority Critical patent/CN103933467A/en
Publication of CN103933467A publication Critical patent/CN103933467A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to the technical field of traditional Chinese medicine and discloses a traditional Chinese medicine composition for treating gall stone. The composition is characterized by being composed of the following medicinal raw materials: kudzu vine root, corn stigma, chicken's gizzard membrane, desmodium, curcuma tuber, magnolia cortex, pinellia ternate, banksia rose, radix bupleuri, laminaria japonica, radix astragali, alga, artemisia capillaris, rhizoma atractylodis, poria cocos, and amber. The composition is orally taken after being decocted with water. The traditional Chinese medicine has the following advantages: (1) different formulas are developed based on comprehensive analysis to treat gall stones caused by different reasons, and thus the composition has the advantages of targeted and prominent effect, high cure rate, no complication, no toxic effect, and difficult relapse; (2) the medicinal raw materials are available, the preparation is simple, the composition is user-friendly, and moreover the medicinal raw materials cooperates with each other to generate a synergetic effect, so the composition has very good functions of soothing the liver, draining the gallbladder, clearing heat, removing dampness, regulating qi, harmonizing nutrients, relieving pains, and dissipating binds.

Description

A kind of Chinese medicine composition for the treatment of cholelithiasis
Technical field
The present invention relates to technical field of Chinese medicines, refer more particularly to a kind of Chinese medicine composition for the treatment of cholelithiasis.
Background technology
Cholelithiasis refers to the caused disease of the calculus occurring in gallbladder, is a kind of commonly encountered diseases.With age growth, sickness rate also raises gradually, and women is obviously more than male.Along with growth in the living standard, the change of dietary habit, the improvement of sanitary condition, the cholelithiasis of China is changed into taking gallbladder cholesterol calculus as main as main gradually by the bile pigment calculus taking bile duct.The origin cause of formation of cholelithiasis is very complicated, and some is not modifiable factor, for example: the age, women, race, gene and the family history that increase gradually; Some is acquired disposition, and part can reverse.Cholelithiasis comprises cholelithiasis, Biliary Calculi, i.e. cholelithiasis.How because stagnation of QI due to depression of the liver, dampness-heat in the liver and gallbladder, biliary tract are damp and hot, biliary obstruction causes drainage difficulty, the long-pending stone of forming.Cloudy stagnant mechanism of qi.Be the violent angor tenderness of upper right abdomen, when pain in, draws back and the inferior place of xiphoid-process has obviously from pain and tenderness.Be divided into three types: type of depression of QI, damp-heat type, blood stasis blocking type.In Zhang Xichun " Records of Tradition Chinese and Western Medicine in Combination symposium on medical topics ", say: " meaning perseverance has the I3 of cholelithiasis obstruction gallbladder, if urethra has the stone of pouring also.Sal Nitri, Alumen use, cholelithiasis can disappear." treatment of cholelithiasis is many sets about from depressed liver-energy dispersing and function of gallbladder promoting, removing damp-heat, blood stasis dispelling calculus.The etiology and pathogenesis of cholelithiasis has following several: (1) stagnation of QI due to depression of the liver: liver happiness bar reaches, and gallbladder is clear bowing in being, if feelings will is unsuccessful, and QI depression of the liver and gallbladder, liver is lost bar and reaches, and gallbladder loses catharsis, and bile excretion is not normal, and the stasis of blood is amassed into stone; (2) damp and hot retardance: eating and drinking without temperance, insufficiency of the spleen leading to overabundance of dampness or diseases caused by exogenous pathogenic factor are damp and hot, strongly fragrant and heat-transformation; Or experience damp and hot, and hindering in liver and gall, catharsis is not normal, and the bile flowing outside the biliary passages hinders in skin, sends out as jaundice, and gallbladder fire is crossed and is contained, and causes bile and condenses into stone.As " Plain Questions six saves the large opinion of micro-purport " cloud: " on few sun, fire of moxibustion is controlled it." (3) biliary obstruction: because residue of ascaris stays in biliary tract, or due to calculus with the passing of time not under, be connected with meat, cause qi depression to blood stasis, biliary obstruction.Therefore cholelithiasis is divided into three types: type of depression of QI, damp-heat type and blood stasis blocking type.At present treatment cholelithiasis method have surgical calculus removing, medicine fossil, because operative treatment is more painful, people comparatively lay particular stress on Drug therapy, and at present commercially available medicine is a lot, but because patient individual difference is to medicine suitable degree difference, cause curative effect to differ, so patients expect to have the new drug of more treatment cholelithiasis, more select to them, what throw off one's illness early and bring is painful and worried.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pointed, and therapeutic effect is good, and cure rate is high, treatment time short treatment cholelithiasis Chinese medicine composition.
For solving the problems of the technologies described above, the present invention by the following technical solutions:
A Chinese medicine composition for the treatment of cholelithiasis, is characterized in that, comprises the crude drug of following weight portion: 15-30 parts of Radix Puerariaes, 15-25 parts of maize palpuses, 10-25 parts of Endothelium Corneum Gigeriae Galli, 15-25 parts of Herba Lysimachiaes, 5-15 parts of Herba Taraxacis, 10-20 parts of Radix Curcumaes, 10-20 parts of Cortex Magnoliae Officinalis, 10-20 parts of the Rhizoma Pinelliaes, 10-25 parts of the Radix Aucklandiae, 10-25 parts of Radix Bupleuri, 10-20 parts of Thallus Laminariae (Thallus Eckloniae)s, 10-25 parts of the Radixs Astragali, 5-15 parts of Sargassums, 20-30 parts of Herba Artemisiae Scopariaes.
Preferably, the Chinese medicine composition of described treatment cholelithiasis comprises the crude drug of following weight portion: 20-30 parts of Radix Puerariaes, 15-20 parts of maize palpuses, 10-15 parts of Endothelium Corneum Gigeriae Galli, 15-25 parts of Herba Lysimachiaes, 10-15 parts of Herba Taraxacis, 15-20 parts of Radix Curcumaes, 15-20 parts of Cortex Magnoliae Officinalis, 15-20 parts of the Rhizoma Pinelliaes, 15-20 parts of the Radix Aucklandiae, 15-25 parts of Radix Bupleuri, 15-20 parts of Thallus Laminariae (Thallus Eckloniae)s, 15-25 parts of the Radixs Astragali, 5-10 parts of Sargassums, 20-30 parts of Herba Artemisiae Scopariaes.
Preferably, the Chinese medicine composition of described treatment cholelithiasis also comprises the crude drug of following weight portion: 10-20 parts of Rhizoma Atractylodis, 15-20 parts, Poria, 5-10 parts of succinums.
Herbal pharmacology effect of the present invention is as follows: Radix Puerariae is cool in nature, sweet in the mouth, pungent, and having induces sweat brings down a fever, promote the production of body fluid, rash, the drug effect of yang invigorating antidiarrheal; Endothelium Corneum Gigeriae Galli heavily fortified point helps digestion and activating the spleen; Herba Lysimachiae relieving stranguria by diuresis and calculus; Herba Taraxaci has heat-clearing and toxic substances removing, effect of diuresis eliminating stagnation; Radix Curcumae has promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, effect of promoting the function of the gallbladder to alleviate jaundice; Cortex Magnoliae Officinalis bitter in the mouth, pungent, warm in nature, there is circulation of qi promoting removing food stagnancy, dampness is removed full, effect of lowering the adverse QI to relieve asthma; Rhizoma Pinelliae acrid in the mouth, warm in nature, there is drying dampness to eliminate phlegm, and middle stomach invigorating, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, effect that external can reducing swelling and alleviating pain; Radix Aucklandiae acrid in the mouth, hardship, warm in nature, there is circulation of qi promoting, pain relieving, spleen invigorating, the effect helping digestion; Radix Bupleuri has expelling pathogenic factors from the exterior and expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, effect of elevate a turnable ladder yang-energy; Thallus Laminariae (Thallus Eckloniae) bitter in the mouth, cold in nature, there is eliminating phlegm and softening indurated mass, effect of diuretic detumescent; Maize must have expel the heat-evil treating stranguria, effect of suppressing the hyperactive liver function of gallbladder promoting; Radix Astragali sweet in the mouth, slightly warm in nature, has effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema; Sargassum nature and flavor are salty-cold, have effect of heat clearing away, hard masses softening and resolving; Herba Artemisiae Scopariae has clearing away heat-damp and promoting diuresis, effect of jaundice eliminating; Rhizoma Atractylodis have drying damp and strengthening spleen, effect of wind-damp dispelling; Poria sweet in the mouth, light, property are flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming; Succinum has calmness, diuresis, the effect of invigorating blood circulation.Using the present invention one to three cycle can cure for 96%-98%, one week is one-period.
The present invention compared with prior art has following advantage: the formula that the cholelithiasis that the comprehensive various factors of (1) the present invention causes works out, and pointed, successful, cure rate is high, and without complication, nonhazardous effect, is difficult for recurrence; (2) crude drug used in the present invention is easy to get, make simple, taking convenience, they influence each other, synergism, thus play good depressed liver-energy dispersing and function of gallbladder promoting, removing damp-heat, regulate the flow of vital energy and battalion, pain-relieving powder for treating mass-dissipating efficacy.
Detailed description of the invention
Detailed description of the invention is further described in detail technical scheme of the present invention below.
Embodiment mono-:
Treat a Chinese medicine composition for cholelithiasis, comprise the crude drug of following weight portion: 25 parts of Radix Puerariaes, 17 parts of maize palpuses, 13 parts of Endothelium Corneum Gigeriae Galli, 20 parts of Herba Lysimachiaes, 15 parts of Herba Taraxacis, 17 parts of Radix Curcumaes, 17 parts of Cortex Magnoliae Officinalis, 17 parts of the Rhizoma Pinelliaes, 17 parts of the Radix Aucklandiae, 20 parts of Radix Bupleuri, 17 parts of Thallus Laminariae (Thallus Eckloniae)s, 20 parts of the Radixs Astragali, 8 parts of Sargassums, 25 parts of Herba Artemisiae Scopariaes, 15 parts of Rhizoma Atractylodis, 17 parts, Poria, 7 parts of succinums.Patient female, 43 years old, often uncomfortable in chest, thick fur, feelings will is not smooth, depression of liver-QI, impatency the liver pulse, often biliary colic, stomachache, comes institute and is diagnosed as type of depression of QI cholelithiasis; Make up the prescription according to the above ratio, with decocting, point three clothes, potion, took two all after dates and cured every day, followed up a case by regular visits to not recurrence after a year.
Embodiment bis-:
Treat a Chinese medicine composition for cholelithiasis, comprise the crude drug of following weight portion: 20 parts of Radix Puerariaes, 15 parts of maize palpuses, 10 parts of Endothelium Corneum Gigeriae Galli, 15 parts of Herba Lysimachiaes, 10 parts of Herba Taraxacis, 15 parts of Radix Curcumaes, 15 parts of Cortex Magnoliae Officinalis, 15 parts of the Rhizoma Pinelliaes, 15 parts of the Radix Aucklandiae, 15 parts of Radix Bupleuri, 15 parts of Thallus Laminariae (Thallus Eckloniae)s, 15 parts of the Radixs Astragali, 5 parts of Sargassums, 20 parts of Herba Artemisiae Scopariaes, 10 parts of Rhizoma Atractylodis, 15 parts, Poria, 5 parts of succinums.Patient female, 23 years old, persistence distending pain, paroxysmal aggravation, when tenderness, pain under traction shoulder back and sword, bitter taste, dry pharynx, fear of cold heating, the jaundice of body order, yellowish urine, constipation, yellow and greasy fur, comes institute and is diagnosed as damp-heat type cholelithiasis; Make up the prescription according to the above ratio, with decocting, point three clothes, every day, potion, took two all after date recoveries from illness, followed up a case by regular visits to not recurrence after a year.
Embodiment tri-:
Treat a Chinese medicine composition for cholelithiasis, comprise the crude drug of following parts by weight: 24 parts of Radix Puerariaes, 16 parts of maize palpuses, 12 parts of Endothelium Corneum Gigeriae Galli, 18 parts of Herba Lysimachiaes, 12 parts of Herba Taraxacis, 16 parts of Radix Curcumaes, 16 parts of Cortex Magnoliae Officinalis, 16 parts of the Rhizoma Pinelliaes, 16 parts of the Radix Aucklandiae, 18 parts of Radix Bupleuri, 16 parts of Thallus Laminariae (Thallus Eckloniae)s, 18 parts of the Radixs Astragali, 6 parts of Sargassums, 24 parts of Herba Artemisiae Scopariaes, 14 parts of Rhizoma Atractylodis, 16 parts, Poria, 6 parts of succinums.Patient man, 46 years old, right flank pain aching as needle stabbing, tenderness, draws under right shoulder back and sword sometimes, and bitter taste, dry pharynx, purplish tongue have petechia, and hesitant pulse comes institute and is diagnosed as blood stasis blocking type cholelithiasis; Make up the prescription by above-mentioned weight portion, with decocting, point three clothes, every day, potion, took three all after date recoveries from illness, followed up a case by regular visits to not recurrence after a year.
Embodiment tetra-:
Treat a Chinese medicine composition for cholelithiasis, comprise the crude drug of following parts by weight: 27 parts of Radix Puerariaes, 17 parts of maize palpuses, 13 parts of Endothelium Corneum Gigeriae Galli, 22 parts of Herba Lysimachiaes, 13 parts of Herba Taraxacis, 18 parts of Radix Curcumaes, 18 parts of Cortex Magnoliae Officinalis, 19 parts of the Rhizoma Pinelliaes, 19 parts of the Radix Aucklandiae, 24 parts of Radix Bupleuri, 19 parts of Thallus Laminariae (Thallus Eckloniae)s, 24 parts of the Radixs Astragali, 9 parts of Sargassums, 29 parts of Herba Artemisiae Scopariaes, 19 parts of Rhizoma Atractylodis, 19 parts, Poria, 9 parts of succinums.Patient man, 53 years old, the heavy pain of right rib, pain is drawn the shoulder back of the body, continue not understand, tenderness tenderness, high hot xerostomia lip early, constipation due to dry stool, yellowish or reddish urine; Make up the prescription by above-mentioned weight portion, with decocting, clothes at twice, every day, potion, took three cycle recoveries from illness, not recurrences.
Embodiment five:
Treat a Chinese medicine composition for cholelithiasis, comprise the crude drug of following parts by weight: 30 parts of Radix Puerariaes, 20 parts of maize palpuses, 15 parts of Endothelium Corneum Gigeriae Galli, 25 parts of Herba Lysimachiaes, 15 parts of Herba Taraxacis, 20 parts of Radix Curcumaes, 20 parts of Cortex Magnoliae Officinalis, 20 parts of the Rhizoma Pinelliaes, 20 parts of the Radix Aucklandiae, 25 parts of Radix Bupleuri, 20 parts of Thallus Laminariae (Thallus Eckloniae)s, 25 parts of the Radixs Astragali, 10 parts of Sargassums, 30 parts of Herba Artemisiae Scopariaes, 20 parts of Rhizoma Atractylodis, 20 parts, Poria, 10 parts of succinums.Patient female, 38 years old, often uncomfortable in chest, thick fur, right flank pain aching as needle stabbing, tenderness, draws under right shoulder back and sword sometimes, high hot xerostomia lip early, constipation due to dry stool, yellowish or reddish urine; Make up the prescription by above-mentioned weight portion, with decocting, clothes at twice, every day, potion, took three cycle recoveries from illness, not recurrences.
Clinical use patient is 300 examples, and men and women half and half, containing type of depression of QI, and the Patients with Cholelithiasis such as damp-heat type and blood stasis blocking type.Make up a prescription according to ratio, take mode for oral administration, most patients can fully recover, and cure rate reaches 97%.
The present invention compared with prior art has following advantage: (1) the present invention is directed to the cholelithiasis that different factors cause and works out different formulas, pointed, successful, and cure rate is high, and without complication, nonhazardous effect, is difficult for recurrence; (2) crude drug used in the present invention is easy to get, make simple, taking convenience, they influence each other, synergism, thus play good depressed liver-energy dispersing and function of gallbladder promoting, removing damp-heat, regulate the flow of vital energy and battalion, pain-relieving powder for treating mass-dissipating efficacy.
It should be noted last that, above detailed description of the invention is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is had been described in detail with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement technical scheme of the present invention, and not departing from the spirit and scope of technical solution of the present invention, it all should be encompassed in the middle of claim scope of the present invention.

Claims (3)

1. a Chinese medicine composition for the treatment of cholelithiasis, is characterized in that, comprises the crude drug of following weight portion: 15-30 parts of Radix Puerariaes, 15-25 parts of maize palpuses, 10-25 parts of Endothelium Corneum Gigeriae Galli, 15-25 parts of Herba Lysimachiaes, 5-15 parts of Herba Taraxacis, 10-20 parts of Radix Curcumaes, 10-20 parts of Cortex Magnoliae Officinalis, 10-20 parts of the Rhizoma Pinelliaes, 10-25 parts of the Radix Aucklandiae, 10-25 parts of Radix Bupleuri, 10-20 parts of Thallus Laminariae (Thallus Eckloniae)s, 10-25 parts of the Radixs Astragali, 5-15 parts of Sargassums, 20-30 parts of Herba Artemisiae Scopariaes.
2. the Chinese medicine composition for the treatment of cholelithiasis according to claim 1, is characterized in that, comprises the crude drug of following weight portion: 20-30 parts of Radix Puerariaes, 15-20 parts of maize palpuses, 10-15 parts of Endothelium Corneum Gigeriae Galli, 15-25 parts of Herba Lysimachiaes, 10-15 parts of Herba Taraxacis, 15-20 parts of Radix Curcumaes, 15-20 parts of Cortex Magnoliae Officinalis, 15-20 parts of the Rhizoma Pinelliaes, 15-20 parts of the Radix Aucklandiae, 15-25 parts of Radix Bupleuri, 15-20 parts of Thallus Laminariae (Thallus Eckloniae)s, 15-25 parts of the Radixs Astragali, 5-10 parts of Sargassums, 20-30 parts of Herba Artemisiae Scopariaes.
3. the Chinese medicine composition for the treatment of cholelithiasis according to claim 1, is characterized in that, also comprises the crude drug of following weight portion: 10-20 parts of Rhizoma Atractylodis, 15-20 parts, Poria, 5-10 parts of succinums.
CN201410111342.0A 2014-03-24 2014-03-24 Traditional Chinese medicine composition for treating gall stone Pending CN103933467A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410111342.0A CN103933467A (en) 2014-03-24 2014-03-24 Traditional Chinese medicine composition for treating gall stone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410111342.0A CN103933467A (en) 2014-03-24 2014-03-24 Traditional Chinese medicine composition for treating gall stone

Publications (1)

Publication Number Publication Date
CN103933467A true CN103933467A (en) 2014-07-23

Family

ID=51181523

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410111342.0A Pending CN103933467A (en) 2014-03-24 2014-03-24 Traditional Chinese medicine composition for treating gall stone

Country Status (1)

Country Link
CN (1) CN103933467A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104524474A (en) * 2015-01-15 2015-04-22 王金强 Chinese herb composition for treating bile duct calculi and making method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101112589A (en) * 2007-07-30 2008-01-30 牛昱翔 Liver-benefiting and calculus-removing traditional Chinese medicine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101112589A (en) * 2007-07-30 2008-01-30 牛昱翔 Liver-benefiting and calculus-removing traditional Chinese medicine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
金渊光: "针灸治疗胆石症研究进展", 《中医药信息》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104524474A (en) * 2015-01-15 2015-04-22 王金强 Chinese herb composition for treating bile duct calculi and making method thereof

Similar Documents

Publication Publication Date Title
CN102772778B (en) Traditional Chinese medicine composition for treating summer heat-dampness
CN102416100A (en) Chinese medicinal composition for treating intestinal obstruction
CN103920074A (en) Traditional Chinese medicine composition for treating hepatitis B
CN101502626A (en) Medicine for treating influenza and preparation method thereof
CN103585401A (en) Traditional Chinese medicine composition for treating bird flu and preparation method therefor.
CN101085231A (en) Internal-applied traditional Chinese medicine composition for treating depression
CN104784548A (en) Traditional Chinese medicine composition for treating cough and application thereof
CN103127351B (en) Traditional Chinese medicine for treating premature menstruation
CN103100035B (en) Traditional Chinese medicine (TCM) decoction for treating globus hysteriocus
CN103933467A (en) Traditional Chinese medicine composition for treating gall stone
CN105535193A (en) Traditional Chinese medicine beverage capable of relaxing bowels
CN101129806A (en) Orally taken traditional Chinese medicine composition for treating melancholia
CN105311460A (en) Traditional Chinese medicine for treating vascular neuralgia headache
CN104042872B (en) Traditional Chinese medicine composition for treating common cold of children and preparation method thereof
CN102552789A (en) Chinese medicine for treating damp-warm flu and preparation method and application thereof
CN105412452A (en) Foot-bath and bathing health traditional Chinese medicine for treating summer-heat and damp cold
CN105213627A (en) A kind of Chinese medicine being used for the treatment of sun exterior deficiency
CN105362596A (en) Traditional Chinese medicine for treating pulmonary emphysema and preparation method thereof
CN104435835A (en) Traditional Chinese medicine lotion used for treating pediatric hand-foot-and-mouth disease
CN104189315B (en) A kind of Chinese medicine for the treatment of expectorant blood stasis type globus hystericus
CN104042727A (en) Drugs for oral administration for treating shallow and deep part muscle abscess and preparation method thereof
CN103893598A (en) Traditional Chinese medicine for treating insomnia
CN105288326A (en) Insomnia treatment medicine
CN104027696A (en) Traditional Chinese medicine decoction for treating chronic atrophic gastritis
CN102698127B (en) Traditional Chinese medicine for treating infantile diarrhea

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20140723