CN101607026A - New six-ingredient rehmannia pill - Google Patents
New six-ingredient rehmannia pill Download PDFInfo
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Abstract
LIUWEI DIHUANG WAN is to have used the ancient prescription famous medicine of nearly one thousand years, also be the situation of selling well medicine that many people pursue health body-building, often take for a long time, but poisoning symptoms such as the Rhizoma Alismatis in its crude drug can cause gastroenteritis, feels sick, vomiting, dizzy, eye dusk, stomachache, diarrhoea, myasthenia of limbs, inappetence, pruritus, vasodilation, allergic rash even respiratory paralysis.Medical literature points out that for a long time Rhizoma Alismatis can not obey many clothes for a long time at all times, also can cause nephrotoxicity and cause serious side effects such as acute tubular necrosis if take for a long time.The Chinese medicine Cortex Phellodendri has the effect of rushing down kidney fire of Rhizoma Alismatis in LIUWEI DIHUANG WAN.The present invention is in order to substitute Rhizoma Alismatis, be improved to new six-ingredient rehmannia pill, the effect of nourishing Yin and invigorating kidney that both can keep the ancient prescription LIUWEI DIHUANG WAN, can avoid many untoward reaction again because of using Rhizoma Alismatis to cause, help further improving the safety of medicine, will with the competition of old LIUWEI DIHUANG WAN in obtain a considerable amount of market shares.
Description
The present invention be with original application (applying date: 2005.8.17, application number: 200510092594.4, title: Liuwei Dihuang preparation.Patent Office sends in 2009.3.20 and authorizes and the enroll in notifications book) be dividing an application that the basis proposes, be the Chinese patent medicine that used LIUWEI DIHUANG WAN process is improved the back preparation, belong to the field of Chinese medicines.
Background technology
Existing LIUWEI DIHUANG WAN is from the Song dynasty application, nearly one thousand years so far, becomes the ancient prescription famous medicine of the Chinese nation, clinically well-known.It is total to Six-element Chinese medicine by Radix Rehmanniae Preparata, Fructus Corni, Rhizoma Dioscoreae, Poria, Cortex Moutan, Rhizoma Alismatis and forms.It is precise and appropriate that three benefits, three are around here rushed down compatibility, and element is the alleged song of medical scholar.Secular clinical practice shows, LIUWEI DIHUANG WAN is rich in potentiality, except original indication, found also to have the new purposes of much preventing and curing diseases, also be that many related personnel particularly suffer from a deficiency of the kidney patient, subhealth state person and middle-aged and elderly people in order to pursue the situation of selling well medicine of health body-building.Why LIUWEI DIHUANG WAN exists so far and is widely used, illustrate and withstood secular curative effect test, therefore, some medium and many medical personnels and this medicine admirer and this medicine description claim that all this medicine can (be fit to) take for a long time, also often have this phenomenon in the reality.
Once there was many doctors family that the Rhizoma Alismatis in the six drugs containing rehmanniae side is repeatedly raised an objection in history, thought " Rhizoma Alismatis row watery diarrhea kidney dusk order " also " dislike oozing of Rhizoma Alismatis and subtract it ".Therefore can not obey many clothes for a long time, the Rhizoma Alismatis of desire in will be somebody's turn to do side rejected, but the corresponding measure that substitutes is not provided simultaneously, will be kept to five tastes ball by pill of Six Ingredients, causes Radix Rehmanniae Preparata to have the nothing of benefit to rush down, " single-minded in benefit, the evil that clothes of a specified duration must the deflection victory." run counter to the principles of formulating prescriptions of six drugs containing rehmanniae " three mend three to rush down, to reside it is suitable to rush down in benefit, equilibrium between yin and yang, sound ".It is all on the books in the documents such as " book on Chinese herbal medicine are looked for the truth " of " Precious Book of Ophthalmology " of Compendium of Material Medica, the Gong of Li Shizhen (1518-1593 A.D.) middle " red stove point snow ", Fu Renyu, Hong Ji " health preserving is secret to be cutd open ", Ke Qin " name hospital opinion at all times " and yellow palace embroidery that these go through hundreds of years dispute on repeatedly.In view of the above as can be known, replace Rhizoma Alismatis in the six drugs containing rehmanniae side and become already that the successive dynasties are left over and pendent historical long-pending case.
Constantly there is document to point out in decades, takes that LIUWEI DIHUANG WAN gastroenteritis occurs, feels sick, poisoning symptoms such as vomiting, dizzy, eye dusk, stomachache, diarrhoea, myasthenia of limbs, inappetence, pruritus, allergic rash, vasodilation even respiratory paralysis; Even this medicine description is also still being reminded the user: " inappetence appears in period in a medicine, stomach discomfort, and it is rare to defecate, and during symptoms such as stomachache, should remove hospital admission." these untoward reaction mainly cause by the Rhizoma Alismatis in the medicine.Modern study is found: the Rhizoma Alismatis Herb is poisonous, be very (the author's notes: the medicinal part of Rhizoma Alismatis is its " subterraneous root head " just) with the subterraneous root head; Contain pungent, be affixed on skin and cause foaming, its leaf can be used as the skin rubefaction agent, causes poisoning after cattle eats, the performance hematuria; The nephrotoxicity that Rhizoma Alismatis causes can cause acute tubular necrosis.Motherland's medical science points out that for a long time Rhizoma Alismatis can not be obeyed many clothes for a long time, obeys the then inevitable many clothes Rhizoma Alismatis of LIUWEI DIHUANG WAN for a long time.The kidney invigorating Chinese patent medicine contains the component that can cause nephrotoxicity for a long time, form self-contradictory unreasonable prescription, be worth people to pay close attention to and attention, otherwise, must in the process of taking the LIUWEI DIHUANG WAN enriching yin and nourishing kidney from now on or preventing and curing diseases, continue the painful and infringement that brought by Rhizoma Alismatis.
Any medicine all should improve its safety as far as possible, and LIUWEI DIHUANG WAN also should reduce its side effect as far as possible.The nephrotoxicity that Chinese medicine causes has been subjected to the great attention of Chinese scholars and has proposed the new ideas of " middle property of medicine nephropathy ".Existing medium propose, for " composition of the existing serious adverse reaction of New Development also should be stopped using in the Chinese medicine courageous and resolutely." " secondary development of Chinese medicine is the main path of the modernization of Chinese medicine, can carry out flavour of a drug to the poisonous medicine in the selected prescription and substitute." therefore, the also the same objective law of maximizing favourable factors and minimizing unfavourable ones, updating that exists of medicine with other commodity.
Summary of the invention
The purpose of this invention is to provide the Chinese patent medicine with functions of nourishing yin and invigorating kidney similar, but do not have the like that not only many but also serious adverse effects of Rhizoma Alismatis to LIUWEI DIHUANG WAN.Solution of the present invention is to provide more rational Chinese medicine to substitute Rhizoma Alismatis to LIUWEI DIHUANG WAN, and used Chinese medicine should all meet following three conditions:
1, possess the function of Rhizoma Alismatis in LIUWEI DIHUANG WAN---can rush down the kidney fire;
2, with the nature and flavor of Rhizoma Alismatis with Gui Jing is identical or major part is identical;
3, untoward reaction reduces significantly than Rhizoma Alismatis.
According to the Chinese medicine and pharmacy theory, the cold and cool Chinese medicine that is included into kidney channel has and rushes down (falling) kidney fire action.(version was one one in 2005 according to the Pharmacopoeia of the People's Republic of China again, Chinese Pharmacopoeia Commission compiles, Chemical Industry Press, January in 2005 the 1st edition) record: the cold and cool Chinese medicine that is included into kidney channel mainly contains Herba Desmodii Styracifolii, Fructus Ligustri Lucidi, Radix Asparagi, Semen Plantaginis, Herba Plantaginis, Herba Dendrobii, Radix Cynanchi Atrati, Radix Scrophulariae, the Fructus Kochiae, Herba Scutellariae Barbatae, Cortex Lycii, Radix Rehmanniae, Radix Panacis Quinquefolii, Cortex Phellodendri, Herba Glechomae, Cortex Moutan, Thallus Laminariae (Thallus Eckloniae), the Rhizoma Anemarrhenae, Herba Lysimachiae, Rhizoma Alismatis, the llex cornuta leaf, Caulis Trachelospermi, Plumula Nelumbinis, Herba Centellae, Sargassum, Fructus Mori, Cortex Phellodendri, the sub-Herba Siegesbeckiae of Fructus Broussonetiae, Herba Ecliptae and Carapax Trionycis etc.This pharmacopeia P214 also puts down in writing: the Cortex Phellodendri hardship, and cold.Return kidney, urinary bladder channel.Function with cure mainly: heat clearing and damp drying, pathogenic fire purging are removed and are steamed, and salt is fried nourishing YIN to lower pathogenic fire, controls hyperactivity of fire caused by deficiency of YIN etc.
In above-mentioned tens of kinds of Chinese medicines, so long as the cold and cool Chinese medicine that is included into kidney channel of state-promulgated pharmacopoeia record all can use according to qualifications by above-mentioned three conditions.Through comparing in many ways, repeated screening can be adopted Chinese medicines such as Cortex Phellodendri.With reference to the standard of above three conditions, the correlated situation of Cortex Phellodendri and Rhizoma Alismatis is as follows:
1, the function of Rhizoma Alismatis in LIUWEI DIHUANG WAN is one of " three rush down "---rush down the kidney fire." Cortex Phellodendri is the kidney channel principal agent, heat clearing away, dampness, pathogenic fire purging, detoxifies, falls YIN-fire, the kidney invigorating water.The kidney invigorating reinforcing YIN-essence specially rushes down the fire of kidney and bladder, lets out damp and hot and clear bladder.The effect that promotes pancreatic secretion is arranged." (the Chinese medicine voluminous dictionary, the new medical college in Jiangsu is compiled, Shanghai science tech publishing house, June in 1986 the 1st edition, volume two, 2031.) show the pathogenic fire purging effect of Cortex Phellodendri and not second to Rhizoma Alismatis.
2, the Rhizoma Alismatis nature and flavor are sweet, and are cold; Go into kidney, urinary bladder channel.Cortex Phellodendri nature and flavor hardship, cold; Go into kidney, urinary bladder channel.The flavour of a drug difference of two medicines, the property of medicine is all identical with Gui Jing." amara has dampness, lets out, consolidates the merit of the moon clearly; Return the medicine of kidney channel with bitter cold,, rush down the kidney fire and the moon that reinforces the kidney as Cortex Phellodendri, the Rhizoma Anemarrhenae." (entertaining Chinese medicine, fourth million flat sennits works, People's Health Publisher, May in 2003 the 1st edition, 16).
3, part is cured nationality and pertinent literature at all times by retrieval, does not see that the record of side effect appears in Cortex Phellodendri in routine dose is used, more find no a lot of untoward reaction as Rhizoma Alismatis.Aspect toxicity, the decoct of Cortex Phellodendri is 9.86 ± 0.96g/kg to mouse peritoneal injection LD50; The Rhizoma Alismatis decoct is 1.27g/kg to mouse peritoneal injection LD50; 7.8 times of the two great disparities show that the safety coefficient of Cortex Phellodendri is bigger.In addition, " Main Ingredients and Appearance of Cortex Phellodendri is a berberine, is important conventional Chinese medicine." (herbal pharmacology and application, the king bathes to give birth to and waits the chief editor, the People's Health Publisher, December was the 2nd edition in 1998, and 1025.) the author is through studying for many years, test and taking, discovery berberine (being berberine) has many-sided beneficial effect and oral as safe as a house to human body, applies for a patent separately.
The relatively prompting of two medicines, Cortex Phellodendri is all up to standard in three conditions, have the ability fully to undertake an important business, substitute the Rhizoma Alismatis in the LIUWEI DIHUANG WAN, form wherein a kind of new six-ingredient rehmannia pill of the present invention, the cold and cool Chinese medicine that also can select the be included into kidney channel of putting down in writing in the above-mentioned state-promulgated pharmacopoeia else uses respectively, determines best a kind of Chinese medicine or scheme at last.
The specific embodiment:
Wherein a kind of new six-ingredient rehmannia pill of the present invention is raw materials used to comprise following Chinese medicine:
Radix Rehmanniae Preparata, Fructus Corni (processed), Rhizoma Dioscoreae, Poria, Cortex Moutan, Cortex Phellodendri (salt is fried, down together).
Weight (part) ratio range of the raw material consumption of preparation said medicine is:
Radix Rehmanniae Preparata 4～16 Fructus Corni (processed)s 2～8 Rhizoma Dioscoreaes 2～8
Poria 1～6 Cortex Moutan 1～6 Cortex Phellodendri 1～6.
Formula optimization weight (part) ratio range of preparation said medicine is:
Radix Rehmanniae Preparata 6～10 Fructus Corni (processed)s 3～6 Rhizoma Dioscoreaes 3～6
Poria 2～4 Cortex Moutans 2～4 Cortex Phellodendris 2～4.
Optimum weight (part) proportioning of preparation said medicine is:
Radix Rehmanniae Preparata 8 Fructus Corni (processed)s 4 Rhizoma Dioscoreaes 4 Poria 3 Cortex Moutans 3 Cortex Phellodendris 3.
Can select for use equal quantity multiple to get material to each flavor Chinese medicine in above ratio with identical unit of weight.
At the select tens of kinds Chinese medicines that are used for mutually relatively, also have the Rhizoma Anemarrhenae etc. also to have and rush down the kidney fire action preferably.Rhizoma Anemarrhenae nature and flavor hardship, sweet, cold; Go into lung, stomach, kidney channel.Nourishing YIN to lower pathogenic fire, rush down the kidney fire of unrooted.Cortex Phellodendri in the new six-ingredient rehmannia pill raw material also can be used the Chinese medicine that also can rush down the kidney fire instead--and comprise that Rhizoma Anemarrhenae etc. is prepared into the new preparation of six ingredients with rehmannia of different component respectively, the consumption of these Chinese medicines is identical with above-mentioned Cortex Phellodendri consumption.From another angle, the present invention also is equivalent at first reject Rhizoma Alismatis in the ZHIBAI DIHUANG WAN raw material, subtracts then with the Rhizoma Anemarrhenae or Cortex Phellodendri.
Above-mentioned Chinese medicine is adopted existing processing or extractive technique, in resulting extract or refining thing, add conventional carrier or excipient, make dosage form said on any pharmaceutics, comprise the dosage form of various pills and other oral formulations or parenterai administration.Pill comprises concentrated pill, honeyed pill, the watered pill, paste pill, drop pill.Other peroral dosage form comprises capsule, soft capsule, tablet, slow releasing tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablets, compound recipe decoction pieces, oral powder, spraying powder, granule, micropowder, microcapsule, micropill, oral liquid, medicated wine, syrup, extractum, soft extract.The parenterai administration dosage form comprises injection, membrane, aerosol.Medicine of the present invention causes the production technology difference because of the dosage form difference, resulting machining object or extract weight also have nothing in common with each other, and dose is widely different, can only calculate according to exsiccant primary crude drug weight at this, general consumption is to amount to every day raw medicinal herbs 8～30g, divides and takes for 2～3 times.
Because the property of medicine of Cortex Phellodendri and Rhizoma Alismatis, return kidney channel, to rush down the kidney fire action all identical, the nature and flavor of the Rhizoma Anemarrhenae etc. and Rhizoma Alismatis, return kidney channel, to rush down the kidney fire action also basic identical, therefore the functions of nourishing yin and invigorating kidney of new six-ingredient rehmannia pill of the present invention and other oral formulations and LIUWEI DIHUANG WAN, usage and dosage, adaptation disease, newly the concocting method etc. of purposes and Fructus Corni is also basic identical.LIUWEI DIHUANG WAN of the present invention refers to the former side Chinese patent medicine of (containing Rhizoma Alismatis).
In the former side of LIUWEI DIHUANG WAN, add some Chinese medicine, can derive serial rehmannia preparations such as ZHIBAI DIHUANG WAN, MAIWEIDIHUANGWAN, attached osmanthus Dihuang Wan, Ji Radix Rehmanniae ball, QIJU DIHUANG WAN, 'Guishao Dihuang ball, Radix Rehmanniae Pilulae for Improving Eyesight, Duqi Wan, ERLONG ZUOCI WAN, medicament of the present invention also can be copied said method to add relevant Chinese medicine and prepare corresponding Chinese patent medicine.
Beneficial effect
Use the poisonous raw material Rhizoma Alismatis in the LIUWEI DIHUANG WAN instead Cortex Phellodendri etc., the effect of nourishing Yin and invigorating kidney that both can keep former side, can avoid many untoward reaction again because of using Rhizoma Alismatis to cause, increase substantially the safety of medicine, meet modern medicines and should possess the most important condition in " safe, effective, controlled, stable " this only international standard; Can impel ancient Chinese medicine doctor that this problem left over by history is argued in the going or staying of Rhizoma Alismatis in the LIUWEI DIHUANG WAN is again properly settled.The present invention further improves ancestor's prescription perfect, classical medicine is done secondary development, indigo blue is extracted from the indigo plant but is bluer than the plant it comes to make it, help reducing the infringement of LIUWEI DIHUANG WAN to human body, help further improving consumers in general's health level, help strengthening this medicine competitiveness in market at home and abroad.New six-ingredient rehmannia pill after the improvement (intending the medication name) etc. will be maximized favourable factors and minimized unfavourable ones, be redoubled one's efforts, for human health is made bigger contribution.
In order to understand essence of the present invention better, the part embodiment of brief description new six-ingredient rehmannia pill and other preparation.
Embodiment 1
Cortex Moutan, Fructus Corni, Poria powder are broken into fine powder, sieve, mixing.Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Cortex Phellodendri decoct with water 3 times, and first and second time respectively is 2 hours, are 1 hour for the third time, and collecting decoction filters, filtrate is condensed into cream, with above-mentioned powder mixes, cold drying, pulverizes, and adds right amount of auxiliary materials, mixing is made dried granule, and is dry again, promptly gets a material agent.
Embodiment 2
Dried granule, drying, compacting that embodiment 1 obtains is in blocks, and coating makes tablet.
Embodiment 3
With the dried granule that embodiment 1 obtains, adopt routine to mould the method for making pill, drying, polishing makes concentrated pill.
Embodiment 4
Dried granule, drying with embodiment 1 obtains incapsulate, and promptly get capsule.
Embodiment 5
Cortex Moutan extracts, separates volatile oil; The Fructus Corni ethanol extraction; Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Cortex Phellodendri decocting boiling down shorten cream into, add the ethanol extraction supernatant in the cream and mix with the extracting solution of Fructus Corni; Warm macerating is 2 times behind the Poria decocting in water, and leachate is condensed into cream; All extract merging are condensed into cream, and drying is ground into fine powder, adds Cortex Moutan volatile oil and vegetable oil, and mixing is made soft capsule.
Embodiment 6
With Six-element Chinese medicine, be ground into fine powder, sieve mixing.Every 100g powder adds refined honey 35～50g and an amount of water, general ball, and drying is made water-honeyed pill; Or add refined honey 80～110g and make big honeyed pills, promptly.
Embodiment 7
With Six-element Chinese medicine drying, use pulverizing mill (Chinese medicine cell grade disintegrating apparatus) to become≤70 microns micropowder with comminution by gas stream, adopt common process to be prepared into oral, interior usefulness, external etc. and adapt to preparation.
Embodiment 8
Adopt conventional method to be extracted as dried cream (respectively containing Cortex Lycii, Cortex Phellodendri, the Rhizoma Anemarrhenae, Herba Desmodii Styracifolii, the Fructus Kochiae totally five kinds respectively) in the Chinese medicine of respectively distinguishing the flavor of of above-mentioned optimum weight (part) proportioning and be prepared as capsule; 120 voluntary triers are divided into five groups at random, take a kind, do the test of enriching yin and nourishing kidney respectively for every group, everyone each oral 2 (being equivalent to crude drug in whole 3g), 3 times on the one, logotype January, all tell and have and the identical effect of former side's LIUWEI DIHUANG WAN, and do not find any untoward reaction.24 people wherein are once to LIUWEI DIHUANG WAN allergy, side effect such as stomachache, diarrhoea or erythra pruritus occur after taking a few days, and irritated elimination factor 100% takes place in these trials again.Show that new preparation of six ingredients with rehmannia of the present invention both can keep original therapeutic effect, can further improve its safety again.
Claims (7)
1, new six-ingredient rehmannia pill, it be select for use can rush down simply the kidney fire wherein comprise Cortex Phellodendri Chinese medicine, substitute the medicament of the Rhizoma Alismatis preparation in the LIUWEI DIHUANG WAN, it is identical with Cortex Phellodendri consumption in the following weight proportioning crude drug to rush down the consumption of kidney fire Chinese medicine:
Radix Rehmanniae Preparata 4～16 Fructus Corni (processed)s 2～8 Rhizoma Dioscoreaes 2～8
Poria 1～6 Cortex Moutan 1～6 Cortex Phellodendri 1～6.
2, new six-ingredient rehmannia pill as claimed in claim 1, wherein the weight proportion of each crude drug is:
Radix Rehmanniae Preparata 6～10 Fructus Corni (processed)s 3～6 Rhizoma Dioscoreaes 3～6
Poria 2～4 Cortex Moutans 2～4 Cortex Phellodendris 2～4.
3, new six-ingredient rehmannia pill as claimed in claim 1, wherein the weight proportion of each crude drug is:
Radix Rehmanniae Preparata 8 Fructus Corni (processed)s 4 Rhizoma Dioscoreaes 4 Poria 3 Cortex Moutans 3 Cortex Phellodendris 3.
4, as each described new six-ingredient rehmannia pill of claim 1～3, each crude drug is adopted conventional processing or extractive technique and adds conventional adjuvant or excipient, make said pill or other oral formulations on any pharmaceutics.
5, pill as claimed in claim 4 comprises concentrated pill, honeyed pill, the watered pill, paste pill, drop pill, micropill.
6, other oral formulations as claimed in claim 4 comprises capsule, soft capsule, tablet, slow releasing tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablets, oral powder, spraying powder, granule, micropowder, microcapsule, oral liquid, medicated wine, syrup, extractum, soft extract.
7, as the application of each described new six-ingredient rehmannia pill of claim 1～3 in the medicine of preparation enriching yin and nourishing kidney.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009102035644A CN101607026A (en) | 2005-01-31 | 2005-08-17 | New six-ingredient rehmannia pill |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200510052289 | 2005-01-31 | ||
| CN200510052289.2 | 2005-01-31 | ||
| CN200510070507.5 | 2005-04-23 | ||
| CN200510078204.8 | 2005-06-05 | ||
| CNA2009102035644A CN101607026A (en) | 2005-01-31 | 2005-08-17 | New six-ingredient rehmannia pill |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100925944A Division CN100490869C (en) | 2005-01-31 | 2005-08-17 | Formulation with six ingredients containing rehmanniae |
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| CN101607026A true CN101607026A (en) | 2009-12-23 |
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| CNA2009102035644A Pending CN101607026A (en) | 2005-01-31 | 2005-08-17 | New six-ingredient rehmannia pill |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223082A (en) * | 2013-03-27 | 2013-07-31 | 张宗升 | Extract product of traditional Chinese medicine |
| CN108653621A (en) * | 2018-06-29 | 2018-10-16 | 文德兴 | A kind of Chinese medicine composition for treating deficiency of kidney-QI |
-
2005
- 2005-08-17 CN CNA2009102035644A patent/CN101607026A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223082A (en) * | 2013-03-27 | 2013-07-31 | 张宗升 | Extract product of traditional Chinese medicine |
| CN108653621A (en) * | 2018-06-29 | 2018-10-16 | 文德兴 | A kind of Chinese medicine composition for treating deficiency of kidney-QI |
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Application publication date: 20091223 |