CN103932173B - 一种解酒护肝的组合物 - Google Patents
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Abstract
本发明涉及一种解酒护肝的组合物，由下述原料配比而得：葛花、积雪草、白芍、石斛、茯苓、木瓜、蒲公英、沙棘、五味子、丁香、白扁豆、胖大海、甘草、枳实、半夏、女贞子、绞股蓝、姜黄、荆芥、竹叶、桂枝、枸杞子、远志。诸药合用，相得益彰，能够加快酒精在体内的代谢，增加酒精的排泄，增强人体对酒精的耐受能力；酒醉后服用能改善与治疗因酒醉引起的头痛、头晕、恶心等不适症状，起到解酒作用。疗效显著可靠，应用前景广阔。
Description
技术领域
本发明属于保健品技术领域，具体的，涉及一种解酒护肝的组合物，以及其制备方法。
背景技术
中国的酒文化历史悠久，节假日走亲访友，同学聚会，工作宴请，放眼于日常工作与生活，酒几乎无处不在，同时饮酒过量而伤人伤己的事情是时常发生。现代研究表明：酒精在人体的吸收代谢途径主要为：肠胃、肝脏、皮肤和呼吸系统等；其中肠胃是酒精的主要吸收场所，90％以上酒精通过肝脏中的酶系统进行氧化代谢，其余则通过皮肤、呼吸和排泄排出体外。过量饮酒、醉酒对人体的危害是十分严重的。急性大量饮酒可引起恶心、呕吐、注意力不集中、精细运动能力受损、情绪不稳定，严重时可引起昏睡、昏迷、呼吸、循环功能衰竭而死亡。长期饮酒可引起消化、神经、循环等系统诸多病变。乙醇在体内有极少量直接经尿、汗或肺排出，绝大部分酒精主要在肝脏代谢，经乙醇脱氢酶将酒精转化为乙醛，乙醛，而乙醛对人体有毒，再经肝乙醛脱氢酶氧化为乙酸，最后变成水和二氧化碳排出体外。长期大量饮酒，可引起酒精性肝病，酒精性脑病、脑萎缩、酒精性痴呆、酒精性骨病，骨质疏松和股骨头坏死，还可引起酒精性心肌病，使冠心病的患病率和病死率增加，男性阳萎，孕期婴儿发育缺陷，被污染酿造出来的酒可以致癌。
肝脏是人体最大的腺体，它在人的代谢、胆汁生成、解毒、凝血、免疫、热量产生及水与电解质的调节中均起着非常重要的作用。一般来说，造成肝损伤主要有两大类致病因素，一类是由病原微生物如病毒感染而引起的肝脏炎症，如甲肝、乙肝等。另一类则是化学性肝损伤，它由各种毒性物质，如食物中的酒精、环境中的化学毒物及某些药物等对肝脏造成的损伤。
目前市场解酒药的分类及作用：1、化学药品：多是兴奋剂、维生素与氨基酸等成分，起到促进酒精分解和醒酒的作用，对酒精造成的脏器伤害和慢性中毒效果甚微。2、酶制剂：含乙醛脱氢酶和中药的解酒胶囊，可以迅速分解乙醛和吸附酒精，但价格昂贵。3、中药制剂：中药解酒有悠久的历史，采用整体观辨证论治，对急慢性酒精中毒均有治疗作用。
中医理论认为，酒为大热有毒之品，过饮之必伤及脾胃肝胆而引发疾病。病机则可归纳为：脾胃气虚、痰湿内阻、水湿内停、气血不和、气滞血瘀等。其中，酒伤肝脾、聚湿生痰为发病之关键；而素体禀赋不足、脾胃虚弱为发病之本。中国有着丰富的药用植物资源，且我国古代历有诸多解酒良方，对饮酒造成的各种症候都有相应的配方。据古籍所载，方剂或治法多种多样，仅对《太平圣惠方》、《世医得效方》、《普济方》和《医方类聚》的不完统计，大小的解酒和戒酒方药约150余种，其中解酒方剂占90％，戒酒方剂占10％。当今我国有部分学者对其中的国粹古方如葛花解醒酒汤、酒仙乐、干钟酒、石膏汤和五子衍宗丸等解酒验方的解酒能力进行研究，并有人研制醒酒口服液、醒酒茶和解酒功能制剂。
发明内容
本发明参考祖国医学对解酒机理的认识以及经验，参阅已有合理组方，辨证论治，按照中国药典及药理配伍，推陈致新有所增益，辨证论治一直是中医药治疗疾病的核心理论，如何针对主要病机用药同时兼顾次要病机，兼顾共性与个性的治疗，从而最大程度体现中医治疗疾病的内涵与外延，是中成药配伍的一个现实难题。
本发明的目的是为了使饮酒过量的人适量饮用后能够解酒、利尿、保肝而提供的一种具有快速降低血中酒精浓度作用的功能性解酒组合物。本发明的解决方案是基于现代生物科学对于酒精在体内吸收代谢的过程结合祖国传统医学对醉酒辩证治疗，依据中医理论，按照减缓吸收，加强代谢，加速排泄，促进恢复的综合醒酒思路，遵循安全营养，综合防治，技术上先进、经济上合理的开发原则。
为实现本发明目的，本发明采用的技术方案如下：
一种解酒护肝的组合物，其特征在于由下述重量配比的原料制备而得：
葛花25份、积雪草25份、白芍25份、石斛22份、茯苓22份、
木瓜20份、蒲公英20份、沙棘18份、五味子18份、丁香18份、
白扁豆15份、胖大海15份、甘草15份、枳实15份、半夏15份、
女贞子13份、绞股蓝13份、姜黄12份、荆芥10份、竹叶10份、
桂枝8份、枸杞子7份、远志7份。
本发明的药物组合物其制备方法为：取上述重量份数的原料药(例如配比单位：克)具体操作如下：
1)称取各原料药，备用；
2)取木瓜添加1倍重量水榨汁获得木瓜汁；
3)将葛花、积雪草、白芍、五味子、丁香、白扁豆、胖大海、甘草、枸杞子、远志混合均匀，加5倍重量的水武火煮沸，然后文火煎煮1小时，过滤收集滤液和滤渣；往滤渣中添加水，以没过滤渣为准，武火煮沸，然后文火煎煮30分钟，过滤收集滤液；合并上述两次滤液得液体A；
3)取剩余成分(即石斛、茯苓、蒲公英、沙棘、枳实、半夏、女贞子、绞股蓝、姜黄、荆芥、竹叶、桂枝)加90％乙醇浸泡1小时，以没过原料为准，提取两次，每次1-2小时，合并提取液，滤过，得液体B；
4)将木瓜汁、液体A、液体B混合搅拌均匀即得。
优选地在组合物中调入木糖醇少许改善风味即为醒酒效果良好的饮料制品。
本发明药物的组分均采用天然的中药原料，其配制简便，药源广泛，成本低廉，其遵循中医的处方用药原则，诸药合用，相得益彰，君臣佐使各施其效，一般反应服用本品后的饮酒量可增加一倍而无不良反应。本品在饮酒前半小时服用，可减少人体对酒精的吸收，同时加快酒精在体内的代谢，增加酒精的排泄，增强人体对酒精的耐受能力；酒醉后服用能改善与治疗因酒醉引起的头痛、头晕、恶心等不适症状，起到解酒作用。疗效显著可靠，应用前景广阔。
具体实施方式
实施例1
一种解酒护肝的组合物，其特征在于由下述重量配比的原料制备而得：
葛花25份、积雪草25份、白芍25份、石斛22份、茯苓22份、
木瓜20份、蒲公英20份、沙棘18份、五味子18份、丁香18份、
白扁豆15份、胖大海15份、甘草15份、枳实15份、半夏15份、
女贞子13份、绞股蓝13份、姜黄12份、荆芥10份、竹叶10份、
桂枝8份、枸杞子7份、远志7份。
上述药物组合物其制备方法为：取上述重量份数的原料药(例如配比单位：克)具体操作如下：
1)称取各原料药，备用；
2)取木瓜添加1倍重量水榨汁获得木瓜汁；
3)将葛花、积雪草、白芍、五味子、丁香、白扁豆、胖大海、甘草、枸杞子、远志混合均匀，加5倍重量的水武火煮沸，然后文火煎煮1小时，过滤收集滤液和滤渣；往滤渣中添加水，以没过滤渣为准，武火煮沸，然后文火煎煮30分钟，过滤收集滤液；合并上述两次滤液得液体A；
3)取剩余成分(即石斛、茯苓、蒲公英、沙棘、枳实、半夏、女贞子、绞股蓝、姜黄、荆芥、竹叶、桂枝)加90％乙醇浸泡1小时，以没过原料为准，提取两次，每次1-2小时，合并提取液，滤过，得液体B；
4)将木瓜汁、液体A以及液体B混合搅拌均匀即得。
实施例2
一、小鼠酒醉预防实验
实验材料：取本发明实施例1制得的解酒护肝的组合物，市售二锅头配成含酒精40％的水溶液备用。
实验方法：取昆明种小白鼠40只，雌雄兼用，体重18-20g，随机分为2组，每组20只，分别设定模型组，本发明实施例1药物组，各组每日灌胃给酒0.4mL／只，模型组每日给酒前30min，灌胃给水0.1mL，给药组每日给酒前30min，均灌胃给药0.1mL，连续进行30日，并分别在第2、5、10、15、20日时对小鼠进行翻正反射实验，观察给酒精后1小时内小鼠出现翻正反射消失的只数，翻正反射消失可认为动物醉酒，累计5次观测结果，计算其醉倒率。
实验结果表明，给药组与模型组相比，醉倒率明显降低，显示其具有良好的预防醉酒的作用。
小鼠酒醉预防实验
| 组别 | 例数 | 醉倒次(只)数 |
| 模型组 | 20 | 76 |
| 给药组 | 20 | 10 |
二、小鼠解酒能力实验
取昆明种小鼠60只，雌雄兼用，在实验室饲养1d。然后禁食5h，称重标记后随机分为模型组(空白对照组)、本发明实施例1组。先灌胃给酒剂量0.25ml／20g，给酒后立即给药，空白对照组给予蒸馏水。以翻正反射消失为睡眠指标，计算耐受时间(从乙醇灌胃到翻正反射消失的时间)及醉睡时间(从翻正反射消失到恢复的时间)，结果如下：
| 组别 | 例数 | 未醉(只) | 醉睡(只) | 耐受时间 |
| 模型组 | 30 | 0 | 30 | 5.4±1.1 |
| 给药组 | 30 | 19 | 11 | 20.5±1.7 |
由上可见，本发明解酒组合物能够明显增强小鼠的耐受时间，解酒效果显著。
实施例3
临床资料
病例选择：在长期饮酒人群中选择易头痛者61人，年龄25-51岁，皆为男性。
治疗方法：饮酒前后半小时各服用实施例1制备的解酒护肝的组合物，饮酒量与此前头痛时饮酒量相当。
疗效判定标准：
显效：无头痛症状。
有效：头痛程度减轻，头痛时间变短。
无效：头痛程度没有改变。
结果：服用实施例1制备的解酒护肝组合物后，嗜睡，头晕，头痛，恶心等症状明显减轻，能正常活动，头痛症状消失的有40人，另有17人反应头痛程度减轻，头痛时间变短，4人头痛程度没有改变，由此计算本发明解酒露的总有效率为：93％。
实施例4
典型病例
于某，男，41岁，饮用泸州老窖500ml，饮酒前服用实施例1制备的护肝组合物100ml，没有以前饮酒出现的呕吐、头晕、难受的症状。
赵某，男，33岁，民企销售，长期大量饮酒，工作性质决定长期大量饮酒，两年后出现发作性遗忘，肋缘下触及肝脏1cm。诊为慢性酒精中毒，坚持每天两次，每次服用实施例1制备的护肝组合物100ml，1个月后症状体征消失，又坚持服1个月，恢复健康。
陈某，男，39岁，酒前半小时服用实施例1制备的护肝组合物100ml，自我感觉酒量比平时增加了，酒后无明显醉酒的反应。
以上列举的仅是本发明的最佳具体实施例。显然，本发明不限于以上实施例，还可以有许多变形。本领域的普通技术人员能从本发明公开的内容直接导出或联想到的所有变形，均应认为是本发明的保护范围。
Claims (2)
1.一种解酒护肝的组合物，其特征在于由下述重量份的原料制备而得：
葛花25份、积雪草25份、白芍25份、石斛22份、茯苓22份、
木瓜20份、蒲公英20份、沙棘18份、五味子18份、丁香18份、
白扁豆15份、胖大海15份、甘草15份、枳实15份、半夏15份、
女贞子13份、绞股蓝13份、姜黄12份、荆芥10份、竹叶10份、
桂枝8份、枸杞子7份、远志7份；
所述组合物的制备方法包括如下步骤：
1)按照重量份称取各原料，备用；
2)取木瓜添加1倍重量水，榨汁获得木瓜汁；
3)取葛花、积雪草、白芍、五味子、丁香、白扁豆、胖大海、甘草、枸杞子以及远志，混合均匀，加5倍重量的水武火煮沸，然后文火煎煮1小时，过滤收集滤液和滤渣；往滤渣中添加水，以没过滤渣为准，武火煮沸，然后文火煎煮30分钟，过滤收集滤液；合并上述两次滤液得液体A；
3)取石斛、茯苓、蒲公英、沙棘、枳实、半夏、女贞子、绞股蓝、姜黄、荆芥、竹叶以及桂枝，加90％乙醇浸泡1小时，提取两次，每次1-2小时，合并提取液，滤过，得液体B；
4)将木瓜汁、液体A以及液体B混合，搅拌均匀即得。
2.权利要求1所述组合物用于制备醒酒护肝的药物的用途。
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| CN105581210A (zh) * | 2016-01-26 | 2016-05-18 | 济南大学 | 一种具有醒酒功效的醋饮料 |
| CN106072564A (zh) * | 2016-07-02 | 2016-11-09 | 威海御膳坊生物科技有限公司 | 一种肝功能衰竭患者特殊医学用途配方食品 |
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| CN112546135A (zh) * | 2020-12-18 | 2021-03-26 | 复旦大学附属金山医院 | 一种解酒、醒酒、护肝的中药组合物及其应用 |
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