CN103930397B - 用于生产n取代的2-(乙酰氨基)-n’-苯甲基-3-甲氧基丙酰胺的方法 - Google Patents
用于生产n取代的2-(乙酰氨基)-n’-苯甲基-3-甲氧基丙酰胺的方法 Download PDFInfo
- Publication number
- CN103930397B CN103930397B CN201280056152.2A CN201280056152A CN103930397B CN 103930397 B CN103930397 B CN 103930397B CN 201280056152 A CN201280056152 A CN 201280056152A CN 103930397 B CN103930397 B CN 103930397B
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- CN
- China
- Prior art keywords
- formula
- compound
- acid
- ethyl
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 CC(N(*)C(COC)C(NCc1ccccc1)=O)=O Chemical compound CC(N(*)C(COC)C(NCc1ccccc1)=O)=O 0.000 description 1
- GMLJQHNLDHDNPX-RXMQYKEDSA-N CN[C@H](COC)C(OC)=O Chemical compound CN[C@H](COC)C(OC)=O GMLJQHNLDHDNPX-RXMQYKEDSA-N 0.000 description 1
- WPLANNRKFDHEKD-SNVBAGLBSA-N COC[C@H](C(NCc1ccccc1)=O)N Chemical compound COC[C@H](C(NCc1ccccc1)=O)N WPLANNRKFDHEKD-SNVBAGLBSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11009048.7 | 2011-11-15 | ||
| EP11009048 | 2011-11-15 | ||
| PCT/EP2012/072548 WO2013072330A1 (en) | 2011-11-15 | 2012-11-14 | Process for the production of n-substituted 2-(acetylamino)-n'-benzyl-3-methoxypropanamides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103930397A CN103930397A (zh) | 2014-07-16 |
| CN103930397B true CN103930397B (zh) | 2015-10-21 |
Family
ID=47178026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280056152.2A Active CN103930397B (zh) | 2011-11-15 | 2012-11-14 | 用于生产n取代的2-(乙酰氨基)-n’-苯甲基-3-甲氧基丙酰胺的方法 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2780318B1 (https=) |
| JP (1) | JP2014533292A (https=) |
| CN (1) | CN103930397B (https=) |
| BR (1) | BR112014011748A2 (https=) |
| EA (1) | EA024260B8 (https=) |
| IL (1) | IL232627A0 (https=) |
| IN (1) | IN2014KN01247A (https=) |
| MX (1) | MX341754B (https=) |
| WO (1) | WO2013072330A1 (https=) |
| ZA (1) | ZA201403237B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016039393A1 (ja) * | 2014-09-10 | 2016-03-17 | 株式会社エーピーアイ コーポレーション | アミノ酸誘導体の製造方法 |
| CN117964512B (zh) * | 2024-04-01 | 2024-06-04 | 山东惟普控股有限公司 | 一种n,n-二甲基-3-甲氧基丙酰胺的合成方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090143472A1 (en) * | 2007-12-04 | 2009-06-04 | Mukesh Kumar Madhra | Intermediate compounds and their use in preparation of lacosamide |
| WO2010107993A2 (en) * | 2009-03-18 | 2010-09-23 | Pliva Hrvatska D.O.O. | Process for preparing (r)-7v-benzyl-2- (benyloxycarbonylamino)-s-methoxypropionamide |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656656A (en) | 1992-11-05 | 1997-08-12 | Dompe Farmaceutici S.P.A. | Tartronic acids, their acetalic ethers and O-esters |
| DE4425466A1 (de) | 1994-07-19 | 1996-01-25 | Thomas & Betts Gmbh | Kabel-Steckverbinder |
| EP1642889A1 (en) | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| SG178158A1 (en) | 2009-08-06 | 2012-03-29 | Shell Int Research | Process for preparing an alkylate |
| EP2480524A1 (en) | 2009-09-25 | 2012-08-01 | Cadila Healthcare Limited | Processes for the preparation of lacosamide and intermediates thereof |
-
2012
- 2012-11-14 CN CN201280056152.2A patent/CN103930397B/zh active Active
- 2012-11-14 WO PCT/EP2012/072548 patent/WO2013072330A1/en not_active Ceased
- 2012-11-14 BR BR112014011748A patent/BR112014011748A2/pt not_active Application Discontinuation
- 2012-11-14 JP JP2014541630A patent/JP2014533292A/ja active Pending
- 2012-11-14 EA EA201490990A patent/EA024260B8/ru not_active IP Right Cessation
- 2012-11-14 IN IN1247KON2014 patent/IN2014KN01247A/en unknown
- 2012-11-14 MX MX2014005593A patent/MX341754B/es active IP Right Grant
- 2012-11-14 EP EP12784603.8A patent/EP2780318B1/en active Active
-
2014
- 2014-05-05 ZA ZA2014/03237A patent/ZA201403237B/en unknown
- 2014-05-14 IL IL232627A patent/IL232627A0/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090143472A1 (en) * | 2007-12-04 | 2009-06-04 | Mukesh Kumar Madhra | Intermediate compounds and their use in preparation of lacosamide |
| WO2010107993A2 (en) * | 2009-03-18 | 2010-09-23 | Pliva Hrvatska D.O.O. | Process for preparing (r)-7v-benzyl-2- (benyloxycarbonylamino)-s-methoxypropionamide |
Also Published As
| Publication number | Publication date |
|---|---|
| IN2014KN01247A (https=) | 2015-10-16 |
| EA024260B1 (ru) | 2016-08-31 |
| EA024260B8 (ru) | 2016-11-30 |
| WO2013072330A1 (en) | 2013-05-23 |
| MX2014005593A (es) | 2015-01-22 |
| MX341754B (es) | 2016-09-02 |
| ZA201403237B (en) | 2015-12-23 |
| CN103930397A (zh) | 2014-07-16 |
| EP2780318A1 (en) | 2014-09-24 |
| JP2014533292A (ja) | 2014-12-11 |
| IL232627A0 (en) | 2014-06-30 |
| EP2780318B1 (en) | 2015-08-26 |
| EA201490990A1 (ru) | 2014-11-28 |
| BR112014011748A2 (pt) | 2017-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |