CN103906738B - 用于治疗趋化因子介导的疾病的新的二取代的3,4-二氨基-3-环丁烯-1,2-二酮化合物 - Google Patents
用于治疗趋化因子介导的疾病的新的二取代的3,4-二氨基-3-环丁烯-1,2-二酮化合物 Download PDFInfo
- Publication number
- CN103906738B CN103906738B CN201280052911.8A CN201280052911A CN103906738B CN 103906738 B CN103906738 B CN 103906738B CN 201280052911 A CN201280052911 A CN 201280052911A CN 103906738 B CN103906738 B CN 103906738B
- Authority
- CN
- China
- Prior art keywords
- methyl
- methylfuran
- amino
- enylamino
- tetrahydrothiophen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC*C(*)(*)NC(C(C1=O)=O)=C1NC Chemical compound CC*C(*)(*)NC(C(C1=O)=O)=C1NC 0.000 description 2
- JBWWOFIQEXLSAB-UHFFFAOYSA-N CN(C)C(c1cccc(NC(C(C2=O)=O)=C2NC(C2OCCC2)c2ccccc2)c1O)=O Chemical compound CN(C)C(c1cccc(NC(C(C2=O)=O)=C2NC(C2OCCC2)c2ccccc2)c1O)=O JBWWOFIQEXLSAB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552940P | 2011-10-28 | 2011-10-28 | |
| FR1159833A FR2981935B1 (fr) | 2011-10-28 | 2011-10-28 | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
| US61/552,940 | 2011-10-28 | ||
| FR1159833 | 2011-10-28 | ||
| PCT/FR2012/052478 WO2013061004A1 (fr) | 2011-10-28 | 2012-10-26 | Nouveaux composés di-substitués de la diamino-3,4-cyclobutène-3-dione-1,2 utiles dans le traitement de pathologies médiées par des chimiokines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103906738A CN103906738A (zh) | 2014-07-02 |
| CN103906738B true CN103906738B (zh) | 2016-09-07 |
Family
ID=45809111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280052911.8A Expired - Fee Related CN103906738B (zh) | 2011-10-28 | 2012-10-26 | 用于治疗趋化因子介导的疾病的新的二取代的3,4-二氨基-3-环丁烯-1,2-二酮化合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9388149B2 (https=) |
| EP (1) | EP2771329B1 (https=) |
| JP (1) | JP6068486B2 (https=) |
| KR (1) | KR20140090168A (https=) |
| CN (1) | CN103906738B (https=) |
| AU (1) | AU2012328198A1 (https=) |
| BR (1) | BR112014009889A2 (https=) |
| CA (1) | CA2848263A1 (https=) |
| CY (1) | CY1117705T1 (https=) |
| DK (1) | DK2771329T3 (https=) |
| ES (1) | ES2569053T3 (https=) |
| FR (1) | FR2981935B1 (https=) |
| HR (1) | HRP20160608T1 (https=) |
| HU (1) | HUE029128T2 (https=) |
| IN (1) | IN2014CN02273A (https=) |
| MX (1) | MX342924B (https=) |
| PL (1) | PL2771329T3 (https=) |
| PT (1) | PT2771329E (https=) |
| RS (1) | RS54775B1 (https=) |
| RU (1) | RU2014121390A (https=) |
| SI (1) | SI2771329T1 (https=) |
| SM (1) | SMT201600151B (https=) |
| WO (1) | WO2013061004A1 (https=) |
| ZA (1) | ZA201401678B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3076968B1 (en) | 2013-12-02 | 2019-04-17 | ChemoCentryx, Inc. | Ccr6 compounds |
| FR3030515B1 (fr) | 2014-12-23 | 2017-01-20 | Galderma Res & Dev | Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines |
| TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
| TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Ｃｘｃｒ２抑制劑 |
| US10660909B2 (en) | 2016-11-17 | 2020-05-26 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| JP2020530848A (ja) | 2017-08-14 | 2020-10-29 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | ３，４−二置換３−シクロブテン−１，２−ジオンおよびその使用 |
| IL275839B2 (en) * | 2018-01-08 | 2024-02-01 | Chemocentryx Inc | Methods for the treatment of generalized abscess psoriasis using a CCR6 or CXCR2 antagonist |
| WO2019165315A1 (en) | 2018-02-23 | 2019-08-29 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists alone or in combination |
| GEP20237476B (en) | 2018-09-21 | 2023-03-27 | Pfizer | N-substituted-dioxocyclobutenylamino-3-hydroxypicolinamides useful as ccr6 inhibitors |
| BR112022021976A2 (pt) | 2020-04-30 | 2022-12-13 | Idorsia Pharmaceuticals Ltd | Composto, e, composição farmacêutica compreendendo um composto |
| WO2023057548A1 (en) | 2021-10-07 | 2023-04-13 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| EP4423082A1 (en) | 2021-10-26 | 2024-09-04 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| KR20240090693A (ko) | 2021-10-28 | 2024-06-21 | 이도르시아 파마슈티컬스 리미티드 | Ccr6 수용체 조절인자 |
| EP4703354A1 (en) * | 2023-04-28 | 2026-03-04 | Wuhan Createrna Science and Technology Co.,Ltd. | Compound as ccr6 antagonist, and pharmaceutical composition and use thereof |
| WO2025092968A1 (zh) * | 2023-11-03 | 2025-05-08 | 武汉朗来科技发展有限公司 | 作为ccr6拮抗剂的化合物、其药物组合物和用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1516687A (zh) * | 2001-04-16 | 2004-07-28 | ���鹫˾ | 作为cxc-趋化因子受体配体的3,4-二取代的环丁烯-1,2-二酮 |
| WO2010063802A1 (en) * | 2008-12-05 | 2010-06-10 | Novartis Ag | 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists |
| CN101772485A (zh) * | 2007-06-06 | 2010-07-07 | 诺瓦提斯公司 | 抗炎的被取代的环丁烯二酮化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6652737B2 (en) * | 2000-07-21 | 2003-11-25 | Exxonmobil Research And Engineering Company | Production of naphtha and light olefins |
| UA103198C2 (en) * | 2008-08-04 | 2013-09-25 | Новартис Аг | Squaramide derivatives as cxcr2 antagonists |
| KR200444641Y1 (ko) * | 2008-12-03 | 2009-05-27 | 강민수 | 헤드작동형 다기능 스패너 |
| WO2010131145A1 (en) * | 2009-05-12 | 2010-11-18 | Pfizer Limited | Cyclobutenedione derivatives |
-
2011
- 2011-10-28 FR FR1159833A patent/FR2981935B1/fr not_active Expired - Fee Related
-
2012
- 2012-10-26 CN CN201280052911.8A patent/CN103906738B/zh not_active Expired - Fee Related
- 2012-10-26 MX MX2014003958A patent/MX342924B/es active IP Right Grant
- 2012-10-26 HR HRP20160608TT patent/HRP20160608T1/hr unknown
- 2012-10-26 BR BR112014009889A patent/BR112014009889A2/pt not_active IP Right Cessation
- 2012-10-26 RS RS20160367A patent/RS54775B1/sr unknown
- 2012-10-26 SI SI201230577A patent/SI2771329T1/sl unknown
- 2012-10-26 ES ES12791825.8T patent/ES2569053T3/es active Active
- 2012-10-26 JP JP2014537704A patent/JP6068486B2/ja not_active Expired - Fee Related
- 2012-10-26 US US14/354,033 patent/US9388149B2/en not_active Expired - Fee Related
- 2012-10-26 RU RU2014121390/04A patent/RU2014121390A/ru not_active Application Discontinuation
- 2012-10-26 AU AU2012328198A patent/AU2012328198A1/en not_active Abandoned
- 2012-10-26 EP EP12791825.8A patent/EP2771329B1/fr active Active
- 2012-10-26 PL PL12791825.8T patent/PL2771329T3/pl unknown
- 2012-10-26 WO PCT/FR2012/052478 patent/WO2013061004A1/fr not_active Ceased
- 2012-10-26 KR KR1020147011443A patent/KR20140090168A/ko not_active Withdrawn
- 2012-10-26 CA CA2848263A patent/CA2848263A1/fr not_active Abandoned
- 2012-10-26 PT PT127918258T patent/PT2771329E/pt unknown
- 2012-10-26 IN IN2273CHN2014 patent/IN2014CN02273A/en unknown
- 2012-10-26 HU HUE12791825A patent/HUE029128T2/en unknown
- 2012-10-26 DK DK12791825.8T patent/DK2771329T3/en active
-
2014
- 2014-03-06 ZA ZA2014/01678A patent/ZA201401678B/en unknown
-
2016
- 2016-05-31 SM SM201600151T patent/SMT201600151B/it unknown
- 2016-06-02 CY CY20161100489T patent/CY1117705T1/el unknown
- 2016-06-07 US US15/175,363 patent/US9580412B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1516687A (zh) * | 2001-04-16 | 2004-07-28 | ���鹫˾ | 作为cxc-趋化因子受体配体的3,4-二取代的环丁烯-1,2-二酮 |
| CN101772485A (zh) * | 2007-06-06 | 2010-07-07 | 诺瓦提斯公司 | 抗炎的被取代的环丁烯二酮化合物 |
| WO2010063802A1 (en) * | 2008-12-05 | 2010-06-10 | Novartis Ag | 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| US20140296254A1 (en) | 2014-10-02 |
| ES2569053T3 (es) | 2016-05-06 |
| JP6068486B2 (ja) | 2017-01-25 |
| SMT201600151B (it) | 2016-07-01 |
| ZA201401678B (en) | 2015-04-29 |
| HRP20160608T1 (hr) | 2016-07-01 |
| RS54775B1 (sr) | 2016-10-31 |
| WO2013061004A1 (fr) | 2013-05-02 |
| US20160362403A1 (en) | 2016-12-15 |
| CA2848263A1 (fr) | 2013-05-02 |
| IN2014CN02273A (https=) | 2015-06-19 |
| AU2012328198A1 (en) | 2014-04-03 |
| RU2014121390A (ru) | 2015-12-10 |
| KR20140090168A (ko) | 2014-07-16 |
| CY1117705T1 (el) | 2017-05-17 |
| DK2771329T3 (en) | 2016-06-06 |
| US9388149B2 (en) | 2016-07-12 |
| MX2014003958A (es) | 2014-08-27 |
| PT2771329E (pt) | 2016-06-17 |
| HUE029128T2 (en) | 2017-02-28 |
| PL2771329T3 (pl) | 2016-09-30 |
| FR2981935A1 (fr) | 2013-05-03 |
| CN103906738A (zh) | 2014-07-02 |
| BR112014009889A2 (pt) | 2017-04-25 |
| FR2981935B1 (fr) | 2015-08-07 |
| US9580412B2 (en) | 2017-02-28 |
| WO2013061004A8 (fr) | 2014-04-17 |
| EP2771329B1 (fr) | 2016-03-16 |
| SI2771329T1 (sl) | 2016-07-29 |
| EP2771329A1 (fr) | 2014-09-03 |
| JP2014530894A (ja) | 2014-11-20 |
| MX342924B (es) | 2016-10-19 |
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