CN103890137B - 具有三个发色团的发光镧系元素螯合物及其用途 - Google Patents

具有三个发色团的发光镧系元素螯合物及其用途 Download PDF

Info

Publication number
CN103890137B
CN103890137B CN201280051442.8A CN201280051442A CN103890137B CN 103890137 B CN103890137 B CN 103890137B CN 201280051442 A CN201280051442 A CN 201280051442A CN 103890137 B CN103890137 B CN 103890137B
Authority
CN
China
Prior art keywords
group
phenylethynyl
reactive
spacer
luminescent lanthanide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280051442.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN103890137A (zh
Inventor
H.塔卡洛
N.梅尔托拉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Drh Finland Oy
Original Assignee
DHR Finland Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DHR Finland Oy filed Critical DHR Finland Oy
Publication of CN103890137A publication Critical patent/CN103890137A/zh
Application granted granted Critical
Publication of CN103890137B publication Critical patent/CN103890137B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/10—Metal complexes of organic compounds not being dyes in uncomplexed form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56933—Mycoplasma
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/18—Metal complexes
    • C09K2211/182—Metal complexes of the rare earth metals, i.e. Sc, Y or lanthanide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Materials Engineering (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CN201280051442.8A 2011-08-19 2012-08-17 具有三个发色团的发光镧系元素螯合物及其用途 Expired - Fee Related CN103890137B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201100630 2011-08-19
DKPA201100630 2011-08-19
DKPA201100996 2011-12-22
DKPA201100996 2011-12-22
PCT/EP2012/066082 WO2013026790A1 (en) 2011-08-19 2012-08-17 Luminescent lanthanide chelates having three chromophores and their use

Publications (2)

Publication Number Publication Date
CN103890137A CN103890137A (zh) 2014-06-25
CN103890137B true CN103890137B (zh) 2016-08-24

Family

ID=46724401

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280051442.8A Expired - Fee Related CN103890137B (zh) 2011-08-19 2012-08-17 具有三个发色团的发光镧系元素螯合物及其用途

Country Status (5)

Country Link
EP (1) EP2753674B1 (enExample)
JP (1) JP5818990B2 (enExample)
CN (1) CN103890137B (enExample)
DK (1) DK2753674T3 (enExample)
WO (1) WO2013026790A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104125997B (zh) * 2011-12-22 2017-03-08 雷度米特图尔库公司 具有提升的激发性质的新型发光镧系元素螯合物
FR3004189B1 (fr) 2013-04-04 2015-09-04 Ecole Norm Superieure Lyon Complexes de lanthanide comprenant au moins deux groupes betaines, utiles comme marqueurs luminescents
JP6310575B2 (ja) * 2014-05-02 2018-04-11 ラジオメーター・トゥルク・オサケユキチュア ランタニドキレートのための新規発色団構造
FR3021325B1 (fr) * 2014-05-26 2018-01-19 Andre Maisonneuve Procede de marquage fluorescent d'un substrat, composition fluorescente de marquage et utilisation d'une telle composition
DK3212733T3 (da) * 2014-10-29 2019-11-04 Radiometer Turku Oy Nye kromofore strukturer til makrocykliske lanthanidchelater
CN105694858B (zh) * 2016-03-18 2018-02-23 北京石油化工学院 一种绿色荧光材料及其制备方法
CN105973856B (zh) * 2016-06-08 2018-12-18 南京工业大学 一种用镧系荧光配合物检测及加速β淀粉样蛋白聚集的方法
WO2017211799A1 (en) 2016-06-09 2017-12-14 Radiometer Turku Oy Background blockers for binding assays
FR3068696B1 (fr) 2017-07-06 2026-01-02 Ecole Normale Superieure Lyon Complexes de terbium et de dysprosium avec antenne optimisee, utiles comme marqueurs luminescents
EP3768665A1 (en) 2018-03-20 2021-01-27 Radiometer Turku Oy Luminescent lanthanide chelates and their use
CN114026070A (zh) * 2019-06-25 2022-02-08 雷度米特图尔库公司 新型发光镧系元素螯合物报道分子、用新型发光镧系元素螯合物报道分子标记的生物特异性结合反应物及其用途
FI128833B (en) * 2019-12-09 2021-01-15 Abacus Diagnostica Oy Luminescent lanthanide (III) chelates
CN111413308B (zh) * 2020-04-13 2023-01-20 延吉海关综合技术服务中心 一种稀土元素配合物在检测矿泉水中微量亚硝酸根的应用
CN113533272B (zh) * 2021-06-26 2024-01-09 浙江工商大学 一种提高时间分辨荧光信号强度的标记方法及应用
CN119751462B (zh) * 2024-12-30 2026-03-10 郑州大学 一种苯并三嗪双自由基类化合物、制备方法及其在有机阻变存储器、近红外探测器和控温膜中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0967205A1 (en) * 1998-06-25 1999-12-29 Wallac Oy Labeling reactants and their use
US20020188111A1 (en) * 1999-02-18 2002-12-12 Raymond Kenneth N. Phthalamide lanthanide complexes for use as luminescent markers
EP1447666A2 (en) * 2003-02-13 2004-08-18 Innotrac Diagnostics Oy Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use
WO2006026038A1 (en) * 2004-08-26 2006-03-09 Mallinckrodt Inc. Luminescent metal complexes for monitoring renal function

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01502271A (ja) * 1987-02-25 1989-08-10 アクアノーティックス　コーポレーション 配位子抽出および再生用のポリアルキルアミン錯体
DE60012485T2 (de) * 1999-02-18 2005-08-18 The Regents Of The University Of California, Oakland Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarker
CN1871233B (zh) 2003-08-29 2011-07-13 沃拉克有限公司 新型螯合剂和螯合物及其应用
EP1694672B1 (en) 2003-12-18 2012-06-20 Wallac Oy Novel chelating agents and highly luminescent and stable chelates and their use
EP2052252B1 (en) 2006-08-18 2010-11-10 Abacus Diagnostica OY Luminescent lanthanide labelling reagents and their use
CN102124346B (zh) 2008-07-16 2014-01-15 雷迪奥米特医学公司 凝血酶底物和测定样本中生物活性凝血酶水平的测定法
FI20080624A0 (fi) 2008-11-17 2008-11-17 Wallac Oy Kelaatteja, kelatoivia yhdisteitä ja niistä johdettuja konjugaatteja

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0967205A1 (en) * 1998-06-25 1999-12-29 Wallac Oy Labeling reactants and their use
US20020188111A1 (en) * 1999-02-18 2002-12-12 Raymond Kenneth N. Phthalamide lanthanide complexes for use as luminescent markers
EP1447666A2 (en) * 2003-02-13 2004-08-18 Innotrac Diagnostics Oy Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use
WO2006026038A1 (en) * 2004-08-26 2006-03-09 Mallinckrodt Inc. Luminescent metal complexes for monitoring renal function

Also Published As

Publication number Publication date
JP5818990B2 (ja) 2015-11-18
JP2014529599A (ja) 2014-11-13
WO2013026790A9 (en) 2013-05-23
EP2753674A1 (en) 2014-07-16
DK2753674T3 (en) 2016-03-21
WO2013026790A1 (en) 2013-02-28
EP2753674B1 (en) 2016-02-10
CN103890137A (zh) 2014-06-25

Similar Documents

Publication Publication Date Title
CN103890137A (zh) 具有三个发色团的发光镧系元素螯合物及其用途
CN104125997B (zh) 具有提升的激发性质的新型发光镧系元素螯合物
JP6310575B2 (ja) ランタニドキレートのための新規発色団構造
US9944657B2 (en) Luminescent lanthanide chelates having three chromophores an their use
CN101796047B (zh) 发光的镧系(iii)螯合物、螯合剂及其衍生的轭合物
JP6480579B2 (ja) 大環状ランタニドキレートのための新規発色団構造
WO2014147288A1 (en) Luminescent triazacyclononane-based lanthanide chelate complexes as labelling reagents
US7018851B2 (en) Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use
EP2880123B1 (en) New iridium-based complexes for ecl
EP2897967B1 (en) Chelates, chelating agents, conjugates derived thereof and their use
JP6924780B2 (ja) 結合アッセイのバックグラウンド遮断剤
EP2794812B1 (en) Novel luminescent lanthanide chelates with enhanced excitation properties
WO2009115644A1 (en) Lanthanide(iii) chelates comprising beta-diketones and conjugates derived thereof
CN114026070A (zh) 新型发光镧系元素螯合物报道分子、用新型发光镧系元素螯合物报道分子标记的生物特异性结合反应物及其用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee
CP01 Change in the name or title of a patent holder

Address after: Turku

Patentee after: DRH FINLAND OY

Address before: Turku

Patentee before: DHR FINLAND OY

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160824

CF01 Termination of patent right due to non-payment of annual fee