CN103877240B - A kind ofly treat Chinese medicine composition of delayed union of fracture and disunion and its preparation method and application - Google Patents
A kind ofly treat Chinese medicine composition of delayed union of fracture and disunion and its preparation method and application Download PDFInfo
- Publication number
- CN103877240B CN103877240B CN201310515807.4A CN201310515807A CN103877240B CN 103877240 B CN103877240 B CN 103877240B CN 201310515807 A CN201310515807 A CN 201310515807A CN 103877240 B CN103877240 B CN 103877240B
- Authority
- CN
- China
- Prior art keywords
- weight portion
- radix
- fracture
- disunion
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses and be a kind ofly used for the treatment of Chinese medicine composition of delayed union of fracture and disunion and its preparation method and application.The present invention is with the Radix Astragali, and Radix Codonopsis is monarch drug, and with Radix Rehmanniae Preparata, Fructus Corni, Colla cornus cervi, Radix Dipsaci, Cortex Cinnamomi is ministerial drug, is aided with the Radix Paeoniae Alba, Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Caulis Spatholobi, Fructus Aurantii, finally to make after Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Wherein, the Radix Astragali, Radix Codonopsis has reinforcing spleen and kidney, effect of benefiting QI and nourishing blood; Radix Rehmanniae Preparata, Fructus Corni, Colla cornus cervi, Radix Dipsaci, Cortex Cinnamomi kidney tonifying, essence replenishing, because the kidney generating marrow and dominating bone, the kidney invigorating can promote the regeneration of new bone, promotes the recovery from illness early of fracture; The Radix Paeoniae Alba, Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Caulis Spatholobi benefiting blood and regulating blood circulation, eliminating blood stasis and smoothing collaterals, Fructus Aurantii circulation of qi promoting.Clinical trial proves that Chinese medicine composition of the present invention is conducive to the growth of bone coffee, achieves desirable therapeutic effect for treatment delayed union of fracture and disunion.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method and application, particularly relate to a kind of be used for the treatment of Chinese medicine composition of delayed union of fracture and disunion and preparation method thereof and preparation treatment delayed union of fracture and disunion medicine in application.The invention belongs to the field of Chinese medicines.
Background technology
Delayed union of fracture and disunion are complication common in a kind of fracture healing process clinically.According to statistics, the fracture of about 5%, 10% can because of a variety of causes, and as bad in local blood fortune, fixing bad after resetting, local infection and general nutritional disease etc., fail to heal within the time that should heal.But find out reason continue fixing after, still can be healed.If the reason of slow concrescence is not eliminated, finally nonunion may be developed into.
For the treatment of delayed union of fracture and disunion, the Therapeutic Method that traditional bone grafting adds internal fixtion is single, and curative effect is not satisfactory.Operation relevant in recent years and non-operative treatment all have made marked progress, and mainly comprise internal fixtion or expopexy, bone grafting operation, electricity irritation, self-bone grafting treatment, local autologous bone marrow transplantation or injection Staphyococcin Aureus, Chinese medicine application etc.But the misery that the therapeutic modality of doctor trained in Western medicine causes patient is large, and healing required time is long, brings a lot of inconvenience to minimal invasive treatment.Therefore seek one and particularly can obtain certain effect by expectant treatment, make patient avoid the method for second operation, will be highly profitable.
Theory of Chinese medical science is thought: damage the muscle and tendon injury of bone energy, muscle and tendon injury also energy loss bone, liver governing tendons, kidney governing bones, lung governing skin and hair, spleen governing muscles, heart governing blood and vessels and the rationale such as impairment of QI resulting in pain, injury of configuration resulting in swelling that " The Yellow Emperor's Canon of Internal Medicine " is elucidated, instruct the clinical practice of orthopedics department always.Though traumatology illness belongs to local damage, relevant with entirety.Indivisible contact is had between internal organs, QI and blood, meridians in body surface muscles and bones, skin and flesh and body, the reason of delayed union of fracture and disunion is because QI and blood liver spleen-kidney deficiency mostly, muscles and bones lose normally moisten foster, deficiency of the kidney can not give birth to marrow by main bone, trace blood does not go, and the raw institute of fresh blood extremely, therefore treats fooled with benefiting QI and nourishing blood, the raw marrow of Psoralen, invigorating blood circulation trace is main.So during the treatment injury of the bone, circulation of qi promoting must to disappear silt, be also noted that Liver and kidney has much energy, skeleton can be impelled effectively strong simultaneously, the reparation of promotion muscles and bones.
At present, the Chinese medicine composition being used for the treatment of delayed union of fracture and disunion has a lot, but all in various degree there is the defect that uncertain therapeutic efficacy cuts, and be difficult to all play extraordinary curative effect to all patients.
The present inventor is by clinical research for many years, in conjunction with the dialectical principle combined with differential diagnosis of diseases, sum up with benefiting QI and nourishing blood, the raw marrow of Psoralen, blood circulation promoting and blood stasis dispelling, channels sootheing and network vessel quickening, strong muscle symplectic bone are the pharmaceutical composition of the present invention of the main rule for the treatment of, be conducive to the growth of bone coffee, desirable therapeutic effect is achieved for treatment delayed union of fracture and disunion.And with the present inventor before the externally applied formulation (patent No. is ZL 200710091020.4) proposed with the use of, more can improve its curative effect significantly.
Summary of the invention
In order to solve problems of the prior art, the present inventor, on the accumulation basis of Chinese medicine experience for many years, comprehensively analyzes the pharmacodynamic characteristics of various medical material and proposes a kind of Chinese medicine composition being used for the treatment of delayed union of fracture and disunion of the present invention according to the compatibility relationship of the monarch of Chinese medicine.The present invention is with the Radix Astragali, and Radix Codonopsis is monarch drug, and with Radix Rehmanniae Preparata, Fructus Corni, Colla cornus cervi, Radix Dipsaci, Cortex Cinnamomi is ministerial drug, is aided with the Radix Paeoniae Alba, Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Caulis Spatholobi, Fructus Aurantii, finally to make after Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Wherein, the Radix Astragali, Radix Codonopsis has reinforcing spleen and kidney, effect of benefiting QI and nourishing blood; Radix Rehmanniae Preparata, Fructus Corni, Colla cornus cervi, Radix Dipsaci, Cortex Cinnamomi kidney tonifying, essence replenishing, because the kidney generating marrow and dominating bone, the kidney invigorating can promote the regeneration of new bone, promotes the recovery from illness early of fracture; The Radix Paeoniae Alba, Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Caulis Spatholobi benefiting blood and regulating blood circulation, eliminating blood stasis and smoothing collaterals, Fructus Aurantii circulation of qi promoting.Clinical trial proves that Chinese medicine composition of the present invention is conducive to the growth of bone coffee, achieves desirable therapeutic effect for treatment delayed union of fracture and disunion.
In order to reach described object, the technical solution adopted in the present invention is:
A kind of Chinese medicine composition being used for the treatment of delayed union of fracture and disunion of the present invention, is characterized in that being made up of each crude drug of following weight portion: Radix Astragali 25-35 weight portion, Radix Codonopsis 10-20 weight portion, Radix Paeoniae Alba 10-20 weight portion, Radix Angelicae Sinensis 5-15 weight portion, Eupolyphaga Seu Steleophaga 5-15 weight portion, Caulis Spatholobi 5-15 weight portion, Radix Rehmanniae Preparata 5-15 weight portion, Radix Dipsaci 5-15 weight portion, Fructus Corni 5-15 weight portion, Colla cornus cervi 5-15 weight portion, Fructus Aurantii 5-15 weight portion, Radix Glycyrrhizae 2-8 weight portion and Cortex Cinnamomi 5-15 weight portion.
In the present invention, preferably, described a kind of Chinese medicine composition being used for the treatment of delayed union of fracture and disunion, is characterized in that being made up of each crude drug of following weight portion: the Radix Astragali 30 weight portion, Radix Codonopsis 15 weight portion, the Radix Paeoniae Alba 15 weight portion, Radix Angelicae Sinensis 10 weight portion, Eupolyphaga Seu Steleophaga 10 weight portion, Caulis Spatholobi 10 weight portion, Radix Rehmanniae Preparata 10 weight portion, Radix Dipsaci 10 weight portion, Fructus Corni 10 weight portion, Colla cornus cervi 10 weight portion, Fructus Aurantii 10 weight portion, Radix Glycyrrhizae 5 weight portion and Cortex Cinnamomi 10 weight portion.
Crude drug used by the present invention all can be bought from common pharmacy and obtain, and its specification meets national medical standards.
In the present invention, described Chinese medicine composition can be prepared into according to Chinese medicine conventional formulation the oral formulations that any one is suitable for clinically.Preferably, described preparation is water decoction.
In addition, the invention allows for a kind of method preparing Chinese medicine composition described in above any one, it is characterized in that comprising the following steps:
(1) each crude drug is taken according to described weight portion;
(2) each crude drug of step (1) is mixed being placed in marmite adds water did not have powder;
(3) soak after 20 ~ 40 minutes and decoct again, after boiling, decoct 30 minutes again, decoct three times altogether, merge three decocting liquids and filter, obtain water decoction.
By Chinese medicine composition of the present invention separately or with the present inventor before the externally applied formulation (patent No. is ZL 200710091020.4) proposed with the use of, good therapeutic effect can both be played to delayed union of fracture and disunion, and with the use of time curative effect more remarkable, therefore, the invention allows for the application of Chinese medicine composition of the present invention in preparation treatment delayed union of fracture and disunion medicine.
Detailed description of the invention
Below in conjunction with embodiment to above-mentioned being described in more detail with other technical characteristic and advantage of the present invention.Should be understood that; the embodiment of the following stated is only be described the preferred embodiment of the present invention; not scope of the present invention is limited; under not departing from the present invention and designing the prerequisite of spirit; the various distortion that those of ordinary skill in the art make technical scheme of the present invention and improvement, all should fall in protection domain that claims of the present invention determines.
The preparation of embodiment 1 water decoction
Pharmaceutical composition of the present invention is made water decoction, carries out according to following steps:
(1) each crude drug is taken: Radix Astragali 30g, Radix Codonopsis 15g, Radix Paeoniae Alba 15g, Radix Angelicae Sinensis 10g, Eupolyphaga Seu Steleophaga 10g, Caulis Spatholobi 10g, Radix Rehmanniae Preparata 10g, Radix Dipsaci 10g, Fructus Corni 10g, Colla cornus cervi 10g, Fructus Aurantii 10g, Radix Glycyrrhizae 5g and Cortex Cinnamomi 10g;
(2) each crude drug of step (1) is mixed being placed in marmite adds water did not have powder;
(3) soak after 30 minutes and decoct again, after boiling, decoct 30 minutes again, decoct three times altogether, merge three decocting liquids and filter, obtain water decoction.
Usage:
Take herb liquid 500ml, each oral 250ml, one day twice, sub-service sooner or later.
The preparation of embodiment 2 water decoction
Pharmaceutical composition of the present invention is made water decoction, carries out according to following steps:
(1) each crude drug is taken: Radix Astragali 25g, Radix Codonopsis 20g, Radix Paeoniae Alba 15g, Radix Angelicae Sinensis 15g, Eupolyphaga Seu Steleophaga 10g, Caulis Spatholobi 5g, Radix Rehmanniae Preparata 15g, Radix Dipsaci 15g, Fructus Corni 5g, Colla cornus cervi 10g, Fructus Aurantii 5g, Radix Glycyrrhizae 3g and Cortex Cinnamomi 15g;
(2) each crude drug of step (1) is mixed being placed in marmite adds water did not have powder;
(3) soak after 30 minutes and decoct again, after boiling, decoct 30 minutes again, decoct three times altogether, merge three decocting liquids and filter, obtain water decoction.
Usage:
Take herb liquid 500ml, each oral 250ml, one day twice, sub-service sooner or later.
The preparation of embodiment 3 water decoction
Pharmaceutical composition of the present invention is made water decoction, carries out according to following steps:
(1) each crude drug is taken: Radix Astragali 35g, Radix Codonopsis 10g, Radix Paeoniae Alba 20g, Radix Angelicae Sinensis 5g, Eupolyphaga Seu Steleophaga 5g, Caulis Spatholobi 15g, Radix Rehmanniae Preparata 10g, Radix Dipsaci 15g, Fructus Corni 5g, Colla cornus cervi 15g, Fructus Aurantii 5g, Radix Glycyrrhizae 6g and Cortex Cinnamomi 10g;
(2) each crude drug of step (1) is mixed being placed in marmite adds water did not have powder;
(3) soak after 30 minutes and decoct again, after boiling, decoct 30 minutes again, decoct three times altogether, merge three decocting liquids and filter, obtain water decoction.
Usage:
Take herb liquid 500ml, each oral 250ml, one day twice, sub-service sooner or later.
The clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating delayed union of fracture of the present invention and disunion
One, clinical data
Be divided into test group and matched group, test group 100 example, man 50 example, female 50 example, wherein, open fracture 58 example, multiple fracture 27 example, recurrence fracture 15 example.
Matched group 100 example, man 50 example, female 50 example, wherein, open fracture 56 example, multiple fracture 29 example, recurrence fracture 15 example.
Two, for reagent thing: the water decoction prepared by the embodiment of the present invention 1.
Three, Therapeutic Method
Test group: adopt outpatient service or hospitalization.Conventional western medicine treatment (such as, please create, select suitable copper coin after the reduction of the fracture, screw or intramedullary needle internal fixtion, plaster slab extenal fixation) is first adopted for fracture patient, more oral for reagent thing, each oral 250ml, one day twice, sub-service sooner or later.
Matched group: adopt outpatient service or hospitalization.Only adopt conventional western medicine treatment for this group fracture patient, western medical treatment method is identical with test group.
Four, therapeutic outcome
1, efficacy assessment standard: excellent: without angulation and lateral deviation displacement, forearm rotary moveable functional rehabilitation is normal.Good: be no more than 10 degree along bone physiology radians angulation deformity, forearm rotary moveable functional rehabilitation is normal.Can: angulation deformity is at about 15 degree, and antetheca rotary moveable function is unrestricted.Difference: angulation deformity is greater than 15 degree, and the activity of forearm spinfunction is obviously restricted.
2, test group: 21 days the earliest clinical healing time, 102 days at the latest, average 31 days.Excellent 85 examples (85%), good 8 examples (8%), can 6 examples (6%), and differ from 1 example (1%), acceptance rate reaches 93%.
Matched group: 35 days the earliest clinical healing time, 128 days at the latest, average 38 days.Excellent 62 examples (62%), good 15 examples (15%), can 19 examples (19%), and differ from 4 examples (4%), acceptance rate is 77%.
Clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention has definite curative effect for delayed union of fracture or disunion.In medication process, patient has no adverse reaction appearance.
Model case:
Zhang, man, 25 years old.Left lower extremity fracture of tibia and fibula, through the capable Plate internal fixiation of certain hospital surgery operation 1 year, remove steel plate left lower extremity tibiofibula portion still fracture end callus rare, without sclerosis or not complete base sclerosis person.Pain, fracture does not heal, and tosses about in bed many hospitalizes and does not heal.Disease is examined to over 16 months, and it is obviously sparse that X-ray shows as fracture end sclerotin, edge blurry, and in lint shape, ancient crust does not form bridge sample and connects, and is diagnosed as delayed union of fracture.Take pharmaceutical composition of the present invention, parallel Gypsum Fibrosum extenal fixation, takes medicine 2 months, and pain disappears, and fracture line is fuzzy, and existing callus generates, and reaches clinical healing.
Test example 2 Chinese medicine composition of the present invention and externally applied formulation (patent No. is ZL200710091020.4) are tested with the use of the clinical observation on the therapeutic effect for the treatment of delayed union of fracture and disunion
One, clinical data
Patient 100 example, man 50 example, female 50 example, wherein, open fracture 55 example, multiple fracture 28 example, recurrence fracture 17 example.
Two, for reagent thing: the water decoction prepared by the embodiment of the present invention 1 and the patent No. are the externally applied formulation of ZL200710091020.4, specifically to specifications prepared by the method for embodiment 1.
Three, Therapeutic Method
Adopt outpatient service or hospitalization.Conventional western medicine treatment is first adopted (such as fracture patient, please create, after the reduction of the fracture, select suitable copper coin, screw or intramedullary needle internal fixtion, plaster slab extenal fixation), oral for reagent thing again, each oral 250ml, twice on the one, sooner or later sub-service, meanwhile, then by the patent No. be ZL 200710091020.4 externally applied formulation heating after spread on fracture outward, every 2-3 days changes dressings once.
Four, therapeutic outcome
1, efficacy assessment standard: excellent: without angulation and lateral deviation displacement, forearm rotary moveable functional rehabilitation is normal.Good: be no more than 10 degree along bone physiology radians angulation deformity, forearm rotary moveable functional rehabilitation is normal.Can: angulation deformity is at about 15 degree, and antetheca rotary moveable function is unrestricted.Difference: angulation deformity is greater than 15 degree, and the activity of forearm spinfunction is obviously restricted.
2, clinical observation result shows, Chinese medicine composition of the present invention and externally applied formulation (patent No. is ZL200710091020.4) with the use of, 19 days the earliest clinical healing time, 95 days at the latest, average 28 days.Excellent 87 examples (87%), good 10 examples (10%), can 2 examples (2%), and differ from 1 example (1%), acceptance rate reaches 97%.
Endo-medicine is with the Radix Astragali, and Radix Codonopsis is monarch drug, and with Radix Rehmanniae Preparata, Fructus Corni, Colla cornus cervi, Radix Dipsaci, Cortex Cinnamomi is ministerial drug, is aided with the Radix Paeoniae Alba, Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Caulis Spatholobi, Fructus Aurantii, finally to make after Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.The Radix Astragali, Radix Codonopsis has reinforcing spleen and kidney, effect of benefiting QI and nourishing blood; Radix Rehmanniae Preparata, Fructus Corni, Colla cornus cervi, Radix Dipsaci, Cortex Cinnamomi kidney tonifying, essence replenishing, because the kidney generating marrow and dominating bone, the kidney invigorating can promote the regeneration of new bone, promotes the recovery from illness early of fracture; The Radix Paeoniae Alba, Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Caulis Spatholobi benefiting blood and regulating blood circulation, eliminating blood stasis and smoothing collaterals, Fructus Aurantii circulation of qi promoting.Externally applied formulation gives birth to marrow for monarch drug with Os Gallus Domesticus Psoralen, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Drynariae, Pyritum, Os Draconis nourishing the liver and kidney, strengthening bone and muscle, synthetism, and it is ministerial drug that Os Draconis continue muscle; Eupolyphaga Seu Steleophaga, Radix Notoginseng, stir-baked SQUAMA MANITIS, Radix Et Rhizoma Rhei, Olibanum (processed), Myrrha (processed), Flos Carthami, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Sanguis Draxonis, Rhizoma Sparganii, Rhizoma Curcumae blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis, enhance metabolism, accelerating union of bone fracture is adjuvant drug, excellent brain, Borneolum Syntheticum, artificial mediocre perfume (or spice), Herba speranskiae tuberculatae can promote that medicine penetrates, and medicine is taken to fracture site for making medicine.
Compared to alone Chinese medicine composition of the present invention or externally applied formulation (patent No. is ZL 200710091020.4), the two conbined usage is shortened treatment cycle, reaches the object for the treatment of both the principal and secondary aspects of a disease, the acceptance rate of therapeutic effect is improved.
Claims (6)
1. be used for the treatment of a Chinese medicine composition for delayed union of fracture and disunion, it is characterized in that being made up of each crude drug of following weight portion: Radix Astragali 25-35 weight portion, Radix Codonopsis 10-20 weight portion, Radix Paeoniae Alba 10-20 weight portion, Radix Angelicae Sinensis 5-15 weight portion, Eupolyphaga Seu Steleophaga 5-15 weight portion, Caulis Spatholobi 5-15 weight portion, Radix Rehmanniae Preparata 5-15 weight portion, Radix Dipsaci 5-15 weight portion, Fructus Corni 5-15 weight portion, Colla cornus cervi 5-15 weight portion, Fructus Aurantii 5-15 weight portion, Radix Glycyrrhizae 2-8 weight portion and Cortex Cinnamomi 5-15 weight portion.
2. a kind of Chinese medicine composition being used for the treatment of delayed union of fracture and disunion as claimed in claim 1, is characterized in that being made up of each crude drug of following weight portion: the Radix Astragali 30 weight portion, Radix Codonopsis 15 weight portion, the Radix Paeoniae Alba 15 weight portion, Radix Angelicae Sinensis 10 weight portion, Eupolyphaga Seu Steleophaga 10 weight portion, Caulis Spatholobi 10 weight portion, Radix Rehmanniae Preparata 10 weight portion, Radix Dipsaci 10 weight portion, Fructus Corni 10 weight portion, Colla cornus cervi 10 weight portion, Fructus Aurantii 10 weight portion, Radix Glycyrrhizae 5 weight portion and Cortex Cinnamomi 10 weight portion.
3. the oral formulations being used for the treatment of delayed union of fracture and disunion suitable clinically, is characterized in that described oral formulations is prepared from according to Chinese medicine conventional formulation by Chinese medicine composition according to claim 1.
4. a kind of oral formulations being used for the treatment of delayed union of fracture and disunion suitable clinically as claimed in claim 3, is characterized in that described preparation is water decoction.
5. the method for the oral formulations of preparation described in claim 3 or 4, is characterized in that comprising the following steps:
(1) each crude drug is taken according to described weight portion;
(2) each crude drug of step (1) is mixed being placed in marmite adds water did not have powder;
(3) soak after 20 ~ 40 minutes and decoct again, after boiling, decoct 30 minutes again, decoct three times altogether, merge three decocting liquids and filter, obtain water decoction.
6. the application of the Chinese medicine composition described in claim 1 or 2 in preparation treatment delayed union of fracture and disunion medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310515807.4A CN103877240B (en) | 2013-10-25 | 2013-10-25 | A kind ofly treat Chinese medicine composition of delayed union of fracture and disunion and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310515807.4A CN103877240B (en) | 2013-10-25 | 2013-10-25 | A kind ofly treat Chinese medicine composition of delayed union of fracture and disunion and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103877240A CN103877240A (en) | 2014-06-25 |
| CN103877240B true CN103877240B (en) | 2015-08-26 |
Family
ID=50946576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310515807.4A Expired - Fee Related CN103877240B (en) | 2013-10-25 | 2013-10-25 | A kind ofly treat Chinese medicine composition of delayed union of fracture and disunion and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103877240B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679894A (en) * | 2005-01-11 | 2005-10-12 | 陈惜春 | Chinese medicinal herb capsule for treating hyperosteogeny |
| CN1709422A (en) * | 2005-06-06 | 2005-12-21 | 广东医学院 | Novel use of Chinese patent medicine formulation with bone-promoting formation for preventing and treating osteoporosis |
| CN101032614A (en) * | 2007-04-05 | 2007-09-12 | 赵子山 | Chinese traditional composition for curing slow concrescence or non-concrescence of fracture and the preparing method |
-
2013
- 2013-10-25 CN CN201310515807.4A patent/CN103877240B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679894A (en) * | 2005-01-11 | 2005-10-12 | 陈惜春 | Chinese medicinal herb capsule for treating hyperosteogeny |
| CN1709422A (en) * | 2005-06-06 | 2005-12-21 | 广东医学院 | Novel use of Chinese patent medicine formulation with bone-promoting formation for preventing and treating osteoporosis |
| CN101032614A (en) * | 2007-04-05 | 2007-09-12 | 赵子山 | Chinese traditional composition for curing slow concrescence or non-concrescence of fracture and the preparing method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103877240A (en) | 2014-06-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100423761C (en) | Chinese medicinal preparation for treating fracture, traumatic injury | |
| CN102512630B (en) | Traditional Chinese medicine composition for treating gallbladder calculus | |
| CN103127253A (en) | Chinese medicinal capsules for treating catagmatic blood stasis and preparation method thereof | |
| CN100484538C (en) | Upper, middle and lower part soup, and method for making same | |
| CN101926867B (en) | Bone fracture recovering soup | |
| CN103142737B (en) | Traditional Chinese medicine capsule for treating fracture Qi-stagnation and blood stasis and preparation method thereof | |
| CN104587186A (en) | Traditional Chinese medicinal composition for treating qi and blood deficiency | |
| CN104306606A (en) | A traditional Chinese medicine preparation for treating osteoarthritis and a preparing method thereof | |
| CN103877240B (en) | A kind ofly treat Chinese medicine composition of delayed union of fracture and disunion and its preparation method and application | |
| CN105477330A (en) | Traditional Chinese medicine composition for treating arrhythmia | |
| CN105250809A (en) | Traditional Chinese medicine composition for treating dermatomyositis | |
| CN104800443A (en) | Bone setting agent with functions of tonifying kidney and regenerating bone marrow | |
| CN104042839A (en) | Traditional Chinese medicine composition for treating tinea versicolor | |
| CN103142757B (en) | Traditional Chinese medicine capsule for treating liver and kidney deficiency after fracture and preparation method thereof | |
| CN103272129B (en) | Traditional Chinese medicine composition for treating neurodermatitis | |
| CN103285108B (en) | Chinese medicinal composition treating lumbago | |
| CN101584846A (en) | Chinese medicament for treating cervical spondylosis | |
| CN105816603A (en) | Traditional Chinese medicine composition for treating postpartum hemorrhage | |
| CN105663612A (en) | Traditional Chinese medicine composition for treating ankylosing spondylitis | |
| CN105343862A (en) | Drug composition for soft tissue injury and fracture | |
| CN105663868A (en) | Traditional Chinese medicinal composition for treating aplastic anemia | |
| CN104587394A (en) | Traditional Chinese medicine composition for treating delayed union and nonunion | |
| CN104758539A (en) | Traditional Chinese medicine composition for treating debilitation | |
| CN104173667A (en) | Traditional Chinese medicine composition for treating osteoarthritis | |
| CN114652797A (en) | Traditional Chinese medicine formula for nourishing blood and benefiting qi of fracture patient and preparation method of traditional Chinese medicine liquid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150826 Termination date: 20191025 |