CN1709422A - Novel use of Chinese patent medicine formulation with bone-promoting formation for preventing and treating osteoporosis - Google Patents
Novel use of Chinese patent medicine formulation with bone-promoting formation for preventing and treating osteoporosis Download PDFInfo
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Abstract
The present invention discloses new application of some Chinese patent medicine preparations, such as Fufang Danshen Pian, Shouwu Wan, Renshen Yangrong Wan, Renshen Jianpi Wan, Buzhong Yiqi Wan, Shiquan Dabu Wan, Kanggu Zengsheng Wan and others. These Chinese patent medicines have the action of promoting formation of bone, and can be used for preventing and curing various osteoporosises.
Description
Technical field the present invention relates to the new purposes with the osteoplastic Chinese patent medicine compound recipe protect against osteoporosis of promotion, and these Chinese patent medicine compound recipes comprise the prescription that the Pharmacopoeia of the People's Republic of China (version in 2005) is announced: FUFANG DANSHEN PIAN, Radix Polygoni Multiflori pill, Ginseng Bolus for Tonification, Ginseng Bolus for tonifying spleen, BUZHONG YIQI WAN, bolus of ten powerful tonics, KANGGU ZENGSHENG WAN, GUILU BUSHEN WAN, SHENGMAI YIN, Yupingfeng Koufuye, WUJI BAIFENG WAN, SHENQI WUWEIZI PIAN, DANGGUI YANGXUE WAN, SHUANGDAN KOUFUYE, ANSHEN JIAONANG, ANSHEN BUNAO YE.These compound preparations have prevention and therapeutical effect preferably to postmenopausal osteoporosis and senile osteoporosis, drug induced osteoporosises such as adrenal gland's glucocorticoid are also had have prevention and therapeutical effect preferably.
The background technology osteoporosis be one worldwide, more and more cause the health problem that people pay attention to.About 200,000,000 people in the whole world suffer from osteoporosis at present, and its sickness rate has leapt to commonly encountered diseases, frequently-occurring disease the 7th.Estimate that ill total number of persons surpasses 200,000,000.Osteoporosis is the modal disease of old people.In the U.S. and western countries, in the age surpasses 55 years old postclimacteric women, there is the people of half to suffer from the different osteoporosis of degree, and in the old people of over-65s, suffers from osteoporosis person up to more than 95%.Along with the reach of science and human progress, the average life span constantly prolongs, and aging population increase sharply, and osteoporotic sickness rate is also along with increase rapidly occurring.Estimate to the year two thousand fifty whole world over-65s the old people will be increased to 15.55 hundred million by present 3.23 hundred million, osteoporosis causes hip fracture generation number also will be increased to 6,260,000 by present 1,660,000 when the time comes, and wherein the patient of Asia, Latin America, the Middle East and African country will account for more than 70%.According to official statistics, the U.S. is used for directly and indirectly costing of osteoporosis aspect every year and reaches 10,000,000,000 dollars; The fund that the health of Britain and social security institution every year provide for osteoporosis is above 500,000,000 pounds; France only pays the patient's of 30,000 fracture of femoral neck about 13.5 hundred million French Francs of hospitalization cost every year on average.Huge social like this and financial burden that osteoporosis caused have constituted a serious global problem, have caused the very big concern of countries in the world.The arrival of aging society is increased osteoporotic incidence rate day by day, serious threat people's quality of life.WHO is defined as 2000-2010 " osteoarthritis 10 years ".
China is the maximum country of world population, wherein aging population account for the Asia aging population 1/2 and world population 1/5.The osteoporosis Epidemiological study result in Beijing, Shanghai and 3 cities, Chengdu shows, 60-69 year osteoporotic incidence rate women of age bracket and male are respectively about 60% and 30%.China's large population base, sufferers of osteoporosis face have reached 6,000 ten thousand～8,000 ten thousand examples, and this brings serious burden [2] for family and society.People according to another statistics national over-65s in 2000 has 1.3 hundred million, accounts for 10.7% of national population, has become typical veteran form country.And the patient who suffers from osteoporosis accounts for 90% in these crowds, and the patient of hip fracture will have 12%～40% to die from various complication in 1 year.50% human action inconvenience is also arranged in the survivor.This has not only caused serious body and mind to wreck to patient, has increased huge manpower and financial resources burden also for simultaneously family and society.Therefore, preventing and treating osteoporosis is defying age, life-saving, the very urgent research topic of the assurance people's quality of life.
At present both at home and abroad the protect against osteoporosis medicine is very limited, and bone mineralising promoter commonly used is limited as calcium preparation, vitamin D curative effect; Though bone resorption inhibitor such as estrogen, calcitonin, diphosphate, ipriflavone etc. have certain effect, untoward reaction is also many, influences clinical practice, and the curative effect of bone formation-promoter such as fluoride is disputed on always, and the U.S. is also not listing [2-5] so far.Aspect clinical treatment, from controversies in hormone replacement in the elderly, to the diphosphonic acid salt, the control of medicines such as the calcitonin several important development phases of having passed by, just changing at present treatment research over to cytokines such as bone morphogenic protein-2 Pseudobulbus Bletillae (Rhizoma Bletillae) interleukin, but, to so far, these are used to prevent and treat osteoporotic medicine, and many side effect are all arranged, and some curative effect is general, some costs an arm and a leg, at present still do not have a kind of generally acknowledged ideal medicament, therefore, the searching high-efficiency low-toxicity is prevented and treated osteoporotic medicine and is remained the urgent task of pharmacology worker.
The theory and the thinking of usefulness " Chinese medicine compound " control " osteoporosis " research that this project team of summary of the invention proposes, through a large amount of animal experiment studies and screening, we find that FUFANG DANSHEN PIAN, Radix Polygoni Multiflori pill, Ginseng Bolus for Tonification, Ginseng Bolus for tonifying spleen, BUZHONG YIQI WAN, bolus of ten powerful tonics, KANGGU ZENGSHENG WAN, GUILU BUSHEN WAN, SHENGMAI YIN, Yupingfeng Koufuye, WUJIBAIFENG WAN, SHENQI WUWEIZI PIAN, DANGGUI YANGXUE WAN, SHUANGDAN KOUFUYE, ANSHEN JIAONANG, ANSHEN BUNAO YE have the promotion bone formation, can be used for preventing and treating osteoporosis.
The approach that solves this task is to realize like this, prescription according to the Pharmacopoeia of the People's Republic of China (version in 2005) announcement: choose following Chinese patent medicine preparation, press the method for making of Pharmacopoeia of the People's Republic of China regulation, be prepared into the preparation of research usefulness, supply experimental applications:
(1) get Radix Salviae Miltiorrhizae 450g, Radix Notoginseng 141g and Borneolum Syntheticum 8g, the method for making according to 527 pages of the Pharmacopoeias of the People's Republic of China (version in 2005) is prepared into FUFANG DANSHEN PIAN, uses for research;
(2) get Radix Polygoni Multiflori Preparata 360g, Radix Rehmanniae 20g, Radix Achyranthis Bidentatae (processed with wine) 40g, Fructus Mori 182g, Fructus Ligustri Lucidi (processed with wine) 40g, Herba Ecliptae 235g, Folium Mori (system) 40g, Semen Sesami Nigrum 16g, Semen Cuscutae (wine steaming) 80g, Fructus Rosae Laevigatae 259g, Fructus Psoraleae (salt stir-fry) 40g, Herba Siegesbeckiae (system) 80g, Flos Lonicerae (system) 20g, method for making according to 545 pages of the Pharmacopoeias of the People's Republic of China (version in 2005), be prepared into Radix Polygoni Multiflori pill, use for research;
(3) get Radix Ginseng 100g, the Rhizoma Atractylodis Macrocephalae (parching with earth) 100g, Poria 75g, Radix Astragali Preparata 100g, Radix Angelicae Sinensis 100g, Radix Rehmanniae Preparata 75g, the Radix Paeoniae Alba (parched with bran) 100g, Pericarpium Citri Reticulatae 100g, Radix Polygalae (system) 50g, Cortex Cinnamomi 100g, Fructus Schisandrae Chinensis (wine steaming) 75g, Radix Glycyrrhizae Preparata 100g, method for making according to 314 pages of the Pharmacopoeias of the People's Republic of China (version in 2005), be prepared into the Ginseng Bolus for Tonification, use for research;
(4) get Radix Ginseng 25g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 150g, Poria 50g, Rhizoma Dioscoreae 100g, Pericarpium Citri Reticulatae 50g, Radix Aucklandiae 12.5g, Fructus Amomi 25g, Radix Astragali Preparata 100g, Radix Angelicae Sinensis 50g, Semen Ziziphi Spinosae (stir-fry) 50g, Radix Polygalae (system) 25g, method for making according to 315 pages of the Pharmacopoeias of the People's Republic of China (version in 2005), be prepared into the Ginseng Bolus for tonifying spleen, use for research;
(5) get Radix Astragali Preparata 200g, Radix Codonopsis 60g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 60g, Radix Angelicae Sinensis 60g, Rhizoma Cimicifugae 60g, Radix Bupleuri 60g, Pericarpium Citri Reticulatae 60g, Radix Glycyrrhizae Preparata 100g, method for making according to 480 pages of the Pharmacopoeias of the People's Republic of China (version in 2005), be prepared into BUZHONG YIQI WAN, use for research;
(6) get Radix Codonopsis 80g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 80g, Poria 80g, Radix Rehmanniae Preparata 120g, Radix Angelicae Sinensis 120g, the Radix Paeoniae Alba (wine stir-fry) 80g, Rhizoma Chuanxiong 40g, Radix Astragali Preparata 80g, Cortex Cinnamomi 20g, Radix Glycyrrhizae Preparata 40g, method for making according to 527 pages of the Pharmacopoeias of the People's Republic of China (version in 2005), be prepared into bolus of ten powerful tonics, use for research;
(7) get Radix Rehmanniae Preparata 175g, Herba Cistanches (steaming) 117g, Rhizoma Cibotii (processed with salt) 117g, Fructus Ligustri Lucidi (processed with salt) 58g, Herba Epimedii 140g, Caulis Spatholobi 140g, Semen Raphani (stir-fry) 70g, Rhizoma Drynariae 140g, Radix Achyranthis Bidentatae 140g, method for making according to 470 pages of the Pharmacopoeias of the People's Republic of China (version in 2005), be prepared into KANGGU ZENGSHENG WAN, use for research;
(8) get Colla Plastri Testudinis (stir-fry) 13g, Colla cornus cervi (stir-fry) 9g, Radix Rehmanniae Preparata 64g, Herba Epimedii (steaming) 43g, Semen Cuscutae (stir-fry) 51g, Herba Cynomorii (steaming) 51g, Radix Dipsaci (steaming) 43g, Rhizoma Cibotii (steaming) 64g, Radix Polygoni Multiflori Preparata 64g, Fructus Rosae Laevigatae (steaming) 51g, Fructus Rubi (steaming) 85g, Radix Astragali Preparata 43g, Semen Ziziphi Spinosae (stir-fry) 43g, Radix Glycyrrhizae Preparata 21g, Pericarpium Citri Reticulatae (steaming) 21g, Rhizoma Dioscoreae (stir-fry) 43g, method for making according to 475 pages of the Pharmacopoeias of the People's Republic of China (version in 2005), be prepared into GUILU BUSHEN WAN, use for research;
(9) get Radix Ginseng Rubra 100g, Radix Ophiopogonis 200g, Fructus Schisandrae Chinensis 100g, the method for making according to 424 pages of the Pharmacopoeias of the People's Republic of China (version in 2005) is prepared into SHENGMAI YIN, uses for research;
(10) get Radix Astragali 600g, Radix Saposhnikoviae 200g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 200g, the method for making according to 409 pages of the Pharmacopoeias of the People's Republic of China (version in 2005) is prepared into Yupingfeng Koufuye, uses for research;
(11) get Gallus Domesticus (unhairing, pawl, intestinal) 640g, Colla cornus cervi 128g, Carapax Trionycis (system) 64g, Concha Ostreae (forging) 48g, Ootheca Mantidis 48g, Radix Ginseng 128g, Radix Astragali 32g, Radix Angelicae Sinensis 144g, Radix Paeoniae Alba 128g, Rhizoma Cyperi (vinegar system) 128g, Radix Asparagi 64g, Radix Glycyrrhizae 32g, Radix Rehmanniae 256g, Radix Rehmanniae Preparata 256g, Rhizoma Chuanxiong 64g, Radix Stellariae 26g, Radix Salviae Miltiorrhizae 128g, Rhizoma Dioscoreae 128g, Semen Euryales (stir-fry) 64g, Cornu Cervi Degelatinatum 48g, method for making according to 398 pages of the Pharmacopoeias of the People's Republic of China (version in 2005), be prepared into WUJIBAIFENG WAN, use for research;
(12) get Fructus Schisandrae Sphenantherae 180g, Radix Codonopsis 60g, Radix Astragali 120g, Semen Ziziphi Spinosae (stir-fry) 30g, the method for making according to 508 pages of the Pharmacopoeias of the People's Republic of China (version in 2005) is prepared into SHENQI WUWEIZI PIAN, uses for research;
(13) get Radix Angelicae Sinensis 150g, the Radix Paeoniae Alba (stir-fry) 150g, Radix Rehmanniae 400g, Colla Corii Asini 150g, Radix Astragali Preparata 150g, Poria 150g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 200g, the Cortex Eucommiae (stir-fry) 200g, Cortex Moutan 100g, Rhizoma Cyperi (system) 150g, method for making according to 437 pages of the Pharmacopoeias of the People's Republic of China (version in 2005), be prepared into DANGGUI YANGXUE WAN, use for research;
(14) get Radix Salviae Miltiorrhizae 600g, Cortex Moutan 300g, the method for making according to 405 pages of the Pharmacopoeias of the People's Republic of China (version in 2005) is prepared into SHUANGDAN KOUFUYE, uses for research;
(15) get Radix Salviae Miltiorrhizae 130g, Fructus Schisandrae Chinensis 97g, Semen Ziziphi Spinosae (stir-fry) 40g, Rhizoma Chuanxiong 47g, Rhizoma Anemarrhenae 112g, Radix Ophiopogonis 92g, Radix Polygoni Multiflori Preparata 32g and Poria 97g, method for making according to 453 pages of the Pharmacopoeias of the People's Republic of China (version in 2005) is prepared into ANSHEN JIAONANG, uses for research;
(16) get Cornu Cervi Pantotrichum, Radix Polygoni Multiflori Preparata, Herba Epimedii, Rhizoma Zingiberis, Radix Glycyrrhizae, Fructus Jujubae, vitamin B1 g, the method for making according to 453 pages of the Pharmacopoeias of the People's Republic of China (version in 2005) is prepared into ANSHEN BUNAO YE, uses for research;
Above compound preparation, be created as the osteocyte extracorporeal culture-ing with this research department, white mice osteoporosis model and rat osteoporosis model are studied respectively, proved that these 16 Chinese medicines have the osteoplastic effect of promotion, also have prevention and treatment preferably to white mice osteoporosis animal model and rat osteoporosis animal model.
Above compound preparation can be made into tablet, capsule, granule, electuary, oral liquid, external preparation, injection and any for clinical practice pharmaceutical preparation.
Claims (3)
1, has the new purposes that promotes osteoplastic Chinese patent medicine FUFANG DANSHEN PIAN, Radix Polygoni Multiflori pill, Ginseng Bolus for Tonification, Ginseng Bolus for tonifying spleen, BUZHONG YIQI WAN, bolus of ten powerful tonics, KANGGU ZENGSHENG WAN, GUILU BUSHEN WAN, SHENGMAI YIN, Yupingfeng Koufuye, WUJI BAIFENG WAN, SHENQI WUWEIZI PIAN, DANGGUI YANGXUE WAN, SHUANGDAN KOUFUYE, ANSHEN JIAONANG, ANSHEN BUNAO YE protect against osteoporosis.
2, have an osteoplastic Chinese patent medicine of promotion as claim 1 is described, its prescription consists of the prescription that the Pharmacopoeia of the People's Republic of China (version in 2005) is announced:
(1) FUFANG DANSHEN PIAN is meant by Radix Salviae Miltiorrhizae, the Chinese patent medicine that Radix Notoginseng and Borneolum Syntheticum are formed;
(2) Radix Polygoni Multiflori pill is meant by Radix Polygoni Multiflori Preparata, Radix Rehmanniae, Radix Achyranthis Bidentatae (processed with wine), Fructus Mori, Fructus Ligustri Lucidi (processed with wine), Herba Ecliptae, Folium Mori (system), Semen Sesami Nigrum, Semen Cuscutae (wine steaming), Fructus Rosae Laevigatae, the Fructus Psoraleae (Chinese patent medicine that salt stir-fry), Herba Siegesbeckiae (system), Flos Lonicerae (system) are formed;
(3) Ginseng Bolus for Tonification is meant the Chinese patent medicine of being made up of Radix Ginseng, the Rhizoma Atractylodis Macrocephalae (parching with earth), Poria, Radix Astragali Preparata, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba (parched with bran), Pericarpium Citri Reticulatae, Radix Polygalae (system), Cortex Cinnamomi, Fructus Schisandrae Chinensis (wine steaming), Radix Glycyrrhizae Preparata;
(4) Ginseng Bolus for tonifying spleen is meant the Chinese patent medicine of being made up of Radix Ginseng, the Rhizoma Atractylodis Macrocephalae (parched with bran), Poria, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Fructus Amomi, Radix Astragali Preparata, Radix Angelicae Sinensis, Semen Ziziphi Spinosae (stir-fry), Radix Polygalae (system);
(5) BUZHONG YIQI WAN is meant the Chinese patent medicine of being made up of Radix Astragali Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (stir-fry), Radix Angelicae Sinensis, Rhizoma Cimicifugae, Radix Bupleuri, Pericarpium Citri Reticulatae, Radix Glycyrrhizae Preparata;
(6) bolus of ten powerful tonics is meant the Chinese patent medicine of being made up of Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (stir-fry), Poria, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba (wine stir-fry), Rhizoma Chuanxiong, Radix Astragali Preparata, Cortex Cinnamomi, Radix Glycyrrhizae Preparata;
(7) KANGGU ZENGSHENG WAN is meant the Chinese patent medicine of being made up of Radix Rehmanniae Preparata, Herba Cistanches, Rhizoma Cibotii (steaming), Fructus Ligustri Lucidi, Herba Epimedii (steaming), Caulis Spatholobi, Semen Raphani, Rhizoma Drynariae, Radix Achyranthis Bidentatae;
(8) GUILU BUSHEN WAN is meant the Chinese patent medicine of being made up of Colla Plastri Testudinis (stir-fry), Colla cornus cervi (stir-fry), Radix Rehmanniae Preparata, Herba Epimedii (steaming), Semen Cuscutae (stir-fry), Herba Cynomorii (steaming), Radix Dipsaci (steaming), Rhizoma Cibotii (steaming), Radix Polygoni Multiflori Preparata, Fructus Rosae Laevigatae (steaming), Fructus Rubi (steaming), Radix Astragali Preparata, Semen Ziziphi Spinosae (stir-fry), Radix Glycyrrhizae Preparata, Pericarpium Citri Reticulatae (steaming), Rhizoma Dioscoreae (stir-fry);
(9) SHENGMAI YIN is meant by Radix Ginseng Rubra, Radix Ophiopogonis, the molecular Chinese patent medicine of the five tastes;
(10) Yupingfeng Koufuye is meant the Chinese patent medicine of being made up of the Radix Astragali, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae (stir-fry);
(11) WUJI BAIFENG WAN is meant the Chinese patent medicine of being made up of Gallus Domesticus (unhairing, pawl, intestinal), Colla cornus cervi, Carapax Trionycis (system), Concha Ostreae (forging), Ootheca Mantidis, Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Cyperi (vinegar system), Radix Asparagi, Radix Glycyrrhizae, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Stellariae, Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae, Semen Euryales, Cornu Cervi Degelatinatum;
(12) SHENQI WUWEIZI PIAN is meant the Chinese patent medicine of being made up of Fructus Schisandrae Sphenantherae, Radix Codonopsis, the Radix Astragali, Semen Ziziphi Spinosae (stir-fry);
(13) DANGGUI YANGXUE WAN is meant the Chinese patent medicine of being made up of Radix Angelicae Sinensis, the Radix Paeoniae Alba (stir-fry), Radix Rehmanniae, Colla Corii Asini, Radix Astragali Preparata, Poria, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Cortex Eucommiae (stir-fry), Cortex Moutan, Rhizoma Cyperi (system);
(14) SHUANGDAN KOUFUYE is meant the Chinese patent medicine of being made up of Radix Salviae Miltiorrhizae and Cortex Moutan;
(15) ANSHEN JIAONANG is meant by Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Semen Ziziphi Spinosae, Rhizoma Chuanxiong, the Rhizoma Anemarrhenae, Radix Ophiopogonis, the Chinese patent medicine that Radix Polygoni Multiflori Preparata and Poria are formed;
(16) ANSHEN BUNAO YE is meant the Chinese patent medicine of being made up of Cornu Cervi Pantotrichum, Radix Polygoni Multiflori Preparata, Herba Epimedii, Rhizoma Zingiberis, Radix Glycyrrhizae, Fructus Jujubae, vitamin B1.
3, describedly have a promotion bone formation as claim 1 and 2, can be used for the Chinese patent medicine of the new purposes of protect against osteoporosis, can be made into tablet, capsule, granule, electuary, oral liquid, external preparation, injection and any for clinical practice pharmaceutical preparation.
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| CNB2005100782315A CN100488529C (en) | 2005-06-06 | 2005-06-06 | Novel use of compound salvia miltiorrhiza tablet for preventing and treating osteoporosis |
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- 2005-06-06 CN CNB2005100782315A patent/CN100488529C/en not_active Expired - Fee Related
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| CN103933055B (en) * | 2014-04-15 | 2015-12-30 | 中国人民解放军第四军医大学 | Saikoside a prevents and treats osteoporotic application |
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| CN105362660A (en) * | 2015-11-25 | 2016-03-02 | 禤燕华 | Traditional Chinese medicine composition for treating osteoporosis and preparation method of traditional Chinese medicine composition for treating osteoporosis |
| CN107184728A (en) * | 2017-05-22 | 2017-09-22 | 漯河医学高等专科学校 | A kind of collaterals and relieving pain cream and preparation method thereof |
| CN114191498A (en) * | 2022-01-27 | 2022-03-18 | 广州白云山花城药业有限公司 | Tortoise and deer kidney tonifying pill extract for resisting osteoporosis as well as preparation method and application thereof |
| CN114191498B (en) * | 2022-01-27 | 2022-09-02 | 广州白云山花城药业有限公司 | Tortoise and deer kidney tonifying pill extract for resisting osteoporosis as well as preparation method and application thereof |
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