CN103860993B - A kind of clearing away lung-heat to relieve cough granule and preparation method - Google Patents
A kind of clearing away lung-heat to relieve cough granule and preparation method Download PDFInfo
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- CN103860993B CN103860993B CN201410101845.XA CN201410101845A CN103860993B CN 103860993 B CN103860993 B CN 103860993B CN 201410101845 A CN201410101845 A CN 201410101845A CN 103860993 B CN103860993 B CN 103860993B
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Abstract
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of clearing away lung-heat to relieve cough granule and preparation method, comprise following component by weight: Folium Mori 2 weight portion, Flos Chrysanthemi 1 weight portion, Rhizoma Phragmitis 3 weight portion, Radix Scutellariae 1 weight portion, Cortex Mori 3 weight portion, Herba Houttuyniae 3 weight portion, Radix Sophorae Tonkinensis 1 weight portion, Folium Eriobotryae 2 weight portion, Exocarpium Citri Rubrum 1 weight portion, Rhizoma Pinelliae (processed) 1 weight portion, Radix Platycodonis 1 weight portion, Semen Armeniacae Amarum (stir-fry) 1 weight portion, Radix Peucedani 1 weight portion, Radix Asteris (processed with honey) 1 weight portion, the Radix Stemonae (processed with honey) 2 weight portion, Radix Glycyrrhizae 1 weight portion.Selection drug embodies the physiological property of lungs, and medication is gently advocated clearly, abandons bitter cold deep, substitutes famous and precious and restricted Chinese crude drug with parts of generic medicinal plants, cheap, drug safety, and prescription comprehensive and reasonable, heat clearing away and preventing phlegm from forming and stopping coughing are laid equal stress on.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of clearing away lung-heat to relieve cough granule and preparation method.
Background technology
" lung is the five internal organs canopy ", " lung being a delicate viscus, not resistance to cold and heat ", these physiological propertys of lung just determine exopathogen and very easily violate lung, cause impairment of dispersing and descending function of the lung, and there is the symptoms such as cough, excessive phlegm, and violate in lung at various exopathogen, common with wind heat, for the treatment of cough due to pathogenic wind-heat, according to the physiological property of lung, the old maxim that Wu Ju Tong " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases " clearly " controls the part of the body cavity above the diaphragm housing the heart and lungs as plumage, non-light erectile problem " should be followed, it is main that Selection drug should gently be advocated clearly, must guard against bitter cold deep.And the product that existing clearing heat, eliminating phlegm, relieving cough class Chinese patent medicine niuhuang shedan chuanbei mixture, fritillary and loquat cough mixture, intensified loquet distillate prescription Calculus Bovis used, Fel Serpentis system bitter cold are deep; Bulbus Fritillariae Cirrhosae natural resources is deficient, expensive; Pericarpium Papaveris belongs to national restricted Chinese crude drug, the easy addiction of long-term taking.From prescription, niuhuang shedan chuanbei mixture clearing away heat-fire power is large, and antitussive action is not enough, and then both are based on cough-relieving, and eliminating heat from the lung strength is inferior.Be used alone the clinical problem being difficult to solve wind heat and phlegm-heat cough, then both need adapted Western medicine anti-inflammation class medicine in use.
Summary of the invention
The object of the invention is to overcome above-mentioned technical problem and the eutherapeutic clearing away lung-heat to relieve cough granule of one provided and preparation method.
A kind of clearing away lung-heat to relieve cough granule, comprises following component by weight:
Folium Mori 2 weight portion, Flos Chrysanthemi 1 weight portion, Rhizoma Phragmitis 3 weight portion, Radix Scutellariae 1 weight portion, Cortex Mori 3 weight portion, Herba Houttuyniae 3 weight portion, Radix Sophorae Tonkinensis 1 weight portion, Folium Eriobotryae 2 weight portion, Exocarpium Citri Rubrum 1 weight portion, Rhizoma Pinelliae (processed) 1 weight portion, Radix Platycodonis 1 weight portion, Semen Armeniacae Amarum (stir-fry) 1 weight portion, Radix Peucedani 1 weight portion, Radix Asteris (processed with honey) 1 weight portion, the Radix Stemonae (processed with honey) 2 weight portion, Radix Glycyrrhizae 1 weight portion.
A preparation method for clearing away lung-heat to relieve cough granule, comprises the steps:
(1) get Herba Houttuyniae, Cortex Mori, Folium Eriobotryae extraction volatile oil, put into container and save backup;
(2) medicinal residues after Herba Houttuyniae, Cortex Mori, Folium Eriobotryae extract volatile oil and other 13 herbal medicine decoct twice altogether, 1 hour first time, second time 0.5 hour, and collecting decoction, filters;
(3) filtrate is concentrated into 1ml and is equivalent to crude drug 2g, adds 1 times amount ethanol, stirs evenly, and leaves standstill 24 hours, filters, and after using decompression tank to reclaim ethanol, leave standstill, filter, filtrate is concentrated into relative density 1.30 ~ 1.35(60 DEG C) thick paste;
(4) get thick paste 1 part, sucrose 3 parts, 1 part, dextrin is mixed into spice, and the volatile oil in the dilution proportion step 1 of ethanol 2:1 is sprayed in above-mentioned spice, adopts the alcoholic solution of 80% to stir spice and makes soft material;
(5) above-mentioned soft material is crossed a sieve, 60 DEG C of oven dry, granule processed, after the sterilizing of epoxy hexane, place 7-10 days, described clearing away lung-heat to relieve cough granule can be obtained.
Selection drug embodies the physiological property of lungs, and medication is gently advocated clearly, abandons bitter cold deep, substitutes famous and precious and restricted Chinese crude drug with parts of generic medicinal plants, cheap, drug safety, and prescription comprehensive and reasonable, heat clearing away and preventing phlegm from forming and stopping coughing are laid equal stress on.
In side, Folium Mori bitter but sweet flavor is cold in nature, and Flos Chrysanthemi sweet-bitter flavor is cool in nature, all enters lung meridian, gently disperses clearly, eliminating heat from the lung, is principal agent altogether; Herba Houttuyniae, Radix Sophorae Tonkinensis heat-clearing and toxic substances removing, Rhizoma Phragmitis, Cortex Mori, Radix Scutellariae clearing heat and purging lung, to help the power of the clear part of the body cavity above the diaphragm housing the heart and lungs lung-heat of Folium Mori, Flos Chrysanthemi; Folium Eriobotryae, the Rhizoma Pinelliae, Exocarpium Citri Rubrum, Radix Peucedani, Semen Armeniacae Amarum, Radix Asteris, Flos Farfarae, Radix Platycodonis, the cough-relieving of Radix Stemonae dispersing lung-QI and dissipating phlegm are accessory drugs altogether; Radix Glycyrrhizae is eliminated the phlegm, coordinating the actions of various ingredients in a prescription is adjuvant; All medicines share the merit of playing removing heat from the lung and dissipating phlegm cough-relieving altogether, the clinical disease for wind heat, phlegm-heat cough.
Folium Mori all have stronger antibacterial action to staphylococcus aureus, beta hemolytic streptococcus, diphtheria corynebacterium and anthrax bacillus.Flos Chrysanthemi is external has some inhibitory action to gram-positive bacterium (staphylococcus aureus and β Hemolytic streptococcus), Bacillus tuberculosis, and high concentration also has antiviral (PB8 strain) and anti-spirillum effect in vitro.
Herba Houttuyniae has significantly antibacterial, antivirus action, all inhibitory action is had to staphylococcus aureus and penicillin resistant strain thereof, Hemolytic streptococcus, Diplococcus pneumoniae, micrococcus catarrhalis, hemophilus influenza, serous secretion can be suppressed, promote tissue regeneration, there is antiinflammatory action, obviously can promote the phagocytic function of leukocyte and macrophage, also have obvious antiasthmatic effect effect.
Dauricine, to various respiratory road antibacterial, as staphylococcus aureus, Candida albicans, tubercule bacillus etc. all have inhibitory action, also has obvious antiinflammatory action.
Radix Scutellariae has wider antimicrobial spectrum, inhibitory action is being had to staphylococcus aureus, Hemolytic streptococcus, Diplococcus pneumoniae, diphtheria corynebacterium, even if to the staphylococcus aureus that the antimicrobial drugs such as penicillin have developed immunity to drugs, still responsive to Radix Scutellariae, Radix Scutellariae also has antiinflammatory anti-allergic effects in addition.
Amygdaloside contained by Folium Eriobotryae, Semen Armeniacae Amarum, can be decomposed by enteric microorganism enzyme in vivo and produce hydrocyanic acid, hydrocyanic acid has inhibitory action to respiratory center, reaches the effect of antitussive and antiasthmatic.
Exocarpium Citri Rubrum, the Rhizoma Pinelliae, Radix Platycodonis, Radix Peucedani, Radix Asteris, Flos Farfarae, the Radix Stemonae, Radix Glycyrrhizae all have expelling phlegm for arresting cough effect in various degree through modern pharmacological research.
Detailed description of the invention
Below, in conjunction with example, substantive distinguishing features of the present invention and advantage are further described, but the present invention is not limited to listed embodiment.
Embodiment
A kind of clearing away lung-heat to relieve cough granule, comprises following component by weight:
Folium Mori 2 weight portion, Flos Chrysanthemi 1 weight portion, Rhizoma Phragmitis 3 weight portion, Radix Scutellariae 1 weight portion, Cortex Mori 3 weight portion, Herba Houttuyniae 3 weight portion, Radix Sophorae Tonkinensis 1 weight portion, Folium Eriobotryae 2 weight portion, Exocarpium Citri Rubrum 1 weight portion, Rhizoma Pinelliae (processed) 1 weight portion, Radix Platycodonis 1 weight portion, Semen Armeniacae Amarum (stir-fry) 1 weight portion, Radix Peucedani 1 weight portion, Radix Asteris (processed with honey) 1 weight portion, the Radix Stemonae (processed with honey) 2 weight portion, Radix Glycyrrhizae 1 weight portion.
A preparation method for clearing away lung-heat to relieve cough granule, comprises the steps:
(1) get Herba Houttuyniae, Cortex Mori, Folium Eriobotryae extraction volatile oil, put into container and save backup;
(2) medicinal residues after Herba Houttuyniae, Cortex Mori, Folium Eriobotryae extract volatile oil and other 13 herbal medicine decoct twice altogether, 1 hour first time, second time 0.5 hour, and collecting decoction, filters;
(3) filtrate is concentrated into 1ml and is equivalent to crude drug 2g, adds 1 times amount ethanol, stirs evenly, and leaves standstill 24 hours, filters, and after using decompression tank to reclaim ethanol, leave standstill, filter, filtrate is concentrated into relative density 1.30 ~ 1.35(60 DEG C) thick paste;
(4) get thick paste 1 part, sucrose 3 parts, 1 part, dextrin is mixed into spice, and the volatile oil in the dilution proportion step 1 of ethanol 2:1 is sprayed in above-mentioned spice, adopts the alcoholic solution of 80% to stir spice and makes soft material;
(5) above-mentioned soft material is crossed a sieve, 60 DEG C of oven dry, granule processed, after the sterilizing of epoxy hexane, place 7-10 days, described particle for relieving heat and cough can be obtained, be distributed into bag after the assay was approved, 15 weight portions/bag.
Usage and dosage: warm water is taken after mixing it with water, according to symptom emergency, each 1 ~ 2 bag 7 days is a course for the treatment of.
The present invention is directed to the physiological property of the lungs such as " lung is the five internal organs canopy ", " lung being a delicate viscus; not resistance to cold and heat "; follow the old maxim that Wu Ju Tong " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases " clearly " controls the part of the body cavity above the diaphragm housing the heart and lungs as plumage; non-light erectile problem "; Selection drug is based on light clear advocation; abandon the product that bitter cold is deep; deep and the Chinese crude drugs such as expensive Calculus Bovis, Fel Serpentis with the alternative bitter cold such as Folium Mori, Flos Chrysanthemi; famous and precious, the restricted Chinese crude drug such as Bulbus Fritillariae Cirrhosae, Pericarpium Papaveris is substituted with Fructus Citri tangerinae Folium Eriobotryae, the Rhizoma Pinelliae, Semen Armeniacae Amarum; and prescription is reasonable more comprehensively, embodies Traditional Chinese Medicine tcm theory.At my institute's Clinical practice for many years, practical proof curative effect is more better than existing similar Chinese patent medicine, and can be used alone in the present invention.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (1)
1. the preparation method of a clearing away lung-heat to relieve cough granule: described clearing away lung-heat to relieve cough granule comprises the component of following parts by weight: Folium Mori 2 weight portion, Flos Chrysanthemi 1 weight portion, Rhizoma Phragmitis 3 weight portion, Radix Scutellariae 1 weight portion, Cortex Mori 3 weight portion, Herba Houttuyniae 3 weight portion, Radix Sophorae Tonkinensis 1 weight portion, Folium Eriobotryae 2 weight portion, Exocarpium Citri Rubrum 1 weight portion, Rhizoma Pinelliae Preparata 1 weight portion, Radix Platycodonis 1 weight portion, Semen Armeniacae Amarum (parched) 1 weight portion, Radix Peucedani 1 weight portion, processed with honey Radix Asteris 1 weight portion, the processed with honey Radix Stemonae 2 weight portion, Radix Glycyrrhizae 1 weight portion,
This preparation method comprises the steps: that (1) gets Herba Houttuyniae, Cortex Mori, Folium Eriobotryae extraction volatile oil, puts into container and saves backup; (2) medicinal residues after Herba Houttuyniae, Cortex Mori, Folium Eriobotryae extract volatile oil and other 13 herbal medicine decoct twice altogether, 1 hour first time, second time 0.5 hour, and collecting decoction, filters; (3) filtrate is concentrated into 1ml and is equivalent to crude drug 2g, the amount of doubling ethanol, stirs, and leaves standstill 24 hours, filters, and after using decompression tank to reclaim ethanol, leaves standstill, filters, the thick paste of relative density 1.30 ~ 1.35 when filtrate is concentrated into 60 DEG C; (4) get thick paste 1 part, sucrose 3 parts, 1 part, dextrin is mixed into spice, and the volatile oil in the dilution proportion step (1) of ethanol 2:1 is sprayed in above-mentioned spice, adopts the alcoholic solution of 80% to stir spice and makes soft material; (5) above-mentioned soft material is crossed a sieve, 60 DEG C of oven dry, granule processed, after the sterilizing of epoxy hexane, place 7-10 days, please lung cough-stopping granule described in can obtaining.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410101845.XA CN103860993B (en) | 2014-03-19 | 2014-03-19 | A kind of clearing away lung-heat to relieve cough granule and preparation method |
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| CN201410101845.XA CN103860993B (en) | 2014-03-19 | 2014-03-19 | A kind of clearing away lung-heat to relieve cough granule and preparation method |
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| CN103860993A CN103860993A (en) | 2014-06-18 |
| CN103860993B true CN103860993B (en) | 2016-03-16 |
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| CN102847026A (en) * | 2011-06-27 | 2013-01-02 | 张红旗 | A Chinese medicinal formulation for treating infiltrative pulmonary tuberculosis |
| CN102743737B (en) * | 2012-07-26 | 2013-10-30 | 赵健 | Chinese medicinal preparation for effectively treating tracheitis |
| CN103463536B (en) * | 2013-08-26 | 2015-04-29 | 宋磊 | Traditional Chinese medicine composition for treating wind-heat affecting lung |
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Granted publication date: 20160316 Termination date: 20180319 |