CN1143682C - Medicine for treating cold and its preparing process - Google Patents

Abstract

The present invention relates to medicine for treating a cold, which is composed of coix seed, Chinese mosla herb, smoked plum, citric acid, chrysanthemum, radix glycyrrhiza, shiitake fungus, slenderstyle acanthopanax bark, heartleaf houttuynia herb, milkvetch root kudzuvine root, coptis, honeysuckle flower, oldenlandia, common yan rhizome, small centipeda herb, dried ginger, lactic acid (a sterilization wetting agent), herba agastachis and vitamin V-C, wherein the fresh chrysanthemum, the heartleaf houttuynia herb and the honeysuckle flower are rapidly refrigerated to-45 to 55 DEG C to be preserved and are dried in a vacuum state and pulverized. The rest dry raw material of coix seed, smoked plum, shiitake fungus, kudzuvine root, etc. is sorted, cleaned and pulverized. The two kinds of sieved raw material are mixed, pulverized and sieved to be below 100 meshes, and disinfection wetting agent lactic acid is added to the mixture to be prepared into particles, namely the medicine. The medicine of The present invention has an effectual rate of 72% and a total effective rate of 91%.

Description

A kind of medicine for the treatment of flu and preparation method thereof

The present invention relates to a kind of medicine for the treatment of flu, be specifically a kind of be the Chinese patent medicine of feedstock production with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.

Common cold is the common frdquently encountered disease of serious harm human health, and child, between twenty and fifty people, old people can be infected, and especially in season, abrupt change of climate, the people is careless slightly, just can suffer from it.In a single day and suffered from flu, resistance of human body descends, and more can bring out other disease.

At present, utilize the treatment coldrex of Chinese herbal medicine development a lot of, as influenza defervesce dash, GANMAOTONG, silver-colored wing detoxifcation sheet etc.But along with people's life-time service, these medicines reduce gradually to the curative effect of flu, and therefore, constantly the new drug of effectively treatment flu of development is one of the world of medicine's problem that will solve for a long time.

The purpose of this invention is to provide a kind of remarkable and safe and reliable medicine of flu effect and preparation method thereof for the treatment of.

Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to flu disease mechanism, achieves with reference to modern pharmacological research, from motherland's pools of traditional Chinese medicine, filter out dispelling wind and heat pathogens, heat-clearing and toxic substances removing, the big portion natural edible-plant medicine of enhancing human body immunity function by the theory of Chinese medical science prescription, skims the cream off milk, it is brought down a fever, end tears, separate nasal obstruction, the pain of decaptitating, stop-spraying is sneezed, and reaches body temperature and unusual physical and chemical index and recovers normal.

Medicine of the present invention is made (consumption is a weight portion) by following component

Semen Coicis 90-110 Herba Moslae 32-36

Fructus Mume 90-110 citric acid 33-39

Flos Chrysanthemi 90-120 Radix Glycyrrhizae 16-18

Lentinus Edodes 90-110 Cortex Acanthopancis 16-19

Herba Houttuyniae 90-110 Radix Astragali 17-20

Radix Puerariae 90-110 Rhizoma Coptidis 15-18

Flos Lonicerae 90-110 Herba Hedyotidis Diffusae 16-18

Rhizoma Dioscoreae 30-38 Herba Centipedae 16-18

Rhizoma Zingiberis 32-38 lactic acid (sterilization wetting agent) 15-20

Herba Pogostemonis 30-36 vitamin V-C 10-16

Modern science experiment discovery Herba Houttuyniae, Lentinus Edodes, the Radix Astragali, Rhizoma Coptidis, Cortex Acanthopancis, Herba Hedyotidis Diffusae can be improved the phagocytic function of reticuloendothelial system: Rhizoma Coptidis, Flos Lonicerae, the Radix Astragali, Lentinus Edodes etc. can promote lymphocytic conversion; Flos Lonicerae, Cortex Acanthopancis can make lymphocyte and leukocytic numerical value improve; Radix Glycyrrhizae has Detoxication, also doubts to have the effectiveness that improves immunologic function.More than medication combined usefulness synergism on varying level simultaneously, should be more more powerful and lasting than the function of single medicine enhancing human body immunity function.

Yet Herba Hedyotidis Diffusae has syngignoscism, and available anti-hypnotic Cortex Acanthopancis and Rhizoma Zingiberis resist it; Rhizoma Zingiberis Recens has the effect of rising blood pressure, effective drop pressing Cortex Acanthopancis, Flos Chrysanthemi, Radix Puerariae balance it; Cortex Acanthopancis has antidiuretic activity, and Herba Houttuyniae, Herba Moslae have diuresis, can correct it mutually: the Radix Astragali suppresses gastric secretion, and Radix Glycyrrhizae has the effectiveness that reduces gastric juice, can adopt to promote Rhizoma Zingiberis, the Herba Pogostemonis of gastric secretion to improve it; Cortex Acanthopancis, Radix Glycyrrhizae, Radix Puerariae, Rhizoma Dioscoreae etc. have hormone-like effect, and available Rhizoma Coptidis, the effect of Semen Coicis hormone antagonist are dissolved it.Cortex Acanthopancis, Lentinus Edodes, Radix Glycyrrhizae, Rhizoma Coptidis, Herba Hedyotidis Diffusae, Semen Coicis have antitumor action in addition, and the Radix Astragali, Flos Chrysanthemi, Herba Houttuyniae, Flos Lonicerae, Rhizoma Coptidis, Herba Centipedae have antivirus action, can accomplish that eliminating pathogenic factor for supporting vital QI assistance improves the effectiveness of immunologic function.More than all medicines may become the potential sensitization of allergic constitution source, available antiallergic agent Fructus Mume improves it, so that enlarge the adaptation population of this compound recipe to greatest extent.

Modern times experimental results show that the Chinese herbal medicine of many QI invigorating YIN nourishing shape sun and heat-clearing and toxic substances removing all has certain influence to immunologic function.In recent years, that medical circle is thought is insufficiency of the spleen, it is relevant with immune state to suffer from a deficiency of the kidney, so warming and recuperating the kidney-YANG is corrected and suffered from a deficiency of the kidney and the insufficiency of the spleen while can be seen immunologic function and improves.Look into motherland's medical treasure-house, find that from the ancient proved recipe of a large amount of these classes the sages of the past often adopt prescriptions such as Semen Coicis, Rhizoma Dioscoreae, Flos Chrysanthemi, Radix Puerariae, Herba Pogostemonis, Rhizoma Zingiberis, Radix Glycyrrhizae, Cortex Acanthopancis, the Radix Astragali, Rhizoma Coptidis, Flos Lonicerae, Fructus Mume, can think that they are the medicine and the ancillary drug of effective raising immunologic function, we should inherit these ancestors' legacy.In fact our experiment also prove first the contained total flavonoid chemical compound of Semen Coicis can remove free radical particularly the damage of O2-the effect that improves immunologic function is also just played in the protective effect of tissue indirectly, this experience with forefathers' summary is consistent.It is to be noted that the Semen Coicis new varieties 85-15 effect in this respect that we utilize the distant hybridization biotechnology to breed first surpasses original farm variety in the world, it adopts the pharmacologic action that will increase Semen Coicis in this compound recipe.The zoopery of this compound recipe significantly improves body's immunity, and particularly animal spleen, normality weight increase, and the macrophage meansigma methods obviously increases in the spleen, these all with theoretical prediction (under " new pharmacology " 657 pages of Radix Et Caulis Acanthopanacis Senticosi items; Under " the big diction of Chinese medicine is bent " 380 pages of Cortex Acanthopancis items) be consistent.

The Chinese herbal medicine crude drug is oral, and generally all taste is not good enough, can improve drug effect again in order to improve mouthfeel, elitely selects citric acid and vitamin V-C makes additive.

The sterilization of Chinese herbal and crude drugs preparations is an a great problem, this prescription utilizes crude drug parenchyma and the fibrous tissue adsorption to liquid, select for use lactic acid to make antiseptic sterilization agent, reach sterilization functions thorough and that continue, can improve mouthfeel again to health is harmless, the wetting agent that but another advantage that adopts lactic acid is a double as when making tabletting has reduced cost.

In this prescription, Lentinus Edodes originally is a food; Belong to that Ministry of Public Health announces two batches be food be again medicine Flos Lonicerae, Radix Puerariae, Herba Houttuyniae, Rhizoma Zingiberis, Rhizoma Dioscoreae, Semen Coicis, Radix Glycyrrhizae, Fructus Mume, Flos Chrysanthemi, Herba Pogostemonis, Lentinus Edodes, Herba Moslae etc. are arranged; Add the chemical medicine citric acid, the vitamin V-C that can be used as food, totally 15 flavors such as lactic acid etc., account for 75% in the full formula 20 flavor medicines, and this 15 flavor accounts for 91.7% of formulation weight, so that this product is called health food is apt.

In conventional medicament is produced, general all from not traditional handicraft such as solarization, baking, roasting, stir-fry or make preparation by the method for chemical extraction.Above-mentioned preparation method is because of drying or the temperature difference of extracting or because of employed solvent difference, the composition of gained preparation, character and pluses and minuses are different.Even some different operation may cause the change of some active ingredient, thereby the drug effect of plant is reduced.Data shows that plant amedica Yin Wendu rising normal enzyme in drying is destroyed, volatile oil degeneration or evaporation, and some vitamin is oxidized, even active component is partly or entirely lost.So various extracts: fluid extract, pilular extract, dried carrying are only contained the part composition that dissolves in the extraction solvent in thing, propellant, powdering agent, the tincture.We the French state-of-the-art plant amedica manufacturing technology of further investigation (Arkotitrat, SIPF) after, in conjunction with Chinese characteristic, part medicine in this prescription is carried out special lyophilization processing to reach the maximum effect effect.

Above-mentioned each component is made medicine production method of the present invention is:

1, select fresh Flos Chrysanthemi for use, Herba Houttuyniae, Flos Lonicerae are cleaned chopping, and are refrigerated to-45 ℃ rapidly--55 ℃ of preservations, and vacuum drying, at-40 ℃--pulverize down for 45 ℃, the back of sieving is standby;

2, dried raw materials such as remaining Semen Coicis, Fructus Mume, Lentinus Edodes, Radix Puerariae, Rhizoma Dioscoreae, Rhizoma Zingiberis, Herba Pogostemonis, Herba Moslae, citric acid, Radix Glycyrrhizae, Cortex Acanthopancis, the Radix Astragali, Rhizoma Coptidis, Herba Hedyotidis Diffusae, Herba Centipedae, vitamin V-C is standby after selecting materials, clean, pulverize, sieving;

3, the raw material after above-mentioned two kinds are sieved mixes, and pulverizes, sieves, to 100 orders, adds the wetting agent lactic acid of sterilization, and corning is this product.

Above-mentioned medicine grain can be made into capsule-type, sheet type etc.

Characteristics of medicine of the present invention are that the joint synergy of each former single medicinal material in this medicine can strengthen immune function of human body greatly; Another characteristics of the present invention are to carry out lyophilization in the preparation method to handle, and to reduce owing to the change of manufacturing procedure to drug effect, reach maximum therapeutic efficiency.

Medicine of the present invention is through zoopery, and clinical trial shows " referring to adnexa 1-3 ", and following advantage is arranged,

1, to select the homologous natural edible-plant medicine of medicated diet for use be raw material to major part, and prescription meets the pharmaceutical control law regulation, utilizes the co-action for treating flu of the Chinese medicine of respectively distinguishing the flavor of, and good effect has no side effect to human body.

2, medicine of the present invention need not decoct, no bitterness sense, taking convenience.

For showing the therapeutic effect of medicine of the present invention to flu, qualified study subject 130 examples of experiment picked at random are divided into two groups, organize 100 examples with the treatment of medicine of the present invention, with matched group 30 examples of GANMAO TUIRE CHONGJI.Wherein age distribution 18-65 year, male 52 people are organized in treatment, women 48 people; Matched group man 19 people, women 11 people; Test method: medicine of the present invention is made capsule three times on the one, each 6-8 grain; GANMAO TUIRE CHONGJI, every day three times, each 10 grams, 3 is a course of treatment.

Result of the test shows, medicine obvious effective rate 72% of the present invention, and total effective rate 91% compares with matched group, general curative effect significant difference (P＜0.05), medicine of the present invention is excellent.

Embodiment 1:

Medicine of the present invention takes by weighing raw material by following proportioning: [unit gram]

Semen Coicis 100 Herba Moslaes 34

Fructus Mume 100 citric acids 34

Flos Chrysanthemi 100 order grass 17.5

Lentinus Edodes 100 Cortex Acanthopanciss 17.5

Herba Houttuyniae 100 Radixs Astragali 17.5

Radix Puerariae 100 Rhizoma Coptidis 17.5

Flos Lonicerae 100 Herba Hedyotidis Diffusaes 17.5

Rhizoma Dioscoreae 34 Herba Centipedae 17.5

Rhizoma Zingiberis 34 lactic acid (sterilization wetting agent) 15

Herba Pogostemonis 34 vitamin Vs-C 10

Above-mentioned each component is made medicine production method of the present invention is:

1, select for use fresh Flos Chrysanthemi, Herba Houttuyniae, Flos Lonicerae to clean chopping, and be refrigerated to-55 ℃ of preservations rapidly, vacuum drying is pulverized down at-45 ℃, sieves, and is standby;

2, with dried raw materials such as remaining Semen Coicis, Fructus Mume, Lentinus Edodes, Radix Puerariaes after selecting materials, clean, pulverize, sieving, standby;

3, the raw material after above-mentioned two kinds are sieved mixes, and pulverizes, is screened to 110 orders again, adds the wetting agent lactic acid of sterilization, and corning is this product.

Embodiment 2

Medicine of the present invention takes by weighing raw material by following proportioning: [unit gram]

Semen Coicis 90 Herba Moslaes 32

Fructus Mume 90 citric acids 33

Flos Chrysanthemi 90 Radix Glycyrrhizaes 16

Lentinus Edodes 90 Cortex Acanthopanciss 16

Herba Houttuyniae 90 Radixs Astragali 17

Radix Puerariae 90 Rhizoma Coptidis 15

Flos Lonicerae 90 Herba Hedyotidis Diffusaes 16

Rhizoma Dioscoreae 30 Herba Centipedae 16

Rhizoma Zingiberis 32 lactic acid (sterilization wetting agent) 18

Herba Pogostemonis 30 vitamin Vs-C 10

The production method of above-mentioned each component being made medicine of the present invention is:

1, select for use fresh Flos Chrysanthemi, Herba Houttuyniae, Flos Lonicerae to clean chopping, and be refrigerated to-45 ℃ of preservations rapidly, vacuum drying is pulverized sieving for standby down at-40 ℃;

2, dried raw materials such as remaining Semen Coicis, Fructus Mume, Lentinus Edodes, Radix Puerariae is standby after selecting materials, clean, pulverize, sieving;

3, the raw material after above-mentioned two kinds are sieved mixes, and pulverizes, is screened to 100 orders again, adds the wetting agent lactic acid of sterilization, corning, and compacting being this product in flakes.

Embodiment 3

Medicine of the present invention takes by weighing raw material by following proportioning: [unit gram]

Semen Coicis 110 Herba Moslaes 36

Fructus Mume 110 citric acids 39

Flos Chrysanthemi 120 Radix Glycyrrhizaes 18

Lentinus Edodes 110 Cortex Acanthopanciss 19

Herba Houttuyniae 110 Radixs Astragali 20

Radix Puerariae 110 Rhizoma Coptidis 18

Flos Lonicerae 110 Herba Hedyotidis Diffusaes 18

Rhizoma Dioscoreae 38 Herba Centipedae 18

Rhizoma Zingiberis 38 lactic acid (sterilization wetting agent) 20

Herba Pogostemonis 36 vitamin Vs-C 16

The production method of above-mentioned each component being made medicine of the present invention is:

1, select for use fresh Flos Chrysanthemi, Herba Houttuyniae, Flos Lonicerae to clean chopping, and be refrigerated to-50 ℃ of preservations rapidly, vacuum drying is pulverized sieving for standby down at-42 ℃;

2, dried raw materials such as remaining Semen Coicis, Fructus Mume, Lentinus Edodes, Radix Puerariae is standby after selecting materials, clean, pulverize, sieving;

3, the raw material after above-mentioned two kinds are sieved mixes, and pulverizes, is screened to 120 orders again, adds the wetting agent lactic acid of sterilization, corning, and compacting being this product in flakes.

Claims (2)

1, a kind of medicine for the treatment of flu is characterized in that: its each component and weight proportion are:

Semen Coicis 90-110 Herba Moslae 32-36

Fructus Mume 90-110 citric acid 33-39

Flos Chrysanthemi 90-120 Radix Glycyrrhizae 16-18

Lentinus Edodes 90-110 Cortex Acanthopancis 16-19

Herba Houttuyniae 90-110 Radix Astragali 17-20

Radix Puerariae 90-110 Rhizoma Coptidis 15-18

Flos Lonicerae 90-110 Herba Hedyotidis Diffusae 16-18

Rhizoma Dioscoreae 30-38 Herba Centipedae 16-18

Rhizoma Zingiberis 32-38 lactic acid 15-20

Herba Pogostemonis 30-36 vitamin V-C 10-16

Flos Chrysanthemi wherein, Herba Houttuyniae, Flos Lonicerae, are used as medicine after the pulverize at low temperature through lyophilization for adopting fresh Flos Chrysanthemi, Herba Houttuyniae, Flos Lonicerae.

2, a kind of preparation method of medicine of treatment flu as claimed in claim 1 is characterized in that:

＜1 〉, select for use fresh Flos Chrysanthemi, Herba Houttuyniae, Flos Lonicerae to clean chopping, and be refrigerated to-45 ℃ rapidly--55 ℃ of preservations, vacuum drying, at-45 ℃--pulverize down for 45 ℃, the back of sieving is standby;

＜2 〉, that remaining Semen Coicis, Fructus Mume, Lentinus Edodes, Radix Puerariae, Rhizoma Dioscoreae, Rhizoma Zingiberis, Herba Pogostemonis, Herba Moslae, citric acid, Radix Glycyrrhizae, Cortex Acanthopancis, the Radix Astragali, Rhizoma Coptidis, Herba Hedyotidis Diffusae, Herba Centipedae, the dried raw material of vitamin V-C is standby after selecting materials, clean, pulverize, sieving;

＜3 〉, the raw material after above-mentioned two kinds sieved mixes, and pulverizes, sieves, to 100 orders, adds the wetting agent lactic acid of sterilization, corning is this product.