CN1965978A - Natural botanical extraction liquid for preventing and treating epidemic febrile disease of birds and livestock and method for preparing same - Google Patents
Natural botanical extraction liquid for preventing and treating epidemic febrile disease of birds and livestock and method for preparing same Download PDFInfo
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- CN1965978A CN1965978A CNA2006100976048A CN200610097604A CN1965978A CN 1965978 A CN1965978 A CN 1965978A CN A2006100976048 A CNA2006100976048 A CN A2006100976048A CN 200610097604 A CN200610097604 A CN 200610097604A CN 1965978 A CN1965978 A CN 1965978A
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Abstract
The invention provides a natural plant extract for the prevention and treatment of epidemic animal fever, wherein the raw materials include (by weight ratio) giant knotweed rhizome 6-10 parts, ligustrum japonicum 5-8 parts, perfoliate knotweed 1.2-2 parts, Chinese yam 0.8-1.5 parts, astragalus root 0.2-0.5 part, aizoon stonecrop 0.8-1.5 parts, creeping euphorbia 1.2-2 parts, barbat skullcap 0.8-1.5 parts, chebula fruit 0.8-1.5 parts, and dandehon herb 0.8-1.5 parts. The process for preparing the extract consists of steps of charging raw material herbs into drinking water, immersing, boiling and concentrating.
Description
Technical field
The present invention relates to the therapeutic activity of medical science or veterinary's chemical compound or pharmaceutical preparation, be meant the natural botanical extraction liquid and preparation method thereof of the control poultry epidemic febrile disease of a kind of being commonly called as " brave loyal mixture " especially.
Background technology
Along with the fast development of animal husbandry, be accompanied by the poultry breeding and introduce, add the influence of various stress factors such as environmental factors, it is complicated that swine diseases more becomes.The pig breeding has become with diseases such as breathing syndrome (PRRS), circovirus disease (PCV), exudative dermatitiss to be influenced the animal husbandry economy benefit in recent years and restricted the key factor that animal husbandry develops in a healthy way.Pig breeding claims " reproductive and respiratory syndrome " again with breathing syndrome, is a kind of breeding and the respiratory infectious disease of the pig that causes of breeding and breathing syndrome virus (PRRSSV) by Arteriviridae, Arterivirus, is listed in the category-B infectious disease by International Office of Epizootics; Though adopt the preventive measure of taking some antiviral drugs can play certain effect at the initial stage of a disease, yet it is still unavoidable in morbidities in particular cases such as the mismanagements that may occur, the disease of falling ill pig mortality rate is up to 80%, at present to still not having the specific treatment medicine on this disease market.Circovirus disease claims the ablactational baby pig multisystemic wasting syndrome again, is a kind of new important immunosuppressant sexually transmitted disease of the pig that caused by porcine circovirus, and the disease of falling ill pig mortality rate is up to 90%; Prevention works such as the sterilization though pay attention to doing the best possible, the control plague of rats, the removing source of infection, but in case morbidity, because existing market do not have the specific treatment medicine, only can use the antibiotics of some antipyretic-antalgics, control secondary infection to treat, can take stopgap measures but can not effect a permanent cure.The exudative dermatitis of pig is that mucus occurring oozing out and form a scab with the skin large tracts of land is feature by a kind of piglet height contact dermatosis due to the pig staphylococcus epidermidis, and serious case mortality can reach 60%; Though use suitable disinfectant under optimum conditions environment and pig body to be carried out disinfection avoiding the generation of this disease, yet staphylococcus extensively is present in nature, adds in the breeding process because feeding and management is not good at still easily causing the generation of this disease.Above-mentioned three kinds of diseases harm is bigger, because the forbidding of antiviral drugs such as ribavirin, amantadine and drug residue and the drug resistance that antibiotics brings still do not have the specific treatment medicine on the market, has therefore caused very big economic loss to the raiser.
Summary of the invention
Technical problem to be solved by this invention just is to be critically ill that evil is big, still not have the present situation of specific treatment medicine on the market at above-mentioned three boars, provides a kind of and selects for use the effective ingredient prescription in the natural plant extracts to be used to natural botanical extraction liquid of preventing and treating the poultry epidemic febrile disease and preparation method thereof.The natural botanical extraction liquid of control poultry epidemic febrile disease of the present invention is made up of Chinese herbal medicine Rhizoma Polygoni Cuspidati, Fructus Ligustri Lucidi, Herba Polygoni cymosi, Rhizoma Dioscoreae, the Radix Astragali, Herba Sedi Aizoon, Herba Hyperici Japonici, Herba Portulacae Grandiflorae, Fructus Chebulae, Herba Taraxaci, and the weight proportion of herbal raw material is: Rhizoma Polygoni Cuspidati 6-10 part, Fructus Ligustri Lucidi 5-8 part, Herba Polygoni cymosi 1.2-2 part, Rhizoma Dioscoreae 0.8-1.5 part, Radix Astragali 0.2-0.5 part, Herba Sedi Aizoon 0.8-1.5 part, Herba Hyperici Japonici 1.2-2 part, Herba Portulacae Grandiflorae 0.8-1.5 part, Fructus Chebulae 0.8-1.5 part, Herba Taraxaci 0.8-1.5 part; After the said herbal medicine prescription adds drinking water,, make the natural botanical extraction liquid of control poultry epidemic febrile disease through soaking, boil and concentrating.Can also add medicinal herb componentses such as Herba Commelinae, Herba Senecionis Scandentis, Herba Physalis pubescentis, Herba Solani Nigri, Herba Sedi, Herba Ardisiae Japonicae, Herba Hedyotidis Diffusae, Fructus Forsythiae, Herba Solani Lyrati, Radix Glycyrrhizae in the raw material, the weight proportion of adding ingredient is Herba Commelinae 0.4-0.8 part, Herba Senecionis Scandentis 0.8-1.2 part, Herba Physalis pubescentis 0.8-1.2 part, Herba Solani Nigri 0.4-0.8 part, Herba Sedi 0.8-1.2 part, 0.4 part of Herba Ardisiae Japonicae, 0.6 part of Herba Hedyotidis Diffusae, 1.2 parts of Fructus Forsythiaes, 0.8 part of Herba Solani Lyrati, 1.5 parts in Radix Glycyrrhizae.Through concentrating the natural botanical extraction liquid of the control poultry epidemic febrile disease that makes, also can dilute during use, the dilution adjuvant is mainly acetic acid.
The pharmacology situation of key component in the natural botanical extraction liquid prescription of control poultry epidemic febrile disease of the present invention: (1) Rhizoma Polygoni Cuspidati: the effect that expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm are arranged, but also microcirculation improvement, shock have heart tonifying, blood fat reducing, protect the liver, antibiotic, antitumor, antiinflammatory, antioxidation.(2) Fructus Ligustri Lucidi: the master contains ursolic acid and oleanolic acid, has the effect of nourishing the liver and kidney, and Fructus Ligustri Lucidi extract has good antitumor action in vivo simultaneously.(3) Herba Polygoni cymosi: cold nature, sour in the mouth have inducing diuresis to remove edema, heat-clearing and toxic substances removing, cough-relieving effect.(4) Rhizoma Dioscoreae: property is flat, not dry, and effect relaxes, and is the medicine of flat tonifying the spleen and stomach, but lung benefiting gas, supports lung yin, but invigorating kidney qi simultaneously.(5) Herba Sedi Aizoon: main product is northern and each province, the Yangtze river basin in China, but dissipating blood stasis, stops blooding, calms the nerves, and is usually used in Peptic Ulcers, bronchiectasis and platelet and supports diseases such as purpura.(6) Herba Hyperici Japonici: can heat-clearing and toxic substances removing, inducing diuresis and reducing edema.(7) Herba Portulacae Grandiflorae: contain scutellarein, scutellarin, carthamin, isocarthamidin and alkaloid, but heat-clearing and toxic substances removing, blood stasis dispelling diuresis.(8) Fructus Chebulae: contain chebulinic acid, terchebin, Chebulagic acid etc., have that astringing intestine to stop diarrhea is astringed the lung, pathogenic fire reducing sore-throat relieving effect, be usually used in the chronic diarrhea chronic dysentery, the proctoptosis of having blood in stool, the deficiency of the lung are breathed with cough, chronic cough is more than etc.(9) Radix Astragali: be the tonifying Qi and lifting yang key medicine, have the effect of invigorating QI to consolidate the body surface resistance, poison holding, holder skin ulcer granulation promoting, diuretic, clinically more be used for insufficiency of vital energy and blood, skin infection difficulty in discharging of pus or burst after do not close up for a long time, be particularly useful for deficiency of both the splenic and pulmonary QI.(10) Herba Taraxaci: but heat-clearing and toxic substances removing is usually used in treating carbuncle furunculosis, lung abscess, acute mastitis etc., and staphylococcus aureus, Hemolytic streptococcus, Diplococcus pneumoniae, bacillus pyocyaneus, Bacillus typhi etc. are had certain killing action, function of gallbladder promoting, diuresis simultaneously.In the above-mentioned ten flavor Chinese crude drugs, Rhizoma Polygoni Cuspidati, Fructus Ligustri Lucidi, Herba Sedi Aizoon originate in Jiangsu, and Herba Polygoni cymosi originates in Jilin, and Rhizoma Dioscoreae, Herba Taraxaci originate in Henan, and the Radix Astragali originates in Gansu, and Herba Hyperici Japonici originates in Guangxi, and Herba Portulacae Grandiflorae originates in Hebei, and the Fructus Chebulae is originated in Guangdong; The appraisal basis of all crude drugs is " People's Republic of China's veterinary drug allusion quotation ".
The preparation process of the natural botanical extraction liquid of control poultry epidemic febrile disease of the present invention comprises:
Crude drug chooses → washs → cut medicine → coarse crushing → drying → extraction → filtration → concentrate → dilution → fill → spiral cover decals → packing
The major control condition
Operating ambient temperature: 18-30 ℃; Relative humidity: 30-70%; Clean rank: general production area.
Extract control: amount of water is the drinking water (W/W) of extraction pot inventory more than 8 times and 8 times; The second extraction amount of water is the drinking water (W/W) of inventory more than 4 times and 4 times; Material adds the back and soaked 30 minutes; Extracting 100 ℃ of temperature of control, controlling extraction time is that heated and boiled was extracted 2 hours; Second extraction is that heated and boiled was extracted 1 hour.
Concentrate control: heating is concentrated into 1/3 of extracting solution original volume.
Dilution control: diluent is selected acetic acid for use, the diluent addition be concentrated solution add the diluent gross weight 30%.
The concrete steps that are used to prevent and treat the natural botanical extraction liquid preparation process of poultry epidemic febrile disease are:
1, the crude drug selection on sorting table, is sorted out the crude drug lay one by one with the impurity in the crude drug.
2, washing will be put in the service sink through the crude drug of selection, and with drinking water washing, and the medical material after will washing puts into second service sink and embathe, and clean in the rearmounted container to drain away the water.
3, cutting medicine puts medicine cutter according to routine with the tubers crude drug and is cut into lamellar.
4, coarse crushing needs the crude drug of coarse crushing to put coarse crushing in the boulder crusher, puts into container, and it is stand-by to send into next procedure.
5, the crude drug after drying will be cut is put in the baking oven, treats to open when temperature reaches 70 ± 2 ℃ the dehumidifying air door, regulates and divide the steam valve door, control temperature maintenance 3 hours; When being dried to 1.5 hours, carry out stirring, simultaneously material disc levels switch.
6, extract and filter
6.1 adopt Steam Heating to extract, check that whether steam pressure is sufficient, opens the steam inlet main valve;
6.2 in extraction pot, be incorporated as the drinking water (w/w) of inventory more than 8 times and 8 times, start stirring motor;
6.3 required various Chinese herbal medicine are added in the jar by the material mouth that is fixed on the cover, close cover, tighten; Material soaked 30 minutes;
6.4 open blanking croquet valve, blowback stream ball valve, start the magnetic force driving pump that links to each other with extraction pot and reflux;
6.5 open hydrophobic bypass valve, bleed off condensed water in the steam pipe; Close hydrophobic bypass valve, open dynamic extraction pot steam inlet valve, record extracts the time started;
Boil extraction time when reaching 2 hours 6.6. treat material, the steam off inlet valve, open the ball valve that flows to storage tank, close blowback stream ball valve, the medicinal liquid that has extracted is transported to storage tank.Can also carry out second extraction and in extraction pot, add the drinking water of inventory more than 4 times and 4 times, repeat 6.36.4 6.5 steps, treat that material boils extraction time steam off inlet valve when reaching 1 hour, opens the ball valve that flows to storage tank, close blowback stream ball valve, the medicinal liquid that has extracted is transported to storage tank after filtering;
6.7 remove the locking of bin gate down, open bin gate discharging down.
7, concentrate
7.1 open basin discharging opening valve, start driving pump; Medicinal liquid in the basin is transported to head tank, opens the head tank return valve;
7.2, allow medicinal liquid flow automatically to concentrator by the time the full medicinal liquid of head tank storage is opened the discharging valve;
7.3 when by the time from the visor of concentrator, seeing medicinal liquid, close head tank discharging valve, close driving pump;
7.4 open hydrophobic bypass valve, bleed off the condensed water in the steam pipe; Close hydrophobic bypass valve, open concentration heater inlet steam valve, the heating medicinal liquid concentrates under vacuum-0.4～-0.6 MPa, until being concentrated into 1/3 of medicinal liquid original volume;
7.5, detect medicinal liquid from the sample tap sampling;
7.6 start single-screw (single screw) pump, the qualified medicinal liquid after concentrating be transported to the concentrated solution basin.
8, dilution adds diluent acetic acid by prescription in dilute preparing tank, and acetic acid is tablet vinegar, adds concentrated solution again to ormal weight, diluent tablet vinegar addition be concentrated solution add the diluent gross weight 30%, open blender, mix homogeneously.
9, fill places plastic bottle on the bottle managing machine feed hopper of fill train line, and bottle cap places on the feed hopper of Cover whirling Machine, perfusion solution.
10, the plastic bottle that the fill of spiral cover decals is good carries out the spiral cover decals on train line, will check the quality situation of spiral cover decals behind the spiral cover, per hour checks once, should be up to specification.The semi-finished product that revolved lid and posted label import make-up room into through conveyer belt, prepare outer package.
11, should check semi-finished product title, specification, lot number and quantity before the packaging operation, should all conform to the packaging material of being received, description, label.At any time check in labeling, the packaging process whether lot number, description conform to packing instructions.Adjust coder, contents such as its lot number, date of manufacture should be consistent with the semi-finished product for the treatment of labeling, checks correctly through the people.Packing finishes, and should accurately add up the number of receiving of label, practical number and remainder, and handle the residue label and scrap label by the administrative provisions of label.
When the natural botanical extraction liquid of preventing and treating the poultry epidemic febrile disease prepares, technical process according to the rules and process control condition, carry out selection, the carrying out washing treatment of crude drug earlier, after cutting medicine, coarse crushing and dried, Chinese crude drug is extracted, extracting solution through carrying out fill, spiral cover decals and packing after concentrated and the dilution of diluent acetic acid, is finished the preparation of the natural botanical extraction liquid of control poultry epidemic febrile disease again.
The natural botanical extraction liquid end product quality of the popular calentura of control poultry reaches following specification requirement:
| Sequence | Project | Index | |
| 1 | Differentiate | (1) in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show in fluorescence speckle (2) the test sample chromatograph of same color, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color | |
| 2 | PH value | 2.5～3.5 | |
| 3 | Relative density | 1.02～1.10 | |
| 4 | Assay | Contain Rhizoma Polygoni Cuspidati by chrysophanol (C 15H 10O 4) meter, every 1ml must not be less than 5 μ g |
The natural botanical extraction liquid of control poultry epidemic febrile disease of the present invention shows through acute toxicity test: acute toxic reaction of mice and mortality rate are directly proportional with dosage, median lethal dose(LD 50) LD
50Be 31.17 ± 1.96ml/kg, LD
50The 95% credible 33.19～29.27ml/kg that is limited to, maximum tolerated dose LD
nBe 23.0ml/kg, substantially exceed clinical medicine dose and show that extracting solution does not have acute toxicity and possesses safety.The natural botanical extraction liquid that is used to prevent and treat the poultry epidemic febrile disease is through subchronic toxicity test, respectively with LD
501/5,1/10 and 1/20 dosage irritate to the equal-volume normal saline for mouse stomach, matched group, observed, measure the variations such as histopathology of clinical symptoms, feed consumption, body weight, routine blood test, serum biochemistry index and liver, lung and the kidney of respectively organizing mice in continuous 14 days, the every index of test group all in normal range, with the matched group no significant difference, show that extracting solution does not have subchronic toxicity and possesses safety.The per mucous membrane irritant test, adopt the zest of rabbit eye dripping method and chickling atomized medicine introducing method observation respectively to the animal mucosa, adopt the extracting solution eye dripping that man lagophthalmos conjunctiva is had slight irritant reaction, atomized medicine introducing is to eyes, oral cavity, nasal cavity and the equal nonirritant of throat mucosa of chicken; The spray delivery mode that test shows recommendation is to the mucosa nonirritant, and droplet is thin more good more.The transdermal stimulation test adopts filter paper absorption medicine application method that the zest of rabbit skin is measured, and test shows intact skin and the equal vacuum response of damaged skin to rabbit, shows that extracting solution possesses safety to animal body surface skin.Through the skin hypersensitive test, adopt filter paper absorption medicine application method that the sensitization of guinea pig skin is measured, skin allergy phenomenon consubstantiality left and right sides contrast no significant differences such as erythema and edema all do not appear in the test group animal skin, with 2, anaphylaxis in various degree all appears in the positive control treated animal of 4-dinitro-chloro-benzene sensitization, the result of the test prompting: extracting solution does not have anaphylaxis to animal skin, the administering mode clinical practice safety of recommendation.By the clinical test of pesticide effectiveness, select 130 of the sick pigs of natural infection breeding and breathing syndrome, be divided into high, medium and low dosetest group and western medicine group and blank group at random, test group adopts the natural botanical extraction liquid spray delivery of control poultry epidemic febrile disease of the present invention, No. 1, western medicine group intramuscular injection ampicillin and antiviral, all every day 2 times, logotypes 3 days, the not administration of blank group; In handling 1 week of back statistics curative effect, by the total effective rate of healing, improvement, invalid each test group of Three Estate level calculation.The therapeutic effect statistics is listed in the table below:
The natural botanical extraction liquid therapeutic effect contrast statistics of control poultry epidemic febrile disease
| Group | Cure rate (%) | Improvement rate (%) | Total effective rate (%) |
| High dose | 86.7 | 6.7 | 93.3 |
| Middle dosage | 80.0 | 10.0 | 90.0 |
| Low dosage | 63.3 | 10.0 | 73.3 |
| The Western medicine contrast | 66.7 | 13.3 | 80.0 |
| Blank | 0.0 | 10.0 | 00.0 |
Result of the test shows: the therapeutic effect of high, middle dosage group is better than the effect of Western medicine slightly, in view of the cure rate and the total effective rate there was no significant difference of middle and high dosage group, and dosage from the angle of saving cost can be selected for use.Select for use spray delivery not only to use conveniently, and can be used for killing or suppress the interior pathogenic microorganism of pig house; Recommended dose is to animal head and whole body spraying, till squirt, prevention 1～2 time weekly, treatment every day 2 times, logotype 3 days after 1～5 times of stock solution or the stock solution dilution.
Advantage of the present invention just is to adopt the natural botanical extraction liquid of control poultry epidemic febrile disease of the present invention that the poultry epidemic febrile disease is treated, in the recommended dose of treatment pig breeding with breathing syndrome, cure rate and improvement rate reach more than 80.0% and 6.7% respectively, total effective rate surpasses 90.0%, the also a little higher than western medicine group of the cure rate of senior middle school's dosage group and total effective rate, curative effect is obvious.Adopt the natural botanical extraction liquid of control poultry epidemic febrile disease of the present invention that the poultry epidemic febrile disease is treated, problems such as use antibiolics deposits yields drug residue and drug resistance have also been solved, drug residue and the animal body having avoided using antibiotic medicine to produce in animal tissue produce the hidden danger that drug resistance causes for animal foodstuff safety, have guaranteed animal foodstuff safety.The natural botanical extraction liquid of control of the present invention poultry epidemic febrile disease is through acute toxicity test, subchronic toxicity test, mucosa irritation test, skin irritation test, skin anaphylactic test, the clinical test of pesticide effectiveness and on probation in the part raiser, guaranteed the natural botanical extraction liquid of control poultry epidemic febrile diseases and according to possessing spray delivery mode, using dosage and course of treatment of recommendation safety.Simple, the easy operating of natural botanical extraction liquid preparation technology of control poultry epidemic febrile disease of the present invention, and low production cost, the natural botanical extraction liquid of control poultry epidemic febrile disease therefore of the present invention has the vast market promotion prospect.
Description of drawings
The present invention is described further below in conjunction with accompanying drawing.
Fig. 1 is the natural botanical extraction liquid preparation technology's of a control poultry epidemic febrile disease of the present invention flow diagram.
With reference to Fig. 1, such as figure, crude drug selection and washing operation cell formation bulk drug treatment process, cut medicine, coarse crushing and drying process cell formation and extract concentrated preparatory process, extraction, filtration and concentration operation cell formation extract enrichment process, dilution, can, spiral cover labeling, packaging operation cell formation packaging process. In practical operation, also can omit according to actual conditions and cut the operating units such as medicine, coarse crushing, drying, directly enter the extraction enrichment process. Water extraction is adopted in extraction to active ingredient, take water as solvent. After in extractor, adding natural vegetable Chinese herbal medicine, adding the drinking water of inventory more than 8 times or 8 times soaked 30 minutes, boiled 2 hours, leach extract and to concentration tank, be concentrated into 1/3 of original volume, be sub-packed in the container by filling apparatus after diluting then, the extractor operating pressure is that normal pressure, concentration tank operation vacuum are-0.4～-0.6 MPa.
The specific embodiment
Below be embodiments of the invention, the actual use of the present invention is not limited to embodiment.
Adopt the natural botanical extraction liquid preparation method of control poultry epidemic febrile disease of the present invention to carry out natural botanical extraction liquid production, production capacity 800kg/ split run.
The natural botanical extraction liquid of control poultry epidemic febrile disease is made up of Chinese herbal medicine Rhizoma Polygoni Cuspidati, Fructus Ligustri Lucidi, Herba Polygoni cymosi, Rhizoma Dioscoreae, the Radix Astragali, Herba Sedi Aizoon, Herba Hyperici Japonici, Herba Portulacae Grandiflorae, Fructus Chebulae, Herba Taraxaci, and the weight proportion of herbal raw material is: Rhizoma Polygoni Cuspidati 100kg, Fructus Ligustri Lucidi 80kg, Herba Polygoni cymosi 20kg, Rhizoma Dioscoreae 15kg, Radix Astragali 5kg, Herba Sedi Aizoon 15kg, Herba Hyperici Japonici 20kg, Herba Scutellariae Barbatae 15kg, Fructus Chebulae 15kg, Herba Taraxaci 15kg.The dilution adjuvant is mainly tablet vinegar.
Main production equipments
| Sequence number | Device name | Type and | Quantity | |
| 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 | Reciprocating medicine cutter heated-air circulation oven boulder crusher dynamic extraction pot basin magnetically-actuated reflux pump scraper-type vacuum concentrator head tank tube still heater hydraulic jet pump preparing tank is for bottle machine Cover whirling Machine SDA-3 core titanium rod filter electronic balance labelling machine filling liquid unit electronic platform scale | WQY240 CT-C2 3m 3 3m 3 40CQ-2 1m 3 1m 3 1000L 4P Y4 0.45μm JJ2000 LT YG TCS-30 | 1 in 111 cover of 1111111111111 cover of cover 2 covers |
The major control condition
Operating ambient temperature 18-30 ℃, relative humidity 30-70%, the general production area of clean rank;
Extract the total addition 2400kg of control drinking water, extract 100 ℃ of control temperature, extraction time is from boiling timing 2 hours, 24 rev/mins of speeds of agitator;
Concentrate 20 rev/mins of control speeds of agitator, concentration time 120 minutes, control vacuum is-0.4～-0.6 MPa;
40 rev/mins of dilution control speeds of agitator, mixing time 15 minutes, the dilution weight proportion is a concentrated solution: tablet vinegar=7: 3.
When the natural botanical extraction liquid of preventing and treating the poultry epidemic febrile disease prepares, technical process according to the rules and process control condition, carry out the selection and the washing of crude drug earlier, cut medicine through reciprocating type medicine cutter, after boulder crusher coarse crushing and the heated-air circulation oven dried Chinese crude drug is extracted, at operating ambient temperature 18-30 ℃, prepare burden according to each component of prescription proportioning weighing under the relative humidity 40-45% condition, the drinking water that in dynamic extraction pot, adds about total amount 1/3, under agitation add load weighted Chinese herbal medicine, add drinking water then to total amount, the total addition of drinking water is 8 times of crude drug weight, reach 2400kg, soak and under 24 rev/mins of stirrings of rotating speed, open the steam valve extraction that heats up after 30 minutes, starting the magnetic force driving pump that links to each other with extraction pot refluxes, timing when temperature reaches 100 ℃, the control temperature kept temperature 120 minutes at 100 ℃, extracted and finished; Filter extracting solution and be delivered to 3M by SDA-3 core titanium rod filter
3Storage tank; 3M
3Extracting solution is sent into the scraper-type vacuum concentrator through head tank in the storage tank, extracting solution is heated concentrated by the tube still heater Steam Heating, when be concentrated into the original liquid amount 70% the time stop the heating, detect medicinal liquid from the sample tap sampling, deliver to the dilution operation after qualified, provide concentrated vacuum condition by hydraulic jet pump, concentration operation control vacuum is-0.4～-0.6 MPa; In the 1000L preparing tank, dilute preparation, the dilution weight proportion is a concentrated solution: tablet vinegar=7: 3,7 parts of 700kg concentrated solutions are added in the preparing tank, add 3 portions of 300kg tablet vinegar simultaneously, open blender stirring 15 minutes, 40 rev/mins of speeds of agitator, operating ambient temperature 20-24 ℃, relative humidity 40-45% are with the dilute liquid medicine mix homogeneously; After the extracting solution after the dilution is by filling liquid unit and weighing and bagging, dispatch from the factory.
Once carried out second extraction in the operating process, once extracting back adding inventory in extraction pot is the drinking water of 1200kg for 4 times, under 24 rev/mins of stirrings of rotating speed, open the steam valve extraction that heats up, starting the magnetic force driving pump that links to each other with extraction pot refluxes, timing when temperature reaches 100 ℃, the control temperature kept temperature 60 minutes at 100 ℃, extracted and finished.
The natural botanical extraction liquid end product quality of control poultry epidemic febrile disease reaches following specification requirement:
| Sequence | Project | Index | |
| 1 | Differentiate | (1) in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show in fluorescence speckle (2) the test sample chromatograph of same color, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color | |
| 2 | PH value | Should be 2.5～3.5 | |
| 3 | Relative density | Should be 1.02～1.10 | |
| 4 | Assay | Contain Rhizoma Polygoni Cuspidati by chrysophanol (C 15H 10O 4) meter, every 1ml must not be less than 5 μ g |
Use the natural botanical extraction liquid of the control poultry epidemic febrile disease that above method produces, carried out acute toxicity test, subchronic toxicity test, mucosa irritation test, skin irritation test, skin anaphylactic test and the clinical test of pesticide effectiveness respectively through Agricultural University Of Nanjing.By acute toxicity test, directly irritate the LD of stomach for mice with the extracted form natural plant stock solution of control poultry epidemic febrile disease
50Be 31.17 ± 1.96ml/kg, LD
50The 95% credible 33.19～29.27ml/kg that is limited to, maximum tolerated dose LD
nBe 23.0ml/kg, substantially exceed clinical medicine dose and show that extracting solution does not have acute toxicity and possesses safety.By subchronic toxicity test, respectively with LD
501/5,1/10 and 1/20 dosage irritate to the equal-volume normal saline for mouse stomach, matched group, observed, measure the variations such as histopathology of clinical symptoms, feed consumption, body weight, routine blood test, serum biochemistry index and liver, lung and the kidney of respectively organizing mice in continuous 14 days, the every index of test group all in normal range, with the matched group no significant difference, show that extracting solution does not have subchronic toxicity and possesses safety.Test by mucosa irritation, adopt the zest of rabbit eye dripping method and chickling atomized medicine introducing method observation respectively to the animal mucosa, adopt the extracting solution eye dripping that man lagophthalmos conjunctiva is had slight irritant reaction, atomized medicine introducing is to eyes, oral cavity, nasal cavity and the equal nonirritant of throat mucosa of chicken; The spray delivery mode that test shows recommendation is to the mucosa nonirritant, and droplet is thin more good more.By the skin irritation test, adopt filter paper absorption medicine application method that the zest of rabbit skin is measured, test shows intact skin and the equal vacuum response of damaged skin to rabbit, shows that extracting solution possesses safety to animal body surface skin.Pass through skin anaphylactic test, adopt filter paper absorption medicine application method that the sensitization of guinea pig skin is measured, skin allergy phenomenon consubstantiality left and right sides contrast no significant differences such as erythema and edema all do not appear in the test group animal skin, with 2, anaphylaxis in various degree all appears in the positive control treated animal of 4-dinitro-chloro-benzene sensitization, the result of the test prompting: extracting solution does not have anaphylaxis to animal skin, the administering mode clinical practice safety of recommendation.By the clinical test of pesticide effectiveness, select 130 of the sick pigs of natural infection breeding and breathing syndrome, be divided into high, medium and low dosetest group and western medicine group and blank group at random, test group adopts the natural botanical extraction liquid spray delivery of control poultry epidemic febrile disease of the present invention, No. 1, western medicine group intramuscular injection ampicillin and antiviral, all every day 2 times, logotypes 3 days, the not administration of blank group; In handling 1 week of back statistics curative effect, by the total effective rate of healing, improvement, invalid each test group of Three Estate level calculation.Result of the test shows: the therapeutic effect of high, middle dosage group is better than the effect of Western medicine slightly, in view of the cure rate and the total effective rate there was no significant difference of middle and high dosage group, and dosage from the angle of saving cost can be selected for use.Recommended dose is to animal head and whole body spraying, till squirt, prevention 1～2 time weekly, treatment every day 2 times, logotype 3 days after 1～5 times of the stock solution dilution.
In addition, the natural botanical extraction liquid of control poultry epidemic febrile disease is through treating the pig circular ring virus 2 viral disease of making a definite diagnosis, do not see in 3 days under the situation of positive effect in application fumaric acid tiamulin soluble powder, chlortetracycline, oxytetracycline, doxycycline treatment, the natural botanical extraction liquid that uses the present invention to prevent and treat the poultry epidemic febrile disease is done to sparge animal body surface and the emphasis spraying is carried out at the serious position of pathological changes after 5 times of dilutions, every day 2 times, uses 3 days continuously.Use back 1 a day morbidity pig spirit to begin to take a turn for the better, use back 3 days sick pig feeds to desire to recover normal substantially, redness or purple focus begin incrustation on the sick Corii Sus domestica skin, and it is obvious not have cough symptom curative effect substantially.Through the pig exudative dermatitis of making a definite diagnosis is treated, the natural botanical extraction liquid that uses the present invention to prevent and treat the poultry epidemic febrile disease is done to sparge animal body surface after 5 times of dilutions, till squirting, uses continuously 3 days, sooner or later each once and mixes a certain amount of electrolysis multidimensional drinking-water.Use the yellow blister of back 1 day sick pig epidermis to begin convergence, use that back 2 days sick pig food amounts begin to increase, body temperature recovers normal substantially, use back 3 days sick pig epidermises to begin incrustation, it is normal that feed intake and body temperature also all recover, and the epidermis incrustation of the 4th day sick pig begins to occur coming off.
Natural botanical extraction liquid of embodiment 2 control poultry epidemic febrile diseases and preparation method thereof
Adopt the natural botanical extraction liquid preparation method of control poultry epidemic febrile disease of the present invention to carry out natural botanical extraction liquid production, production capacity 800kg/ split run.
The natural botanical extraction liquid of control poultry epidemic febrile disease is made up of Chinese herbal medicine Rhizoma Polygoni Cuspidati, Fructus Ligustri Lucidi, Herba Polygoni cymosi, Rhizoma Dioscoreae, the Radix Astragali, Herba Sedi Aizoon, Herba Hyperici Japonici, Herba Portulacae Grandiflorae, Fructus Chebulae, Herba Taraxaci, Herba Commelinae, Herba Senecionis Scandentis, Herba Physalis pubescentis, Herba Solani Nigri, Herba Sedi, and the weight proportion of herbal raw material is: Rhizoma Polygoni Cuspidati 80kg, Fructus Ligustri Lucidi 64kg, Herba Polygoni cymosi 16kg, Rhizoma Dioscoreae 12kg, Radix Astragali 4kg, Herba Sedi Aizoon 12kg, Herba Hyperici Japonici 16kg, Herba Scutellariae Barbatae 12kg, Fructus Chebulae 12kg, Herba Taraxaci 12kg, Herba Commelinae 8kg, Herba Senecionis Scandentis 12kg, Herba Physalis pubescentis 12kg, Herba Solani Nigri 8kg, Herba Sedi 12kg.The dilution adjuvant is mainly tablet vinegar.
Main production equipments is with embodiment 1.
The major control condition
Operating ambient temperature 18-30 ℃, relative humidity 30-70%, the general production area of clean rank;
Extract the total addition 2336kg of control drinking water, extract 100 ℃ of control temperature, extraction time is from boiling timing 2 hours, 24 rev/mins of speeds of agitator;
Concentrate 20 rev/mins of control speeds of agitator, concentration time 120 minutes, control vacuum is-0.4～-0.6 MPa;
40 rev/mins of dilution control speeds of agitator, mixing time 15 minutes, the dilution weight proportion is a concentrated solution: tablet vinegar=7: 3.
When the natural botanical extraction liquid of preventing and treating the poultry epidemic febrile disease prepares, technical process according to the rules and process control condition, carry out the selection and the washing of crude drug earlier, cut medicine through reciprocating type medicine cutter, after boulder crusher coarse crushing and the heated-air circulation oven dried Chinese crude drug is extracted, at operating ambient temperature 18-30 ℃, prepare burden according to each component of prescription proportioning weighing under the relative humidity 40-45% condition, the drinking water that in dynamic extraction pot, adds about total amount 1/3, under agitation add load weighted Chinese herbal medicine, add drinking water then to total amount, the total addition of drinking water is 8 times of crude drug weight, reach 2336kg, soak and under 24 rev/mins of stirrings of rotating speed, open the steam valve extraction that heats up after 30 minutes, starting the magnetic force driving pump that links to each other with extraction pot refluxes, timing when temperature reaches 100 ℃, the control temperature kept temperature 120 minutes at 100 ℃, extracted and finished; Filter extracting solution and be delivered to 3M by SDA-3 core titanium rod filter
3Storage tank; 3M
3Extracting solution is sent into the scraper-type vacuum concentrator through head tank in the storage tank, extracting solution is heated concentrated by the tube still heater Steam Heating, when be concentrated into the original liquid amount 70% the time stop the heating, detect medicinal liquid from the sample tap sampling, deliver to the dilution operation after qualified, provide concentrated vacuum condition by hydraulic jet pump, concentration operation control vacuum is-0.4～-0.6 MPa; In the 1000L preparing tank, dilute preparation, the dilution weight proportion is a concentrated solution: tablet vinegar=7: 3,7 parts of 700kg concentrated solutions are added in the preparing tank, add 3 portions of 300kg tablet vinegar simultaneously, open blender stirring 15 minutes, 40 rev/mins of speeds of agitator, operating ambient temperature 20-24 ℃, relative humidity 40-45% are with the dilute liquid medicine mix homogeneously; After the extracting solution after the dilution is by filling liquid unit and weighing and bagging, dispatch from the factory.
The natural botanical extraction liquid end product quality of control poultry epidemic febrile disease reaches following specification requirement:
| Sequence | Project | Index | |
| 1 | Differentiate | (1) in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show in fluorescence speckle (2) the test sample chromatograph of same color, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color | |
| 2 | PH value | Should be 2.5～3.5 | |
| 3 | Relative density | Should be 1.02～1.10 | |
| 4 | Assay | Contain Rhizoma Polygoni Cuspidati by chrysophanol (C 15H 10O 4) meter, every 1ml must not be less than 5 μ g |
Use the natural botanical extraction liquid of the control poultry epidemic febrile disease that above method produces, carried out acute toxicity test, subchronic toxicity test, mucosa irritation test, skin irritation test, skin anaphylactic test and the clinical test of pesticide effectiveness respectively through Agricultural University Of Nanjing.By acute toxicity test, directly irritate the LD of stomach for mice with the extracted form natural plant stock solution of control poultry epidemic febrile disease
50Be 31.17 ± 1.96ml/kg, LD
50The 95% credible 33.19～29.27ml/kg that is limited to, maximum tolerated dose LD
nBe 23.0ml/kg, substantially exceed clinical medicine dose and show that extracting solution does not have acute toxicity and possesses safety.By subchronic toxicity test, respectively with LD
501/5,1/10 and 1/20 dosage irritate to the equal-volume normal saline for mouse stomach, matched group, observed, measure the variations such as histopathology of clinical symptoms, feed consumption, body weight, routine blood test, serum biochemistry index and liver, lung and the kidney of respectively organizing mice in continuous 14 days, the every index of test group all in normal range, with the matched group no significant difference, show that extracting solution does not have subchronic toxicity and possesses safety.Test by mucosa irritation, adopt the zest of rabbit eye dripping method and chickling atomized medicine introducing method observation respectively to the animal mucosa, adopt the extracting solution eye dripping that man lagophthalmos conjunctiva is had slight irritant reaction, atomized medicine introducing is to eyes, oral cavity, nasal cavity and the equal nonirritant of throat mucosa of chicken; The spray delivery mode that test shows recommendation is to the mucosa nonirritant, and droplet is thin more good more.By the skin irritation test, adopt filter paper absorption medicine application method that the zest of rabbit skin is measured, test shows intact skin and the equal vacuum response of damaged skin to rabbit, shows that extracting solution possesses safety to animal body surface skin.Pass through skin anaphylactic test, adopt filter paper absorption medicine application method that the sensitization of guinea pig skin is measured, skin allergy phenomenon consubstantiality left and right sides contrast no significant differences such as erythema and edema all do not appear in the test group animal skin, with 2, anaphylaxis in various degree all appears in the positive control treated animal of 4-dinitro-chloro-benzene sensitization, the result of the test prompting: extracting solution does not have anaphylaxis to animal skin, the administering mode clinical practice safety of recommendation.By the clinical test of pesticide effectiveness, select 130 of the sick pigs of natural infection breeding and breathing syndrome, be divided into high, medium and low dosetest group and western medicine group and blank group at random, test group adopts the natural botanical extraction liquid spray delivery of control poultry epidemic febrile disease of the present invention, No. 1, western medicine group intramuscular injection ampicillin and antiviral, all every day 2 times, logotypes 3 days, the not administration of blank group; In handling 1 week of back statistics curative effect, by the total effective rate of healing, improvement, invalid each test group of Three Estate level calculation.Result of the test shows: the therapeutic effect of high, middle dosage group is better than the effect of Western medicine slightly, in view of the cure rate and the total effective rate there was no significant difference of middle and high dosage group, and dosage from the angle of saving cost can be selected for use.Owing to increased medicinal herb components than embodiment 1, produced more significantly antibiotic and antiviral effect, also have the antifungal effect simultaneously.Recommended dose is to animal head and whole body spraying, till squirt, prevention 1～2 time weekly, treatment every day 2 times, logotype 3 days after 1～5 times of the stock solution dilution.
Embodiment 3: natural botanical extraction liquid of control poultry epidemic febrile disease and preparation method thereof
Adopt the natural botanical extraction liquid preparation method of control poultry epidemic febrile disease of the present invention to carry out natural botanical extraction liquid production, production capacity 800kg/ split run.
The natural botanical extraction liquid of control poultry epidemic febrile disease is by the Chinese herbal medicine Rhizoma Polygoni Cuspidati, Fructus Ligustri Lucidi, Herba Polygoni cymosi, Rhizoma Dioscoreae, the Radix Astragali, Herba Sedi Aizoon, Herba Hyperici Japonici, Herba Portulacae Grandiflorae, the Fructus Chebulae, Herba Taraxaci, Herba Commelinae, Herba Senecionis Scandentis Herba Physalis pubescentis, Herba Solani Nigri, Herba Sedi, Herba Ardisiae Japonicae, Herba Hedyotidis Diffusae, Fructus Forsythiae, Herba Solani Lyrati, Radix Glycyrrhizae is formed, and the weight proportion of herbal raw material is: Rhizoma Polygoni Cuspidati 60kg, Fructus Ligustri Lucidi 50kg, Herba Polygoni cymosi 12kg, Rhizoma Dioscoreae 8kg, Radix Astragali 2kg, Herba Sedi Aizoon 8kg, Herba Hyperici Japonici 12kg, Herba Scutellariae Barbatae 8kg, Fructus Chebulae 8kg, Herba Taraxaci 8kg, Herba Commelinae 4kg, Herba Senecionis Scandentis 8kg Herba Physalis pubescentis 8kg, Herba Solani Nigri 4kg, Herba Sedi 8kg, Herba Ardisiae Japonicae 4kg, Herba Hedyotidis Diffusae 6kg, Fructus Forsythiae 12kg, Herba Solani Lyrati 8kg, Radix Glycyrrhizae 15kg.The dilution adjuvant is mainly acetic acid.
Main production equipments is with embodiment 1.
The major control condition
Operating ambient temperature 18-30 ℃, relative humidity 30-70%, the general production area of clean rank;
Extract the total addition 2880kg of control drinking water, extract 100 ℃ of control temperature, extraction time is from boiling timing 2 hours, 24 rev/mins of speeds of agitator;
Concentrate 20 rev/mins of control speeds of agitator, concentration time 120 minutes, control vacuum is-0.4～-0.6 MPa;
40 rev/mins of dilution control speeds of agitator, mixing time 15 minutes, the dilution weight proportion is a concentrated solution: tablet vinegar=7: 3.
When the natural botanical extraction liquid of preventing and treating the poultry epidemic febrile disease prepares, technical process according to the rules and process control condition, carry out the selection and the washing of crude drug earlier, cut medicine through reciprocating type medicine cutter, after boulder crusher coarse crushing and the heated-air circulation oven dried Chinese crude drug is extracted, at operating ambient temperature 18-30 ℃, prepare burden according to each component of prescription proportioning weighing under the relative humidity 40-45% condition, the drinking water that in dynamic extraction pot, adds about total amount 1/3, under agitation add load weighted Chinese herbal medicine, add drinking water then to total amount, the total addition of drinking water is 8 times of crude drug weight, reach 2880kg, soak and under 24 rev/mins of stirrings of rotating speed, open the steam valve extraction that heats up after 30 minutes, starting the magnetic force driving pump that links to each other with extraction pot refluxes, timing when temperature reaches 100 ℃, the control temperature kept temperature 120 minutes at 100 ℃, extracted and finished; Filter extracting solution and be delivered to 3M by SDA-3 core titanium rod filter
3Storage tank; 3M
3Extracting solution is sent into the scraper-type vacuum concentrator through head tank in the storage tank, extracting solution is heated concentrated by the tube still heater Steam Heating, when be concentrated into the original liquid amount 70% the time stop the heating, detect medicinal liquid from the sample tap sampling, deliver to the dilution operation after qualified, provide concentrated vacuum condition by hydraulic jet pump, concentration operation control vacuum is-0.4～-0.6 MPa; In the 1000L preparing tank, dilute preparation, the dilution weight proportion is a concentrated solution: tablet vinegar=7: 3,7 parts of 700kg concentrated solutions are added in the preparing tank, add 3 portions of 300kg tablet vinegar simultaneously, open blender stirring 15 minutes, 40 rev/mins of speeds of agitator, operating ambient temperature 20-24 ℃, relative humidity 40-45% are with the dilute liquid medicine mix homogeneously; After the extracting solution after the dilution is by filling liquid unit and weighing and bagging, dispatch from the factory.
The natural botanical extraction liquid end product quality of control poultry epidemic febrile disease reaches following specification requirement:
| Sequence | Project | Index | |
| 1 | Differentiate | (1) in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show in fluorescence speckle (2) the test sample chromatograph of same color, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color | |
| 2 | PH value | Should be 2.5～3.5 | |
| 3 | Relative density | Should be 1.02～1.10 | |
| 4 | Assay | Contain Rhizoma Polygoni Cuspidati by chrysophanol (C 15H 10O 4) meter, every 1ml must not be less than 5 μ g |
Use the natural botanical extraction liquid of the control poultry epidemic febrile disease that above method produces, carried out acute toxicity test, subchronic toxicity test, mucosa irritation test, skin irritation test, skin anaphylactic test and the clinical test of pesticide effectiveness respectively through Agricultural University Of Nanjing.By acute toxicity test, directly irritate the LD of stomach for mice with the extracted form natural plant stock solution of control poultry epidemic febrile disease
50Be 31.17 ± 1.96ml/kg, LD
50The 95% credible 33.19～29.27ml/kg that is limited to, maximum tolerated dose LD
nBe 23.0ml/kg, substantially exceed clinical medicine dose and show that extracting solution does not have acute toxicity and possesses safety.By subchronic toxicity test, respectively with LD
501/5,1/10 and 1/20 dosage irritate to the equal-volume normal saline for mouse stomach, matched group, observed, measure the variations such as histopathology of clinical symptoms, feed consumption, body weight, routine blood test, serum biochemistry index and liver, lung and the kidney of respectively organizing mice in continuous 14 days, the every index of test group all in normal range, with the matched group no significant difference, show that extracting solution does not have subchronic toxicity and possesses safety.Test by mucosa irritation, adopt the zest of rabbit eye dripping method and chickling atomized medicine introducing method observation respectively to the animal mucosa, adopt the extracting solution eye dripping that man lagophthalmos conjunctiva is had slight irritant reaction, atomized medicine introducing is to eyes, oral cavity, nasal cavity and the equal nonirritant of throat mucosa of chicken; The spray delivery mode that test shows recommendation is to the mucosa nonirritant, and droplet is thin more good more.By the skin irritation test, adopt filter paper absorption medicine application method that the zest of rabbit skin is measured, test shows intact skin and the equal vacuum response of damaged skin to rabbit, shows that extracting solution possesses safety to animal body surface skin.Pass through skin anaphylactic test, adopt filter paper absorption medicine application method that the sensitization of guinea pig skin is measured, skin allergy phenomenon consubstantiality left and right sides contrast no significant differences such as erythema and edema all do not appear in the test group animal skin, with 2, anaphylaxis in various degree all appears in the positive control treated animal of 4-dinitro-chloro-benzene sensitization, the result of the test prompting: extracting solution does not have anaphylaxis to animal skin, the administering mode clinical practice safety of recommendation.By the clinical test of pesticide effectiveness, select 130 of the sick pigs of natural infection breeding and breathing syndrome, be divided into high, medium and low dosetest group and western medicine group and blank group at random, test group adopts the natural botanical extraction liquid spray delivery of control poultry epidemic febrile disease of the present invention, No. 1, western medicine group intramuscular injection ampicillin and antiviral, all every day 2 times, logotypes 3 days, the not administration of blank group; In handling 1 week of back statistics curative effect, by the total effective rate of healing, improvement, invalid each test group of Three Estate level calculation.Result of the test shows: the therapeutic effect of high, middle dosage group is better than the effect of Western medicine slightly, in view of the cure rate and the total effective rate there was no significant difference of middle and high dosage group, and dosage from the angle of saving cost can be selected for use.Owing to increased medicinal herb components again than embodiment 2, the control Schweineseuche had certain effect.Recommended dose is to animal head and whole body spraying, till squirt, prevention 1～2 time weekly, treatment every day 2 times, logotype 3 days after 1～5 times of the stock solution dilution.
Claims (10)
1, a kind of natural botanical extraction liquid of preventing and treating the poultry epidemic febrile disease, it is characterized in that being made up of Chinese herbal medicine Rhizoma Polygoni Cuspidati, Fructus Ligustri Lucidi, Herba Polygoni cymosi, Rhizoma Dioscoreae, the Radix Astragali, Herba Sedi Aizoon, Herba Hyperici Japonici, Herba Portulacae Grandiflorae, Fructus Chebulae, Herba Taraxaci, the weight proportion of herbal raw material is: Rhizoma Polygoni Cuspidati 6-10 part, Fructus Ligustri Lucidi 5-8 part, Herba Polygoni cymosi 1.2-2 part, Rhizoma Dioscoreae 0.8-1.5 part, Radix Astragali 0.2-0.5 part, Herba Sedi Aizoon 0.8-1.5 part, Herba Hyperici Japonici 1.2-2 part, Herba Portulacae Grandiflorae 0.8-1.5 part, Fructus Chebulae 0.8-1.5 part, Herba Taraxaci 0.8-1.5 part; After the said herbal medicine prescription adds drinking water,, make the natural botanical extraction liquid of control poultry epidemic febrile disease through soaking, boil and concentrating.
2, the natural botanical extraction liquid of control poultry epidemic febrile disease according to claim 1, it is characterized in that also adding in the raw material Herba Commelinae, Herba Senecionis Scandentis, Herba Physalis pubescentis, Herba Solani Nigri, Herba Sedi, Herba Ardisiae Japonicae, Herba Hedyotidis Diffusae, Fructus Forsythiae, Herba Solani Lyrati, Radix Glycyrrhizae medicinal herb components, the weight proportion of adding ingredient is Herba Commelinae 0.4-0.8 part, Herba Senecionis Scandentis 0.8-1.2 part, Herba Physalis pubescentis 0.8-1.2 part, Herba Solani Nigri 0.4-0.8 part, Herba Sedi 0.8-1.2 part, 0.4 part of Herba Ardisiae Japonicae, 0.6 part of Herba Hedyotidis Diffusae, 1.2 parts of Fructus Forsythiaes, 0.8 part of Herba Solani Lyrati, 1.5 parts in Radix Glycyrrhizae.
3,, the natural botanical extraction liquid of control according to claim 1 poultry epidemic febrile disease, it is characterized in that the dilution adjuvant is an acetic acid to diluting through the natural botanical extraction liquid that concentrates the control poultry epidemic febrile disease that makes.
4, the natural botanical extraction liquid of control poultry epidemic febrile disease according to claim 1 is characterized in that the weight proportion of herbal raw material is: Rhizoma Polygoni Cuspidati 100kg, Fructus Ligustri Lucidi 80kg, Herba Polygoni cymosi 20kg, Rhizoma Dioscoreae 15kg, Radix Astragali 5kg, Herba Sedi Aizoon 15kg, Herba Hyperici Japonici 20kg, Herba Scutellariae Barbatae 15kg, Fructus Chebulae 15kg, Herba Taraxaci 15kg.
5, the natural botanical extraction liquid of control poultry epidemic febrile disease according to claim 1 and 2 is characterized in that the weight proportion of herbal raw material is: Rhizoma Polygoni Cuspidati 80kg, Fructus Ligustri Lucidi 64kg, Herba Polygoni cymosi 16kg, Rhizoma Dioscoreae 12kg, Radix Astragali 4kg, Herba Sedi Aizoon 12kg, Herba Hyperici Japonici 16kg, Herba Scutellariae Barbatae 12kg, Fructus Chebulae 12kg, Herba Taraxaci 12kg, Herba Commelinae 8kg, Herba Senecionis Scandentis 12kg, Herba Physalis pubescentis 12kg, Herba Solani Nigri 8kg, Herba Sedi 12kg.
6, the natural botanical extraction liquid of control poultry epidemic febrile disease according to claim 1 and 2 is characterized in that the weight proportion of herbal raw material is: Rhizoma Polygoni Cuspidati 60kg, Fructus Ligustri Lucidi 50kg, Herba Polygoni cymosi 12kg, Rhizoma Dioscoreae 8kg, Radix Astragali 2kg, Herba Sedi Aizoon 8kg, Herba Hyperici Japonici 12kg, Herba Scutellariae Barbatae 8kg, Fructus Chebulae 8kg, Herba Taraxaci 8kg, Herba Commelinae 4kg, Herba Senecionis Scandentis 8kg, Herba Physalis pubescentis 8kg, Herba Solani Nigri 4kg, Herba Sedi 8kg, Herba Ardisiae Japonicae 4kg, Herba Hedyotidis Diffusae 6kg, Fructus Forsythiae 12kg, Herba Solani Lyrati 8kg, Radix Glycyrrhizae 15kg.
7, the natural botanical extraction liquid of control according to claim 1 poultry epidemic febrile disease is characterized in that preparation process comprises: crude drug chooses → washs → cut medicine → coarse crushing → drying → extraction → filtration → concentrated → dilution → fill → spiral cover decals → packing; The major control condition, operating ambient temperature: 18-30 ℃; Relative humidity: 30-70%; Clean rank: general production area; Extract control: amount of water is the extraction pot drinking water of weight more than 8 times and 8 times that feed intake; Material adds the back and soaked 30 minutes; Extracting 100 ℃ of temperature of control, controlling extraction time is that heated and boiled was extracted 2 hours; Concentrate control: heating is concentrated into 1/3 of extracting solution original volume; Dilution control: diluent is selected acetic acid for use, the diluent addition be concentrated solution add the diluent gross weight 30%.
8, the natural botanical extraction liquid of control poultry epidemic febrile disease according to claim 7, it is characterized in that extracting in the preparation process control second extraction amount of water is the drinking water of weight more than 4 times and 4 times that feed intake, and second extraction is that heated and boiled was extracted 1 hour.
9, the natural botanical extraction liquid of control poultry epidemic febrile disease according to claim 7 is characterized in that concentrating in the preparation process control heating medicinal liquid and carries out under vacuum-0.4～-0.6 MPa.
10, the natural botanical extraction liquid of control poultry epidemic febrile disease according to claim 1, it is characterized in that end product quality reaches following specification requirement: pH value 2.5～3.5, relative density 1.02～1.10 contains Rhizoma Polygoni Cuspidati by chrysophanol (C
15H
10O
4) meter, every 1ml must not be less than 5 μ g.
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| CNB2006100976048A CN100453104C (en) | 2006-11-09 | 2006-11-09 | Natural botanical extraction liquid for preventing and treating epidemic febrile disease of birds and livestock and method for preparing same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585409A (en) * | 2013-11-18 | 2014-02-19 | 镇江天和生物技术有限公司 | Polygonum cuspidatum and glossy privet fruit mixture and preparation method thereof |
| CN105641655A (en) * | 2016-01-22 | 2016-06-08 | 江西傲新生物科技有限公司 | Traditional Chinese medicine composition for preventing foot-and-mouth disease and preparing method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1147954A (en) * | 1996-08-16 | 1997-04-23 | 孙桂昕 | Broad spectrum antitoxic and bacteriostatic verterinary medicine and prodn. method |
| CN1092026C (en) * | 2000-06-05 | 2002-10-09 | 塔志丽 | Pure traditional Chinese medicine fodder additives |
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2006
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585409A (en) * | 2013-11-18 | 2014-02-19 | 镇江天和生物技术有限公司 | Polygonum cuspidatum and glossy privet fruit mixture and preparation method thereof |
| CN105641655A (en) * | 2016-01-22 | 2016-06-08 | 江西傲新生物科技有限公司 | Traditional Chinese medicine composition for preventing foot-and-mouth disease and preparing method and application thereof |
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