CN103845626A - Medicine for treating schizophrenia and preparation method thereof - Google Patents
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- CN103845626A CN103845626A CN201410103300.2A CN201410103300A CN103845626A CN 103845626 A CN103845626 A CN 103845626A CN 201410103300 A CN201410103300 A CN 201410103300A CN 103845626 A CN103845626 A CN 103845626A
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Abstract
The invention discloses a medicine for treating schizophrenia and a preparation method of the medicine, belonging to the field of traditional Chinese medicines. The effective components of the medicine are prepared from the following raw materials: areca-nut, rhizoma acori graminei, lycopodiastrum casuarinoides, hematoxylon, broad-leaved epiphyllum, gastrodia elata, spina gleditsiae, camphor, rhizoma alismatis, immature bitter orange, human placenta, hawthorn, murdanniadivergens, crotalaria assamica, leonurus pseudo-macranthus and burmann cinnamon bark. The medicine disclosed by the invention selects high-quality traditional Chinese medicine materials which are proportioned scientifically, has the effects of smoothening the nerve, reducing heat to remove phlegm, smoothening the live to remove stasis and promoting qi circulation to relieve pain, has remarkable curative effects on symptoms of upset, anxiety, insomnia, amnesia climacteric symptoms and the like caused by schizophrenia, and is convenient to take, good in drug resistance, low in cost, free of toxic or side effect and worthy of wide clinical popularization and application as the diseases do not reoccur after being healed.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to one and treat schizoid medicine and preparation method.
Background technology
Schizophrenia is one group of major psychosis that the cause of disease is not bright, the how slow or subacute onset person between twenty and fifty, often show as clinically the different syndrome of symptom, relate to the inharmonious of many-sided obstacles such as sensory perception, thinking, emotion and behavior and ergasia.The general Clear consciousness of patient, intelligent normal, but some patients were there will be the infringement of cognitive function in lysis.The course of disease is generally delayed, and is repeatedly and shows effect, increases the weight of or worsen, and decline and mental handicap finally appear in some patients were, but some patients can keep recovery from illness or the state that is almost recovered after treatment.
The clinical syndrome that schizophrenia is made up of one group of syndrome, it is multifactorial disease.Although at present still not bery clear and definite to the understanding of its cause of disease, the effect of the susceptible quality of individual mind and the undesirable element of the outside social environment generation development to disease is known together by everybody.Be the generation that susceptible quality or outside undesirable element all may cause by inherent biological factor combined effect disease, the factor of different its morbidities of patient may be with outbalance in a certain respect.
For schizoid treatment, under existence conditions, antipsychotic medications is the treatment measure of schizophrenia disease first-selection, and Drug therapy is answered system and standard is emphasized early stage, enough, pedicure journey, notes single drug principle and personalized medicine principle.The general second filial generation (atypia) antipsychotic drug of recommending is selected as first-line drug as risperidone, olanzapine, Kui sulfur equality.The clozapine of the first generation and atypical antipsychotic uses as Second line Drug; Part patients during acute stage or curative effect are not good enough, and patient can share ECT; But above-mentioned therapy is invalid to 10%～30% treatment of schizophrenia, and other patients are the temporary inhibition state of an illness mostly, after drug withdrawal, just can recur, effect is very unstable.
Chinese medicine is as China's traditional medicine, be devoted to the treatment of various diseases always, conveniently there is especially long research history in schizophrenia, Chinese crude drug is drawn materials extensively, safety has no side effect, and uses a kind of new medicine of its development to treat schizophrenia for medically will having important medical value.
Summary of the invention
The invention provides one and treat schizoid medicine and preparation method; Choice of drug high-quality Chinese crude drug science compatibility of the present invention, there is effect of tranquilizing the mind, lowering fire and expelling phlegm, soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain, for the vexed anxiety that causes for the treatment of schizophrenia, insomnia forgetfulness, climacteric the symptom such as disease there is significant curative effect, taking convenience, better tolerance, with low cost, without any side effects, and non-relapse after healing, clinic wide popularization and application.
For achieving the above object, technical scheme of the present invention is implemented as follows:
One is treated schizoid medicine, and raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Treat a preparation method for schizoid medicine, comprise following processing step:
(1) Semen Arecae, Radix et Rhizoma Dispori Cantoniensis, Caulis et Folium Crotalariae Assamicae, Herba leonuri pseudoma cranthi and Cortex Cinnamomi Burmannii are put into container, carry out pulverization process, grind into powder, cross 200 order fine powders, for subsequent use;
(2) Rhizoma Acori Graminei, Lignum Sappan, Flos Epiphylli Oxypetali, Rhizoma Gastrodiae, Rhizoma Alismatis, Fructus Aurantii Immaturus and Placenta Hominis are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.10～1.15, for subsequent use;
(3) Lycopodium casuarinoides Spring, Spina Gleditsiae and Camphora are cleaned, immersed 80% the alcohol solution dipping 1～2 hour of 4 times of amounts, heating extraction 3 hours, reclaims ethanol, filter, and the thick paste that at 70 ℃ of simmer down tos, relative density is 1.13～1.16, for subsequent use;
(4) Fructus Crataegi is cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(5) above-mentioned steps (1)～(4) prepared fine powder, thick paste and juice are mixed, make tablet, obtain the schizoid medicine for the treatment of of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Semen Arecae: bitter in the mouth, pungent, warm in nature; Return stomach, large intestine channel.Killing insect and eliminating accumulation, the capable water of sending down the abnormal ascending QI, preventing the attack (or recurrence) of malaria.For cestode, ascarid, fasciolopsiasis buski, abdominal pain due to worm stagnation, stagnant dysentery, tenesmus, edema beriberi, malaria.Modern medicine study confirmation, Semen Arecae infusion has inhibitory action in various degree to dermatophytess such as trichophytons in vitro, and decoct and some strain of water logging agent infected by influenza A type have certain inhibitory action.
Rhizoma Acori Graminei: acrid in the mouth, hardship, warm in nature, nontoxic.Happy key, kind ventilation, arresting enursis, antiabortive, except unhappy, can control forgetful.
Lycopodium casuarinoides Spring: taste is micro-sweet, warm in nature, nontoxic; Return liver, kidney channel.Expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation, improving eyesight removing toxic substances.Cure mainly rheumatic arthritis, traumatic injury, bones and muscles pain, menoxenia, tetany, nyctalopia, night sweat, lumbago due to pathogenic wind-dampness, lumbar muscle strain, burn due to hot liquid or fire, sore swollen toxin." the practical Chinese herbal medicine in Guangxi newly selects " carries: " relaxing muscles and tendons and activating QI and blood in the collateral, antiinflammatory dehumidifying.Cure mainly nyctalopia, night sweat, lumbago due to pathogenic wind-dampness, infantile fever caused by exogenous pathogens.”
Lignum Sappan: sweet in the mouth, salty, property is pungent, cool; GUIXIN, liver, stomach, spleen channel.Dispelling phlegm and alleviating pain, invigorating blood and dispelling wind.Blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.Cure mainly married woman's amenorrhea due to stagnation of blood, dysmenorrhea, postpartum stagnation cardiac and abdominal pain, puerperal blood faints, carbuncle, traumatic injury, tetanus." Japan hanako materia medica " carries: " evacuation of pus pain relieving, subduing inflammation is flutterred damage blood stasis, woman's aphonia, blood is kept silent, dysentery with red and white feces rear point shoot.”
Flos Epiphylli Oxypetali: sweet in the mouth, property is flat; Return lung, heart channel.Clearing away lung-heat to relieve cough, cooling blood for hemostasis, tranquilizing by nourishing the heart.Cure mainly cough due to lung-heat, pulmonary tuberculosis, spitting of blood, metrorrhagia, cardiopalmus, insomnia." Luchuan book on Chinese herbal medicine " carries: " lung heat clearing, cough-relieving are reduced phlegm.Control heart peratodynia, spit blood, be suitable for pulmonary tuberculosis most.”
Rhizoma Gastrodiae: sweet in the mouth, property is flat; Enter Liver Channel.Suppressing liver-wind to relieve spasm contraction, calmness, analgesia, convulsion.Cure mainly dizziness and headache, infantile convulsion is twitched.Modern medicine study confirmation, Rhizoma Gastrodiae can improve the threshold value of clicking spasm, can prevent again the outbreak of guinea pig experimental epilepsy.
Spina Gleditsiae: acrid in the mouth, warm in nature; Return lung, Liver Channel.Cure mainly swollen ulcer drug, scrofula, skin ulcer rash stubborn dermatitis, puerperal hypogalactia, placenta retention, leprosy.Compendium of Material Medica is carried: " control carbuncle, acute mastitis, scrofula caused by pathogenic wind malignant boil, retention of placenta, parasite killing." research of modern Anticancer shows, Spina Gleditsiae has anticancer tumor-suppression activity.
Camphora: acrid in the mouth, hot in nature; Gui Jing, the heart, spleen channel.Orifice opening, qi stagnation removing, ward off foul, killing parasites for relieving itching, reducing swelling and alleviating pain." detailed outline " carries: " orifice opening, qi stagnation removing are controlled pathogen, cholera, and cardiac and abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, scabies, wind scabies, dental caries, parasite killing, and in footwear, goes beriberi." modern medicine study confirmation, Camphora is applied to skin gentle stimulation and antisepsis.
Rhizoma Alismatis: sweet in the mouth, light, cold in nature; Return kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen, expels the heat-evil treating stranguria.Cure mainly dysuria, the puckery pain of pyretic stranguria; Edema distension, has loose bowels, dizziness due to fluid-retention, seminal emission." not Lu " carries: " tonifying deficiency five kinds of over strain, except the five internal organs feeling of fullness, plays cloudy gas, stopping leak essence, quenches one's thirst, drenches drop, cuts off the water by bladder, three warmers." modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Rhizoma Alismatis and preparation modern times thereof are also used for the treatment of auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.
Fructus Aurantii Immaturus: bitter in the mouth, pungent, cold in nature; Return spleen, stomach, liver, heart channel.Cure mainly in stagnant and stop, feeling of fullness distending pain, constipation, heavy after dysentery, blocked-up chest, gastroptosis, uterine prolapse, proctoptosis.Modern medicine study confirms, the intestine in vitro of water decoction, tincture and the fluid extract of Fructus Aurantii Immaturus to mice, rabbit and rabbit all have inhibitory action at body intestinal tube, it is strong that decocting liquid makes the gastrointestinal of stomach, intestinal fistula Canis familiaris L. shrink the rhythm and pace of moving things, be excitation, in addition Fructus Aurantii Immaturus decoct can be used for stagnant for circulation of qi promoting, except distension.
Placenta Hominis: property is sweet, salty, warm in nature; Enter lung, the heart, kidney channel.The kidney invigorating and essence nourishing, benefiting QI and nourishing blood.Modern medicine study is thought, Placenta Hominis inner protein, sugar, calcium, vitamin, immune factor, estrogen, gravidity assisting ketone, steroid hormone, promoting sexual gland hormone, thyroliberin etc., can promote the growth of mammary gland, uterus, vagina, testis, thyroid is also had to facilitation, pulmonary tuberculosis, bronchial asthma, anemia etc. are also had to good effect, grind oral or coloclysis into powder and can prevent measles or mitigation symptoms.
Fructus Crataegi: sweet in the mouth, acid, slightly warm in nature.Removing food stagnancy, clots absorbing, changes stagnant.Modern medicine study confirms, in Fructus Crataegi, having relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea, the immunity of energy enhancing body, have anti-aging, anticancer effect, Fructus Crataegi decoct and ethanol extraction all have antibacterial action to shigella flexneri, sonne bacillus, Bacillus proteus, escherichia coli.
Radix et Rhizoma Dispori Cantoniensis: sweet in the mouth, micro-hardship, property is flat.Tonifying the lung kidney, antitussive, stomach invigorating hemostasis.Cure mainly deficiency of vital energy dizziness, tinnitus void is coughed, and inappetence is after being ill spitted blood.
Caulis et Folium Crotalariae Assamicae: lightly seasoned, cold in nature, poisonous; Return lung, spleen channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis, inducing diuresis to remove edema.Cure mainly children's's head sore, aphtha, toothache, cough due to lung-heat's spitting of blood, traumatic injury, traumatic hemorrhage, edema, renal calculus, cystitis, rheumatic ostalgia.Modern medicine study confirms, the monocrotaline that Caulis et Folium Crotalariae Assamicae includes can be synthesized and metabolism by tumoricidal albumen, thereby promote its degeneration, tumor cell is had to obvious inhibition and destruction, have a karyokinesis or the proliferation of oncocyte are had to obvious inhibition.
Herba leonuri pseudoma cranthi: acrid in the mouth, micro-hardship, cold nature.Promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.Cure mainly menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis stomachache, metrorrhagia, traumatic pain, carbuncle sore.Supplement to the Herbal carries: " main removing blood stasis.Puerperal abdonimal pain, liquor takes it; Also smash deposited furuncle to pieces.”
Cortex Cinnamomi Burmannii: acrid in the mouth, micro-sweet, warm in nature; Return spleen channel.Warming middle-JIAO to relieve pain, expelling wind and cold, removing toxic substances and promoting subsidence of swelling, hemostasis.Cure mainly cold stomachache, stomachache is had loose bowels, inappetence, anemofrigid-damp arthralgia, lumbago and skelalgia, traumatic injury, wound hemorrhage, furuncle toxic swelling.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " expelling wind and cold, warming middle-JIAO to relieve pain.Control cold stomachache, abdominal distention, diarrhoea.”
The present invention compared with prior art, has following beneficial effect:
Choice of drug high-quality Chinese crude drug science compatibility of the present invention, there is effect of tranquilizing the mind, lowering fire and expelling phlegm, soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain, for the vexed anxiety that causes for the treatment of schizophrenia, insomnia forgetfulness, climacteric the symptom such as disease there is significant curative effect, taking convenience, better tolerance, with low cost, without any side effects, and non-relapse after healing, clinic wide popularization and application.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Raw material composition and the weight of effective ingredient of the present invention are:
Treat a preparation method for schizoid medicine, comprise following processing step:
(1) Semen Arecae, Radix et Rhizoma Dispori Cantoniensis, Caulis et Folium Crotalariae Assamicae, Herba leonuri pseudoma cranthi and Cortex Cinnamomi Burmannii are put into container, carry out pulverization process, grind into powder, cross 200 order fine powders, for subsequent use;
(2) Rhizoma Acori Graminei, Lignum Sappan, Flos Epiphylli Oxypetali, Rhizoma Gastrodiae, Rhizoma Alismatis, Fructus Aurantii Immaturus and Placenta Hominis are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.10～1.15, for subsequent use;
(3) Lycopodium casuarinoides Spring, Spina Gleditsiae and Camphora are cleaned, immersed 80% the alcohol solution dipping 1～2 hour of 4 times of amounts, heating extraction 3 hours, reclaims ethanol, filter, and the thick paste that at 70 ℃ of simmer down tos, relative density is 1.13～1.16, for subsequent use;
(4) Fructus Crataegi is cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(5) above-mentioned steps (1)～(4) prepared fine powder, thick paste and juice are mixed, make tablet, obtain the schizoid medicine for the treatment of of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 2 (every 0.5g), warm water delivery service after meal; Within 20 days, be 1 course for the treatment of, can fully recover 2～3 courses for the treatment of, and the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Embodiment 2
Raw material composition and the weight of effective ingredient of the present invention are:
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
Raw material composition and the weight of effective ingredient of the present invention are:
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
Raw material composition and the weight of effective ingredient of the present invention are:
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 5
Raw material composition and the weight of effective ingredient of the present invention are:
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection:
As the schizoid medicine for the treatment of, select the routine clinical observation of schizophrenic 110 of making a definite diagnosis, patient is divided into two groups for the treatment of group and matched groups at random, treatment group 55 examples, wherein male's 25 examples, women's 30 examples, 16～55 years old age, 35.5 years old mean age, the course of disease 1～6 year; Matched group 55 examples, wherein male's 66 examples, women's 63 examples, 17～56 years old age, 36.5 years old mean age, the course of disease 1～5 year;
The course of disease, the degrees of symptoms for the treatment of group and two groups of cases of matched group are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group is taken medicine of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2 (every 0.5g), warm water delivery service after meal; Within 20 days, be 1 course for the treatment of, take continuously 2～3 courses for the treatment of, the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Matched group is taken haloperidol, and quiet note 5mg, slowly to inject in 1～2 minute after 25% Glucose Liquid dilution, every 8 hours 1 time, can double dosage as invalid; As the clothes of can withdrawing the previous remark that take a turn for the better.
3, efficacy determination:
(1) cure: symptom disappears completely, and thinking compared with normal, is emotionally stable, it is normal that social function is recovered.
(2) effective: symptom is most of to disappear, and thinking compared with normal, is emotionally stable, and social function is obviously recovered, and insight has part to recover.
(3) effective: symptom part disappears, and thinking is more random, flat affect, insight part is recovered.
(4) invalid: symptom is without improvement, without insight.
4, result:
Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is given an example:
1, Xue, female, 18 years old, people from Shenyang, Liaoning.Patient spirit is easily excited or tired, irritated in emotion, often occurs the performances such as insomnia, unable, headache, blunt, absent minded, study and work scarce capacity, and household sends certain mental hospital to him, and doctor is judged as schizophrenia omen.Doctor advised is taken Drug therapy of the present invention, takes after 1 course for the treatment of, and above-mentioned symptom takes a turn for the better to some extent, continues to take above-mentioned symptom after 1 course for the treatment of and disappears, and follows up a case by regular visits to without recurrence after 1 year.
2, Wei, man, 27 years old, people from Liaoyuan, Jilin.Patient starts when ill, feel to have always people key he, others' expression in the eyes, an action all serves as a hint to him, prepares to he lead off an attack (delusion of persecution).In addition, he has a hunch and hears that other people constantly give an order to him himself, starts soliloquy (occurring auditory hallucination).After finding that patient all day is by illusory idea institute fear, household sends certain mental hospital to him, and doctor is judged as schizophrenia.By taking Drug therapy of the present invention, to take after 1 course for the treatment of, the illusory thing in patient's brain also disappears on one point, and he flees from out from the illusory world suddenly one day, finds that oneself is in mental hospital, just knows own ill.So patient actively coordinates doctor's treatment, continue to take after 1 course for the treatment of of medicine of the present invention, the state of an illness is under control, and the trend that take a favorable turn; After patient leaves hospital under doctor's license, continue to take after 1 course for the treatment of of medicine of the present invention, recover normal, former abnormal symptom all disappears, and follows up a case by regular visits to equally with normal person after 3 years, and symptom did not recur again.
3, Liao, female, 36 years old, people from Huaian, Jiangsu.Patient hears of people's language, suspects, and confusion of thinking, speech word indigestion, emotional instability, eating disorder, stay at home, untidy, behavior is shunk back, solitarily not group, effectively work and study, can't take care of oneself, inter personal contact anxiety, the symptom such as do not admit to control oneself ill, household is with it to hospital admission, takes medicine of the present invention, takes after 1 course for the treatment of, above symptom takes a turn for the better to some extent, spirit is obviously stable a lot, continues to take after 2 courses for the treatment of of medicine of the present invention recovery from illness, mental restoration is normal, follows up a case by regular visits to without recurrence after 5 years.
4, Cui, man, 42 years old, Ningbo of Zhejiang people.Patient does oneself great harm and impulsive behavior because sensitivity is suspicious, doubt people, sometimes speaks and drags in irrelevant matters, and does not know its cloud.Patient also often tells dizzy headache, look into head CT no abnormality seen (family members provide), after household, be with it in certain hospital admission, be diagnosed as schizophrenia, use after certain medicine, it is extremely unstable that patient becomes emotion, often curses and beats household, sleep poor, often get up to cry not only but also scold midnight, household is sent to hospital admission, and doctor advised is taken Drug therapy of the present invention, take after 1 course for the treatment of, patient's symptom is clearly better, and continues to take after 2 courses for the treatment of, and above-mentioned symptom disappears, patient's mental restoration is normal, follows up a case by regular visits to so far not recurrence.
5, Xiong, man, 57 years old, people from Yangzhou, Jiangsu.Patient is excited, impulsion suddenly, gibberish, conduct disorder, segment hallucination and vain hope.Household's hospital admission of taking, doctor is diagnosed as schizophrenia, and patient used several different methods treatment, had no special effect, introduce through doctor, take Drug therapy of the present invention, treat after 1 course for the treatment of, symptom is clearly better, treat transference cure after 2 courses for the treatment of, mental restoration is normal, follows up a case by regular visits to without recurrence after half a year.
6, Pan, female, 66 years old, people from Hefei ,Anhui.Sense of discomfort and the neurosis symptoms such as patient insomnia, headache, dizzy, unable, emotional lability, remove certain hospital admission, is diagnosed as schizophrenia, doctor advised is taken Drug therapy of the present invention, takes after 1 course for the treatment of, and above-mentioned symptom takes a turn for the better to some extent, emotion is stable a little, continues to take after 2 courses for the treatment of of the present invention, and above-mentioned symptom is clearly better, emotion is obviously stable, continue to take after 1 course for the treatment of, above-mentioned symptom disappears, and is emotionally stable, recovery from illness, follows up a case by regular visits to after 2 years without recurring.
Claims (5)
1. the schizoid medicine for the treatment of, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
42～66 parts of 43～67 portions of Lignum Sappans of 44～71 parts of Lycopodium casuarinoides Springs of 50～74 parts of Rhizoma Acori Graminei of Semen Arecae
31～54 parts of 34～59 parts of Camphoras of 37～61 parts of Spina Gleditsiaes of 40～64 parts of Rhizoma Gastrodiaes of Flos Epiphylli Oxypetali
14～38 parts of 16～40 portions of Fructus Crataegis of 20～44 parts of Placenta Hominiss of 25～49 parts of Fructus Aurantii Immaturuss of Rhizoma Alismatis
3～22 parts of 7～27 parts of Cortex Cinnamomi Burmanniis of 12～31 parts of Herba leonuri pseudoma cranthi of 12～32 parts of Caulis et Folium Crotalariae Assamicaes of Radix et Rhizoma Dispori Cantoniensis.
2. one according to claim 1 is treated schizoid medicine, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
47～61 parts of 48～62 portions of Lignum Sappans of 49～66 parts of Lycopodium casuarinoides Springs of 55～69 parts of Rhizoma Acori Graminei of Semen Arecae
36～49 parts of 40～54 parts of Camphoras of 42～56 parts of Spina Gleditsiaes of 45～59 parts of Rhizoma Gastrodiaes of Flos Epiphylli Oxypetali
19～33 parts of 21～35 portions of Fructus Crataegis of 25～39 parts of Placenta Hominiss of 30～44 parts of Fructus Aurantii Immaturuss of Rhizoma Alismatis
8～19 parts of 10～24 parts of Cortex Cinnamomi Burmanniis of 15～28 parts of Herba leonuri pseudoma cranthi of 15～29 parts of Caulis et Folium Crotalariae Assamicaes of Radix et Rhizoma Dispori Cantoniensis.
3. one according to claim 1 is treated schizoid medicine, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
50～58 parts of 51～59 portions of Lignum Sappans of 52～61 parts of Lycopodium casuarinoides Springs of 58～66 parts of Rhizoma Acori Graminei of Semen Arecae
39～47 parts of 43～51 parts of Camphoras of 45～53 parts of Spina Gleditsiaes of 48～56 parts of Rhizoma Gastrodiaes of Flos Epiphylli Oxypetali
22～30 parts of 24～32 portions of Fructus Crataegis of 28～36 parts of Placenta Hominiss of 33～41 parts of Fructus Aurantii Immaturuss of Rhizoma Alismatis
12～16 parts of 13～21 parts of Cortex Cinnamomi Burmanniis of 18～25 parts of Herba leonuri pseudoma cranthi of 18～26 parts of Caulis et Folium Crotalariae Assamicaes of Radix et Rhizoma Dispori Cantoniensis.
4. one according to claim 1 is treated schizoid medicine, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
54 parts of 55 portions of Lignum Sappans of 57 parts of Lycopodium casuarinoides Springs of 62 parts of Rhizoma Acori Graminei of Semen Arecae
43 parts of 47 parts of Camphoras of 49 parts of Spina Gleditsiaes of 52 parts of Rhizoma Gastrodiaes of Flos Epiphylli Oxypetali
26 parts of 28 portions of Fructus Crataegis of 32 parts of Placenta Hominiss of 37 parts of Fructus Aurantii Immaturuss of Rhizoma Alismatis
14 parts of 17 parts of Cortex Cinnamomi Burmanniis of 22 parts of Herba leonuri pseudoma cranthi of 22 parts of Caulis et Folium Crotalariae Assamicaes of Radix et Rhizoma Dispori Cantoniensis.
5. a preparation method for the treatment of schizoid medicine as described in claim 1～4 any one, is characterized in that: comprise following processing step:
(1) Semen Arecae, Radix et Rhizoma Dispori Cantoniensis, Caulis et Folium Crotalariae Assamicae, Herba leonuri pseudoma cranthi and Cortex Cinnamomi Burmannii are put into container, carry out pulverization process, grind into powder, cross 200 order fine powders, for subsequent use;
(2) Rhizoma Acori Graminei, Lignum Sappan, Flos Epiphylli Oxypetali, Rhizoma Gastrodiae, Rhizoma Alismatis, Fructus Aurantii Immaturus and Placenta Hominis are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.10～1.15, for subsequent use;
(3) Lycopodium casuarinoides Spring, Spina Gleditsiae and Camphora are cleaned, immersed 80% the alcohol solution dipping 1～2 hour of 4 times of amounts, heating extraction 3 hours, reclaims ethanol, filter, and the thick paste that at 70 ℃ of simmer down tos, relative density is 1.13～1.16, for subsequent use;
(4) Fructus Crataegi is cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(5) above-mentioned steps (1)～(4) prepared fine powder, thick paste and juice are mixed, make tablet, obtain the schizoid medicine for the treatment of of the present invention.
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| CN103285266A (en) * | 2013-07-02 | 2013-09-11 | 李伟丽 | Chinese medicine composition for treating schizophrenia |
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| CN104399053A (en) * | 2014-12-12 | 2015-03-11 | 付希涛 | Drug for treating schizophrenia and preparation method |
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| CN103845626B (en) | 2016-02-03 |
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