CN103830717B - A kind of Chinese medicine for the treatment of atrophic gastritis and preparation method thereof - Google Patents

A kind of Chinese medicine for the treatment of atrophic gastritis and preparation method thereof Download PDF

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CN103830717B
CN103830717B CN201410126535.3A CN201410126535A CN103830717B CN 103830717 B CN103830717 B CN 103830717B CN 201410126535 A CN201410126535 A CN 201410126535A CN 103830717 B CN103830717 B CN 103830717B
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rhizoma
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centipede
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CN103830717A (en
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李泉
萧峰
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Abstract

The invention discloses a kind of Chinese medicine for the treatment of atrophic gastritis, comprise interior use side and medicine for external application, it is characterized in that: medicine for oral administration is made up of the bulk drug of following weight: Radix Codonopsis 24g, rhizoma zingiberis 12g, rhizoma atractylodis macrocephalae 20g, Poria cocos 20g, rhizoma pinellinae praeparata 12g, coptis 12g, rhizoma nardostachyos 18g, fructus amomi 12g, fleece-flower root 20g, pseudo-ginseng 12g, house lizard 9g, centipede 15g, stir-fry Fructus Aurantii 12g, red sage root 18g, Radix Angelicae Sinensis tail 18g, stir-baked RADIX PAEONIAE ALBA 12g, honey-fried licorice root 10g; Medicine for external application is made up of the bulk drug of following weight: fructus amomi 12g, borneol 12g, saltcake 240g; Through clinical testing, the present invention has good curative effect to treatment atrophic gastritis, generation and diffusion that can inhibition cancer cell, safety, has no side effect, treatment cost is low, be two weeks days per courses for the treatment of, takes and both can take effect a course for the treatment of, take 2 to 3 courses for the treatment of after symptom greatly alleviate, particularly remarkable in the commitment effect of atrophic gastritis, atrophic gastritis middle and advanced stage is also had to good retarding action.

Description

A kind of Chinese medicine for the treatment of atrophic gastritis and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, specifically a kind of Chinese medicine and preparation side thereof for the treatment of atrophic gastritisMethod.
Background technology
Atrophic gastritis also claims atrophic gastritis, with gastric epithelial and body of gland atrophy, and decreased number, stomach lining becomesThin, mucous membrane basic unit thickens, or companion gland metaplasia and intestinal gland metaplasia, or to have atypical hyperplasia be the chronic digestible system disease of featureDisease, often shows as upper abdomen secret anguish, turgor, belch, poor appetite, or become thin, anaemia etc., without specificity.
The symptom of atrophic gastritis, sign, without specificity, can not be served as the foundation of diagnosis, make a definite diagnosis main glutinous by gastroscope and stomachFilm living tissue pathologic finding, symptom and sign, long-term indigestion, gastral cavilty portion turgor discomfort, receive poor, weak, become thin, anaemia etc.
Main illness is: 1, stomach lining color is thin out; 2, under mucous membrane, blood vessel is shown in thoroughly; 3, duplicature is tiny even disappears;4, when atrophic gastritis is during with body of gland neck hyperplasia or intestinal metaplasia, the coarse injustice of mucous membrane surface, be graininess orNodositas, visible pseudopolyp forms sometimes, and under mucous membrane, the feature of exposed vessel is often covered; 5, atrophy mucous membrane fragility increases,Easily hemorrhage, and can have rotten to the corn kitchen range; 6, atrophic gastritis can be simultaneously with the performance of chronic superficial gastritis, as congested erythema, attachedMucus, and reflective enhancing etc.
Summary of the invention
The problem to be solved in the present invention is for above problem, provides side effect little, and the one that result for the treatment of is good is treated slowlyChinese medicine of property atrophic gastritis and preparation method thereof.
For addressing the above problem, the technical solution adopted in the present invention is:
Treat a Chinese medicine for atrophic gastritis, comprise innerlich anwenden and medicine for external application, it is characterized in that: medicine for oral administration by withThe bulk drug of lower weight is made: Radix Codonopsis 20-50g, rhizoma zingiberis 8-16g, rhizoma atractylodis macrocephalae 10-30g, Poria cocos 10-30g, rhizoma pinellinae praeparata 8-25g,Coptis 8-16g, rhizoma nardostachyos 15-35g, fructus amomi 8-24g, fleece-flower root 10-30g, pseudo-ginseng 6-15g, house lizard 6-15g, centipede 10-20g, stir-fryFructus Aurantii 6-15g, red sage root 16-26g, Radix Angelicae Sinensis tail 10-30g, stir-baked RADIX PAEONIAE ALBA 6-16g, honey-fried licorice root 5-15g;
Medicine for external application is made up of the bulk drug of following weight: fructus amomi 6-18g, borneol 8-16g, saltcake 200-260g.
Below the further improvement to technique scheme:
Treat a Chinese medicine for atrophic gastritis, comprise interior use side and medicine for external application, it is characterized in that: medicine for oral administration by withThe bulk drug of lower weight is made: Radix Codonopsis 24g, rhizoma zingiberis 12g, rhizoma atractylodis macrocephalae 20g, Poria cocos 20g, rhizoma pinellinae praeparata 12g, coptis 12g, rhizoma nardostachyos18g, fructus amomi 12g, fleece-flower root 20g, pseudo-ginseng 12g, house lizard 9g, centipede 15g, stir-fry Fructus Aurantii 12g, red sage root 18g, Radix Angelicae Sinensis tail 18g, stir-fry are in vainChinese herbaceous peony 12g, honey-fried licorice root 10g;
Medicine for external application is made up of the bulk drug of following weight: fructus amomi 12g, borneol 12g, saltcake 240g.
Below the further improvement to technique scheme:
Treat a preparation method for the Chinese medicine of atrophic gastritis, comprise medicine for oral administration preparation and medicine for external application preparation:
Medicine for oral administration preparation: comprise the following steps:
1), get Radix Codonopsis, rhizoma zingiberis, rhizoma atractylodis macrocephalae, Poria cocos, rhizoma pinellinae praeparata, the coptis, rhizoma nardostachyos, fructus amomi, the fleece-flower root, three of above-mentioned weightSeven, fry Fructus Aurantii, the red sage root, Radix Angelicae Sinensis tail, stir-baked RADIX PAEONIAE ALBA, honey-fried licorice root, add the water of 10 times of total raw material drug weight to decoct, keep temperatureDegree decocts 40-50 minute at 60-70 degree, is then warmed up to 95-100 degree and decocts 20-30 minute, and drop goes out to obtain liquid A;
2), the centipede of above-mentioned weight is worn into fine powder, add the yellow rice wine of 3 times of centipede weight to stir into pasty state, obtain centipede and stick with pasteB;
3), the rice vinegar of getting 3 times of the house lizard house lizard weight of above-mentioned weight soaks, then pull house lizard out and stir-fry,In stir-frying, add the rice vinegar that soaks house lizard, until by rice vinegar fried dry; Obtain vinegar house lizard C processed;
4), drop to 60 while spending until the temperature of liquid A, add centipede to stick with paste B and vinegar house lizard C processed stirs, then add rapidlyHot to boiling, keep boiling 2-5 minute, drop goes out liquid and had both obtained medicine for oral administration;
The preparation of medicine for external application, gets fructus amomi, borneol and the saltcake of above-mentioned weight, fructus amomi, borneol are ground as smalls, by smalls withSaltcake mixes to be mixed thoroughly.
Below the further improvement to technique scheme:
Described centipede be 3 the age centipede, the length of centipede is in about 10cm.
Described yellow rice wine is Ji Me Lao Jiu.
Medicine for oral administration every day 3 times, 2 courses for the treatment of Monday, medicine for external application packs in the gauze bag of 15cm × 20cm size, with godExternal application umbilical region centered by fault cave; Apply at dusk every day to morning next day, after medicine deliquescence, remove, clean skin of abdomen, every day 1Inferior. 2 courses for the treatment of Monday.
While taking, liquid being divided into two parts, is that 50-60 takes while spending at liquid, point sooner or later twice one after each meal, 2 weeksIt is a course for the treatment of.
Through clinical testing, the present invention has good curative effect to treatment atrophic gastritis, can inhibition cancer cellGenerate and diffusion, safety, has no side effect, and treatment cost is low, and be two weeks days per course for the treatment of, takes and both can take effect a course for the treatment of, clothesGreatly alleviate by symptom after 2 to 3 courses for the treatment of, particularly remarkable in the commitment effect of atrophic gastritis, to slowlyProperty atrophic gastritis middle and advanced stage also has good retarding action.
Detailed description of the invention
Embodiment 1, a kind of Chinese medicine for the treatment of atrophic gastritis, comprises interior use side and medicine for external application, it is characterized in that: inTake medicine and made by the bulk drug of following weight: Radix Codonopsis 24g, rhizoma zingiberis 12g, rhizoma atractylodis macrocephalae 20g, Poria cocos 20g, rhizoma pinellinae praeparata 12g, the coptis12g, rhizoma nardostachyos 18g, fructus amomi 12g, fleece-flower root 20g, pseudo-ginseng 12g, house lizard 9g, centipede 15g, stir-fry Fructus Aurantii 12g, red sage root 18g, Radix Angelicae Sinensis tail18g, stir-baked RADIX PAEONIAE ALBA 12g, honey-fried licorice root 10g;
Medicine for external application is made up of the bulk drug of following weight: fructus amomi 12g, borneol 12g, saltcake 240g.
Embodiment 2, a kind of Chinese medicine for the treatment of atrophic gastritis, comprises innerlich anwenden and medicine for external application, it is characterized in that: inTake medicine and made by the bulk drug of following weight: Radix Codonopsis 20g, rhizoma zingiberis 8g, rhizoma atractylodis macrocephalae 10g, Poria cocos 10g, rhizoma pinellinae praeparata 8g, coptis 8g,Rhizoma nardostachyos 15g, fructus amomi 8g, fleece-flower root 10g, pseudo-ginseng 6g, house lizard 6g, centipede 10g, stir-fry Fructus Aurantii 6g, red sage root 16g, Radix Angelicae Sinensis tail 10g, stir-fryRoot of herbaceous peony 6g, honey-fried licorice root 5g;
Medicine for external application is made up of the bulk drug of following weight: fructus amomi 6g, borneol 8g, saltcake 200g.
Embodiment 3, a kind of Chinese medicine for the treatment of atrophic gastritis, comprises innerlich anwenden and medicine for external application, it is characterized in that: inTake medicine and made by the bulk drug of following weight: Radix Codonopsis 50g, rhizoma zingiberis 16g, rhizoma atractylodis macrocephalae 30g, Poria cocos 30g, rhizoma pinellinae praeparata 25g, the coptis16g, rhizoma nardostachyos 35g, fructus amomi 24g, fleece-flower root 30g, pseudo-ginseng 15g, house lizard 15g, centipede 20g, stir-fry Fructus Aurantii 15g, red sage root 26g, Radix Angelicae SinensisTail 30g, stir-baked RADIX PAEONIAE ALBA 16g, honey-fried licorice root 15g;
Medicine for external application is made up of the bulk drug of following weight: fructus amomi 18g, borneol 16g, saltcake 260g.
Treat a preparation method for the Chinese medicine of atrophic gastritis, comprise medicine for oral administration preparation and medicine for external application preparation:
Medicine for oral administration preparation: comprise the following steps:
1), get Radix Codonopsis, rhizoma zingiberis, rhizoma atractylodis macrocephalae, Poria cocos, rhizoma pinellinae praeparata, the coptis, rhizoma nardostachyos, fructus amomi, the fleece-flower root, three of above-mentioned weightSeven, fry Fructus Aurantii, the red sage root, Radix Angelicae Sinensis tail, stir-baked RADIX PAEONIAE ALBA, honey-fried licorice root, add the water of 10 times of total raw material drug weight to decoct, keep temperatureDegree decocts 40-50 minute at 60-70 degree, is then warmed up to 95-100 degree and decocts 20-30 minute, and drop goes out to obtain liquid A;
2), the centipede of above-mentioned weight is worn into fine powder, add the yellow rice wine of 3 times of centipede weight to stir into pasty state, obtain centipede and stick with pasteB;
3), the rice vinegar of getting 3 times of the house lizard house lizard weight of above-mentioned weight soaks, then pull house lizard out and stir-fry,In stir-frying, add the rice vinegar that soaks house lizard, until by rice vinegar fried dry; Obtain vinegar house lizard C processed;
4), drop to 60 while spending until the temperature of liquid A, add centipede to stick with paste B and vinegar house lizard C processed stirs, then add rapidlyHot to boiling, keep boiling 2-5 minute, drop goes out liquid and had both obtained medicine for oral administration;
The preparation of medicine for external application, gets fructus amomi, borneol and the saltcake of above-mentioned weight, fructus amomi, borneol are ground as smalls, by smalls withSaltcake mixes to be mixed thoroughly.
Centipede be 3 the age centipede, the length of centipede is in about 10cm; Using for 3 ages when centipede, make medicine through experimentThe drug effect of thing is better than and uses the centipede at other ages, particularly the length of centipede during in 10cm left and right drug effect particularly remarkable,Be far superior to the centipede of other sizes.
Described yellow rice wine is Ji Me Lao Jiu, adopts Ji Me Lao Jiu through experiment, is used the medicine of the medicine that other yellow rice wine makeEffect will be got well.
Medicine for oral administration every day 3 times, 2 courses for the treatment of Monday, medicine for external application packs in the gauze bag of 15cm × 20cm size, with godExternal application umbilical region centered by fault cave; Apply at dusk every day to morning next day, after medicine deliquescence, remove, clean skin of abdomen, every day 1Inferior. 2 courses for the treatment of Monday.
Through clinical testing, the present invention has good curative effect to treatment atrophic gastritis, has no side effect, and treats intoThis is low, take 2 to 3 courses for the treatment of after symptom greatly alleviate, particularly aobvious in the commitment effect of atrophic gastritisWork, also has good retarding action to atrophic gastritis middle and advanced stage.
Medicine for oral administration every day 3 times, 2 courses for the treatment of Monday, medicine for external application packs in the gauze bag of 15cm × 20cm size, with godExternal application umbilical region centered by fault cave; Apply at dusk every day to morning next day, after medicine deliquescence, remove, clean skin of abdomen, every day 1Inferior. 2 courses for the treatment of Monday.
Through experiment, the proportioning of medicine of the present invention is made up of the bulk drug of following weight at medicine for oral administration: Radix Codonopsis 20-50g, dryGinger 8-16g, rhizoma atractylodis macrocephalae 10-30g, Poria cocos 10-30g, rhizoma pinellinae praeparata 8-25g, coptis 8-16g, rhizoma nardostachyos 15-35g, fructus amomi 8-24g, whatTuber of multiflower knotweed 10-30g, pseudo-ginseng 6-15g, house lizard 6-15g, centipede 10-20g, stir-fry Fructus Aurantii 6-15g, red sage root 16-26g, Radix Angelicae Sinensis tail 10-30g, stir-baked RADIX PAEONIAE ALBA 6-16g, honey-fried licorice root 5-15g; Medicine for external application is made up of the bulk drug of following weight: fructus amomi 6-18g, borneol 8-16g,Saltcake 200-260g; , the curative effect of medicine is far above the curative effect of other weight proportion.
Particularly the proportioning of medicine is Radix Codonopsis 24g, rhizoma zingiberis 12g, rhizoma atractylodis macrocephalae 20g, Poria cocos 20g, rhizoma pinellinae praeparata 12g, the coptis12g, rhizoma nardostachyos 18g, fructus amomi 12g, fleece-flower root 20g, pseudo-ginseng 12g, house lizard 9g, centipede 15g, stir-fry Fructus Aurantii 12g, red sage root 18g, Radix Angelicae Sinensis tail18g, stir-baked RADIX PAEONIAE ALBA 12g, honey-fried licorice root 10g; Medicine for external application is made up of the bulk drug of following weight: fructus amomi 12g, borneol 12g, saltcake 240gTime medicine curative effect the most remarkable.
Through experiment, in the embodiment of the present invention, centipede be 3 the age centipede, the length of centipede is in about 10cm; Through experimentUsing for 3 ages when centipede, the drug effect that makes medicine is better than the centipede that uses other ages, particularly exists in the length of centipede, drug effect is particularly remarkable when 10cm the left and right, is far superior to the centipede of other sizes; Described yellow rice wine is Ji Me Lao Jiu, adopts through experimentJi Me Lao Jiu, the drug effect that is used the medicine that other yellow rice wine make will be got well.
The patient of the 2013 100 routine atrophic gastritis in the court treats, and 25 examples are taken in the embodiment of the present invention 1Chinese medicine, as treatment 1 group; 25 examples are taken the Chinese medicine in the embodiment of the present invention 2, as 2 groups of treatments; It is real that 25 examples are taken the present inventionExecute the Chinese medicine in example 3, as 3 groups of treatments; 25 examples are taken domperidone, the results are shown in Table one.
As shown in Table 1, embodiment 1 is optimum embodiment, takes Chinese medicine of the present invention, and the efficient and obvious effective rate for the treatment of is highIn adopting Western medicine, and side effect is little.
Table one
Case 1, Zhang, female, 46 years old, readme was suffered from atrophic gastritis 9 years, and gastrocopy is atrophic gastritis companionIntestinesization are raw, inscribe disease: gastral cavilty portion secret anguish, and be and continue outbreak, noisy acid regurgitation, do not feel like eating, feeling thirst but no desire to drink, body is tired weak, largeConstipation knot, 2-3 day a line, pale tongue with white fur is slightly dry, forceless deep pulse. Give decoction oral prescription as follows: Radix Codonopsis 24g, rhizoma zingiberis 12g, stir-fry are in vainArt 20g, Poria cocos 20g, rhizoma pinellinae praeparata 12g, coptis 12g, rhizoma nardostachyos 18g, fructus amomi 12g, fleece-flower root 20g, pseudo-ginseng 12g, house lizard 9g, centipede15g, stir-fry Fructus Aurantii 12g, red sage root 18g, Radix Angelicae Sinensis tail 18g, stir-baked RADIX PAEONIAE ALBA 12g, honey-fried licorice root 10g; 1 dose of every day, decocting divide 3 times half little after mealTook up to 1 hour, meanwhile, medicine for external application is with fructus amomi 12g, borneol 12g, saltcake 240g, external application umbilical region centered by SHENQUE acupoint;Apply at dusk every day to morning next day, after medicine deliquescence, remove, 2 courses for the treatment of Monday, and advise that patient's diet is greasy, maror. OneFurther consultation after the course for the treatment of: all diseases subtract greatly, Ou You stomach institute secret anguish, diet increases, and spirit takes a turn for the better, a line on the 1st of defecating, slightly dry legibility, tongue is lightWhite and moist fur, forceless deep pulse. No more side effects, continues and treats a course for the treatment of again with former side, and two examine: if all diseases are lost, diet increases, just two, gastroscopeBefore check atrophy of gastric mucosa, be improved greatly, intestinesization are raw to disappear. Follow up a case by regular visits to 1 year, not recurrence.
Case 2, Wang, female, 67 years old, stomach headquarters or seat of leading organs of an institute like the Chinese Academy of Sciences secret anguish, scorching hot 1 year, increased the weight of January. Disease is seen: the thin god of body is tired, weak, faceLook sallow, poor appetite, sour regurgitation, the light few tongue of tongue, small and wiry pulse. Gastrocopy is diagnosed as atrophic gastritis accompanied hyperplasia, bile regurgitation;Pathological biopsy: atrophic gastritis (in to severe) companion's intestinal metaplasia (moderate). Give prescriptions of traditional Chinese medicine as follows: Radix Codonopsis 24g,Rhizoma zingiberis 12g, rhizoma atractylodis macrocephalae 20g, Poria cocos 20g, rhizoma pinellinae praeparata 12g, coptis 12g, rhizoma nardostachyos 18g, fructus amomi 12g, fleece-flower root 20g, pseudo-ginseng12g, house lizard 9g, centipede 15g, stir-fry Fructus Aurantii 12g, red sage root 18g, Radix Angelicae Sinensis tail 18g, stir-baked RADIX PAEONIAE ALBA 12g, honey-fried licorice root 10g; 1 dose of every day, waterDecoct and point take half an hour to 1 hour after meal for 3 times, meanwhile, external application is with fructus amomi 12g, borneol 12g, saltcake 240g, taking SHENQUE acupoint asCenter external application umbilical region; Treated for 2 courses for the treatment of, Stomach in Patients institute secret anguish, scorching hot, sour regurgitation obviously alleviate, and the state of mind takes a turn for the better, but tells random thoughts stomachCool. Symptom is obviously improved, and check gastroscope shows: chronic superficial gastritis. Advise it to continue to take medicine to consolidate curative effect.
Case 3, Bai, man, 56 years old, suffers from chronic superficial gastritis, atrophic gastritis companion intestinal metaplasia 3 years, stomachSpectroscopy is shown: erosive gastritis. Disease is seen: stomach institute turgor, scorching hot, occasionally there are secret anguish, sour regurgitation, and heating installation, it is poor to receive, weak, foreign body in pharynxSense, without bitter taste, stool is dry, urine still can, sallow complexion, tongue is dark red, the micro-Huang of tongue, middle see thin greasy, a little less than small and wiry pulse. Give Chinese medicine placeSide: Radix Codonopsis 24g, rhizoma zingiberis 12g, rhizoma atractylodis macrocephalae 20g, Poria cocos 20g, rhizoma pinellinae praeparata 12g, coptis 12g, rhizoma nardostachyos 18g, fructus amomi 12g, the fleece-flower root20g, pseudo-ginseng 12g, house lizard 9g, centipede 15g, stir-fry Fructus Aurantii 12g, red sage root 18g, Radix Angelicae Sinensis tail 18g, stir-baked RADIX PAEONIAE ALBA 12g, honey-fried licorice root 10g; AndMedicine for external application fructus amomi 12g, borneol 12g, saltcake 240g, patient's sour regurgitation after January, heartburn and foreign body in pharynx sense alleviate, and food is received increasing, remaining diseaseAnd tongue arteries and veins is as front. All diseases disappear substantially. Check gastroscope shows superficial gastritis. Follow up a case by regular visits to 1 year, have no recurrence.

Claims (2)

1. treat a Chinese medicine for atrophic gastritis, comprise innerlich anwenden and medicine for external application, it is characterized in that: medicine for oral administration by belowThe bulk drug of weight is made: Radix Codonopsis 24g, rhizoma zingiberis 12g, rhizoma atractylodis macrocephalae 20g, Poria cocos 20g, rhizoma pinellinae praeparata 12g, coptis 12g, rhizoma nardostachyos 18g,Fructus amomi 12g, fleece-flower root 20g, pseudo-ginseng 12g, house lizard 9g, centipede 15g, stir-fry Fructus Aurantii 12g, red sage root 18g, Radix Angelicae Sinensis tail 18g, stir-baked RADIX PAEONIAE ALBA12g, honey-fried licorice root 10g;
Medicine for external application is made up of the bulk drug of following weight: fructus amomi 12g, borneol 12g, saltcake 240g.
2. treat the preparation method of the Chinese medicine of atrophic gastritis as one kind of claim 1, it is characterized in that: comprise medicine for oral administrationPreparation and medicine for external application preparation:
Medicine for oral administration preparation: comprise the following steps:
1), get Radix Codonopsis, rhizoma zingiberis, rhizoma atractylodis macrocephalae, Poria cocos, rhizoma pinellinae praeparata, the coptis, rhizoma nardostachyos, fructus amomi, the fleece-flower root, pseudo-ginseng, the stir-fry of above-mentioned weightFructus Aurantii, the red sage root, Radix Angelicae Sinensis tail, stir-baked RADIX PAEONIAE ALBA, honey-fried licorice root, add the water of 10 times of total raw material drug weight to decoct, and maintains the temperature at60-70 degree decocts 40-50 minute, is then warmed up to 95-100 degree and decocts 20-30 minute, and drop goes out to obtain liquid A;
2), the centipede of above-mentioned weight is worn into fine powder, add the yellow rice wine of 3 times of centipede weight to stir into pasty state, obtain centipede and stick with paste B;
3), the rice vinegar of getting 3 times of the house lizard house lizard weight of above-mentioned weight soaks, and then pulls house lizard out and stir-fries, turning overWhen stir-fry, add the rice vinegar that soaks house lizard, until by rice vinegar fried dry; Obtain vinegar house lizard C processed;
4), drop to 60 while spending until the temperature of liquid A, add centipede to stick with paste B and vinegar house lizard C processed stirs, be then heated to rapidlyBoiling, keeps boiling 2-5 minute, and drop goes out liquid and obtains medicine for oral administration;
The preparation of medicine for external application, gets fructus amomi, borneol and the saltcake of above-mentioned weight, fructus amomi, borneol is ground as smalls, by smalls and saltcakeMixing is mixed thoroughly.
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