CN104435522A - Compound preparation for treating duodenal ulcer and preparation method thereof - Google Patents
Compound preparation for treating duodenal ulcer and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a compound preparation for treating duodenal ulcer. The compound preparation for treating duodenal ulcer is prepared from the following raw material medicines in parts by weight: 12-25 parts of rhizoma polygoni paleacei, 10-20 parts of sweet potato, 15-25 parts of concha arcae, 10-20 parts of cyclea polytata, 10-20 parts of astragalus membranaceus, 15-25 parts of immature bitter orange, 18-30 parts of hericium erinaceus, 3-9 parts of carrot, 9-16 parts of cistanche, 1-5 parts of honey, 8-20 parts of white atractylodes rhizome and 12-20 parts of garden burnet. The compound preparation disclosed by the invention is capable of suppressing gastric acid secretion, and reducing the irritation of gastric acid during ulcer healing repair, thus enabling tissue regeneration and repair to be greatly carried out; the compound preparation disclosed by the invention is clinically proven to be remarkable in curative effect, convenient, economic and safe to use, high in the compliance of patients, and worthy of clinical popularization.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of compound preparation for the treatment of duodenal ulcer and preparation method thereof.
Background technology
The defect of the Duodenal Mucosa layer that duodenal ulcer causes due to many factors and muscle layer.Though similar to gastric ulcer in clinical manifestation, at incidence, but there is obvious difference the aspects such as age, sex, pathogenesis.
The cause of disease: 1. gene: the susceptibility of inherited genetic factors to primary disease plays more important effect, and its Main Basis is: the 1. high incidence of patient family; 2. the dependency of genetic beautiful (blood group and blood group secretory substance, HLA antigen, high pepsinogen), in the compatriot of duodenal ulcer patients, duodenal ulcer sickness rate is higher than population 2.6 times; Duodenal ulcer is 50% in the concordance of monozygotic twins compatriot morbidity even more noteworthy, also increases in the concordance of pairing twins compatriot morbidity.2. gastroxia: duodenal ulcer pathogenesis is not single clear and definite process, but compound, interactional factor is formed; Cause because the balance between damage factor and defence is not normal.3. Duodenal Mucosa defense mechanism weakens: duodenum is by the receptor of specificity pH sensitivity, acidification reaction, feedback delays the emptying of stomach, to keep in duodenum pH close to neutral, and hydrion and be not subject to the damage of cholate, in duodenal ulcer patients in Duodenal Mucosa energy absorbing cavity, this feedback delays the declines of gastric emptying and gastric acid inhibitory, and gastric emptying accelerates, pyloric cap intracavity acid loading is strengthened, causes mucosa lesions to form ulcer.4. helicobacter pylori infections: helicobacter pylori infections is closely related with the morbidity of peptic ulcer.When gastric acid secretion increases, pyloric cap is by excessive acidify, make in pyloric cap, to occur gastric metaplasia stove, transplant pyloric cap for helicobacter pylori from antral gastric mucosa to create conditions, acute duodenal inflammation is there is in helicobacter pylori at bulb survival and reproduction, ulcer is there is under other cause the induction of ulcer factor, but this duodenal ulcer mechanism, still treat further confirmation.
The main clinical manifestation of duodenal ulcer is epigastrium pain, can be dull pain, causalgia, distending pain or severe pain, also can show as the only dull pain discomfort when hunger.Typical case person shows as slightly or rest pain under moderate xiphoid-process, can be alleviated by antacid or feed.About there is the pain of 2/3 to be rhythmicity clinically: early within 1 ~ 3 hour after the meal, to start to occur upper abdominal pain, if do not taken medicine or taking food, just alleviate after lunch be continued to.Food also must have meal to alleviate for latter 2 ~ 4 hours again bitterly.About half patient has pain at midnight, and patient often can be bitterly awake.Rhythmicity pain continues a few week mostly, along with the alleviation several months, can repeatedly occur.
The Chinese patent literature of Authorization Notice No. CN102824445B (application number 201210350173.7) discloses a kind of Chinese medicine composition for the treatment of duodenal ulcer, it is characterized in that it is made up of following raw material medicaments: mountain Herba Kalimeridis 40-70 part, Ficus Variolosa Lindl. Ex Benth. 30-50 part, Gigartina intermedia Sur. 30-50 part, Folium Sennae 30-50 part, Rhizoma Corydalis 20-40 part, Hodgsonia macrocarpa 20-40 part, Radix Astragali 20-40 part, Grifola frondosa 10-30 part, Herba Urariae crinitae 10-30 part, Pericarpium Citri Reticulatae 10-30 part, Fructus Akebiae 10-30 part, Herba Taraxaci 10-20 part.The Chinese patent literature of Authorization Notice No. CN102416158B (application number 201110413874.6) discloses the pharmaceutical composition of a kind of prevention or treatment duodenal ulcer, is prepared from: Radix Astragali 8-12 part, Fructus Aurantii 12-16 part, Rhizoma Atractylodis Macrocephalae 12-16 part, Rhizoma Cyperi 15-20 part, Semen Arecae 12-16 part, Radix Glycyrrhizae 8-12 part, Rhizoma Zingiberis 8-12 part, Radix Sophorae Flavescentis 8-12 part, Semen Persicae 15-20 part by the Chinese crude drug of following weight portion.
In a word, Chinese medicine achieves good curative effect in treatment primary disease, but also there are some problems: have much room for improvement to improving the misery that duodenal ulcer brings.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, the compound preparation of the easy treatment duodenal ulcer of clothes for a long time.
Technical scheme of the present invention is:
Treat a compound preparation for duodenal ulcer, be prepared from by the primary raw material of following weight proportioning: Rhizoma Polygoni Paleachi 12-25 part, Rhizoma Dioscoreae esculentae 10-20 part, Concha Arcae 15-25 part, DABAIJIE summer-heat 10-20 part, Radix Astragali 10-20 part, Fructus Aurantii Immaturus 15-25 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 18-30 part, Radix Dauci Sativae 3-9 part, Herba Cistanches 9-16 part, Mel 1-5 part, Rhizoma Atractylodis Macrocephalae 8-20 part, Radix Sanguisorbae 12-20 part.
Treat a compound preparation for duodenal ulcer, preferred scheme is, is prepared from by the primary raw material of following weight proportioning: Rhizoma Polygoni Paleachi 18-23 part, Rhizoma Dioscoreae esculentae 13-18 part, Concha Arcae 18-23 part, DABAIJIE summer-heat 13-18 part, Radix Astragali 13-18 part, Fructus Aurantii Immaturus 18-23 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 22-26 part, Radix Dauci Sativae 5-7 part, Herba Cistanches 12-14 part, Mel 2-4 part, Rhizoma Atractylodis Macrocephalae 14-16 part, Radix Sanguisorbae 14-18 part.
Treat a compound preparation for duodenal ulcer, better preferred scheme is prepared from by the primary raw material of following weight proportioning: Rhizoma Polygoni Paleachi 21 parts, Rhizoma Dioscoreae esculentae 15 parts, Concha Arcae 20 parts, DABAIJIE summer-heat 15 parts, the Radix Astragali 15 parts, Fructus Aurantii Immaturus 20 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 24 parts, 6 parts, Radix Dauci Sativae, Herba Cistanches 13 parts, Mel 3 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Sanguisorbae 16 parts.
According to the preparation method of the compound preparation for the treatment of duodenal ulcer noted earlier, step is as follows:
(1) Concha Arcae is broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and uses mortar pulverization, crosses 80-120 mesh sieve;
(2) by Hericium erinaceus (Bull. Ex Fr.) Pers. as in marmite, add the warm water soaking 30 minutes of 30-40 DEG C, intense fire is fried open, and turns slow fire boiling 20-40 minute, and filter, filtrate is for subsequent use;
(3) Rhizoma Polygoni Paleachi, Rhizoma Dioscoreae esculentae, DABAIJIE summer-heat, the Radix Astragali and the Rhizoma Atractylodis Macrocephalae are ground into smalls, cross 70-90 mesh sieve;
(4) Radix Dauci Sativae stripping and slicing and Fructus Aurantii Immaturus, Herba Cistanches and Radix Sanguisorbae are together placed in step (2) gained filtrate, soak 10-30 minute, be heated to boiling, continue to filter after 30 minutes, by gained concentrating filter liquor to 1/2 of original volume, obtain concentrated solution;
(5) gained smalls in gained smalls in step (1) and step (3) is poured in the concentrated solution of step (4) gained, fully stir into thick paste;
(6) added by Mel in step (5) gained thick paste, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 20-40 mesh sieve crossed by soft material, make wet granular, wet granular bake drying, dry temperature is 50-80 DEG C, namely obtains this Chinese medicinal granule after cooling.
The foregoing preparation method of agent, preferred scheme is: step (1) crosses 90-110 mesh sieve (preferred mistake 100 mesh sieve).
Foregoing preparation method, preferred scheme is: step (2) adds the warm water soaking 30 minutes warm water soaking of 35 DEG C (preferably add 30 minutes) of 33-38 DEG C.
Foregoing preparation method, preferred scheme is: the consumption of step (2) warm water is the 4-9 of Hericium erinaceus (Bull. Ex Fr.) Pers. consumption doubly (preferred 5-8 times, better preferably 6 times).
Foregoing preparation method, preferred scheme is: step (3) crosses 75-85 mesh sieve (preferably 80 mesh sieves).
Foregoing preparation method, preferred scheme is: step (4) soaks 15-25 minute (preferably 20 minutes).
Foregoing preparation method, preferred scheme is: the temperature of step (6) drying is 60-70 DEG C (preferably dry temperature is 65 DEG C).
Using method: for making the present invention reach optimum therapeuticing effect, half an hour takes after breakfast, lunch and dinner, each 3-5 gram, warm boiled water, 5 is a course for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Polygoni Paleachi: base is former: be the rhizome of Polygonaceae arsesmart Rhizoma Polygoni Paleachi.Composition: Rhizoma Polygoni Paleachi rhizome is containing Combination tannin.The property of medicine: bitter, acrid, cold.Function cures mainly: dissipating blood stasis stops blooding, therapeutic method to keep the adverse QI flowing downwards removing food stagnancy, removing toxic substances, dampness removing.Cure mainly leprosy abdominal mass to gather, traumatic injury, traumatic hemorrhage, spit blood, spitting of blood, epistaxis, amenorrhea, metrorrhagia, chronic gastritis, taste-blindness rate, food stagnation is stagnated, dysentery, enteritis, edema, sore, venom, burn and scald.
Rhizoma Dioscoreae esculentae: another name Zhu potato, Rhizoma Dioscoreae, Red Hill medicine, golden potato, sweet potato, Radix Pachyrhizi Erosi.Flavor efficacy is sweet, flat, nontoxic.Enter spleen, kidney channel.Function invigorating middle warmer and blood, supplementing QI for promoting the production of body fluid, wide the intestines and stomach, relieving constipation is secret.Be applicable to the dyspepsia caused by weakness of the spleen and stomach, have loose bowels, external can control carbuncle pyogenic infections from tumour or sore etc.
Concha Arcae: have another name called Carnis Arca inflata shell, watt room, blood clam skin, row of tiles on a roof clam skin, for Carnis Arca inflata section Carnis Arca inflata belongs to the shell that animal Scapharca subcrenata, Scapharca broughtonii and Tegillarca granosa belong to animal Tegillarca granosa.The property of medicine: matter is hard, sweet in the mouth, salty, property is put down.Composition: main component is calcium carbonate, also containing a small amount of calcium phosphate and magnesium, ferrum, silicate.Find according to modern pharmacological research, this medical instrument has effect of expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache, for pertinacious phlegm chronic cough, and stomachache acid regurgitation, traumatic hemorrhage, gastric and duodenal ulcers.
DABAIJIE summer-heat: base is former: be the tuber of Aristolochiaceae birthwort kwangsi dutchmanspipe root.Composition: root is containing allantoin, and aristolochic acid A, cupreol, 6-methoxyl group removes nitro Aristolochic Acid methanol and 6-methoxyl group aristolochic acid A methyl ester, the alkaloids such as magnoflorine.The property of medicine: bitter, cold.GUIXIN, stomach, large intestine channel.Function cures mainly: regulating QI to relieve pain, heat-clearing and toxic substances removing, hemostasis.Cure mainly spastic stomachache, stomachache, acute gastroenteritis, gastric and duodenal ulcers, dysentery, traumatic injury, sore and toxic, venom, bone tuberculosis, traumatic hemorrhage.
The Radix Astragali: have effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating, raw by consolidating superficial resistance holder skin ulcer.
Fructus Aurantii Immaturus: nature and flavor: bitter, pungent, sour, temperature.Gui Jing: return spleen, stomach warp.Effect: dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Cure mainly: stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest; Gastroptosis. proctoptosis, uterine prolapse.
Hericium erinaceus (Bull. Ex Fr.) Pers.: base is former: be the sporophore of hedgehog fungus section Hericium fungus Hericium erinaceus (Bull. Ex Fr.) Pers., Hydnum.Composition: containing Hericium erinaceus (Bull. Ex Fr.) Pers. Ketone A, B, C, D, E, F, G, H in Hericium erinaceus, Hericium erinaceus (Bull. Ex Fr.) Pers. alkali etc.Dry sporophore is containing protein, lipid, fiber and glucosan.Also containing sterols: ergosterol etc.Mycelium culture contains Hericium erinaceus (Bull. Ex Fr.) Pers. pyrone A, B etc.The property of medicine: " national Chinese herbal medicine compilation ": " sweet, flat." function cures mainly: strengthening the spleen and nourishing the stomach, calms the nerves, anticancer.Cure mainly body void weak, dyspepsia, insomnia, gastroduodenal ulcer, chronic gastritis, digestive tract tumor.
Radix Dauci Sativae: rhizome vegetable, Cruciferae Rhaphanus plant.According to nutritionist analysis, white turnip biotic energy index is 5.5555, and disease prevention index is 2.7903.So far plant and be implanted with history in thousand, be all widely used at diet and dietary therapy of Chinese medicine field.Clear Qianrong's year noon in heptan (1750 Christian eras) " the Rugao county annals " compiled is carried: " have red white two kinds, all can plant when four, only do good at the beginning of the first day of the last period of the hot season, broken first can be for food for Radix Raphani, a Radix Raphani, and raw husky earth person is sweet and crisp, and raw poor soil person is hard and peppery." its color is white, belong to gold, enter lung, property Gan Pingxin, returns lung spleen channel, has the therapeutic method to keep the adverse QI flowing downwards, helps digestion, promotes the production of body fluid except disease lung moistening, removing toxic substances, effect of diuresis relieving constipation.Cure mainly consumptive lung disease, lung-heat, constipation, haematemesis, flatulence, dyspepsia, dyspepsia, abundant expectoration, sphincter disturbance smooth etc., white turnip be well suited for ripe with decocting in water after, drink Radix Raphani water, put a white sugar, can drink as beverage, have good effect to digestion and nourishing the stomach.
Herba Cistanches: nature and flavor: sweet, salty, temperature.Gui Jing: return kidney, large intestine channel.Effect: kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.Cure mainly: for sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.
Mel: another name: SHIMI, stone maltosemalt sugar, Mel, Mel, husky honey.Mel is a kind of nutritious natural nourishing food, is also one of the most frequently used tonic.According to analysis, containing the trace element with the multiple organic acid such as the plurality of inorganic salt of human serum concentration comparable and vitamin, ferrum, calcium, copper, manganese, potassium, phosphorus and useful health, and fructose, glucose, amylase, oxidase, reductase etc., there is nourishing, moisturize, detoxify, effect of beauty face-whitening-nourishing, loosening bowel to relieve constipation.
The Rhizoma Atractylodis Macrocephalae: the Rhizoma Atractylodis Macrocephalae, another name: small wooden raft Ji, Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, sheet art, Rhizoma Atractylodis etc., Latin literary fame: Atractylodes macrocephala Koidz. belongs to Compositae, [WTBX herbaceos perennial, root stock nodositas.Stem is upright, the long branch from middle and lower part usually, whole Glabrous.The nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function.The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, and for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." medicine origin " is recorded: " dehumidifying benefit is dry, and middle QI invigorating, warming middle-JIAO, go in taste wet, except gastric heat, strong taste, enter diet, antiabortive.”
Radix Sanguisorbae: nature and flavor: bitter, sour, puckery, is slightly cold.Gui Jing: return liver, large intestine channel.Effect: cooling blood for hemostasis, removing toxic substances sore.Cure mainly: for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Compound preparation scientific formula provided by the invention, the preparation method of dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, selected materials is all Chinese medicine material, without any side effects, energy gastric acid secretion inhibiting, reduces the stimulation of gastric acid in ulcer healing reparation, regeneration and restoration is well carried out;
2, this prescription meets patient's body and mind feature of Chinese medicine principle and duodenal ulcer completely, under the prerequisite of general principle, can have different prescription according to different crowd, and function is different.
3, medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
Embodiment 1 one kinds treats the compound preparation of duodenal ulcer, gets the raw materials ready (getting 10g for every part): Rhizoma Polygoni Paleachi 12 parts by following weight parts, Rhizoma Dioscoreae esculentae 10 parts, Concha Arcae 15 parts, DABAIJIE summer-heat 10 parts, the Radix Astragali 10 parts, Fructus Aurantii Immaturus 15 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 18 parts, 3 parts, Radix Dauci Sativae, Herba Cistanches 9 parts, Mel 1 part, the Rhizoma Atractylodis Macrocephalae 8 parts, Radix Sanguisorbae 12 parts.
The preparation method of the compound preparation of above-mentioned treatment duodenal ulcer:
(1) Concha Arcae is broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and uses mortar pulverization, crosses 80 mesh sieves;
(2) by Hericium erinaceus (Bull. Ex Fr.) Pers. as in marmite, add the warm water soaking 30 minutes of 30 DEG C, the consumption of warm water is 4 of Hericium erinaceus (Bull. Ex Fr.) Pers. consumption, and intense fire is fried open, and turns slow fire boiling 20 minutes, and filter, filtrate is for subsequent use;
(3) Rhizoma Polygoni Paleachi, Rhizoma Dioscoreae esculentae, DABAIJIE summer-heat, the Radix Astragali and the Rhizoma Atractylodis Macrocephalae are ground into smalls, cross 70 mesh sieves;
(4) Radix Dauci Sativae stripping and slicing and Fructus Aurantii Immaturus, Herba Cistanches and Radix Sanguisorbae are together placed in step (2) gained filtrate, soak 10 minutes, be heated to boiling, continue to filter after 30 minutes, by gained concentrating filter liquor to 1/2 of original volume, obtain concentrated solution;
(5) gained smalls in gained smalls in step (1) and step (3) is poured in the concentrated solution of step (4) gained, fully stir into thick paste;
(6) added by Mel in step (5) gained thick paste, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 20 mesh sieves crossed by soft material, make wet granular, wet granular bake drying, dry temperature is 50 DEG C, namely obtains this Chinese medicinal granule after cooling.
Typical case one: Lee XX, man 45 years old, Jinan, Shandong Province personage, cadre at their posts.Often drink outside, have a meal irregular, patient the year before because of eating and drinking without temperance sense paroxysmal abdominal pain, nausea and vomiting, abdominal tympanites, epigastrium pain, patient thinks it oneself is the appearance above-mentioned symptom of drank, just hospital is not gone to check, distending pain aggravation after two weeks, occasionally have severe pain sense at postabdomen of having a meal, Sui Qu hospital checks, doctor, by going the inquiry of patient and being diagnosed as duodenal ulcer in conjunction with its diet problem, takes the compound preparation that the present invention does.
Take the embodiment of the present invention 1 gained compound preparation, after 1 course for the treatment of, patient's sensation is so inviolent in pain, does not have the symptoms such as Nausea and vomiting yet, after continuing to take 2 courses for the treatment of, basic malaise symptoms disappears, and the state of an illness is basicly stable, continue to take to do 1 course for the treatment of and consolidate, without recurrence after drug withdrawal.
Embodiment 2 one kinds treats the compound preparation of duodenal ulcer, gets the raw materials ready (getting 15g for every part): Rhizoma Polygoni Paleachi 25 parts by following weight parts, Rhizoma Dioscoreae esculentae 20 parts, Concha Arcae 25 parts, DABAIJIE summer-heat 20 parts, the Radix Astragali 20 parts, Fructus Aurantii Immaturus 25 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 30 parts, 9 parts, Radix Dauci Sativae, Herba Cistanches 16 parts, Mel 5 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Sanguisorbae 20 parts.
The preparation method of the compound preparation of above-mentioned treatment duodenal ulcer is:
(1) Concha Arcae is broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and uses mortar pulverization, crosses 120 mesh sieves;
(2) by Hericium erinaceus (Bull. Ex Fr.) Pers. as in marmite, add the warm water soaking 30 minutes of 40 DEG C, the consumption of warm water is 9 times of Hericium erinaceus (Bull. Ex Fr.) Pers. consumption, and intense fire is fried open, and turns slow fire boiling 40 minutes, and filter, filtrate is for subsequent use;
(3) Rhizoma Polygoni Paleachi, Rhizoma Dioscoreae esculentae, DABAIJIE summer-heat, the Radix Astragali and the Rhizoma Atractylodis Macrocephalae are ground into smalls, cross 90 mesh sieves;
(4) Radix Dauci Sativae stripping and slicing and Fructus Aurantii Immaturus, Herba Cistanches and Radix Sanguisorbae are together placed in step (2) gained filtrate, soak 30 minutes, be heated to boiling, continue to filter after 30 minutes, by gained concentrating filter liquor to 1/2 of original volume, obtain concentrated solution;
(5) gained smalls in gained smalls in step (1) and step (3) is poured in the concentrated solution of step (4) gained, fully stir into thick paste;
(6) added by Mel in step (5) gained thick paste, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 40 mesh sieves crossed by soft material, make wet granular, wet granular bake drying, dry temperature is 80 DEG C, namely obtains this Chinese medicinal granule after cooling.
Typical case two: grandson XX, man 38 years old.Jiyang, Jinan personage, certain university teacher, started the upper abdominal pain, the abdominal distention that occur unknown cause after early 3 hours after the meal before 2 months, originally think and oneself eaten thing bad, bought JIANWEI XIAOSHI PIAN voluntarily and taken, effective when taking at the beginning, serious all the more after drug withdrawal, the hospital of accompanying down of layman checks, is diagnosed as duodenal ulcer by gastroscopy, because Western medicine side effect is large, patient admission doctor is to having opened compound preparation of the present invention.
Give the oral embodiment of the present invention 2 and obtain compound preparation, after 1 course for the treatment of, the symptom of patient's self-induction abdominal distention, upper abdominal pain alleviates to some extent, after continuing to have taken 3 courses for the treatment of, appetite is normal, and malaise symptoms disappears substantially, continue again to take 1 course for the treatment of, cure completely, not showing effect 1 year more so far.
Embodiment 3 one kinds treats the compound preparation of duodenal ulcer, get the raw materials ready (getting 20g for every part) by following weight parts: Rhizoma Polygoni Paleachi 18 parts, Rhizoma Dioscoreae esculentae 13 parts, Concha Arcae 18 parts, DABAIJIE summer-heat 13 parts, the Radix Astragali 13 parts, Fructus Aurantii Immaturus 18 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 22 parts, 5 parts, Radix Dauci Sativae, Herba Cistanches 12 parts, Mel 2 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Sanguisorbae 14 parts.
The preparation method of the compound preparation of above-mentioned treatment duodenal ulcer is:
(1) Concha Arcae is broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and uses mortar pulverization, crosses 90 mesh sieves;
(2) by Hericium erinaceus (Bull. Ex Fr.) Pers. as in marmite, add the warm water soaking 30 minutes of 33 DEG C, the consumption of warm water is 5 of Hericium erinaceus (Bull. Ex Fr.) Pers. consumption, and intense fire is fried open, and turns slow fire boiling 25 minutes, and filter, filtrate is for subsequent use;
(3) Rhizoma Polygoni Paleachi, Rhizoma Dioscoreae esculentae, DABAIJIE summer-heat, the Radix Astragali and the Rhizoma Atractylodis Macrocephalae are ground into smalls, cross 75 mesh sieves;
(4) Radix Dauci Sativae stripping and slicing and Fructus Aurantii Immaturus, Herba Cistanches and Radix Sanguisorbae are together placed in step (2) gained filtrate, soak 15 minutes, be heated to boiling, continue to filter after 30 minutes, by gained concentrating filter liquor to 1/2 of original volume, obtain concentrated solution;
(5) gained smalls in gained smalls in step (1) and step (3) is poured in the concentrated solution of step (4) gained, fully stir into thick paste;
(6) added by Mel in step (5) gained thick paste, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 25 mesh sieves crossed by soft material, make wet granular, wet granular bake drying, dry temperature is 60 DEG C, namely obtains this Chinese medicinal granule after cooling.
Typical case three: king XX, female, 65 years old, Jiangzhou, Qingdao personage, peasant.2 ~ 4 hours abdominal pains after food, must by having meal to alleviate when pain serious.Moreover patient's pain at every midnight strengthens, almost every night all can be bitterly awake, this pain continues a few week, and sons and daughters see that conditions of patients increases the weight of, and Bian Qu hospital checks, find that patient has myocarditis through checking, again because older, doctor advised x-ray barium meal examination, is diagnosed as duodenal ulcer through x-ray barium meal examination, due to patient's financial difficulties, so doctor advised takes compound preparation of the present invention.
Take the embodiment of the present invention 3 gained compound preparation, after 1 course for the treatment of, patient's readme, the symptom of abdominal distention alleviates, and after having meal, pain alleviates, and 2 day evening, sleep was not waken up by pain, and after continuing again to take 3 courses for the treatment of, malaise symptoms disappears substantially, without recurrence after drug withdrawal.
Embodiment 4 one kinds treats the compound preparation of duodenal ulcer, get the raw materials ready (getting 25g for every part) by following weight parts: Rhizoma Polygoni Paleachi 23 parts, Rhizoma Dioscoreae esculentae 18 parts, Concha Arcae 23 parts, DABAIJIE summer-heat 18 parts, the Radix Astragali 18 parts, Fructus Aurantii Immaturus 23 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 26 parts, 7 parts, Radix Dauci Sativae, Herba Cistanches 14 parts, Mel 4 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Radix Sanguisorbae 18 parts.
The preparation method of the compound preparation of above-mentioned treatment duodenal ulcer is:
(1) Concha Arcae is broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and uses mortar pulverization, crosses 110 mesh sieves;
(2) by Hericium erinaceus (Bull. Ex Fr.) Pers. as in marmite, add the warm water soaking 30 minutes of 38 DEG C, the consumption of warm water is 8 times of Hericium erinaceus (Bull. Ex Fr.) Pers. consumption, and intense fire is fried open, and turns slow fire boiling 35 minutes, and filter, filtrate is for subsequent use;
(3) Rhizoma Polygoni Paleachi, Rhizoma Dioscoreae esculentae, DABAIJIE summer-heat, the Radix Astragali and the Rhizoma Atractylodis Macrocephalae are ground into smalls, cross 85 mesh sieves;
(4) Radix Dauci Sativae stripping and slicing and Fructus Aurantii Immaturus, Herba Cistanches and Radix Sanguisorbae are together placed in step (2) gained filtrate, soak 25 minutes, be heated to boiling, continue to filter after 30 minutes, by gained concentrating filter liquor to 1/2 of original volume, obtain concentrated solution;
(5) gained smalls in gained smalls in step (1) and step (3) is poured in the concentrated solution of step (4) gained, fully stir into thick paste;
(6) added by Mel in step (5) gained thick paste, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 35 mesh sieves crossed by soft material, make wet granular, wet granular bake drying, dry temperature is 70 DEG C, namely obtains this Chinese medicinal granule after cooling.
Embodiment 5 one kinds treats the compound preparation of duodenal ulcer, gets the raw materials ready (getting 30g for every part): Rhizoma Polygoni Paleachi 21 parts by following weight parts, Rhizoma Dioscoreae esculentae 15 parts, Concha Arcae 20 parts, DABAIJIE summer-heat 15 parts, the Radix Astragali 15 parts, Fructus Aurantii Immaturus 20 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 24 parts, 6 parts, Radix Dauci Sativae, Herba Cistanches 13 parts, Mel 3 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Sanguisorbae 16 parts.
The preparation method of the compound preparation of above-mentioned treatment duodenal ulcer is:
(1) Concha Arcae is broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and uses mortar pulverization, crosses 100 mesh sieves;
(2) by Hericium erinaceus (Bull. Ex Fr.) Pers. as in marmite, add the warm water soaking 30 minutes of 35 DEG C, the consumption of warm water is 6 times of Hericium erinaceus (Bull. Ex Fr.) Pers. consumption, and intense fire is fried open, and turns slow fire boiling 30 minutes, and filter, filtrate is for subsequent use;
(3) Rhizoma Polygoni Paleachi, Rhizoma Dioscoreae esculentae, DABAIJIE summer-heat, the Radix Astragali and the Rhizoma Atractylodis Macrocephalae are ground into smalls, cross 80 mesh sieves;
(4) Radix Dauci Sativae stripping and slicing and Fructus Aurantii Immaturus, Herba Cistanches and Radix Sanguisorbae are together placed in step (2) gained filtrate, soak 20 minutes, be heated to boiling, continue to filter after 30 minutes, by gained concentrating filter liquor to 1/2 of original volume, obtain concentrated solution;
(5) gained smalls in gained smalls in step (1) and step (3) is poured in the concentrated solution of step (4) gained, fully stir into thick paste;
(6) added by Mel in step (5) gained thick paste, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 30 mesh sieves crossed by soft material, make wet granular, wet granular bake drying, dry temperature is 65 DEG C, namely obtains this Chinese medicinal granule after cooling.
The clinical practice of the compound preparation of test example 1 embodiment 5 gained treatment duodenal ulcer: in June ,-2013 in June, 2010, screen 300 routine patients in 10 hospitals, wherein women 150 example, male 150 example, oldest 70 years old, minimal ages 20 years old, 45 years old mean age.Before test 1 week, Continuous Observation is carried out to this crowd, record symptom and change, experimental group 200 people, matched group 100 people, experimental group takes embodiment 5 products obtained therefrom, and matched group takes other medicine (conventional medication such as furazolidone, bismuth potassium citrate, lansoprazole capsule, clarithromycin tablet).Using method is: after breakfast, lunch and dinner, half an hour takes, each 3-5 gram, warm boiled water, and 5 is a course for the treatment of.Curative effect situation criterion: cure: after taking this product, malaise symptoms has clear improvement, pain disappears; Effective: after taking this product, malaise symptoms makes moderate progress, and abdominal distention, stomachache alleviate to some extent; Invalid: after taking this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take this product 20-70 year duodenal ulcer patients therapeutic outcome
Therapeutic effect: experimental group cures 190 examples (cure rate 95%), and total effective rate 99%, exceeds 30% than matched group cure rate, and total effective rate exceeds 19%, and successful is better than matched group.
Take period self-induction symptom and physical change of spirit as shown in table 2.
Table 2:
Take 5 days, more than 67% feel takes a turn for the better to some extent, and malaise symptoms improves, and pain alleviates to some extent; Take 10 days, more than 75% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and the symptom of abdominal distention is obviously improved; Take 20 days, more than 97% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and some patients self-induction is fully recovered.Take more than 20 days in experimental group, effective percentage can reach 98%, and matched group is only 78%.The present invention has effect of spleen invigorating warming middle-JIAO, activating qi for lowering adverse qi, reducing swelling and alleviating pain, eliminating blood stasis and inducing menstruation, gastrointestinal peristalsis can be increased, improve intestinal blood circulation, remarkable through clinical proof clinical efficacy of the present invention, easy to use, economy, safety, patient compliance is high, and clinic is promoted.
Claims (10)
1. treat a compound preparation for duodenal ulcer, it is characterized in that: be prepared from by the primary raw material of following weight proportioning: Rhizoma Polygoni Paleachi 12-25 part, Rhizoma Dioscoreae esculentae 10-20 part, Concha Arcae 15-25 part, DABAIJIE summer-heat 10-20 part, Radix Astragali 10-20 part, Fructus Aurantii Immaturus 15-25 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 18-30 part, Radix Dauci Sativae 3-9 part, Herba Cistanches 9-16 part, Mel 1-5 part, Rhizoma Atractylodis Macrocephalae 8-20 part, Radix Sanguisorbae 12-20 part.
2. the compound preparation for the treatment of duodenal ulcer according to claim 1, it is characterized in that: be prepared from by the primary raw material of following weight proportioning: Rhizoma Polygoni Paleachi 18-23 part, Rhizoma Dioscoreae esculentae 13-18 part, Concha Arcae 18-23 part, DABAIJIE summer-heat 13-18 part, Radix Astragali 13-18 part, Fructus Aurantii Immaturus 18-23 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 22-26 part, Radix Dauci Sativae 5-7 part, Herba Cistanches 12-14 part, Mel 2-4 part, Rhizoma Atractylodis Macrocephalae 14-16 part, Radix Sanguisorbae 14-18 part.
3. the compound preparation for the treatment of duodenal ulcer according to claim 1, is characterized in that: be prepared from by the primary raw material of following weight proportioning: Rhizoma Polygoni Paleachi 21 parts, Rhizoma Dioscoreae esculentae 15 parts, Concha Arcae 20 parts, DABAIJIE summer-heat 15 parts, the Radix Astragali 15 parts, Fructus Aurantii Immaturus 20 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 24 parts, 6 parts, Radix Dauci Sativae, Herba Cistanches 13 parts, Mel 3 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Sanguisorbae 16 parts.
4., according to the preparation method of the compound preparation of the arbitrary described treatment duodenal ulcer of claim 1-3, it is characterized in that: step is as follows:
(1) Concha Arcae is broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and uses mortar pulverization, crosses 80-120 mesh sieve;
(2) by Hericium erinaceus (Bull. Ex Fr.) Pers. as in marmite, add the warm water soaking 30 minutes of 30-40 DEG C, intense fire is fried open, and turns slow fire boiling 20-40 minute, and filter, filtrate is for subsequent use;
(3) Rhizoma Polygoni Paleachi, Rhizoma Dioscoreae esculentae, DABAIJIE summer-heat, the Radix Astragali and the Rhizoma Atractylodis Macrocephalae are ground into smalls, cross 70-90 mesh sieve;
(4) Radix Dauci Sativae stripping and slicing and Fructus Aurantii Immaturus, Herba Cistanches and Radix Sanguisorbae are together placed in step (2) gained filtrate, soak 10-30 minute, be heated to boiling, continue to filter after 30 minutes, by gained concentrating filter liquor to 1/2 of original volume, obtain concentrated solution;
(5) gained smalls in gained smalls in step (1) and step (3) is poured in the concentrated solution of step (4) gained, fully stir into thick paste;
(6) added by Mel in step (5) gained thick paste, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 20-40 mesh sieve crossed by soft material, make wet granular, wet granular bake drying, dry temperature is 50-80 DEG C, namely obtains this Chinese medicinal granule after cooling.
5. preparation method according to claim 4, is characterized in that: step (1) crosses 90-110 mesh sieve (preferred mistake 100 mesh sieve).
6. preparation method according to claim 4, is characterized in that: step (2) adds the warm water soaking 30 minutes warm water soaking of 35 DEG C (preferably add 30 minutes) of 33-38 DEG C.
7. preparation method according to claim 4, is characterized in that: the consumption of step (2) warm water is the 4-9 of Hericium erinaceus (Bull. Ex Fr.) Pers. consumption doubly (preferred 5-8 times, better preferably 6 times).
8. preparation method according to claim 4, is characterized in that: step (3) crosses 75-85 mesh sieve (preferably 80 mesh sieves).
9. preparation method according to claim 4, is characterized in that: step (4) soaks 15-25 minute (preferably 20 minutes).
10. preparation method according to claim 4, is characterized in that: the temperature of step (6) drying is 60-70 DEG C (preferably dry temperature is 65 DEG C).
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