CN103827078B - 制备阿戈美拉汀的晶型i的方法 - Google Patents
制备阿戈美拉汀的晶型i的方法 Download PDFInfo
- Publication number
- CN103827078B CN103827078B CN201180072630.4A CN201180072630A CN103827078B CN 103827078 B CN103827078 B CN 103827078B CN 201180072630 A CN201180072630 A CN 201180072630A CN 103827078 B CN103827078 B CN 103827078B
- Authority
- CN
- China
- Prior art keywords
- agomelatine
- solvent
- solution
- organic solvent
- crystal form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Battery Electrode And Active Subsutance (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2011/001805 WO2013017903A1 (en) | 2011-08-03 | 2011-08-03 | Process for the preparation of crystalline form i of agomelatine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103827078A CN103827078A (zh) | 2014-05-28 |
| CN103827078B true CN103827078B (zh) | 2015-08-05 |
Family
ID=44802320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180072630.4A Expired - Fee Related CN103827078B (zh) | 2011-08-03 | 2011-08-03 | 制备阿戈美拉汀的晶型i的方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20150291508A1 (enExample) |
| EP (1) | EP2739605B1 (enExample) |
| CN (1) | CN103827078B (enExample) |
| BR (1) | BR112014002523A2 (enExample) |
| CA (1) | CA2843827A1 (enExample) |
| CY (1) | CY1117823T1 (enExample) |
| DK (1) | DK2739605T3 (enExample) |
| EA (1) | EA024650B1 (enExample) |
| ES (1) | ES2577177T3 (enExample) |
| HR (1) | HRP20160767T1 (enExample) |
| HU (1) | HUE030282T2 (enExample) |
| IN (1) | IN2014CN00348A (enExample) |
| PL (1) | PL2739605T3 (enExample) |
| PT (1) | PT2739605E (enExample) |
| SI (1) | SI2739605T1 (enExample) |
| WO (1) | WO2013017903A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104876830A (zh) * | 2015-06-09 | 2015-09-02 | 江苏中邦制药有限公司 | 一种阿戈美拉汀i晶型晶体的制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101921205A (zh) * | 2010-08-30 | 2010-12-22 | 江苏恩华药业股份有限公司 | 阿戈美拉汀ⅰ晶型的制备方法 |
| EP2319827A1 (en) * | 2009-11-09 | 2011-05-11 | Ratiopharm GmbH | Process for the production of polymorph form I of agomelatine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2658818B1 (fr) | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2866335B1 (fr) | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
| CN101704763B (zh) | 2009-11-25 | 2012-03-28 | 天津泰普药品科技发展有限公司 | 阿戈美拉汀i型晶体的制备方法 |
-
2011
- 2011-08-03 BR BR112014002523A patent/BR112014002523A2/pt not_active Application Discontinuation
- 2011-08-03 PT PT117705079T patent/PT2739605E/pt unknown
- 2011-08-03 WO PCT/IB2011/001805 patent/WO2013017903A1/en not_active Ceased
- 2011-08-03 PL PL11770507.9T patent/PL2739605T3/pl unknown
- 2011-08-03 EP EP11770507.9A patent/EP2739605B1/en not_active Not-in-force
- 2011-08-03 CN CN201180072630.4A patent/CN103827078B/zh not_active Expired - Fee Related
- 2011-08-03 ES ES11770507.9T patent/ES2577177T3/es active Active
- 2011-08-03 EA EA201400188A patent/EA024650B1/ru not_active IP Right Cessation
- 2011-08-03 US US14/236,772 patent/US20150291508A1/en not_active Abandoned
- 2011-08-03 IN IN348CHN2014 patent/IN2014CN00348A/en unknown
- 2011-08-03 DK DK11770507.9T patent/DK2739605T3/en active
- 2011-08-03 SI SI201130880A patent/SI2739605T1/sl unknown
- 2011-08-03 HU HUE11770507A patent/HUE030282T2/en unknown
- 2011-08-03 HR HRP20160767TT patent/HRP20160767T1/hr unknown
- 2011-08-03 CA CA2843827A patent/CA2843827A1/en not_active Abandoned
-
2016
- 2016-07-20 CY CY20161100712T patent/CY1117823T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2319827A1 (en) * | 2009-11-09 | 2011-05-11 | Ratiopharm GmbH | Process for the production of polymorph form I of agomelatine |
| CN101921205A (zh) * | 2010-08-30 | 2010-12-22 | 江苏恩华药业股份有限公司 | 阿戈美拉汀ⅰ晶型的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| SI2739605T1 (sl) | 2016-08-31 |
| EA024650B1 (ru) | 2016-10-31 |
| EP2739605B1 (en) | 2016-04-27 |
| WO2013017903A1 (en) | 2013-02-07 |
| EA201400188A1 (ru) | 2014-07-30 |
| DK2739605T3 (en) | 2016-07-25 |
| ES2577177T3 (es) | 2016-07-13 |
| PL2739605T3 (pl) | 2016-11-30 |
| BR112014002523A2 (pt) | 2017-03-14 |
| EP2739605A1 (en) | 2014-06-11 |
| CN103827078A (zh) | 2014-05-28 |
| IN2014CN00348A (enExample) | 2015-04-03 |
| HUE030282T2 (en) | 2017-05-29 |
| HRP20160767T1 (hr) | 2016-08-12 |
| CY1117823T1 (el) | 2017-05-17 |
| US20150291508A1 (en) | 2015-10-15 |
| PT2739605E (pt) | 2016-06-20 |
| CA2843827A1 (en) | 2013-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150805 Termination date: 20180803 |