CN103827078B - 制备阿戈美拉汀的晶型i的方法 - Google Patents

制备阿戈美拉汀的晶型i的方法 Download PDF

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Publication number
CN103827078B
CN103827078B CN201180072630.4A CN201180072630A CN103827078B CN 103827078 B CN103827078 B CN 103827078B CN 201180072630 A CN201180072630 A CN 201180072630A CN 103827078 B CN103827078 B CN 103827078B
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CN
China
Prior art keywords
agomelatine
solvent
solution
organic solvent
crystal form
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Expired - Fee Related
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CN201180072630.4A
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English (en)
Chinese (zh)
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CN103827078A (zh
Inventor
G·贝尔托利尼
B·德安杰利斯
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Laboratorio Chimico Internazionale SpA
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Laboratorio Chimico Internazionale SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Battery Electrode And Active Subsutance (AREA)
CN201180072630.4A 2011-08-03 2011-08-03 制备阿戈美拉汀的晶型i的方法 Expired - Fee Related CN103827078B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2011/001805 WO2013017903A1 (en) 2011-08-03 2011-08-03 Process for the preparation of crystalline form i of agomelatine

Publications (2)

Publication Number Publication Date
CN103827078A CN103827078A (zh) 2014-05-28
CN103827078B true CN103827078B (zh) 2015-08-05

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Country Link
US (1) US20150291508A1 (enExample)
EP (1) EP2739605B1 (enExample)
CN (1) CN103827078B (enExample)
BR (1) BR112014002523A2 (enExample)
CA (1) CA2843827A1 (enExample)
CY (1) CY1117823T1 (enExample)
DK (1) DK2739605T3 (enExample)
EA (1) EA024650B1 (enExample)
ES (1) ES2577177T3 (enExample)
HR (1) HRP20160767T1 (enExample)
HU (1) HUE030282T2 (enExample)
IN (1) IN2014CN00348A (enExample)
PL (1) PL2739605T3 (enExample)
PT (1) PT2739605E (enExample)
SI (1) SI2739605T1 (enExample)
WO (1) WO2013017903A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104876830A (zh) * 2015-06-09 2015-09-02 江苏中邦制药有限公司 一种阿戈美拉汀i晶型晶体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101921205A (zh) * 2010-08-30 2010-12-22 江苏恩华药业股份有限公司 阿戈美拉汀ⅰ晶型的制备方法
EP2319827A1 (en) * 2009-11-09 2011-05-11 Ratiopharm GmbH Process for the production of polymorph form I of agomelatine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658818B1 (fr) 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2866335B1 (fr) 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine
CN101704763B (zh) 2009-11-25 2012-03-28 天津泰普药品科技发展有限公司 阿戈美拉汀i型晶体的制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2319827A1 (en) * 2009-11-09 2011-05-11 Ratiopharm GmbH Process for the production of polymorph form I of agomelatine
CN101921205A (zh) * 2010-08-30 2010-12-22 江苏恩华药业股份有限公司 阿戈美拉汀ⅰ晶型的制备方法

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Publication number Publication date
BR112014002523A2 (pt) 2017-03-14
HRP20160767T1 (hr) 2016-08-12
SI2739605T1 (sl) 2016-08-31
HUE030282T2 (en) 2017-05-29
PT2739605E (pt) 2016-06-20
WO2013017903A1 (en) 2013-02-07
CA2843827A1 (en) 2013-02-07
EP2739605A1 (en) 2014-06-11
ES2577177T3 (es) 2016-07-13
DK2739605T3 (en) 2016-07-25
CY1117823T1 (el) 2017-05-17
US20150291508A1 (en) 2015-10-15
EP2739605B1 (en) 2016-04-27
PL2739605T3 (pl) 2016-11-30
IN2014CN00348A (enExample) 2015-04-03
CN103827078A (zh) 2014-05-28
EA024650B1 (ru) 2016-10-31
EA201400188A1 (ru) 2014-07-30

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