CN103800766A - Chinese medicinal composition for prevention and treatment of aquatic animal parasites, preparation method and application thereof - Google Patents
Chinese medicinal composition for prevention and treatment of aquatic animal parasites, preparation method and application thereof Download PDFInfo
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- CN103800766A CN103800766A CN201210447171.XA CN201210447171A CN103800766A CN 103800766 A CN103800766 A CN 103800766A CN 201210447171 A CN201210447171 A CN 201210447171A CN 103800766 A CN103800766 A CN 103800766A
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Abstract
The invention relates to a Chinese medicinal composition for prevention and treatment of aquatic animal parasites. The Chinese medicinal composition comprises the following components by weight: 10-30 parts of sophora flavescens; 20-50 parts of Phytolacca acinosa; 10-30 parts of Stemona japonica; 5-15 parts of Antifebrile Dichroa; and 10-30 parts of spina date seeds. The Chinese medicinal composition provided by the invention contains a variety of active ingredients for killing parasites, has no toxic or side effect, does not produce drug residue, is convenient to use, has high parasite killing efficiency and is difficult to generate drug resistance, is easy to be decomposed, and has no influence to the environment.
Description
Technical field
The invention belongs to field of veterinary, especially parasitic Chinese medicine composition of a kind of control aquatic animal and preparation method thereof.
Background technology
China is the country of aquaculture amount maximum in the world, and in recent years, Chinese Lakes, river, marine site, reservoir, rice field Aquatic product cultured area are progressively expanding, and agricultural, fishery, hydraulic department are all at participation aquaculture.Except Qinghai-Tibet Platean, each province and city, the equal cultivating large area fresh-water fishes of autonomous region.China's sea water cultured output increases progressively more than 10% every year, within 2006, Chinese exports aquatic products total value reaches 89.7 hundred million dollars, in the face of the market trend who becomes better and better, some problems that run in aquaculture are badly in need of solving, for example, in water body, parasite affects the problem of the output value, and the parasite in aquaculture has following kind at present: Trichodina, little melonworm, ciliate, sporozoon, oblique tube insect, dactylogyrider etc., in annual aquaculture, parasite all can be caused very large loss to culture fishery.In the process of control parasite in aquiculture, now a large amount of uses is chemicals as a series of in metrifonate, potassium permanganate etc. and chemical pesticide, although this series of chemicals and chemical pesticide play an important role in the process of control parasite in aquiculture, but still exist the toxic and side effects of chemicals and chemical pesticide larger, may have influence on the healthy of eater; Chemicals and chemical pesticide natural degradation in water body is slow, and target worm drug resistance constantly strengthens, and causes the increasing vicious cycle of dosage; Chemicals and chemical pesticide can make the drug residue in the bodies such as fish in aquaculture, shrimp, Eriocheir sinensis exceed standard, and have had a strong impact on the outlet of China's aquaculture series products and the international fame of China's aquatic products.
Summary of the invention
The object of the present invention is to provide the parasitic Chinese medicine composition of a kind of control aquatic animal, this Chinese medicine composition contains multiple parasiticidal effective ingredient, has no side effect and drug residue, easy to use, cost is lower, the high and difficult generation drug resistance to parasitic kill efficiency.
Another object of the present invention is to provide a kind of preparation method of preventing and treating the parasitic Chinese medicine composition of aquatic animal.
The present invention is achieved by the following technical solutions:
The parasitic Chinese medicine composition of a kind of control aquatic animal, its Chinese medicine composition component and percentage by weight thereof are respectively:
Radix Sophorae Flavescentis 10-30 part;
Radix Phytolaccae 20-50 part;
Radix Stemonae 10-30 part;
Radix Dichroae 5-15 part;
Semen Ziziphi Spinosae 10-30 part.
And said composition component and optimum ratio of weight and number thereof are respectively:
22 parts of Radix Sophorae Flavescentiss;
36 parts of Radix Phytolaccaes;
18 parts of the Radixs Stemonae;
12 parts of Radix Dichroaes;
23 parts of Semen Ziziphi Spinosaes.
Prevent and treat a preparation method for the parasitic Chinese medicine composition of aquatic animal, the step of its preparation method is as follows:
(1) take by weight ratio that Radix Sophorae Flavescentis, Radix Phytolaccae, the Radix Stemonae, Radix Dichroae add 8 times of amounts, 6 times of water gagings decoct twice, each 1 hour, decocting liquid obtained A decocting liquid after merging, for subsequent use;
(2) take Semen Ziziphi Spinosae according to weight proportion, after pulverizing, decoct with water 3 times, 2 hours for the first time, for the second time and each 1 hour for the third time, merge decoction liquor, filter, filtrate be concentrated into relative density be 1.20～1.25 and in the time of 80 ℃, add 2mol/L hydrochloric acid solution regulate pH value to 1.0～2.0, be incubated 1 hour, leave standstill 11～13 hours, filter, be precipitated, in precipitation, add 6～8 times of water gagings, form mixed liquor, with 40% sodium hydroxide solution adjust pH to 7.0, the alcoholic solution that to add with the isopyknic concentration of mixed liquor be 90～95% again, be stirred to dissolve, filter, filtrate is used 2mol/L hydrochloric acid solution adjust pH to 2.0, at 55～65 ℃, be incubated 25～35 minutes, leave standstill 10～14 hours, filter, precipitation is washed till pH value to 7.0 with ethanol, wave after most ethanol, merge with gained A decocting liquid in step (1), being concentrated into density reaches 1.20g/ml and obtains B decocting liquid, for subsequent use,
(3) by the spray-dried device of step (2) gained B decocting liquid, at 120 ℃, 250 turn under condition, are spray dried to fine powder, obtain the parasitic Chinese medicine composition finished product of a kind of control aquatic animal.
Advantage of the present invention and beneficial effect are:
1, the present invention contains Radix Sophorae Flavescentis, Radix Phytolaccae, the Radix Stemonae and Radix Dichroae, its effective ingredient is the structure that nature itself has, can be by biological decomposition or photolysis at occurring in nature, also can oxidation by air, and in application, can not produce drug residue, can enrichment method and contaminated environment yet, killing in parasitic process, the quality of the aquatic products such as fish, shrimp, Eriocheir sinensis is not exerted an influence.
2, preparation method of the present invention is simple, and cost is lower, and its effective ingredient can easily be absorbed by cultivated animals, and the time is short, efficiency is high.
3, the invention by Chinese medicine composition through extraction process process after; use spray drying device that extracting solution is dusted fast; change traditional drying technique in the past, greatly reduced production time and production cost, protected the effective ingredient in Chinese medicine extract can at high temperature not go bad.After the shower nozzle ejection of the spray-dried device high speed rotating of Chinese medicine extraction liquid, without pulverizing, be dried to rapidly micropowders, be beneficial to body and absorb, can greatly reduce dosage and dispensing time, reduce aquaculture cost.
The specific embodiment
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Radix Sophorae Flavescentis, Radix Phytolaccae, the Radix Stemonae, Radix Dichroae and Semen Ziziphi Spinosae in the present invention all can be bought and obtain on market.
Embodiment 1
The parasitic Chinese medicine composition of a kind of control aquatic animal, its Chinese medicine composition component and weight thereof are respectively: Radix Sophorae Flavescentis 10kg; Radix Phytolaccae 20kg; Radix Stemonae 10kg; Radix Dichroae 5kg; Semen Ziziphi Spinosae 10kg.
Prevent and treat a preparation method for the parasitic Chinese medicine composition of aquatic animal, its step is as follows:
(1) take by weight ratio that Radix Sophorae Flavescentis, Radix Phytolaccae, the Radix Stemonae, Radix Dichroae add 8 times of amounts, 6 times of water gagings decoct twice, each 1 hour, decocting liquid obtained A decocting liquid after merging, for subsequent use;
(2) take Semen Ziziphi Spinosae according to weight proportion, after pulverizing, decoct with water 3 times, 2 hours for the first time, for the second time and each 1 hour for the third time, merge decoction liquor, filter, filtrate be concentrated into relative density be 1.20～1.25 and in the time of 80 ℃, add 2mol/L hydrochloric acid solution regulate pH value to 1.0～2.0, be incubated 1 hour, leave standstill 11～13 hours, filter, be precipitated, in precipitation, add 6～8 times of water gagings, form mixed liquor, with 40% sodium hydroxide solution adjust pH to 7.0, the alcoholic solution that to add with the isopyknic concentration of mixed liquor be 90～95% again, be stirred to dissolve, filter, filtrate is used 2mol/L hydrochloric acid solution adjust pH to 2.0, at 55～65 ℃, be incubated 25～35 minutes, leave standstill 10～14 hours, filter, precipitation is washed till pH value to 7.0 with ethanol, wave after most ethanol, merge with gained A decocting liquid in step (1), being concentrated into density reaches 1.20g/ml and obtains B decocting liquid, for subsequent use,
(3) by the spray-dried device of step (2) gained B decocting liquid, at 120 ℃, 250 turn under condition, are spray dried to fine powder, obtain the parasitic Chinese medicine composition finished product of a kind of control aquatic animal.
Embodiment 2
The parasitic Chinese medicine composition of a kind of control aquatic animal, its Chinese medicine composition component and weight thereof are respectively: Radix Sophorae Flavescentis 30kg; Radix Phytolaccae 50kg; Radix Stemonae 30kg; Radix Dichroae 15kg; Semen Ziziphi Spinosae 30kg.
The step of its preparation method is with embodiment 1.
Embodiment 3
The parasitic Chinese medicine composition of a kind of control aquatic animal, its Chinese medicine composition component and weight thereof are respectively: Radix Sophorae Flavescentis 20kg; Radix Phytolaccae 35kg; Radix Stemonae 15kg; Radix Dichroae 12kg; Semen Ziziphi Spinosae 26kg.
The step of its preparation method is with embodiment 1.
Embodiment 4
The parasitic Chinese medicine composition of a kind of control aquatic animal, its Chinese medicine composition component and weight thereof are respectively: Radix Sophorae Flavescentis 22kg; Radix Phytolaccae 36kg; Radix Stemonae 18kg; Radix Dichroae 12kg; Semen Ziziphi Spinosae 23kg.
The step of its preparation method is with embodiment 1.
The present invention's use of can directly splashing in breeding water body, dosage is pressed 10-15kg/ mu
Clinical trial
1, test method
In the aquarium of 3 formed objects, add respectively the tap water of gas explosion, 100L/ case, in each experimental box, add the tilapia Seedling that has infected trichodinasis, 15 tails/cylinder, if blank group, copper sulfate and Ferrous Sulphate for Treatment group and test group of the present invention, the regularly gill portion of (every 24h) microscopy experiment fish, the variation of the infected degree of checking experiment fish.
2, result of the test
Survival rate by each group fish after different treatment group medication 24,48,72,96h can find out, in medication 24h, the sick fish survival rate for the treatment of group of the present invention is a little more than copper sulfate and Ferrous Sulphate for Treatment matched group; During to 48h, the survival rate for the treatment of group of the present invention has been significantly higher than copper sulfate and Ferrous Sulphate for Treatment group; After 96h, check live fish discovery, the fish body surface for the treatment of group of the present invention is clean, vigor is obviously better than matched group, illustrate that the present invention has good therapeutical effect to Fish trichodinasis, microscopy found that in addition, other parasite quantity on the fish gill is also less than before test, and wherein dactylogyrider is all killed, and illustrates that the present invention treats in addition other parasite of Fish and kills the effect of Fish dactylogyrider.
The present invention is pressed to 0.1ppm external, the killing rate of Trichodina is reached more than 95%, the killing rate of little melonworm is reached more than 92%, the killing rate of dactylogyrider is reached more than 90%, the killing rate of Myxosporean is reached more than 95%, the killing rate of anchor head Sao is reached more than 92%, the killing rate of oblique tube insect is reached more than 96%.
Claims (3)
1. the parasitic Chinese medicine composition of control aquatic animal, is characterized in that: this Chinese medicine composition component and percentage by weight thereof are respectively:
Radix Sophorae Flavescentis 10-30 part;
Radix Phytolaccae 20-50 part;
Radix Stemonae 10-30 part;
Radix Dichroae 5-15 part;
Semen Ziziphi Spinosae 10-30 part.
2. the parasitic Chinese medicine composition of a kind of control aquatic animal according to claim 1, is characterized in that: said composition component and optimum ratio of weight and number thereof are respectively:
22 parts of Radix Sophorae Flavescentiss;
36 parts of Radix Phytolaccaes;
18 parts of the Radixs Stemonae;
12 parts of Radix Dichroaes;
23 parts of Semen Ziziphi Spinosaes.
3. an a kind of preparation method of preventing and treating the parasitic Chinese medicine composition of aquatic animal as claimed in claim 1, is characterized in that: the step of this preparation method is:
(1) take by weight ratio that Radix Sophorae Flavescentis, Radix Phytolaccae, the Radix Stemonae, Radix Dichroae add 8 times of amounts, 6 times of water gagings decoct twice, each 1 hour, decocting liquid obtained A decocting liquid after merging, for subsequent use;
(2) take Semen Ziziphi Spinosae according to weight proportion, after pulverizing, decoct with water 3 times, 2 hours for the first time, for the second time and each 1 hour for the third time, merge decoction liquor, filter, filtrate be concentrated into relative density be 1.20～1.25 and in the time of 80 ℃, add 2mol/L hydrochloric acid solution regulate pH value to 1.0～2.0, be incubated 1 hour, leave standstill 11～13 hours, filter, be precipitated, in precipitation, add 6～8 times of water gagings, form mixed liquor, with 40% sodium hydroxide solution adjust pH to 7.0, the alcoholic solution that to add with the isopyknic concentration of mixed liquor be 90～95% again, be stirred to dissolve, filter, filtrate is used 2mol/L hydrochloric acid solution adjust pH to 2.0, at 55～65 ℃, be incubated 25～35 minutes, leave standstill 10～14 hours, filter, precipitation is washed till pH value to 7.0 with ethanol, wave after most ethanol, merge with gained A decocting liquid in step (1), being concentrated into density reaches 1.20g/ml and obtains B decocting liquid, for subsequent use,
(3) by the spray-dried device of step (2) gained B decocting liquid, at 120 ℃, 250 turn under condition, are spray dried to fine powder, obtain the parasitic Chinese medicine composition finished product of a kind of control aquatic animal.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108261518A (en) * | 2016-12-31 | 2018-07-10 | 天津瑞贝特科技发展有限公司 | Prevent Chinese medicine composition of aquatic livestock parasite and preparation method thereof |
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| CN101618168A (en) * | 2008-07-04 | 2010-01-06 | 天津瑞贝特科技发展有限公司 | Chinese medicinal composition for preventing and controlling parasite in aquiculture and preparation method and application thereof |
| CN101810848A (en) * | 2009-11-09 | 2010-08-25 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composite for reducing stress response of aquatic animals and preparation method and application thereof |
| CN101810690A (en) * | 2009-11-16 | 2010-08-25 | 天津瑞贝特科技发展有限公司 | Livestock Chinese medicinal composition for enhancing body immunity and preparation method thereof |
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- 2012-11-12 CN CN201210447171.XA patent/CN103800766A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618168A (en) * | 2008-07-04 | 2010-01-06 | 天津瑞贝特科技发展有限公司 | Chinese medicinal composition for preventing and controlling parasite in aquiculture and preparation method and application thereof |
| CN101810848A (en) * | 2009-11-09 | 2010-08-25 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composite for reducing stress response of aquatic animals and preparation method and application thereof |
| CN101810690A (en) * | 2009-11-16 | 2010-08-25 | 天津瑞贝特科技发展有限公司 | Livestock Chinese medicinal composition for enhancing body immunity and preparation method thereof |
Non-Patent Citations (1)
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| 邢跃楠等: "中草药在水产养殖中应用的研究进展", 《中国水产》, no. 04, 5 April 2007 (2007-04-05), pages 64 - 66 * |
Cited By (1)
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| CN108261518A (en) * | 2016-12-31 | 2018-07-10 | 天津瑞贝特科技发展有限公司 | Prevent Chinese medicine composition of aquatic livestock parasite and preparation method thereof |
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Application publication date: 20140521 |