CN109821004A - A kind of composition and preparation method thereof with sobering up and liver protecting functions - Google Patents
A kind of composition and preparation method thereof with sobering up and liver protecting functions Download PDFInfo
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Abstract
The present invention relates to functional food field, especially a kind of composition and preparation method thereof with sobering up and liver protecting functions.Composition of the invention is made including following components by weight: 40-60 parts of hoveniae semoveniae semen, 30-40 parts of pueraria lobata, 21-35 parts of rhizoma imperatae, 4-7 parts of dark plum, 20-30 parts of antierythrite, 8-15 parts of maize oligopeptide, 21-26 parts of microcrystalline cellulose, 0.1-0.3 parts of magnesium stearate, 0.05-0.6 parts of curcumin.Composition of the invention contains the extract and purifying biological active constituent of wholefood, has effective sobering up and liver protecting functions；It is a kind of health-oriented products of sugar-free using antierythrite as generation sugar；Component be free of in, western drug ingredient, it is safe to eat.The effect of preparation method of the invention is simple, can effectively play each component, high production efficiency are suitable for industrialized production.
Description
Technical field
The present invention relates to functional food fields, especially a kind of with the composition of sobering up and liver protecting functions and its preparation side
Method.
Background technique
With development social now, people also increase the demand of alcohol, and health problem caused by wine is also got over
It has carried out the coffin upon burial the concern of people.It is drunk to be damaged caused by human health greatly, on the one hand, alcohol can be to corticocerebral excitement
Inhibiting effect is generated, person's development speed and accuracy are reduced, after drunk, serious person can enter sound sleep coma stage, what is more can
Therefore dead；On the other hand, about 90% alcohol is by liver metabolism, and the excessive drunk alcohol metabolism product that will lead to is to human body
The destruction of liver cell injures liver.The product of relieving alcoholism and protecting liver can be divided into chemicals, Chinese materia medica preparation, three kinds of health care product at present,
Chemicals and Chinese materia medica preparation can cause metabolic burden to liver, kidney, generate different degrees of injury while relieving the effect of alcohol.
Develop a kind of need for meeting market without the product to human body generation toxic side effect with sobering up and liver protecting functions
It asks.However, current product has the following problems: the component effect contained is unknown or preparation method cannot effectively play its component
The effect of, cause most products without healthcare function or its healthcare function without scientific appraisal；Contain traditional participation machine
The sugar of body metabolism, it is edible excessively to cause added burden to body, functional food daily consumption should not be used as；It is added to body
The auxiliary material of body generation toxic side effect.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide a kind of composition with sobering up and liver protecting functions and
Preparation method.Composition of the invention contains the extract and purifying biological active constituent of wholefood, has effective
Sobering up and liver protecting functions；It is a kind of health-oriented products of sugar-free using antierythrite as generation sugar；Component used is from natural
The extract and food supplementary material of food, be free of in, western drug ingredient, it is safe to eat.Preparation method of the invention is simple,
The effect of each component can effectively be played, high production efficiency are suitable for industrialized production.
The invention adopts the following technical scheme:
A kind of composition with sobering up and liver protecting functions, is made: hoveniae semoveniae semen including following components by weight
40-60 parts, 30-40 parts of pueraria lobata, 21-35 parts of rhizoma imperatae, 4-7 parts of dark plum, 20-30 parts of antierythrite, 8-15 parts of maize oligopeptide,
21-26 parts of microcrystalline cellulose, 0.1-0.3 parts of magnesium stearate, 0.05-0.6 parts of curcumin.
A kind of composition with sobering up and liver protecting functions, is made: hoveniae semoveniae semen including following components by weight
50 parts, 37.5 parts of pueraria lobata, 25 parts of rhizoma imperatae, 5 parts of dark plum, 25.7 parts of antierythrite, 10 parts of maize oligopeptide, microcrystalline cellulose
24.5 parts, 0.26 part of magnesium stearate, 0.05 part of curcumin.
A kind of composition with sobering up and liver protecting functions, is made: hoveniae semoveniae semen including following components by weight
42 parts, it is 30 parts of pueraria lobata, 22 parts of rhizoma imperatae, 4 parts of dark plum, 20 parts of antierythrite, 8 parts of maize oligopeptide, 21 parts of microcrystalline cellulose, hard
0.1 part of fatty acid magnesium, 0.6 part of curcumin.
A kind of composition with sobering up and liver protecting functions, is made: hoveniae semoveniae semen including following components by weight
60 parts, 40 parts of pueraria lobata, 32 parts of rhizoma imperatae, 7 parts of dark plum, 28 parts of antierythrite, 15 parts of maize oligopeptide, 25 parts of microcrystalline cellulose,
0.3 part of magnesium stearate, 0.3 part of curcumin.
Hoveniae semoveniae semen: the mature seed of Rhamnaceae trifoliate orange Dulcis platymiscium, with relieving alcoholism, relieving restlessness of quenching the thirst, preventing or arresting vomiting, sharp stool and urine
Effect is usually used in drunk, polydipsia, vomiting, difficulty in urination and defecation.
Pueraria lobata:, can relieve muscle fever and thirst, promoting eruption, clearing and activating the channels and collaterals, relieving alcoholism for the root of legume pueraria lobata.
Polysaccharide and flavone compound in hoveniae semoveniae semen, pueraria lobata also have protect liver, remove free radical, antifatigue, enhancing machine
Body immunity, the physiological activity such as build up health.
Rhizoma imperatae: the rhizome of gramineae plant cogongrass has the effect of cool blood, reducing fever and causing diuresis, the hot relieving thirst and restlessness that is usually used in dispelling,
The clear jaundice of clearing damp.
Dark plum: the ripening fruits of rose department plant plum has the benefits of promoting the production of body fluid, quench one's thirst, anti-nausea.
Above four be integration of drinking and medicinal herbs food, and property is mild, has no toxic side effect, and takes four individually to extract resulting extraction
Object is combined the preparation of object, can remove useless and not edible part, and functional component is concentrated, has both promoted mouthfeel, instant edible,
Also the effect of product relieving alcoholism and protecting liver is promoted.
Maize oligopeptide: using corn as raw material, generation is hydrolyzed under given conditions through Protein Extraction, specific protease
Target peptide fragment, using separation, purifying etc. the refined efficient bio-active substance of processes, have it is anti-oxidant, antifatigue, mention
It high immunity, especially protect liver and relieves the effect of alcohol and other effects.
Curcumin: the diketone substance extracted from the rhizome of zingiberaceous plant turmeric has sterilization, reducing blood lipid, resists
Tumour, prevention senile dementia and other effects, in the present invention, curcumin has the function of anti-inflammatory, anti-oxidant, protect liver cholagogue etc.
Effect.
Maize oligopeptide, curcumin are the bioactive ingredients that extraction purification obtains from common food raw material,
Body can be used as ordinary food raw material, therefore have effects that the characteristics of edible safety, content of material are high, activity is strong, obvious effect.
By four kinds of hoveniae semoveniae semen, pueraria lobata, rhizoma imperatae, dark plum extracts, add bioactive ingredients maize oligopeptide and
Curcumin, various substance synergistic effects, the effect of existing extract mildly improved promote body detoxification and reinvigoration, from
The comprehensive improvement body of multipath promotes the purpose of liver detoxification ability to reach maintenance liver, and has maize oligopeptide, turmeric
The high activity of element, can be with fast lifting liver function, removing free radical to reduce damage of the Ethanol intake to liver.Various components are comprehensive
Cooperation is used, and is learnt from other's strong points to offset one's weaknesses, synergistic, preferably plays the function of relieving alcoholism and protecting liver.
Antierythrite: antierythrite is a kind of novel polyol sweeteners, be widely present in nature animals and plants and
In fungi.Antierythrite calorific value is low, mouthfeel is good, causes digestive discomfort, nothing to diabetes patient's safety, azymic after human body is edible
Cariogenic tooth, and have many advantages, such as that taste flavor is excellent.Due to its good crystallinity, hygroscopicity is low, stablizes to heat and acid,
In composition preparation, in addition to assigning product health sweet taste, it can also make end product properties stabilization, long shelf-life, not send out in storage life
Raw brown stain, disintegration or moisture absorption etc..
The preparation method of combinations of the above object, comprising the following steps:
(1) hoveniae semoveniae semen, pueraria lobata, rhizoma imperatae, dark plum are decocted 2 times with water respectively, is decocted for the first time with the water of 7-8 times of weight
1.2-1.5 hours, second of the water with 5-6 times of weight decocted 0.8-1 hours, and then 2 decoction liquors are merged and are concentrated, point
Raisin tree seed extract, kudzu root extract, cogongrass rhizome extractive, smoked plum extractive are not obtained；
(2) raisin tree seed extract, kudzu root extract, cogongrass rhizome extractive, smoked plum extractive, antierythrite, corn is low
Poly- peptide, microcrystalline cellulose, curcumin are uniformly mixed, and obtain mixture；Mixture is pelletized by 16 meshes, obtains particulate matter A；
(3) for dry particle object A to its moisture≤5.0%, dry temperature is 50-60 DEG C, and the time is 0.8-1.5 hours,
Then by 18 mesh sieves, particulate matter B is obtained；
(4) particulate matter B is uniformly mixed with magnesium stearate, is then suppressed, obtains composition.
Preferably, the parts by weight of raisin tree seed extract described in step (1) are 6-6.5 parts, the weight of the kudzu root extract
Measuring part is 7-7.5 parts, and the parts by weight of the cogongrass rhizome extractive are 6-7 parts, the parts by weight of the smoked plum extractive are 0.8-1.2
Part.
Preferably, combined decoction liquor is concentrated into relative density is 1.25-1.30, and the temperature of concentration is 55-65 DEG C.
In the present invention, the proportion and preparation step of each component for the stability of composition of the invention, effect extremely
It closes important.Inventor is by practice discovery, after such as mixing hoveniae semoveniae semen, pueraria lobata, rhizoma imperatae, dark plum ratio same as the present invention
The same terms extract again, and the volume factor of the viscosity enhancing, homogenous quantities concentrate that will lead to extract concentrated solution increases, is hot to the cold
The variation of property influences the preparation of composition and destroys the structure of wherein active component so that subsequent process is difficult to carry out,
The effect of influencing component.Therefore, the present invention respectively extracts hoveniae semoveniae semen, pueraria lobata, rhizoma imperatae, dark plum, then carries out again
Mixing.By the optimization of the proportion and preparation step of each component science, the smooth processing and the matter of finished product of product ensure that
Measure stability, effect.
The utility model has the advantages that
(1) composition of the invention contains the extract and purifying biological active constituent from wholefood, various
Component plays coordinative role, has effective sobering up and liver protecting functions；
(2) composition of the invention participates in the sugar of organism metabolism without tradition using antierythrite as generation sugar, eats
After will not cause added burden to body, reduce high-carbonhydrate diet damage caused by liver, be conducive to prevent the livers such as fatty liver
The formation that popular name for becomes maintains good ability of relieving the effect of alcohol to protect liver；Containing there are many extract of wholefood, mouths
Ganfeng is rich, and taste is pure and fresh palatable；
(3) component used in composite formula of the invention be from wholefood extract and food original it is auxiliary
Material, be free of in, western drug ingredient, toxic side effect, edible safety will not be caused to body；
(4) preparation method of the invention is simple, and the function of each component can be effectively played by simple manufacturing condition
Effect, high production efficiency are suitable for industrialized production.
Specific embodiment
Below by embodiment, the present invention will be described in detail.
Embodiment 1
A kind of composition with sobering up and liver protecting functions, is made: hoveniae semoveniae semen including following components by weight
50 parts, 37.5 parts of pueraria lobata, 25 parts of rhizoma imperatae, 5 parts of dark plum, 25.7 parts of antierythrite, 10 parts of maize oligopeptide, microcrystalline cellulose
24.5 part, 0.26 part of magnesium stearate, 0.05 part of curcumin.
The preparation method of combinations of the above object, comprising the following steps:
(1) hoveniae semoveniae semen, pueraria lobata, rhizoma imperatae, dark plum are decocted 2 times with water respectively, is decocted for the first time with the water of 8 times of weight
1.5 hours, second was decocted 1 hour with the water of 6 times of weight, then merged 2 decoction liquors, and temperature be at 60 DEG C it is dense
Being reduced to relative density is 1.30, respectively obtains 6 parts of raisin tree seed extract, 7 parts of kudzu root extract, 6.8 parts of cogongrass rhizome extractive, crow
1 part of prunus mume extract；
(2) raisin tree seed extract, kudzu root extract, cogongrass rhizome extractive, smoked plum extractive, antierythrite, corn is low
Poly- peptide, microcrystalline cellulose, curcumin are uniformly mixed, and obtain mixture；Mixture is pelletized by 16 meshes, obtains particulate matter A；
(3) for dry particle object A to its moisture≤5.0%, dry temperature is 60 DEG C, and the time is 1 hour, then passes through 18
Mesh sieve obtains particulate matter B；
(4) particulate matter B is uniformly mixed with magnesium stearate, is then suppressed, obtains composition.
Embodiment 2
A kind of composition with sobering up and liver protecting functions, is made: hoveniae semoveniae semen including following components by weight
42 parts, it is 30 parts of pueraria lobata, 22 parts of rhizoma imperatae, 4 parts of dark plum, 20 parts of antierythrite, 8 parts of maize oligopeptide, 21 parts of microcrystalline cellulose, hard
0.1 part of fatty acid magnesium, 0.6 part of curcumin.
The preparation method of combinations of the above object, comprising the following steps:
(1) hoveniae semoveniae semen, pueraria lobata, rhizoma imperatae, dark plum are decocted 2 times with water respectively, is decocted for the first time with the water of 7 times of weight
1.5 hours, second was decocted 1 hour with the water of 5 times of weight, then merged 2 decoction liquors, and temperature be at 65 DEG C it is dense
Being reduced to relative density is 1.25, respectively obtains 6 parts of raisin tree seed extract, 7 parts of kudzu root extract, 6 parts of cogongrass rhizome extractive, dark plum
0.8 part of extract；
(2) raisin tree seed extract, kudzu root extract, cogongrass rhizome extractive, smoked plum extractive, antierythrite, corn is low
Poly- peptide, microcrystalline cellulose, curcumin are uniformly mixed, and obtain mixture；Mixture is pelletized by 16 meshes, obtains particulate matter A；
(3) for dry particle object A to its moisture≤5.0%, dry temperature is 55 DEG C, and the time is 1.5 hours, is then passed through
18 mesh sieves obtain particulate matter B；
(4) particulate matter B is uniformly mixed with magnesium stearate, is then suppressed, obtains composition.
Embodiment 3
A kind of composition with sobering up and liver protecting functions, is made: hoveniae semoveniae semen including following components by weight
60 parts, 40 parts of pueraria lobata, 32 parts of rhizoma imperatae, 7 parts of dark plum, 28 parts of antierythrite, 15 parts of maize oligopeptide, 25 parts of microcrystalline cellulose,
0.3 part of magnesium stearate, 0.3 part of curcumin.
The preparation method of combinations of the above object, comprising the following steps:
(1) hoveniae semoveniae semen, pueraria lobata, rhizoma imperatae, dark plum are decocted 2 times with water respectively, is decocted for the first time with the water of 8 times of weight
1.2 hours, second of the water with 6 times of weight decocted 0.8 hour, then merged 2 decoction liquors, and in the case where temperature is 55 DEG C
Being concentrated into relative density is 1.25, respectively obtains 6.5 parts of raisin tree seed extract, 7.5 parts of kudzu root extract, cogongrass rhizome extractive 6
Part, 1.2 parts of smoked plum extractive；
(2) raisin tree seed extract, kudzu root extract, cogongrass rhizome extractive, smoked plum extractive, antierythrite, corn is low
Poly- peptide, microcrystalline cellulose, curcumin are uniformly mixed, and obtain mixture；Mixture is pelletized by 16 meshes, obtains particulate matter A；
(3) for dry particle object A to its moisture≤5.0%, dry temperature is 50 DEG C, and the time is 1.5 hours, is then passed through
18 mesh sieves obtain particulate matter B；
(4) particulate matter B is uniformly mixed with magnesium stearate, is then suppressed, obtains composition.
In order to evaluate the antialcoholism action of composition of the invention, theoretical foundation is provided for its application, has carried out following experiment:
Experimental example 1
Experiment purpose
Composition of the invention is measured to the maximal tolerable concentration of alcohol induced zebra fish excitation period drunk model
(MTC)。
Experimental animal
Wild type AB strain zebra fish, with the progress of natural paired cross modes of reproduction.Age is 5dpf (after fertilization number of days),
Totally 210 tail, every group is 30 tails.
Zebra fish, which is raised in 28 DEG C of fish culture water, (water quality: is added 200mg Instant Ocean, electricity in every 1L reverse osmosis water
Conductance is 480-510 μ S/cm；PH is 6.9-7.2；Hardness is 53.7-71.6mg/L CaCO3), experimental animal uses licensing
Number are as follows: SYXK (Zhejiang) 2012-0171.Feeding management meets the requirement of international AAALAC certification.
Experimental drug
The composition of embodiment 1 is configured to 50mg/mL mother liquor with fish culture water, and ultrasonic 10min is spare, matching while using.
Instrument and reagent
Disecting microscope (SZX7, Olympus, Japan)；The camera (VertA1) being connected with microscope；Precise electronic day
Flat (CP214, Ao Haosi, the U.S.)；6 orifice plates (flying generation, you are scientific and technological, China).Ethyl alcohol (lot number: 20170918, Chinese medicines group chemistry
Reagent Co., Ltd)
Concentration group
Normal group: fish culture water handles zebra fish；Model control group；The composition of experimental group 1:250 μ g/mL；It is real
Test a group composition of 2:500 μ g/mL；The composition of experimental group 3:1000 μ g/mL；The composition of experimental group 4:1500 μ g/mL；It is real
Test a group composition of 5:2000 μ g/mL.
Modelling
With 1.5% alcohol treatment 6dpf wild type AB strain zebra fish, zebra fish excitation period drunk model is established.
Experimental method
210 tail 5dpf wild type AB strain zebra fish are randomly selected in six orifice plates, every hole (group) handles 30 tail zebras
Fish.Experimental group 1-5 is respectively with the water-soluble composition for giving 250,500,1000,1500 and 2000 μ g/ml concentration, Normal group
And model control group handles zebra fish with fish culture water, every hole (group) capacity is 3mL.The compositions-treated 24 of various concentration is small
Shi Hou, in addition to Normal group, remaining group gives 1.5% ethyl alcohol with water-soluble, establishes zebra fish excitation period drunk model.Combination
After object and ethyl alcohol are jointly processed by 1 hour, the phenotype and death condition of zebra fish are observed and recorded, determines composition of the invention to second
The MTC of alcohol-induced zebra fish excitation period drunk model.
Experimental result
By studying the influence of composition concentration of the invention to the zebra fish death rate, composition pair of the invention is determined
The MTC of zebra fish excitation period drunk model, the results are shown in Table 1.
Table 1
| Group | Total (tail) | Death toll (tail) | The death rate (%) |
| Normal group | 30 | 0 | 0 |
| Model control group | 30 | 0 | 0 |
| Experimental group 1 | 30 | 0 | 0 |
| Experimental group 2 | 30 | 0 | 0 |
| Experimental group 3 | 30 | 0 | 0 |
| Experimental group 4 | 30 | 0 | 0 |
| Experimental group 5 | 30 | 0 | 0 |
As shown in Table 1, the composition of embodiment 1 is under 250-2000 μ g/mL concentration, to zebra fish excitation period drunk model
Any apparent toxic side effect is not generated, does not cause death yet, therefore determines that composition of the invention is drunk to zebra fish excitation period
The MTC of model is 2000 μ g/mL (this concentration is maximal tolerable concentration upper limit of detection).
Experimental example 2
Experiment purpose
Composition of the invention is measured on the excitation period ethological influence of drunk zebra fish.
Experimental animal
Wild type AB strain zebra fish, with the progress of natural paired cross modes of reproduction.Age is 5dpf, totally 240 tail, every group
For 30 tails.
The above zebra fish is raised under the same conditions in experimental example 1.
Experimental drug
The composition of embodiment 1 is configured to 50mg/mL mother liquor with fish culture water, and ultrasonic 10min is spare, matching while using.
Positive control medicine " RU21 ", white tablet, lot number 25747, shady and cool cabinet save, and are purchased from Spirit
It is spare to be configured to 100mg/mL mother liquor with ultrapure water for the U.S. Sciences.
Instrument and reagent
Disecting microscope (SZX7, Olympus, Japan)；The camera (VertA1) being connected with microscope；Precise electronic day
Flat (CP214, Ao Haosi, the U.S.)；Movement/behavioural analysis recorder (V3.11, ViewPoint Life Sciences, method
State)；6 orifice plates and 96 orifice plates (flying generation, you are scientific and technological, China)；Ethyl alcohol (lot number: 20170918, the limited public affairs of Chinese medicines group chemical reagent
Department).
Concentration group
Normal group: fish culture water handles zebra fish；Model control group；Positive controls: the RU21 of 100 μ g/mL；It is real
Test a group composition of 1:125 μ g/mL；The composition of experimental group 2:250 μ g/mL；The composition of experimental group 3:500 μ g/mL；Experiment
The composition of group 4:1000 μ g/mL；The composition of experimental group 5:2000 μ g/mL.
Modelling
With experimental example 2.
Experimental method
240 tail 5dpf wild type AB strain zebra fish are randomly selected in six orifice plates, every hole (group) handles 30 tail zebras
Fish.Experimental group 1-5 is respectively with the water-soluble composition for giving 125,250,500,1000 and 2000 μ g/mL concentration, positive controls
It gives the RU21 of 100 μ g/mL concentration, Normal group and model control group and model zebra fish, every hole is handled with fish culture water
(group) capacity is 3mL.After the composition of various concentration and RU21 handle 24 hours respectively, every group randomly select 10 tail zebra fish in
In 96 orifice plates, every 1 tail zebra fish of hole, capacity is 200 μ L, and in addition to Normal group, remaining group gives 1.5% second with water-soluble
Alcohol establishes zebra fish excitation period drunk model.The fortune of each group zebra fish in 1 hour is recorded using movement/behavioural analysis recorder
Emotionally condition, and the motion state of each group of zebra fish of videograph is shot, total move distance (D) of analysis statistics zebra fish.With
The results of statistical analysis evaluation composition of total move distance makees alcohol induced zebra fish excitation period drunk solution to model wine
With.Statistical procedures result indicates that composition is as follows to the antialcoholism action calculation formula of zebra fish with mean ± SE:
With variance analysis and Dunnett ' s T- inspection carry out statistical analysis, p < 0.05 shows with significant difference.
Experimental result
By the statistical analysis of total move distance, the composition for having rated embodiment 1 is emerging to alcohol induced zebra fish
It puts forth energy phase drunk solution to model wine effect, the results are shown in Table 2.
Table 2
Compared with model control group, p < 0.001 * p < 0.05, * * p < 0.01, * * *.
The total move distance of drunk zebra fish can dramatically increase.As shown in Table 2, total movement of the zebra fish of model control group
Distance (13764mm) is compared with Normal group (7304mm), p < 0.001, shows model foundation success.Positive controls
Total move distance of zebra fish is 11719mm, and compared with model control group, the antialcoholism action to zebra fish is 32%, is shown
RU21 has antialcoholism action to alcohol induced zebra fish excitation period drunk model.The zebra fish of experimental group 1-5 it is total movement away from
From respectively 12699,12558,11393,10588 and 10546mm, antialcoholism action is respectively 16%, 19%, 37%, 49% and
50%, compared with model control group, total move distance of the zebra fish of experimental group 3-5 has notable difference, shows embodiment 1
Composition has alcohol induced zebra fish excitation period drunk model under 500,1000 and 2000 μ g/mL concentration conditions obvious
Antialcoholism action, and be in dosage positive correlation, have the trend of relieving the effect of alcohol under 125 and 250 μ g/mL concentration conditions, but poor without statistics
It is different.
The above result shows that composition edible safety of the invention, has no toxic side effect, there is effective relieving alcoholism and protecting liver function
Energy.
Claims (7)
1. a kind of composition with sobering up and liver protecting functions, which is characterized in that including following components production by weight
At: 40-60 parts of hoveniae semoveniae semen, 30-40 parts of pueraria lobata, 21-35 parts of rhizoma imperatae, 4-7 parts of dark plum, 20-30 parts of antierythrite, corn are oligomeric
8-15 parts of peptide, 21-26 parts of microcrystalline cellulose, 0.1-0.3 parts of magnesium stearate, 0.05-0.6 parts of curcumin.
2. composition according to claim 1, which is characterized in that be made including following components by weight:
50 parts of hoveniae semoveniae semen, 37.5 parts of pueraria lobata, 25 parts of rhizoma imperatae, 5 parts of dark plum, 25.7 parts of antierythrite, 10 parts of maize oligopeptide, crystallite are fine
Tie up plain 24.5 parts, 0.26 part of magnesium stearate, 0.05 part of curcumin.
3. composition according to claim 1, which is characterized in that be made including following components by weight:
42 parts of hoveniae semoveniae semen, 30 parts of pueraria lobata, 22 parts of rhizoma imperatae, 4 parts of dark plum, 20 parts of antierythrite, 8 parts of maize oligopeptide, microcrystalline cellulose
21 parts, 0.1 part of magnesium stearate, 0.6 part of curcumin.
4. composition according to claim 1, which is characterized in that be made including following components by weight:
60 parts of hoveniae semoveniae semen, 40 parts of pueraria lobata, 32 parts of rhizoma imperatae, 7 parts of dark plum, 28 parts of antierythrite, 15 parts of maize oligopeptide, microcrystalline cellulose
25 parts, 0.3 part of magnesium stearate, 0.3 part of curcumin.
5. the preparation method of composition of any of claims 1-4, which comprises the following steps:
(1) hoveniae semoveniae semen, pueraria lobata, rhizoma imperatae, dark plum are decocted 2 times with water respectively, decocts 1.2- with the water of 7-8 times of weight for the first time
1.5 hours, second of the water with 5-6 times of weight decocted 0.8-1 hours, and then 2 decoction liquors are merged and are concentrated, respectively
To raisin tree seed extract, kudzu root extract, cogongrass rhizome extractive, smoked plum extractive；
(2) by raisin tree seed extract, kudzu root extract, cogongrass rhizome extractive, smoked plum extractive, antierythrite, maize oligopeptide,
Microcrystalline cellulose, curcumin are uniformly mixed, and obtain mixture；Mixture is pelletized by 16 meshes, obtains particulate matter A；
(3) for dry particle object A to its moisture≤5.0%, dry temperature is 50-60 DEG C, and the time is 0.8-1.5 hours, then
By 18 mesh sieves, particulate matter B is obtained；
(4) particulate matter B is uniformly mixed with magnesium stearate, is then suppressed, obtains composition.
6. the preparation method of composition according to claim 5, which is characterized in that hoveniae semoveniae semen described in step (1) extracts
The parts by weight of object are 6-6.5 parts, and the parts by weight of the kudzu root extract are 7-7.5 parts, the parts by weight of the cogongrass rhizome extractive
Parts by weight for 6-7 parts, the smoked plum extractive are 0.8-1.2 parts.
7. the preparation method of composition according to claim 5, which is characterized in that combined decoction liquor to be concentrated into relatively
Density is 1.25-1.30, and the temperature of concentration is 55-65 DEG C.
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| CN109821004B (en) | 2022-03-18 |
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