CN103783052B - A kind of novel mouse sterile bait and preparation method thereof - Google Patents
A kind of novel mouse sterile bait and preparation method thereof Download PDFInfo
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- CN103783052B CN103783052B CN201410034293.5A CN201410034293A CN103783052B CN 103783052 B CN103783052 B CN 103783052B CN 201410034293 A CN201410034293 A CN 201410034293A CN 103783052 B CN103783052 B CN 103783052B
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Abstract
The invention belongs to field of pharmacology, be specifically related to a kind of novel mouse sterile bait and preparation method thereof.The present invention adopts quinestrol and anticoagulant as active ingredient, and composition is simple, has both been applicable to male mouse, and has also been applicable to female mouse.In sterile bait, add anticoagulant, not only can deratize further, sterile bait can also be avoided the unconspicuous defect of some mouse effect.And quinestrol can reduce the toxicity of anticoagulant further, make anticoagulant longer for action time in mouse body, solve the problem of mouse food refusal further.Meanwhile, the present invention, by adding oleandrin as active ingredient, facilitates quinestrol and anticoagulant greatly to the action effect of mouse.By adopting the present invention, sterile and dead mouse is more than 97% of total number, and action effect is obvious.
Description
Technical field
The invention belongs to field of pharmacology, be specifically related to a kind of novel mouse sterile bait and preparation method thereof.
Background technology
The population that murine is most species in mammal, distribution is the widest, quantity is maximum.Rodent poison bait consumption is little, and mouse can not produce antifeedant to poison bait; Two is meet the habit that mouse steals food.Mouse is eaten to eat often and stops, and intermittently, and most chronic rodenticide is to mouse, and once edible toxicity is not too strong, also without uncomfortable sensation after mouse eats, a couple of days continuation can steal food continuously, until poison runs up to a certain amount of, mouse just can be poisoned to death.In contrast, mouse easily produces food refusal phenomenon to Apodemus agrarius, and simultaneously because Apodemus agrarius effect is rapid, part has taken food poison bait but do not reached the mouse health generation discomfort of lethal dose, can not eat second time again, also can not eat later again, be survived.Therefore, Apodemus agrarius deratization effect is poor, generally only has the control efficiency of 50% ~ 60%.
Anticoagulant rat-bane is a class chronic rodenticide the most frequently used at present.General employing low concentration, the mode of repeatedly throwing in.But along with long-term a large amount of anticoagulant that uses kills mouse, cause the resistance problem of muroid more and more outstanding, carrying out of the serious puzzlement anti-work of mouse.
At present, the sustainable control new technology of the research plague of rats is all being devoted to, especially apholate technology in countries in the world.Anti-fertility control refers to and makes male or female sexual sterilization by biology of reproduction and ecological techniques and methods, or blocks larval growth and grow, and to reduce fertility-rate, controls pest population density.Compared with killing with traditional chemistry, apholate is safer, little to the pollution of environment, comparatively light to the hazard ratio of non-target organism, easily accept by the public, the effectiveness comparison of Anti-fertility control is lasting.But only Anti-fertility control is carried out to mouse, can not the maximized control plague of rats.Sterile mouse still can bring certain economic loss.And sterile bait is not obvious to some mouse effect.
Summary of the invention
The object of this invention is to provide a kind of novel mouse sterile bait and preparation method thereof.The fertility-rate of muroid can not only be reduced, control pest population density, and can deratize further, effectively avoid sterile bait to the unconspicuous defect of some mouse effect.
The technical solution adopted in the present invention is, a kind of novel mouse sterile bait, described bait is made up of fish meal, silkworm chrysalis, blood meal, corn, soya-bean oil, soya bean, sodium chloride, anticoagulant, quinestrol and oleandrin, and in every portion of bait, the parts by weight of each component are respectively fish meal 8 ~ 12 parts, silkworm chrysalis 8 ~ 12 parts, blood meal 8 ~ 12 parts, corn 440 ~ 460 parts, 55 ~ 65 parts, soya-bean oil, soya bean 440 ~ 460 parts, 8 ~ 12 parts, sodium chloride, anticoagulant 0.5 ~ 1 part, quinestrol 1.5 ~ 3.5 parts, oleandrin 0.1 ~ 0.5 part; Described anticoagulant is the one in heparin, edetate, sodium citrate.
A preparation method for novel mouse sterile bait, comprises the following steps:
Step one: take each component according to the parts by weight of described each component;
Step 2: it is broken soya bean and corn to be carried out low-temperature submicron powder, after pulverizing, grain diameter is 0.5 ~ 1 μm, the soya bean after pulverizing and corn is stirred, and obtained mixture I is for subsequent use;
Step 3: first add fish meal, silkworm chrysalis, blood meal, sodium chloride, quinestrol and oleandrin in mixture I, then add isopyknic water wherein, add anticoagulant while stirring afterwards, obtained mixture II after stirring;
Step 4: mixture II is placed in granulator and processes, obtains the sterile bait that grain diameter is 1 ~ 3mm after process, afterwards that sterile bait is dry and seal preservation.
The invention has the beneficial effects as follows:
The present invention adopts quinestrol and anticoagulant as active ingredient, composition is simple, both be applicable to male mouse, and be also applicable to female mouse, quinestrol is by interference Reproductive Axis Hypothalamus-pituitary-testis (ovary), Developing restraint hormone secretion, promote apoptosis of germ cells, antiproliferative effect, the atrophy of induction reproductive organs, reduces ripe sperm and egg cell, cause sterile, persistent.In sterile bait, add anticoagulant, not only can deratize further, sterile bait can also be avoided the unconspicuous defect of some mouse effect.And quinestrol can reduce the toxicity of anticoagulant further, make anticoagulant longer for action time in mouse body, solve the problem of mouse food refusal further.Meanwhile, the present invention, by adding oleandrin as active ingredient, facilitates quinestrol and anticoagulant greatly to the action effect of mouse.By adopting the present invention, sterile and dead mouse is more than 97% of total number, and action effect is obvious.
Embodiment
Elaborate to embodiments of the invention below, the present embodiment is implemented under premised on technical solution of the present invention, give detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
A kind of novel mouse sterile bait, described bait is made up of fish meal, silkworm chrysalis, blood meal, corn, soya-bean oil, soya bean, sodium chloride, anticoagulant, quinestrol and oleandrin, and in every portion of bait, the parts by weight of each component are respectively fish meal 8 ~ 12 parts, silkworm chrysalis 8 ~ 12 parts, blood meal 8 ~ 12 parts, corn 440 ~ 460 parts, 55 ~ 65 parts, soya-bean oil, soya bean 440 ~ 460 parts, 8 ~ 12 parts, sodium chloride, anticoagulant 0.5 ~ 1 part, quinestrol 1.5 ~ 3.5 parts, oleandrin 0.1 ~ 0.5 part; Described anticoagulant is the one in heparin, edetate, sodium citrate.
A preparation method for novel mouse sterile bait, comprises the following steps:
Step one: take each component according to the parts by weight of each component according to claim 1;
Step 2: it is broken soya bean and corn to be carried out low-temperature submicron powder, after pulverizing, grain diameter is 0.5 ~ 1 μm, the soya bean after pulverizing and corn is stirred, and obtained mixture I is for subsequent use;
Step 3: first add fish meal, silkworm chrysalis, blood meal, sodium chloride, quinestrol and oleandrin in mixture I, then add isopyknic water wherein, add anticoagulant while stirring afterwards, obtained mixture II after stirring;
Step 4: mixture II is placed in granulator and processes, obtains the sterile bait that grain diameter is 1 ~ 3mm after process, afterwards that sterile bait is dry and seal preservation.
Embodiment 1
A kind of novel mouse sterile bait, described bait is made up of fish meal, silkworm chrysalis, blood meal, corn, soya-bean oil, soya bean, sodium chloride, anticoagulant, quinestrol and oleandrin, and in every portion of bait, the parts by weight of each component are respectively fish meal 8 parts, silkworm chrysalis 8 parts, blood meal 8 parts, corn 440 parts, 55 parts, soya-bean oil, soya bean 440 parts, 8 parts, sodium chloride, anticoagulant 0.5 part, quinestrol 1.5 parts, oleandrin 0.1 part; Described anticoagulant is the one in heparin, edetate, sodium citrate.
A preparation method for novel mouse sterile bait, comprises the following steps:
Step one: take each component according to the parts by weight of each component according to claim 1;
Step 2: it is broken soya bean and corn to be carried out low-temperature submicron powder, after pulverizing, grain diameter is 0.5 μm, the soya bean after pulverizing and corn is stirred, and obtained mixture I is for subsequent use;
Step 3: first add fish meal, silkworm chrysalis, blood meal, sodium chloride, quinestrol and oleandrin in mixture I, then add isopyknic water wherein, add anticoagulant while stirring afterwards, obtained mixture II after stirring;
Step 4: mixture II is placed in granulator and processes, obtains the sterile bait that grain diameter is 1mm after process, afterwards that sterile bait is dry and seal preservation.
Embodiment 2
A kind of novel mouse sterile bait, described bait is made up of fish meal, silkworm chrysalis, blood meal, corn, soya-bean oil, soya bean, sodium chloride, anticoagulant, quinestrol and oleandrin, and in every portion of bait, the parts by weight of each component are respectively fish meal 12 parts, silkworm chrysalis 12 parts, blood meal 12 parts, corn 460 parts, 65 parts, soya-bean oil, soya bean 460 parts, 12 parts, sodium chloride, anticoagulant 1 part, quinestrol 3.5 parts, oleandrin 0.5 part; Described anticoagulant is the one in heparin, edetate, sodium citrate.
A preparation method for novel mouse sterile bait, comprises the following steps:
Step one: take each component according to the parts by weight of each component according to claim 1;
Step 2: it is broken soya bean and corn to be carried out low-temperature submicron powder, after pulverizing, grain diameter is 1 μm, the soya bean after pulverizing and corn is stirred, and obtained mixture I is for subsequent use;
Step 3: first add fish meal, silkworm chrysalis, blood meal, sodium chloride, quinestrol and oleandrin in mixture I, then add isopyknic water wherein, add anticoagulant while stirring afterwards, obtained mixture II after stirring;
Step 4: mixture II is placed in granulator and processes, obtains the sterile bait that grain diameter is 3mm after process, afterwards that sterile bait is dry and seal preservation.
Embodiment 3
A kind of novel mouse sterile bait, described bait is made up of fish meal, silkworm chrysalis, blood meal, corn, soya-bean oil, soya bean, sodium chloride, anticoagulant, quinestrol and oleandrin, and in every portion of bait, the parts by weight of each component are respectively fish meal 10 parts, silkworm chrysalis 10 parts, blood meal 10 parts, corn 450 parts, 60 parts, soya-bean oil, soya bean 450 parts, 10 parts, sodium chloride, anticoagulant 0.75 part, quinestrol 2.5 parts, oleandrin 0.3 part; Described anticoagulant is the one in heparin, edetate, sodium citrate.
A preparation method for novel mouse sterile bait, comprises the following steps:
Step one: take each component according to the parts by weight of each component according to claim 1;
Step 2: it is broken soya bean and corn to be carried out low-temperature submicron powder, after pulverizing, grain diameter is 0.75 μm, the soya bean after pulverizing and corn is stirred, and obtained mixture I is for subsequent use;
Step 3: first add fish meal, silkworm chrysalis, blood meal, sodium chloride, quinestrol and oleandrin in mixture I, then add isopyknic water wherein, add anticoagulant while stirring afterwards, obtained mixture II after stirring;
Step 4: mixture II is placed in granulator and processes, obtains the sterile bait that grain diameter is 2mm after process, afterwards that sterile bait is dry and seal preservation.
Comparative example
Adopt said method to prepare sterile bait, difference is not add oleandrin in step 3.
Testing inspection
Step one: choose 400 healthy small white mouses, be divided into A, B, C, D tetra-groups, often organize each 100;
Step 2: prepare sterile bait according to embodiment 1 and embodiment 2 respectively, the sterile bait of A group feeding embodiment 1 preparation, the sterile bait of B group feeding embodiment 2 preparation, the sterile bait of C group feeding embodiment 3 preparation, the sterile bait prepared after removing oleandrin in the present invention of D group feeding.
Step 3: the upgrowth situation recording mouse every day.
Result of the test shows, after 10 days, what mouse was sterile and dead amounts to 99 to A group, after 10 days, what mouse was sterile and dead amounts to 98 to B group, and C group after 10 days, what mouse was sterile and dead amounts to 97, and after 10 days, what mouse was sterile and dead amounts to 85 to B group.In sum, the present invention is a kind of method of the effectively preventing plague of rats.
Claims (1)
1. a novel mouse sterile bait, it is characterized in that: described bait is made up of fish meal, silkworm chrysalis, blood meal, corn, soya-bean oil, soya bean, sodium chloride, anticoagulant, quinestrol and oleandrin, each composition weight number contained in every portion of bait is respectively fish meal 8 ~ 12 parts, silkworm chrysalis 8 ~ 12 parts, blood meal 8 ~ 12 parts, corn 440 ~ 460 parts, 55 ~ 65 parts, soya-bean oil, soya bean 440 ~ 460 parts, 8 ~ 12 parts, sodium chloride, anticoagulant 0.5 ~ 1 part, quinestrol 1.5 ~ 3.5 parts, oleandrin 0.1 ~ 0.5 part; Described anticoagulant is the one in heparin, edetate, sodium citrate.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410034293.5A CN103783052B (en) | 2014-01-24 | 2014-01-24 | A kind of novel mouse sterile bait and preparation method thereof |
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| CN201410034293.5A CN103783052B (en) | 2014-01-24 | 2014-01-24 | A kind of novel mouse sterile bait and preparation method thereof |
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| CN103783052B true CN103783052B (en) | 2015-12-02 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113545358A (en) * | 2021-07-07 | 2021-10-26 | 中国科学院动物研究所 | Rat and insect killing composition and rat and insect killing method |
| CN114946840A (en) * | 2022-06-21 | 2022-08-30 | 四川世纪万森生物科技有限公司 | Synergistic formula of poison mouse bait |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1225794A (en) * | 1998-02-10 | 1999-08-18 | 韩崇选 | Pollution-free anticoagulant rodenticide |
| CN1301643C (en) * | 2002-11-13 | 2007-02-28 | 中国科学院动物研究所 | Bait for controlling the fertility number of rats and the use thereof |
| CN101352443B (en) * | 2007-07-23 | 2011-01-12 | 中国科学院动物研究所 | Male-sterilant for mammalian |
| CN101664038A (en) * | 2008-09-03 | 2010-03-10 | 广东省昆虫研究所 | Bait for controlling sterilization of female pest rats |
| CN101664039A (en) * | 2008-09-03 | 2010-03-10 | 广东省昆虫研究所 | Female chemically sterilizing rat bait |
| CN102176819A (en) * | 2008-10-14 | 2011-09-07 | 拜耳作物科学股份公司 | Synergistic rodenticidal agent |
| CN102396476A (en) * | 2010-09-10 | 2012-04-04 | 中国农业大学 | Murine sterilant bait for controlling rodent damage in farmland and grassland |
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