CN103783052A - Novel rodent sterile bait and preparation method thereof - Google Patents
Novel rodent sterile bait and preparation method thereof Download PDFInfo
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- CN103783052A CN103783052A CN201410034293.5A CN201410034293A CN103783052A CN 103783052 A CN103783052 A CN 103783052A CN 201410034293 A CN201410034293 A CN 201410034293A CN 103783052 A CN103783052 A CN 103783052A
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Abstract
The invention belongs to the field of pharmacology, and specifically relates to novel rodent sterile bait and a preparation method of the novel rodent sterile bait. By using quinestrol and an anti-coagulant as effective components, the bait provided by the invention is simple in component and is suitable for male rodents, but also suitable for female rodents. The anti-coagulant is added into the sterile bait, so that the rodents are further killed, and the deficiency that the sterile bait has no remarkable effect on some rodents is avoided. Quinestrol can further reduce the toxicity of the anti-coagulant, so that the anti-coagulant acts in the bodies of the rodents for a long time so as to further solve the problem of food refusal of the rodents. Meanwhile, by adding oleandrin C as an effective component, the effect to the rodents by the quinestrol and anti-coagulant is greatly promoted. By adopting the bait provided by the invention, the total quantity of sterile and dead rodents is over 97%, so that the effect is remarkable.
Description
Technical field
The invention belongs to field of pharmacology, be specifically related to a kind of novel mouse sterile bait and preparation method thereof.
Background technology
Muroid animal is most species in mammal, the widest, the maximum population of quantity distribute.Rodent poison bait consumption is little, and mouse can not produce food refusal to poison bait; The 2nd, meet mouse and steal the habit of eating.Mouse is eaten and eats and stop often, and intermittently, and most chronic rodenticide is to mouse, once edible toxicity is not too strong, and after mouse eats, also without uncomfortable sensation, a couple of days continues to steal and eats continuously, until that poison runs up to is a certain amount of, mouse just can be poisoned to death.In contrast, mouse easily produces food refusal phenomenon to Apodemus agrarius, and simultaneously because Apodemus agrarius effect is rapid, part has taken food poison bait but the mouse health that do not reach lethal dose produces uncomfortablely, can not eat for the second time again, also can not eat later again, is survived.Therefore, Apodemus agrarius deratization effect is poor, generally only has 50%～60% control efficiency.
Anticoagulant rat-bane is a current the most frequently used class chronic rodenticide.General low concentration, the mode of throwing in repeatedly of adopting.But along with long-term a large amount of anticoagulants that use kill mouse, cause the resistance problem of muroid more and more outstanding, seriously perplex carrying out of the anti-work of mouse.
At present, the plague of rats sustainable control new technology, especially apholate technology are all being devoted to study in countries in the world.Sterile control refers to by biology of reproduction and ecological technology and method and makes male or female sexual sterilization, or blocking-up larval growth grows, and to reduce fertility-rate, controls pest population density.Compared with killing with traditional chemistry, apholate is safer, little to the pollution of environment, low weight to the harm of non-target biology, is easily accepted by the public, and the effect of sterile control is more lasting.But only mouse is carried out to sterile control, can not the maximized control plague of rats.Sterile mouse still can bring certain economic loss to people.And sterile bait is not obvious to some mouse effect.
Summary of the invention
The object of this invention is to provide a kind of novel mouse sterile bait and preparation method thereof.Not only can reduce the fertility-rate of muroid, control pest population density, and can further deratize, effectively avoid sterile bait to the unconspicuous defect of some mouse effect.
The technical solution adopted in the present invention is, a kind of novel mouse sterile bait, described bait is made up of fish meal, silkworm chrysalis, blood meal, corn, soya-bean oil, soya bean, sodium chloride, anticoagulant, quinestrol and oleandrin, and in every portion of bait, the parts by weight of each component are respectively 8 ~ 12 parts of fish meal, 8 ~ 12 parts of silkworm chrysalises, 8 ~ 12 parts of blood meals, 440 ~ 460 parts of corns, 55 ~ 65 parts, soya-bean oil, 440 ~ 460 parts of soya beans, 8 ~ 12 parts, sodium chloride, 0.5 ~ 1 part of anticoagulant, 1.5 ~ 3.5 parts of quinestrols, 0.1 ~ 0.5 part of oleandrin.
Described anticoagulant is the one in heparin, edetate, sodium citrate.
A preparation method for novel mouse sterile bait, comprises the following steps:
Step 1: take each component according to the parts by weight of described each component;
Step 2: soya bean and corn are carried out to low temperature ultramicro grinding, and after pulverizing, grain diameter is 0.5 ~ 1 μ m, and soya bean and corn after pulverizing are stirred, and makes mixture I, for subsequent use;
Step 3: first add fish meal, silkworm chrysalis, blood meal, sodium chloride, quinestrol and oleandrin in mixture I, then add wherein isopyknic water, add while stirring afterwards anticoagulant, make mixture II after stirring;
Step 4: mixture II is placed in to granulator and processes, obtaining grain diameter after processing is the sterile bait of 1 ~ 3mm, afterwards sterile bait is dried and seals preservation.
The invention has the beneficial effects as follows:
The present invention adopts quinestrol and anticoagulant as active ingredient, composition is simple, both be applicable to male mouse, and be also applicable to female mouse, quinestrol is by disturbing Reproductive Axis Hypothalamus-pituitary-testis (ovary), suppress growth hormone secretion, promote apoptosis of germ cells, suppress cell proliferation, the atrophy of induction reproductive organs, reduces ripe sperm and egg cell, cause sterilely, effect is lasting.In sterile bait, add anticoagulant, not only can further deratize, can also avoid sterile bait to the unconspicuous defect of some mouse effect.And quinestrol can further reduce the toxicity of anticoagulant, make anticoagulant longer action time in mouse body, further solve the problem of mouse food refusal.Meanwhile, the present invention, by adding oleandrin as active ingredient, has promoted quinestrol and the anticoagulant action effect to mouse greatly.By adopting the present invention, it is more than 97% that sterile and dead mouse is total number, and action effect is obvious.
Embodiment
Below embodiments of the invention are elaborated, the present embodiment is implemented under take technical solution of the present invention as prerequisite, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
A kind of novel mouse sterile bait, described bait is made up of fish meal, silkworm chrysalis, blood meal, corn, soya-bean oil, soya bean, sodium chloride, anticoagulant, quinestrol and oleandrin, and in every portion of bait, the parts by weight of each component are respectively 8 ~ 12 parts of fish meal, 8 ~ 12 parts of silkworm chrysalises, 8 ~ 12 parts of blood meals, 440 ~ 460 parts of corns, 55 ~ 65 parts, soya-bean oil, 440 ~ 460 parts of soya beans, 8 ~ 12 parts, sodium chloride, 0.5 ~ 1 part of anticoagulant, 1.5 ~ 3.5 parts of quinestrols, 0.1 ~ 0.5 part of oleandrin.
Described anticoagulant is the one in heparin, edetate, sodium citrate.
A preparation method for novel mouse sterile bait, comprises the following steps:
Step 1: take each component according to the parts by weight of each component claimed in claim 1;
Step 2: soya bean and corn are carried out to low temperature ultramicro grinding, and after pulverizing, grain diameter is 0.5 ~ 1 μ m, and soya bean and corn after pulverizing are stirred, and makes mixture I, for subsequent use;
Step 3: first add fish meal, silkworm chrysalis, blood meal, sodium chloride, quinestrol and oleandrin in mixture I, then add wherein isopyknic water, add while stirring afterwards anticoagulant, make mixture II after stirring;
Step 4: mixture II is placed in to granulator and processes, obtaining grain diameter after processing is the sterile bait of 1 ~ 3mm, afterwards sterile bait is dried and seals preservation.
Embodiment 1
A kind of novel mouse sterile bait, described bait is made up of fish meal, silkworm chrysalis, blood meal, corn, soya-bean oil, soya bean, sodium chloride, anticoagulant, quinestrol and oleandrin, and in every portion of bait, the parts by weight of each component are respectively 8 parts of fish meal, 8 parts of silkworm chrysalises, 8 parts of blood meals, 440 parts of corns, 55 parts, soya-bean oil, 440 parts of soya beans, 8 parts, sodium chloride, 0.5 part of anticoagulant, 1.5 parts of quinestrols, 0.1 part of oleandrin.
Described anticoagulant is the one in heparin, edetate, sodium citrate.
A preparation method for novel mouse sterile bait, comprises the following steps:
Step 1: take each component according to the parts by weight of each component claimed in claim 1;
Step 2: soya bean and corn are carried out to low temperature ultramicro grinding, and after pulverizing, grain diameter is 0.5 μ m, and soya bean and corn after pulverizing are stirred, and makes mixture I, for subsequent use;
Step 3: first add fish meal, silkworm chrysalis, blood meal, sodium chloride, quinestrol and oleandrin in mixture I, then add wherein isopyknic water, add while stirring afterwards anticoagulant, make mixture II after stirring;
Step 4: mixture II is placed in to granulator and processes, obtaining grain diameter after processing is the sterile bait of 1mm, afterwards sterile bait is dried and seals preservation.
Embodiment 2
A kind of novel mouse sterile bait, described bait is made up of fish meal, silkworm chrysalis, blood meal, corn, soya-bean oil, soya bean, sodium chloride, anticoagulant, quinestrol and oleandrin, and in every portion of bait, the parts by weight of each component are respectively 12 parts of fish meal, 12 parts of silkworm chrysalises, 12 parts of blood meals, 460 parts of corns, 65 parts, soya-bean oil, 460 parts of soya beans, 12 parts, sodium chloride, 1 part of anticoagulant, 3.5 parts of quinestrols, 0.5 part of oleandrin.
Described anticoagulant is the one in heparin, edetate, sodium citrate.
A preparation method for novel mouse sterile bait, comprises the following steps:
Step 1: take each component according to the parts by weight of each component claimed in claim 1;
Step 2: soya bean and corn are carried out to low temperature ultramicro grinding, and after pulverizing, grain diameter is 1 μ m, and soya bean and corn after pulverizing are stirred, and makes mixture I, for subsequent use;
Step 3: first add fish meal, silkworm chrysalis, blood meal, sodium chloride, quinestrol and oleandrin in mixture I, then add wherein isopyknic water, add while stirring afterwards anticoagulant, make mixture II after stirring;
Step 4: mixture II is placed in to granulator and processes, obtaining grain diameter after processing is the sterile bait of 3mm, afterwards sterile bait is dried and seals preservation.
Embodiment 3
A kind of novel mouse sterile bait, described bait is made up of fish meal, silkworm chrysalis, blood meal, corn, soya-bean oil, soya bean, sodium chloride, anticoagulant, quinestrol and oleandrin, and in every portion of bait, the parts by weight of each component are respectively 10 parts of fish meal, 10 parts of silkworm chrysalises, 10 parts of blood meals, 450 parts of corns, 60 parts, soya-bean oil, 450 parts of soya beans, 10 parts, sodium chloride, 0.75 part of anticoagulant, 2.5 parts of quinestrols, 0.3 part of oleandrin.
Described anticoagulant is the one in heparin, edetate, sodium citrate.
A preparation method for novel mouse sterile bait, comprises the following steps:
Step 1: take each component according to the parts by weight of each component claimed in claim 1;
Step 2: soya bean and corn are carried out to low temperature ultramicro grinding, and after pulverizing, grain diameter is 0.75 μ m, and soya bean and corn after pulverizing are stirred, and makes mixture I, for subsequent use;
Step 3: first add fish meal, silkworm chrysalis, blood meal, sodium chloride, quinestrol and oleandrin in mixture I, then add wherein isopyknic water, add while stirring afterwards anticoagulant, make mixture II after stirring;
Step 4: mixture II is placed in to granulator and processes, obtaining grain diameter after processing is the sterile bait of 2mm, afterwards sterile bait is dried and seals preservation.
Comparative example
Adopt said method to prepare sterile bait, difference is not add in step 3 oleandrin.
Test detects
Step 1: choose 400 healthy small white mouses, be divided into tetra-groups of A, B, C, D, every group each 100;
Step 2: prepare sterile bait according to embodiment 1 and embodiment 2 respectively, sterile bait prepared by A group feeding embodiment 1, sterile bait prepared by B group feeding embodiment 2, sterile bait prepared by C group feeding embodiment 3, removes the sterile bait of preparing after oleandrin in the present invention of D group feeding.
Step 3: the upgrowth situation that records mouse every day.
Result of the test shows, A group is after 10 days, and what mouse was sterile and dead amounts to 99, B group is after 10 days, and what mouse was sterile and dead amounts to 98, and C group is after 10 days, what mouse was sterile and dead amounts to 97, and B group is after 10 days, and what mouse was sterile and dead amounts to 85.In sum, the present invention is a kind of method of the effectively preventing plague of rats.
Claims (3)
1. a novel mouse sterile bait, it is characterized in that: described bait is made up of fish meal, silkworm chrysalis, blood meal, corn, soya-bean oil, soya bean, sodium chloride, anticoagulant, quinestrol and oleandrin, the each composition weight umber containing in every portion of bait is respectively 8 ~ 12 parts of fish meal, 8 ~ 12 parts of silkworm chrysalises, 8 ~ 12 parts of blood meals, 440 ~ 460 parts of corns, 55 ~ 65 parts, soya-bean oil, 440 ~ 460 parts of soya beans, 8 ~ 12 parts, sodium chloride, 0.5 ~ 1 part of anticoagulant, 1.5 ~ 3.5 parts of quinestrols, 0.1 ~ 0.5 part of oleandrin.
2. the novel mouse sterile bait of one according to claim 1, is characterized in that: described anticoagulant is the one in heparin, edetate, sodium citrate.
3. the preparation method of a kind of novel mouse sterile bait according to claim 1 and 2, is characterized in that, comprises the following steps:
Step 1: take each component according to the parts by weight of each component claimed in claim 1;
Step 2: soya bean and corn are carried out to low temperature ultramicro grinding, and after pulverizing, grain diameter is 0.5 ~ 1 μ m, and soya bean and corn after pulverizing are stirred, and makes mixture I, for subsequent use;
Step 3: first add fish meal, silkworm chrysalis, blood meal, sodium chloride, quinestrol and oleandrin in mixture I, then add wherein isopyknic water, add while stirring afterwards anticoagulant, make mixture II after stirring;
Step 4: mixture II is placed in to granulator and processes, obtaining grain diameter after processing is the sterile bait of 1 ~ 3mm, afterwards sterile bait is dried and seals preservation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410034293.5A CN103783052B (en) | 2014-01-24 | 2014-01-24 | A kind of novel mouse sterile bait and preparation method thereof |
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| CN201410034293.5A CN103783052B (en) | 2014-01-24 | 2014-01-24 | A kind of novel mouse sterile bait and preparation method thereof |
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| CN103783052A true CN103783052A (en) | 2014-05-14 |
| CN103783052B CN103783052B (en) | 2015-12-02 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113545358A (en) * | 2021-07-07 | 2021-10-26 | 中国科学院动物研究所 | Rat and insect killing composition and rat and insect killing method |
| CN114946840A (en) * | 2022-06-21 | 2022-08-30 | 四川世纪万森生物科技有限公司 | Synergistic formula of poison mouse bait |
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| CN1225794A (en) * | 1998-02-10 | 1999-08-18 | 韩崇选 | Pollution-free anticoagulant rodenticide |
| CN1500387A (en) * | 2002-11-13 | 2004-06-02 | 中国科学院动物研究所 | Bait for controlling the fertility number of rats and the use thereof |
| CN101352443A (en) * | 2007-07-23 | 2009-01-28 | 中国科学院动物研究所 | Male-sterilant for mammalian |
| CN101664039A (en) * | 2008-09-03 | 2010-03-10 | 广东省昆虫研究所 | Female chemically sterilizing rat bait |
| CN101664038A (en) * | 2008-09-03 | 2010-03-10 | 广东省昆虫研究所 | Bait for controlling sterilization of female pest rats |
| WO2010043322A1 (en) * | 2008-10-14 | 2010-04-22 | Bayer Cropscience Aktiengesellschaft | Synergistic rodenticidal agent |
| CN102396476A (en) * | 2010-09-10 | 2012-04-04 | 中国农业大学 | Murine sterilant bait for controlling rodent damage in farmland and grassland |
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2014
- 2014-01-24 CN CN201410034293.5A patent/CN103783052B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1225794A (en) * | 1998-02-10 | 1999-08-18 | 韩崇选 | Pollution-free anticoagulant rodenticide |
| CN1500387A (en) * | 2002-11-13 | 2004-06-02 | 中国科学院动物研究所 | Bait for controlling the fertility number of rats and the use thereof |
| CN101352443A (en) * | 2007-07-23 | 2009-01-28 | 中国科学院动物研究所 | Male-sterilant for mammalian |
| CN101664039A (en) * | 2008-09-03 | 2010-03-10 | 广东省昆虫研究所 | Female chemically sterilizing rat bait |
| CN101664038A (en) * | 2008-09-03 | 2010-03-10 | 广东省昆虫研究所 | Bait for controlling sterilization of female pest rats |
| WO2010043322A1 (en) * | 2008-10-14 | 2010-04-22 | Bayer Cropscience Aktiengesellschaft | Synergistic rodenticidal agent |
| CN102396476A (en) * | 2010-09-10 | 2012-04-04 | 中国农业大学 | Murine sterilant bait for controlling rodent damage in farmland and grassland |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113545358A (en) * | 2021-07-07 | 2021-10-26 | 中国科学院动物研究所 | Rat and insect killing composition and rat and insect killing method |
| CN114946840A (en) * | 2022-06-21 | 2022-08-30 | 四川世纪万森生物科技有限公司 | Synergistic formula of poison mouse bait |
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| CN103783052B (en) | 2015-12-02 |
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