CN103781904A - 含有胰液成分的生物试样中的蛋白酶的抑制方法 - Google Patents

含有胰液成分的生物试样中的蛋白酶的抑制方法 Download PDF

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Publication number
CN103781904A
CN103781904A CN201280043967.7A CN201280043967A CN103781904A CN 103781904 A CN103781904 A CN 103781904A CN 201280043967 A CN201280043967 A CN 201280043967A CN 103781904 A CN103781904 A CN 103781904A
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China
Prior art keywords
pancreatic juice
biological material
proteinase inhibitor
proteolytic enzyme
inhibitor
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Pending
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CN201280043967.7A
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English (en)
Chinese (zh)
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片冈理惠
中田真理
守屋奈绪
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Olympus Corp
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Olympus Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN201280043967.7A 2011-09-13 2012-06-22 含有胰液成分的生物试样中的蛋白酶的抑制方法 Pending CN103781904A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011-199357 2011-09-13
JP2011199357 2011-09-13
PCT/JP2012/066004 WO2013038767A1 (ja) 2011-09-13 2012-06-22 膵液成分を含有する生体試料中のプロテアーゼの阻害方法

Publications (1)

Publication Number Publication Date
CN103781904A true CN103781904A (zh) 2014-05-07

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CN201280043967.7A Pending CN103781904A (zh) 2011-09-13 2012-06-22 含有胰液成分的生物试样中的蛋白酶的抑制方法

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Country Link
US (1) US20140186869A1 (ja)
EP (1) EP2757151B1 (ja)
JP (1) JP6000956B2 (ja)
CN (1) CN103781904A (ja)
WO (1) WO2013038767A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104395749A (zh) * 2012-06-22 2015-03-04 奥林巴斯株式会社 含胰液成分的试样的调制方法、以及含胰液成分的生物试样的室温储存用试剂盒
CN107533044A (zh) * 2015-11-11 2018-01-02 奥林巴斯株式会社 十二指肠液试样的保存方法
CN109563501A (zh) * 2016-08-03 2019-04-02 株式会社岛津制作所 肽片段的制备方法和其中所使用的蛋白酶的制备方法、以及肽片段制备用试剂盒
CN109761858A (zh) * 2019-02-12 2019-05-17 成都苑东生物制药股份有限公司 一种甲磺酸加贝酯的精制方法
CN117683074A (zh) * 2023-12-13 2024-03-12 山东绿邦生物科技有限公司 蜡样芽孢杆菌、蛋白酶抑制剂以及提高蛋白渣产量的方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109890299A (zh) * 2016-08-18 2019-06-14 普罗根尼蒂公司 采样系统及相关材料和方法
US20210156868A1 (en) * 2019-11-21 2021-05-27 Tournament BioVenture LLC Compositions and methods for detecting albumin

Citations (3)

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WO2006097793A2 (en) * 2004-04-15 2006-09-21 Chiasma, Ltd. Compositions capable of facilitating penetration across a biological barrier
CN101340893A (zh) * 2005-10-20 2009-01-07 纳斯泰克制药公司 速效胰岛素的鼻内施用
CN101547702A (zh) * 2005-09-06 2009-09-30 奥拉姆德医药公司 用于口服给药蛋白质的方法和组合物

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MXPA04011129A (es) * 2002-05-13 2005-02-17 Becton Dickinson Co Sistema de recoleccion de muestra de inhibidor de proteasa.
JP2007222062A (ja) * 2006-02-23 2007-09-06 Ehime Univ スーパーオキサイド発生剤およびその製造方法
US9482677B2 (en) * 2008-02-27 2016-11-01 Scios Inc. Method, composition and device for sampling natriuretic peptides in a biological fluid
JP2011005009A (ja) 2009-06-26 2011-01-13 Olympus Corp 標本採取チューブ及びそれを備える内視鏡装置
CN103460045B (zh) * 2011-04-05 2016-01-20 奥林巴斯株式会社 胰脏检查方法及胰脏检查试剂盒

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006097793A2 (en) * 2004-04-15 2006-09-21 Chiasma, Ltd. Compositions capable of facilitating penetration across a biological barrier
CN101547702A (zh) * 2005-09-06 2009-09-30 奥拉姆德医药公司 用于口服给药蛋白质的方法和组合物
CN101340893A (zh) * 2005-10-20 2009-01-07 纳斯泰克制药公司 速效胰岛素的鼻内施用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SILKE WANDSCHNEIDER等: "autoimmune pancreatic disease:preparation of pancreatic juice for proteome analysis", 《ELECTROPHORESIS》, 31 December 2001 (2001-12-31) *
张梅等: "丝氨酸蛋白酶抑制剂的研究及应用", 《生物化学与生物物理进展》, vol. 23, no. 3, 31 December 1996 (1996-12-31) *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104395749A (zh) * 2012-06-22 2015-03-04 奥林巴斯株式会社 含胰液成分的试样的调制方法、以及含胰液成分的生物试样的室温储存用试剂盒
US9376675B2 (en) 2012-06-22 2016-06-28 Olympus Corporation Method for preserving components of pancreatic juice in a sample, and kit for preserving components of pancreatic juice in a sample
CN104395749B (zh) * 2012-06-22 2016-12-28 奥林巴斯株式会社 含胰液成分的试样的调制方法、以及含胰液成分的生物试样的室温储存用试剂盒
CN107533044A (zh) * 2015-11-11 2018-01-02 奥林巴斯株式会社 十二指肠液试样的保存方法
CN107533044B (zh) * 2015-11-11 2019-10-25 奥林巴斯株式会社 十二指肠液试样的保存方法
CN109563501A (zh) * 2016-08-03 2019-04-02 株式会社岛津制作所 肽片段的制备方法和其中所使用的蛋白酶的制备方法、以及肽片段制备用试剂盒
CN109761858A (zh) * 2019-02-12 2019-05-17 成都苑东生物制药股份有限公司 一种甲磺酸加贝酯的精制方法
CN109761858B (zh) * 2019-02-12 2021-05-14 成都苑东生物制药股份有限公司 一种甲磺酸加贝酯的精制方法
CN117683074A (zh) * 2023-12-13 2024-03-12 山东绿邦生物科技有限公司 蜡样芽孢杆菌、蛋白酶抑制剂以及提高蛋白渣产量的方法

Also Published As

Publication number Publication date
WO2013038767A1 (ja) 2013-03-21
JPWO2013038767A1 (ja) 2015-03-23
EP2757151B1 (en) 2017-08-30
EP2757151A4 (en) 2015-03-04
US20140186869A1 (en) 2014-07-03
EP2757151A1 (en) 2014-07-23
JP6000956B2 (ja) 2016-10-05

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Application publication date: 20140507