CN1037512C - 咪唑基－取代的环己烷衍生物及其制备和应用 - Google Patents

咪唑基－取代的环己烷衍生物及其制备和应用 Download PDF

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Publication number
CN1037512C
CN1037512C CN93107418A CN93107418A CN1037512C CN 1037512 C CN1037512 C CN 1037512C CN 93107418 A CN93107418 A CN 93107418A CN 93107418 A CN93107418 A CN 93107418A CN 1037512 C CN1037512 C CN 1037512C
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CN
China
Prior art keywords
formula
acid
group
compound
imidazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN93107418A
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English (en)
Chinese (zh)
Other versions
CN1082538A (zh
Inventor
U·E·米勒
J·德雷塞尔
P·费
R·汉科
W·胡布什
T·克雷默
M·米勒-格里曼
M·博克
S·卡茨达
A·克诺尔
J·P·施塔什
S·沃尔费尔
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Bayer AG
Original Assignee
Bayer AG
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Filing date
Publication date
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Publication of CN1082538A publication Critical patent/CN1082538A/zh
Application granted granted Critical
Publication of CN1037512C publication Critical patent/CN1037512C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/39—Unsaturated compounds containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/75—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of acids with a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN93107418A 1992-06-26 1993-06-26 咪唑基－取代的环己烷衍生物及其制备和应用 Expired - Fee Related CN1037512C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4221009.7 1992-06-26
DE4221009A DE4221009A1 (de) 1992-06-26 1992-06-26 Imidazolyl-substituierte Cyclohexanderivate

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN97109705A Division CN1182734A (zh) 1992-06-26 1997-04-16 咪唑基－取代的环己烷衍生物

Publications (2)

Publication Number Publication Date
CN1082538A CN1082538A (zh) 1994-02-23
CN1037512C true CN1037512C (zh) 1998-02-25

Family

ID=6461902

Family Applications (2)

Application Number Title Priority Date Filing Date
CN93107418A Expired - Fee Related CN1037512C (zh) 1992-06-26 1993-06-26 咪唑基－取代的环己烷衍生物及其制备和应用
CN97109705A Pending CN1182734A (zh) 1992-06-26 1997-04-16 咪唑基－取代的环己烷衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN97109705A Pending CN1182734A (zh) 1992-06-26 1997-04-16 咪唑基－取代的环己烷衍生物

Country Status (22)

Country Link
US (1) US5508299A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0581003B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH0673016A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR940000435A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (2) CN1037512C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE196136T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU666732B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2099078A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ282309B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE4221009A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2151891T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI932952A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUT64753A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL106107A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX9303599A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO303825B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ247974A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH31425A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2110514C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (1) SK281028B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW245713B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA934583B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW215434B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1992-03-07 1993-11-01 Hoechst Ag
HRP960015B1 (en) * 1995-02-01 2000-12-31 Bayer Ag Substituted indole derivatives
US5844318A (en) 1997-02-18 1998-12-01 Micron Technology, Inc. Aluminum film for semiconductive devices
DE19924818A1 (de) * 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide
WO2001082858A2 (de) * 2000-05-04 2001-11-08 Ipf Pharmaceuticals Gmbh Neue verbindungen zur behandlung inflammatorischer und kardiovaskulärer erkrankungen
US20240336638A1 (en) * 2021-07-01 2024-10-10 Guoqin ZHUGE Imidazole compound, and intermediate and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0253310A2 (en) * 1986-07-11 1988-01-20 E.I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
EP0324377A2 (en) * 1988-01-07 1989-07-19 E.I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
HU215834B (hu) * 1989-06-30 1999-04-28 E. I. Du Pont De Nemours And Co. Eljárás aromás csoporttal szubsztituált imidazolszármazékok, valamint ezeket hatóanyagként tartalmazó gyógyszerkészítmények előállítására

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0253310A2 (en) * 1986-07-11 1988-01-20 E.I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
EP0324377A2 (en) * 1988-01-07 1989-07-19 E.I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids

Also Published As

Publication number Publication date
EP0581003A1 (de) 1994-02-02
CZ282309B6 (cs) 1997-06-11
PH31425A (en) 1998-10-29
DE59310098D1 (de) 2000-10-12
SK281028B6 (sk) 2000-11-07
ZA934583B (en) 1994-02-02
RU2110514C1 (ru) 1998-05-10
CA2099078A1 (en) 1993-12-27
FI932952L (fi) 1993-12-27
CN1082538A (zh) 1994-02-23
MX9303599A (es) 1994-01-31
NO932133L (no) 1993-12-27
DE4221009A1 (de) 1994-01-05
NO303825B1 (no) 1998-09-07
AU4146393A (en) 1994-01-06
HUT64753A (en) 1994-02-28
SK66893A3 (en) 1994-02-02
FI932952A0 (fi) 1993-06-24
FI932952A7 (fi) 1993-12-27
TW245713B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1995-04-21
AU666732B2 (en) 1996-02-22
US5508299A (en) 1996-04-16
ES2151891T3 (es) 2001-01-16
NO932133D0 (no) 1993-06-10
JPH0673016A (ja) 1994-03-15
HU9301870D0 (en) 1993-09-28
CZ117393A3 (en) 1994-01-19
EP0581003B1 (de) 2000-09-06
IL106107A (en) 1997-09-30
IL106107A0 (en) 1993-10-20
ATE196136T1 (de) 2000-09-15
NZ247974A (en) 1996-07-26
KR940000435A (ko) 1994-01-03
CN1182734A (zh) 1998-05-27

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