CN103750207B - Gordon euryale yam dispersible tablet and preparation method thereof - Google Patents
Gordon euryale yam dispersible tablet and preparation method thereof Download PDFInfo
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- CN103750207B CN103750207B CN201310748591.6A CN201310748591A CN103750207B CN 103750207 B CN103750207 B CN 103750207B CN 201310748591 A CN201310748591 A CN 201310748591A CN 103750207 B CN103750207 B CN 103750207B
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- 244000268590 Euryale ferox Species 0.000 title claims abstract description 46
- 235000006487 Euryale ferox Nutrition 0.000 title claims abstract description 46
- 239000007919 dispersible tablet Substances 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title description 9
- 239000000843 powder Substances 0.000 claims abstract description 39
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 22
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 12
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 11
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 11
- 240000005373 Panax quinquefolius Species 0.000 claims abstract description 11
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 11
- 229920002472 Starch Polymers 0.000 claims abstract description 11
- 239000004376 Sucralose Substances 0.000 claims abstract description 11
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 11
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 11
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims abstract description 11
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 11
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 11
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 11
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 11
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 claims abstract description 11
- 235000020717 hawthorn extract Nutrition 0.000 claims abstract description 11
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 11
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 11
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 11
- 239000011734 sodium Substances 0.000 claims abstract description 11
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 11
- 239000008107 starch Substances 0.000 claims abstract description 11
- 235000019698 starch Nutrition 0.000 claims abstract description 11
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 11
- 235000019408 sucralose Nutrition 0.000 claims abstract description 11
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 11
- 239000011719 vitamin A Substances 0.000 claims abstract description 11
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 11
- 239000011718 vitamin C Substances 0.000 claims abstract description 11
- 229940045997 vitamin a Drugs 0.000 claims abstract description 11
- 235000011478 zinc gluconate Nutrition 0.000 claims abstract description 11
- 239000011670 zinc gluconate Substances 0.000 claims abstract description 11
- 229960000306 zinc gluconate Drugs 0.000 claims abstract description 11
- 235000002722 Dioscorea batatas Nutrition 0.000 claims description 25
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims description 25
- 240000001811 Dioscorea oppositifolia Species 0.000 claims description 25
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims description 25
- 235000013399 edible fruits Nutrition 0.000 claims description 25
- 235000009508 confectionery Nutrition 0.000 claims description 20
- 235000004879 dioscorea Nutrition 0.000 claims description 17
- 239000002994 raw material Substances 0.000 claims description 11
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 10
- 239000000741 silica gel Substances 0.000 claims description 10
- 229910002027 silica gel Inorganic materials 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 206010012735 Diarrhoea Diseases 0.000 abstract description 6
- 210000000952 spleen Anatomy 0.000 abstract description 6
- 230000007812 deficiency Effects 0.000 abstract description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 208000019902 chronic diarrheal disease Diseases 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 20
- 238000001035 drying Methods 0.000 description 13
- 238000007605 air drying Methods 0.000 description 10
- 239000004615 ingredient Substances 0.000 description 5
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 4
- 229940105329 carboxymethylcellulose Drugs 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000001291 vacuum drying Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000019637 Infantile Diarrhea Diseases 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000028399 Critical Illness Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 206010041969 Steatorrhoea Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 208000001162 steatorrhea Diseases 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940126672 traditional medicines Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/03—Products from fruits or vegetables; Preparation or treatment thereof consisting of whole pieces or fragments without mashing the original pieces
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention discloses a gordon euryale yam dispersible tablet which comprises the following components in parts by weight: 200 to 400 parts of gordon euryale, 200 to 400 parts of yam, 1.75 to 3.75 parts of vitamin C, 0.01 to 0.02 parts of vitamin A, 0.15 to 0.35 parts of zinc gluconate, 40 to 60 parts of microcrystalline cellulose, 0.12 to 0.32 parts of hawthorn extract, 0.12 to 0.32 parts of American ginseng extract, 100 to 170 parts of mannitol, 1.2 to 3.2 parts of chitosan oligosaccharide, 1.2 to 3.2 parts of crude polysaccharide, 10 to 15 parts of sucralose, 10 to 50 parts of superfine silica powder, 3 to 5 parts of carboxymethyl cellulose, 55 to 80 parts of sodium carboxymethyl starch and 4 to 6 parts of magnesium stearate. The gordon euryale yam dispersible tablet has the function of strengthening the spleen to cure diarrhea, thereby being suitable for treating the chronic diarrhea caused by spleen deficiency, the thin sloppy stool and the like of infants.
Description
Technical field
The invention belongs to nutritional health food field, be specially a kind of gordon euryale yam dispersible tablet and preparation method.
Background technology
Infantile diarrhea is clinical common disease.The spleen and stomach in children is weak, and no matter internal damage caused by infantile dyspepsia, the diseases caused by external factors six external factors which cause diseases all can cause digestion, disturbance of absorptive function and causing has loose bowels, this sick four time all have, autumn is multiple, and within two years old, Infants Below is particularly common.Easily consume liquid of feeling frustrated after morbidity, severe impairment of yin can damage sun, produces the change of critically ill.Be equivalent to the illnesss such as the infantile dyspepsia of modern medicine, steatorrhea, Celiac syndrome, viral enteritis.Although also have Chinese Traditional Medicines or the formula of a lot of infantile diarrhea at present, although treatment prescribed preparation is a lot, be all occur with the form of medicine, the dietary product being applicable to long-term edible supplemental treatment is little.Therefore the dietary product researching and developing a kind of safe adjunct therapy is very with practical value.
Summary of the invention
For above-mentioned situation, technical problem solved by the invention is to provide a kind of gordon euryale yam dispersible tablet and preparation method of invigorating the spleen to arrest diarrhea, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of gordon euryale yam dispersible tablet, comprises following parts by weight ingredient: Gorgon fruit 200-400 part, Chinese yam 200-400 part, vitamin C 1.75-3.75 part, vitamin A 0.01-0.02 part, zinc gluconate 0.15-0.35 part, microcrystalline cellulose 40-60 part, haw thorn extract 0.12-0.32 part, American ginseng extract 0.12-0.32 part, sweet mellow wine 100-170 part, chitosan oligosaccharide 1.2-3.2 part, Thick many candies 1.2-3.2 part, Sucralose 10-15 part, superfine silica gel powder 10-50 part, carboxymethyl cellulose 3-5 part, sodium carboxymethyl starch 55-80 part, dolomol 4-6 part.
As preferably, described a kind of gordon euryale yam dispersible tablet, comprises following parts by weight ingredient: Gorgon fruit 300 parts, Chinese yam 300 parts, vitamin C 2.75 parts, vitamin A 0.015 part, zinc gluconate 0.25 part, microcrystalline cellulose 50 parts, haw thorn extract 0.22 part, American ginseng extract 0.22 part, 135 parts, sweet mellow wine, chitosan oligosaccharide 2.2 parts, Thick many candies 2.2 parts, Sucralose 12.5 parts, superfine silica gel powder 30 parts, carboxymethyl cellulose 4 parts, sodium carboxymethyl starch 67.5 parts, dolomol 5 parts.
A preparation method for gordon euryale yam dispersible tablet, comprises the following steps:
(1) get raw material Chinese yam to clean, at 45-55 DEG C of scope inner drying 20-40min, dried Chinese yam is first ground into granularity 100-180 order with common grinder, put into micronizer again to pulverize, be crushed to the Ultramicro-powder that particle diameter is 200-300 μm, then carry out heated-air drying, within the scope of 50-60 DEG C, time is 1-3h, the Chinese yam Ultramicro-powder obtained, for subsequent use;
(2) get raw material Gorgon fruit to clean, at 45-55 DEG C of scope inner drying 20-40min, dried Gorgon fruit is first ground into granularity 100-180 order with common grinder, put into micronizer again to pulverize, be crushed to the Ultramicro-powder that particle diameter is 200-300 μm, then carry out heated-air drying, within the scope of 50-60 DEG C, time is 0.5-2.5h, the Gorgon fruit Ultramicro-powder obtained, for subsequent use;
(3) be uniformly mixed by gained Gorgon fruit Ultramicro-powder in gained Chinese yam Ultramicro-powder in step (1) and step (2), mixer speed is 50-75r/min, and the time is 10-15min, obtains mixture I, for subsequent use;
(4) adding ethanol to gained mixture I in step (3) makes determining alcohol reach 75%, filter after leaving standstill 8-16h, impurity is discharged, at temperature 40-60 DEG C after recovery ethanol, under vacuum 0.58-0.68MPa condition, Vacuum Concentration reaches 50-70% to dry substance, carry out vacuum drying again, within the scope of baking temperature 40-60 DEG C, obtain dry extract, for subsequent use;
(5) add after step (4) gained dry extract being pulverized vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, haw thorn extract, American ginseng extract, sweet mellow wine, chitosan oligosaccharide, Thick many candies, Sucralose, superfine silica gel powder mixing machine mixing make particle, rotating speed is 10-15r/min, time is 6-8min, by mixing after particle 50-60 DEG C of scope inner drying to water content between 1-3%, for subsequent use;
(6) add sodium carboxymethyl starch, dolomol mixing to gained particle in step (5), tabletted, obtains gordon euryale yam dispersible tablet.
Get raw material Chinese yam in described step (1) to clean, dry 25min 45 DEG C time, dried Chinese yam is first ground into granularity 180 order with common grinder, put into micronizer again to pulverize, be crushed to the Ultramicro-powder that particle diameter is 280 μm, carrying out heated-air drying again, is 1h 60 DEG C of times, the Chinese yam Ultramicro-powder obtained.
Get raw material Gorgon fruit in described step (2) to clean, at 45 DEG C of scope inner drying 20min, dried Gorgon fruit is first ground into granularity 150 order with common grinder, put into micronizer again to pulverize, be crushed to the Ultramicro-powder that particle diameter is 250 μm, then carry out heated-air drying, within the scope of 50 DEG C, time is 0.5h, the Gorgon fruit Ultramicro-powder obtained.
In sum, beneficial effect of the present invention:
The present invention has invigorating the spleen to arrest diarrhea.Be applicable to that infantile spleen deficiency rushes down for a long time, large loose stool is thin.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described gained technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on gained embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
A kind of gordon euryale yam dispersible tablet, comprises following parts by weight ingredient: Gorgon fruit 200 parts, Chinese yam 200 parts, vitamin C 1.75 parts, vitamin A 0.01 part, zinc gluconate 0.15 part, microcrystalline cellulose 40 parts, haw thorn extract 0.12 part, American ginseng extract 0.12 part, 100 parts, sweet mellow wine, chitosan oligosaccharide 1.2 parts, Thick many candies 1.2 parts, Sucralose 10 parts, superfine silica gel powder 10 parts, carboxymethyl cellulose 3 parts, sodium carboxymethyl starch 55 parts, dolomol 4 parts.
A preparation method for gordon euryale yam dispersible tablet, comprises the following steps:
(1) get raw material Chinese yam to clean, at 45-55 DEG C of scope inner drying 20-40min, dried Chinese yam is first ground into granularity 100-180 order with common grinder, put into micronizer again to pulverize, be crushed to the Ultramicro-powder that particle diameter is 200-300 μm, then carry out heated-air drying, within the scope of 50-60 DEG C, time is 1-3h, the Chinese yam Ultramicro-powder obtained, for subsequent use;
(2) get raw material Gorgon fruit to clean, at 45-55 DEG C of scope inner drying 20-40min, dried Gorgon fruit is first ground into granularity 100-180 order with common grinder, put into micronizer again to pulverize, be crushed to the Ultramicro-powder that particle diameter is 200-300 μm, then carry out heated-air drying, within the scope of 50-60 DEG C, time is 0.5-2.5h, the Gorgon fruit Ultramicro-powder obtained, for subsequent use;
(3) be uniformly mixed by gained Gorgon fruit Ultramicro-powder in gained Chinese yam Ultramicro-powder in step (1) and step (2), mixer speed is 50-75r/min, and the time is 10-15min, obtains mixture I, for subsequent use;
(4) adding ethanol to gained mixture I in step (3) makes determining alcohol reach 75%, filter after leaving standstill 8-16h, impurity is discharged, at temperature 40-60 DEG C after recovery ethanol, under vacuum 0.58-0.68MPa condition, Vacuum Concentration reaches 50-70% to dry substance, carry out vacuum drying again, within the scope of baking temperature 40-60 DEG C, obtain dry extract, for subsequent use;
(5) add after step (4) gained dry extract being pulverized vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, haw thorn extract, American ginseng extract, sweet mellow wine, chitosan oligosaccharide, Thick many candies, Sucralose, superfine silica gel powder mixing machine mixing make particle, rotating speed is 10-15r/min, time is 6-8min, by mixing after particle 50-60 DEG C of scope inner drying to water content between 1-3%, for subsequent use;
(6) add sodium carboxymethyl starch, dolomol mixing to gained particle in step (5), tabletted, obtains gordon euryale yam dispersible tablet.
Embodiment 2
A kind of gordon euryale yam dispersible tablet, comprises following parts by weight ingredient: Gorgon fruit 300 parts, Chinese yam 300 parts, vitamin C 2.75 parts, vitamin A 0.015 part, zinc gluconate 0.25 part, microcrystalline cellulose 50 parts, haw thorn extract 0.22 part, American ginseng extract 0.22 part, 135 parts, sweet mellow wine, chitosan oligosaccharide 2.2 parts, Thick many candies 2.2 parts, Sucralose 12.5 parts, superfine silica gel powder 30 parts, carboxymethyl cellulose 4 parts, sodium carboxymethyl starch 67.5 parts, dolomol 5 parts.
A preparation method for gordon euryale yam dispersible tablet, comprises the following steps:
(1) get raw material Chinese yam to clean, at 45-55 DEG C of scope inner drying 20-40min, dried Chinese yam is first ground into granularity 100-180 order with common grinder, put into micronizer again to pulverize, be crushed to the Ultramicro-powder that particle diameter is 200-300 μm, then carry out heated-air drying, within the scope of 50-60 DEG C, time is 1-3h, the Chinese yam Ultramicro-powder obtained, for subsequent use;
(2) get raw material Gorgon fruit to clean, at 45-55 DEG C of scope inner drying 20-40min, dried Gorgon fruit is first ground into granularity 100-180 order with common grinder, put into micronizer again to pulverize, be crushed to the Ultramicro-powder that particle diameter is 200-300 μm, then carry out heated-air drying, within the scope of 50-60 DEG C, time is 0.5-2.5h, the Gorgon fruit Ultramicro-powder obtained, for subsequent use;
(3) be uniformly mixed by gained Gorgon fruit Ultramicro-powder in gained Chinese yam Ultramicro-powder in step (1) and step (2), mixer speed is 50-75r/min, and the time is 10-15min, obtains mixture I, for subsequent use;
(4) adding ethanol to gained mixture I in step (3) makes determining alcohol reach 75%, filter after leaving standstill 8-16h, impurity is discharged, at temperature 40-60 DEG C after recovery ethanol, under vacuum 0.58-0.68MPa condition, Vacuum Concentration reaches 50-70% to dry substance, carry out vacuum drying again, within the scope of baking temperature 40-60 DEG C, obtain dry extract, for subsequent use;
(5) add after step (4) gained dry extract being pulverized vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, haw thorn extract, American ginseng extract, sweet mellow wine, chitosan oligosaccharide, Thick many candies, Sucralose, superfine silica gel powder mixing machine mixing make particle, rotating speed is 10-15r/min, time is 6-8min, by mixing after particle 50-60 DEG C of scope inner drying to water content between 1-3%, for subsequent use;
(6) add sodium carboxymethyl starch, dolomol mixing to gained particle in step (5), tabletted, obtains gordon euryale yam dispersible tablet.
Embodiment 3
A kind of gordon euryale yam dispersible tablet, comprises following parts by weight ingredient: Gorgon fruit 400 parts, Chinese yam 400 parts, vitamin C 3.75 parts, vitamin A 0.02 part, zinc gluconate 0.35 part, microcrystalline cellulose 60 parts, haw thorn extract 0.32 part, American ginseng extract 0.32 part, 170 parts, sweet mellow wine, chitosan oligosaccharide 3.2 parts, Thick many candies 3.2 parts, Sucralose 15 parts, superfine silica gel powder 50 parts, carboxymethyl cellulose 5 parts, sodium carboxymethyl starch 80 parts, dolomol 6 parts.
A preparation method for gordon euryale yam dispersible tablet, comprises the following steps:
(1) get raw material Chinese yam to clean, at 45-55 DEG C of scope inner drying 20-40min, dried Chinese yam is first ground into granularity 100-180 order with common grinder, put into micronizer again to pulverize, be crushed to the Ultramicro-powder that particle diameter is 200-300 μm, then carry out heated-air drying, within the scope of 50-60 DEG C, time is 1-3h, the Chinese yam Ultramicro-powder obtained, for subsequent use;
(2) get raw material Gorgon fruit to clean, at 45-55 DEG C of scope inner drying 20-40min, dried Gorgon fruit is first ground into granularity 100-180 order with common grinder, put into micronizer again to pulverize, be crushed to the Ultramicro-powder that particle diameter is 200-300 μm, then carry out heated-air drying, within the scope of 50-60 DEG C, time is 0.5-2.5h, the Gorgon fruit Ultramicro-powder obtained, for subsequent use;
(3) be uniformly mixed by gained Gorgon fruit Ultramicro-powder in gained Chinese yam Ultramicro-powder in step (1) and step (2), mixer speed is 50-75r/min, and the time is 10-15min, obtains mixture I, for subsequent use;
(4) adding ethanol to gained mixture I in step (3) makes determining alcohol reach 75%, filter after leaving standstill 8-16h, impurity is discharged, at temperature 40-60 DEG C after recovery ethanol, under vacuum 0.58-0.68MPa condition, Vacuum Concentration reaches 50-70% to dry substance, carry out vacuum drying again, within the scope of baking temperature 40-60 DEG C, obtain dry extract, for subsequent use;
(5) add after step (4) gained dry extract being pulverized vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, haw thorn extract, American ginseng extract, sweet mellow wine, chitosan oligosaccharide, Thick many candies, Sucralose, superfine silica gel powder mixing machine mixing make particle, rotating speed is 10-15r/min, time is 6-8min, by mixing after particle 50-60 DEG C of scope inner drying to water content between 1-3%, for subsequent use;
(6) add sodium carboxymethyl starch, dolomol mixing to gained particle in step (5), tabletted, obtains gordon euryale yam dispersible tablet.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or essential characteristic, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and in each embodiment, gained technical scheme also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (1)
1. a gordon euryale yam dispersible tablet, is characterized in that: its raw material consists of the following composition by weight: Gorgon fruit 300 parts, Chinese yam 300 parts, vitamin C 2.75 parts, vitamin A 0.015 part, zinc gluconate 0.25 part, microcrystalline cellulose 50 parts, haw thorn extract 0.22 part, American ginseng extract 0.22 part, 135 parts, sweet mellow wine, chitosan oligosaccharide 2.2 parts, Thick many candies 2.2 parts, Sucralose 12.5 parts, superfine silica gel powder 30 parts, carboxymethyl cellulose 4 parts, sodium carboxymethyl starch 67.5 parts, dolomol 5 parts.
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| CN1245703A (en) * | 1998-11-18 | 2000-03-01 | 李乐 | Nutrient health-care tea |
| CN1785395A (en) * | 2005-07-28 | 2006-06-14 | 江西汇仁药业有限公司 | Spleen-tonifying Zisheng fast dispersion solid preparation and its preparation method |
| CN103356933A (en) * | 2013-07-18 | 2013-10-23 | 苏州市天灵中药饮片有限公司 | Stomach-nourishing spleen-strengthening chewing tablets and preparation method thereof |
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| CN1245703A (en) * | 1998-11-18 | 2000-03-01 | 李乐 | Nutrient health-care tea |
| CN1785395A (en) * | 2005-07-28 | 2006-06-14 | 江西汇仁药业有限公司 | Spleen-tonifying Zisheng fast dispersion solid preparation and its preparation method |
| CN103356933A (en) * | 2013-07-18 | 2013-10-23 | 苏州市天灵中药饮片有限公司 | Stomach-nourishing spleen-strengthening chewing tablets and preparation method thereof |
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