CN105770488A - Composition containing royal jelly and preparing method thereof - Google Patents

Composition containing royal jelly and preparing method thereof Download PDF

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Publication number
CN105770488A
CN105770488A CN201610104330.4A CN201610104330A CN105770488A CN 105770488 A CN105770488 A CN 105770488A CN 201610104330 A CN201610104330 A CN 201610104330A CN 105770488 A CN105770488 A CN 105770488A
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China
Prior art keywords
extract
parts
lac regis
regis apis
present
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CN201610104330.4A
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Chinese (zh)
Inventor
杨德勇
刘虹
朱荣斌
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Priority to CN201610104330.4A priority Critical patent/CN105770488A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8984Dendrobium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8988Gastrodia

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Husbandry (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a composition containing royal jelly.The composition contains the royal jelly, dendrobium officinale extract, radix notoginseng extract, ginseng extract, gastrodia elata extract, dandelion extract and yolk powder.The composition has the advantages of being capable of effectively relieving physical fatigue by means of a scientific formula and rich nutrition.

Description

A kind of composition and method of making the same containing Lac regis apis
Technical field
The present invention relates to medicines and health protection technical field, be specifically related to a kind of composition and method of making the same containing Lac regis apis.
Background technology
Lac regis apis is as a kind of good health product, containing abundant nutritional labeling, such as materials such as protein, aminoacid, saccharide, organic acid, phytosterol, vitaminss.Lac regis apis has the multiple pharmacological effect such as antioxidation, antibacterial bacteriostatic, defying age, blood sugar lowering, blood fat reducing, immunomodulating so that it is be widely used in fields such as medicine, food, cosmetics.The health food of development and utilization Lac regis apis, its social benefit and economic well-being of workers and staff prospect are very optimistic.
Summary of the invention
It is an object of the invention to provide the compositions containing Lac regis apis of a kind of alleviating physical fatigue.
The technical solution used in the present invention is a kind of compositions containing Lac regis apis, comprises Lac regis apis, Herba Dendrobii extract, Radix Notoginseng extract, Radix Ginseng extract, Rhizoma Gastrodiae extract, Herba Taraxaci extract and yolk powder.
As preferably, it is made up of the raw material of following parts by weight: Lac regis apis 4~12 parts, Herba Dendrobii extract 1~10 part, Radix Notoginseng extract 1~5 part, Radix Ginseng extract 1~5 part, Rhizoma Gastrodiae extract 1~5 part, Herba Taraxaci extract 0.1~3 part and yolk powder 0.1~3 part.
As preferably, it is made up of the raw material of following parts by weight: Lac regis apis 6~10 parts, Herba Dendrobii extract 2~6 parts, Radix Notoginseng extract 1~3 part, Radix Ginseng extract 1~3 part, Rhizoma Gastrodiae extract 1~3 part, Herba Taraxaci extract 0.5~2 part and yolk powder 0.5~2 part.
As preferably, it is made up of the raw material of following parts by weight: Lac regis apis 8 parts, Herba Dendrobii extract 4 parts, Radix Notoginseng extract 2 parts, Radix Ginseng extract 2 parts, Rhizoma Gastrodiae extract 2 parts, Herba Taraxaci extract 1 part and yolk powder 1 part.
As preferably, described compositions comprises pharmaceutically conventional adjuvant.Described adjuvant pharmaceutically can comprise one or more the mixture in Fruit powder, edible essence, sweeting agent, acidic flavoring agent, filler, lubricant, preservative, suspending agent, food coloring, diluent, emulsifying agent, disintegrating agent or plasticizer.
As preferably, Fruit powder is a kind of or both mixture above in orange powder, orange powder, Fructus Citri Limoniae powder, cherry powder, apple powder or coconut palm powder.But those skilled in the art think that feasible Fruit powder is all within protection scope of the present invention, and Fruit powder kind is not limited thereto, and the present invention does not limit at this.
As preferably, edible essence is a kind of or both mixture above in flavoring orange essence, orange essence, Fructus Citri Limoniae essence, cherry essence, Mentholum, apple essence or coconut palm essence.But those skilled in the art think that feasible edible essence is all within protection scope of the present invention, and edible essence kind is not limited thereto, and the present invention does not limit at this.
For increasing the sugariness of medicine, it is easy to take.As preferably, sweeting agent is a kind of or both mixture above in sucralose, acesulfame potassium, aspartame or mogroside.But those skilled in the art think that feasible sweeting agent is all within protection scope of the present invention, and sweeting agent kind is not limited thereto, and the present invention does not limit at this.
As preferably, acidic flavoring agent is a kind of or both mixture above in citric acid, malic acid, lactic acid or citric acid.But those skilled in the art think that feasible acidic flavoring agent is all within protection scope of the present invention, and acidic flavoring agent kind is not limited thereto, and the present invention does not limit at this.
Filler refers to increase the weight and volume of tablet, is beneficial to the adjuvant of tabletting.Filler as tablet requires that mobility, compressibility are good, and adhesion is strong, and medicine has bigger saturation.As preferably, filler is a kind of or both mixture above in fructose, sugar alcohols, sucrose, starch, pregelatinized Starch, microcrystalline Cellulose or dextrin.But those skilled in the art think that feasible disintegrating agent is all within protection scope of the present invention, and filler kind is not limited thereto, and the present invention does not limit at this.
Lubricant refers to reduce the adjuvant of frictional force between tablet and die wall, makes tabletting difficulty to prevent frictional force big, and when can make tabletting, pressure distribution is uniform, and makes the even density of tablet, it is also possible to improves the outward appearance of tablet, makes tablet surface bright, smooth.As preferably, lubricant is a kind of or both mixture above in Pulvis Talci, magnesium stearate, silicon dioxide or stearic acid.But those skilled in the art think that feasible lubricant is all within protection scope of the present invention, and lubricant kind is not limited thereto, and the present invention does not limit at this.
As preferably, preservative is a kind of or both mixture above in sodium benzoate, Potassium Benzoate, sorbic acid methyl ester, ethylparaben or P-hydroxybenzoic acid phenyl ester.But those skilled in the art think that feasible preservative is all within protection scope of the present invention, and preservative kind is not limited thereto, and the present invention does not limit at this.
As preferably, suspending agent is a kind of or both mixture above in sodium carboxymethyl cellulose, sodium alginate or Cera Flava.But those skilled in the art think that feasible suspending agent is all within protection scope of the present invention, and suspending agent kind is not limited thereto, and the present invention does not limit at this.
As preferably, food coloring is a kind of or both mixture above in caramel color, Gardenia Yellow, curcumin or chlorophyll.But those skilled in the art think that feasible food coloring is all within protection scope of the present invention, and food coloring kind is not limited thereto, and the present invention does not limit at this.
As preferably, diluent is edible vegetable oil, propylene glycol or molecular weight is a kind of or both mixture above in the Polyethylene Glycol of 400~6000.But those skilled in the art think that feasible diluent is all within protection scope of the present invention, and diluent kind is not limited thereto, and the present invention does not limit at this.
As preferably, emulsifying agent is S-40, sodium stearoyl lactate/calcium, diacetyl tartarate monoglyceride, sucrose fatty acid ester, molecular weight be 400~6000 Polyethylene Glycol or distillation monoglyceride in a kind of or mixture that both are above.But those skilled in the art think that feasible emulsifying agent is all within protection scope of the present invention, and emulsifier is not limited thereto, and the present invention does not limit at this.
The Main Function of disintegrating agent is in that to eliminate because of binding agent or is formed the adhesion of tablet by pressurizeing and make the rapid disintegrate of tablet, makes tablet can play rapidly drug effect.As preferably, disintegrating agent is a kind of or both mixture above in dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone or sodium carboxymethyl cellulose.But those skilled in the art think that feasible disintegrating agent is all within protection scope of the present invention, and filler kind is not limited thereto, and the present invention does not limit at this.
As preferably, plasticizer is a kind of or both mixture above in glycerol, sodium carboxymethyl cellulose, sorbitol or oleamide sodium sulfonate.But those skilled in the art think that feasible plasticizer is all within protection scope of the present invention, and plasticizer kind is not limited thereto, and the present invention does not limit at this.
As preferably, described medicament is the one in tablet, granule, pill, capsule, powder or liquid preparation.
As preferably, described liquid preparation is oral liquid.
Present invention also offers a kind of method preparing described oral liquid, comprise the following steps: by weight, weigh Lac regis apis, Herba Dendrobii extract, Radix Notoginseng extract, Radix Ginseng extract, Rhizoma Gastrodiae extract, Herba Taraxaci extract and yolk powder dosing.
The beneficial effects of the present invention is: with Lac regis apis for monarch drug in compositions, Herba Dendrobii extract is ministerial drug, Radix Notoginseng extract, Radix Ginseng extract, Rhizoma Gastrodiae extract, Herba Taraxaci extract and yolk powder are for making medicine, common compatibility, there is YIN nourishing and QI supplementing, effect of active meridians, can effective alleviating physical fatigue.
Detailed description of the invention
For making those skilled in the art understand production technology and the technique effect of the present invention in detail, it is further described application and the technique effect of the present invention below with concrete production instance.
Embodiment 1
By weight, weigh Lac regis apis 12 parts, Herba Dendrobii extract 10 parts, Radix Notoginseng extract 5 parts, Radix Ginseng extract 5 parts, Rhizoma Gastrodiae extract 5 parts, Herba Taraxaci extract 3 parts and yolk powder 3 parts, mixing, add appropriate amount of starch, dextrin, it is pressed into the buccal tablet that specification is 1 gram/piece, to obtain final product.
Embodiment 2
By weight, weigh Lac regis apis 4 parts, Herba Dendrobii extract 1 part, Radix Notoginseng extract 1 part, Radix Ginseng extract 1 part, Rhizoma Gastrodiae extract 1 part, Herba Taraxaci extract 0.1 part and yolk powder 0.1 part, mixing, cross 60 mesh sieves, add appropriate amount of starch, tabletting, to obtain final product.
Embodiment 3
By weight, weigh Lac regis apis 10 parts, Herba Dendrobii extract 2 parts, Radix Notoginseng extract 3 parts, Radix Ginseng extract 1 part, Rhizoma Gastrodiae extract 1 part, Herba Taraxaci extract 0.5 part and yolk powder 0.5 part, mixing, add appropriate micropowder silica gel, fill, obtain capsule.
Embodiment 4
By weight, weigh Lac regis apis 6 parts, Herba Dendrobii extract 6 parts, Radix Notoginseng extract 1 part, Radix Ginseng extract 3 parts, Rhizoma Gastrodiae extract 3 parts, Herba Taraxaci extract 2 parts and yolk powder 2 parts, mixing, granulate, obtain granule.
Embodiment 5
By weight, weigh Lac regis apis 8 parts, Herba Dendrobii extract 4 parts, Radix Notoginseng extract 2 parts, Radix Ginseng extract 2 parts, Rhizoma Gastrodiae extract 2 parts, Herba Taraxaci extract 1 part and yolk powder 1 part, mixing, add pure water dosing, mixing, fill, sterilizing, packaging, obtain the oral liquid of 2000 parts.This oral liquid is micro-sweet, micro-hardship.When edible, each 30ml, every day 2 times.It is placed in shady and cool dry place to preserve.
For verifying the technique effect of the present invention, spy makes tests below:
The research that Endurance is affected by embodiment of the present invention products obtained therefrom.For every set product, take mice 20, male and female half and half.At the load of the afterbody system body weight 10% of every mice, by above-mentioned sample with same concentration gavage after white mice, putting into water temperature is 27 DEG C, and the depth of water is in the swimming pool of Mice Body length 3 times, and record mice continues swimming time and power and exhausts the time.In Table 1.
The table 1 impact on mouse anti-reflecting fatigue ability
Product Continue swimming time Swimming time
Distilled water 9.32±3.19 27.21±2.36
Embodiment 1 15.56±2.11 41.96±3.11
Embodiment 2 14.97±1.68 40.37±1.62
Embodiment 3 15.61±3.06 41.62±2.26
Embodiment 4 15.21±2.52 41.35±4.21
Embodiment 5 15.89±5.84 42.77±1.67
As it can be seen from table 1 the present invention has significant anti-fatigue ability.
Choose crowd 150 example of hypoimmunity, take embodiment of the present invention products obtained therefrom respectively.Result shows, continues to take product of the present invention after 1 month, all has clear improvement.Illustrating, the present invention has the function of significant enhancing immunity.
Above example is only in order to illustrative not limiting technical scheme, although the present invention being described in detail with reference to above-described embodiment, skilled artisan would appreciate that, still the present invention can be modified or equivalent replacement, without deviating from any modification or partial replacement of the spirit and scope of the present invention, it all should be encompassed in scope of the presently claimed invention.

Claims (8)

1. the compositions containing Lac regis apis, it is characterised in that: comprise Lac regis apis, Herba Dendrobii extract, Radix Notoginseng extract, Radix Ginseng extract, Rhizoma Gastrodiae extract, Herba Taraxaci extract and yolk powder.
2. a kind of compositions containing Lac regis apis according to claim 1, it is characterised in that: it is made up of the raw material of following parts by weight: Lac regis apis 4~12 parts, Herba Dendrobii extract 1~10 part, Radix Notoginseng extract 1~5 part, Radix Ginseng extract 1~5 part, Rhizoma Gastrodiae extract 1~5 part, Herba Taraxaci extract 0.1~3 part and yolk powder 0.1~3 part.
3. a kind of compositions containing Lac regis apis according to claim 2, it is characterised in that: it is made up of the raw material of following parts by weight: Lac regis apis 6~10 parts, Herba Dendrobii extract 2~6 parts, Radix Notoginseng extract 1~3 part, Radix Ginseng extract 1~3 part, Rhizoma Gastrodiae extract 1~3 part, Herba Taraxaci extract 0.5~2 part and yolk powder 0.5~2 part.
4. a kind of compositions containing Lac regis apis according to claim 3, it is characterised in that: it is made up of the raw material of following parts by weight: Lac regis apis 8 parts, Herba Dendrobii extract 4 parts, Radix Notoginseng extract 2 parts, Radix Ginseng extract 2 parts, Rhizoma Gastrodiae extract 2 parts, Herba Taraxaci extract 1 part and yolk powder 1 part.
5. a kind of compositions containing Lac regis apis according to any one in claim 1-4, it is characterised in that: described compositions comprises pharmaceutically conventional adjuvant.
6. contain the medicament of the compositions of Lac regis apis according to claim 5, it is characterised in that: described medicament is the one in tablet, granule, pill, capsule, powder or liquid preparation.
7. contain the medicament of the compositions of Lac regis apis according to claim 6, it is characterised in that: described liquid preparation is oral liquid.
8. the method preparing oral liquid described in claim 7, it is characterized in that: comprise the following steps: by weight, weigh Lac regis apis, Herba Dendrobii extract, Radix Notoginseng extract, Radix Ginseng extract, Rhizoma Gastrodiae extract, Herba Taraxaci extract and yolk powder dosing.
CN201610104330.4A 2016-02-25 2016-02-25 Composition containing royal jelly and preparing method thereof Pending CN105770488A (en)

Priority Applications (1)

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CN105770488A true CN105770488A (en) 2016-07-20

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106343468A (en) * 2016-08-25 2017-01-25 明光市昊昊蜂业有限公司 Antihypertensive royal jelly composition
CN106360543A (en) * 2016-09-19 2017-02-01 陈亚杰 Royal jelly health-care particles and preparation method thereof
CN106376882A (en) * 2016-08-30 2017-02-08 钓鱼台医药集团吉林天强制药股份有限公司 Ginseng royal-jelly and preparation method thereof
CN109717434A (en) * 2019-01-30 2019-05-07 宁夏碧蜂源蜂产业有限公司 It is suitable for health-care honey sauce and preparation method designed for old people

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102648959A (en) * 2012-04-28 2012-08-29 十堰市神农蜂语生物科技有限公司 Royal jelly enteric preparation and preparation method thereof
CN104623272A (en) * 2013-11-12 2015-05-20 呼和浩特市通瑞科技有限责任公司 Preparation method of compound traditional Chinese medicine containing royal jelly
CN104783161A (en) * 2015-04-15 2015-07-22 威海御膳坊生物科技有限公司 Compound oral preparation of royal jelly

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN102648959A (en) * 2012-04-28 2012-08-29 十堰市神农蜂语生物科技有限公司 Royal jelly enteric preparation and preparation method thereof
CN104623272A (en) * 2013-11-12 2015-05-20 呼和浩特市通瑞科技有限责任公司 Preparation method of compound traditional Chinese medicine containing royal jelly
CN104783161A (en) * 2015-04-15 2015-07-22 威海御膳坊生物科技有限公司 Compound oral preparation of royal jelly

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106343468A (en) * 2016-08-25 2017-01-25 明光市昊昊蜂业有限公司 Antihypertensive royal jelly composition
CN106376882A (en) * 2016-08-30 2017-02-08 钓鱼台医药集团吉林天强制药股份有限公司 Ginseng royal-jelly and preparation method thereof
CN106360543A (en) * 2016-09-19 2017-02-01 陈亚杰 Royal jelly health-care particles and preparation method thereof
CN109717434A (en) * 2019-01-30 2019-05-07 宁夏碧蜂源蜂产业有限公司 It is suitable for health-care honey sauce and preparation method designed for old people

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