CN104116987A - Traditional Chinese medicinal composition for improving irregular menstruation and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for improving irregular menstruation and preparation method thereof Download PDFInfo
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- CN104116987A CN104116987A CN201410317469.8A CN201410317469A CN104116987A CN 104116987 A CN104116987 A CN 104116987A CN 201410317469 A CN201410317469 A CN 201410317469A CN 104116987 A CN104116987 A CN 104116987A
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Abstract
The invention discloses a traditional Chinese medicinal composition for improving irregular menstruation and a preparation method thereof. The traditional Chinese medicinal composition comprises the following components by the weight percentage: 1.2%-25% of salvia miltiorrhiza, 1.1%-20% of poria cocos, 1.2%-22% of angelica sinensis, 1%-30% of peach kernel, 1%-25% of folium sennae, 1%-25% of coix seeds, 1%-15% of galagal rhizome, 10%-30% of black-bone chicken, 5%-25% of donkey-hide gelatin, 1.1%-8% of vitamin C, 1.1%-8% of vitamin E, and 0.2-25% of auxiliary materials. With adopting of the traditional Chinese medicinal materials of pearls, black-bone chicken, donkey-hide gelatin, salvia miltiorrhiza, poria cocos, angelica sinensis, peach kernel, galagal rhizome, eucommia ulmoides, coix seeds and the like as main raw materials, and with compatibility and resultant action of various medicines, the human body internal functions can be conditioned and improved, obsessions of body weakness lassitude, deficiency cold syndrome and other symptoms are effectively improved, and especially, female irregular menstruation, dysmenorrhea and other symptoms are improved obviously.
Description
Technical field
The invention belongs to the field of Chinese medicines, more particularly, relate to a kind of Chinese medicine composition that improves menoxenia and preparation method thereof.
Background technology
Menoxenia, a kind of can be a property crossed because weather, emotion, weather condition etc. have influence on menstruation, can oneself regulate, and plays the brain central action of releiving, thus endocrine regulation; The second just refers to that central gland axle is disorderly, and the synthetic aspect of hormone secretion that hypothalamic-pituitary-ovarian axis causes declines; The change of organic menoxenia sexual glands generation clinically physiology and appearance, the endocrine disturbance of initiation, pituitary tumor for example, premature ovarian failure late period, polycystic ovary, intrauterine adhesion etc.
Now along with the increase of operating pressure, the quickening of rhythm of life, in a lot of situations women be cannot be very fast self regulation, drainage pressure, thereby make menoxenia, cause menoxenia, affect the inside function of human body.No matter there is the menoxenia of which kind of situation, all can endanger the healthy of women.
Gallus Domesticus has the effect of " yin nourishing is brought down a fever, the liver and the kidney tonifying, benefiting QI and nourishing blood "; The Colla Corii Asini yin nourishing of enriching blood; Radix Salviae Miltiorrhizae energy nourishing blood to tranquillize the mind, the silt pain relieving of dispelling; Poria promoting diuresis to eliminate damp pathogen; Radix Angelicae Sinensis nature and flavor are sweet, pungent, warm, have the effect of benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the intestine moistening of increasing liquid; Semen Persicae bitter in the mouth and enter conscience blood system, be apt to let out stasis, the silt power of dispelling is stronger, for the common drug for the treatment of congestion internal resistance disease, and can lubricate intestinal wall, to lead to it just. Folium Sennae is the dry lobule of leguminous plant leaf Senna fruit or cassia acutifolia Delile, nature and flavor are sweet, bitter, cold, return large intestine channel, thering is the function of purge heat stagnant, the relieving constipation of row, diuretic, cure mainly that accumulation of heat is stagnant, constipation stomachache, edema overflow; The medicinal name of Rhizoma Alpiniae Officinarum begins to be loaded in < < Mingyi Bielu > >, all middle burnt cold coagulation, or cold thing hinders, coldness and pain in the epigastrium person.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine material of selecting is primary raw material, and the menoxenia causing for various situations, dysmenorrhea etc., can nurse one's health and improve inside of human body function, thereby reaches the Chinese medicine composition of endocrine regulation, recovery menstrual cycle.
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition.
The object of the invention is to be achieved by the following technical programs:
Chinese medicine composition of the present invention, counts by weight percentage and comprises following component:
Radix Salviae Miltiorrhizae 1.2%～25%, Poria 1.1%～20%, Radix Angelicae Sinensis 1.2%～22%,
Semen Persicae 1%～30%, Folium Sennae 1%～25%, Semen Coicis 1%～25%,
Rhizoma Alpiniae Officinarum 1%～15%, Gallus Domesticus 10%～30%, Colla Corii Asini 5%～25%,
Vitamin C 1.1%～8%, vitamin e1 .1%～8%.
In the present invention, described Chinese medicine composition adjuvant comprises Fruit powder 0.5%～25%, edible essence 0.5%～25%, sweeting agent 0.5%～25%, acidic flavoring agent 0.5%～25%, lubricant 0.5%～25%, antiseptic 0.5%～25%, suspending agent 0.5%～25%, food coloring 0.5%～25%, diluent 0.5%～25%, plasticizer 0.5%～25%, makes peroral dosage form.
The preparation method of Chinese medicine composition of the present invention is: each component is mixed, and water decocts, and is then condensed into extractum, after being dried.
In the present invention, the preparation method of above-mentioned Chinese medicine composition is still: by Radix Salviae Miltiorrhizae 1.2%～25%, Poria 1.1%～20%, Radix Angelicae Sinensis 1.2%～22%, Semen Persicae 1%～30%, Folium Sennae 1%～25%, Semen Coicis 1%～25%, after mixing, water decocts, and is then condensed into concentrated solution, and spraying is dried to obtain powder; Gallus Domesticus 10%～30% water decocts, and filtrate is concentrated, and spraying is dried to obtain powder; Colla Corii Asini 5%～25%, Rhizoma Alpiniae Officinarum 1%～15%, pulverize and sieve respectively; Vitamin C 1.1%～8%, vitamin e1 .1%～8%, pulverizes respectively; After above-mentioned raw materials is mixed.
In the present invention, the preparation method of above-mentioned Chinese medicine composition is: directly with the extract of each component, allocate.
Chinese medicine composition of the present invention can be made various peroral dosage forms together with acceptable adjuvant in bromatology, as tablet, hard capsule, soft capsule.
Chinese medicine composition of the present invention can be made together with acceptable composition in bromatology, makes various peroral dosage forms, as powder, granule, tablet, hard capsule, soft capsule, oral liquid, soft sweet.
The invention has the beneficial effects as follows, in described Chinese medicine composition, adopt Chinese medicine material Margarita, Gallus Domesticus, Colla Corii Asini, Radix Salviae Miltiorrhizae, Poria, Radix Angelicae Sinensis, Semen Persicae, the Cortex Eucommiae, Semen Coiciss etc. are primary raw material, all medicine compatibilities, force action can be nursed one's health and improve inside of human body function, pass through depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, the large function of toxin expelling speckle removing three regulates, reach integrally-regulated internal organs, the two objects of adjusting of QI and blood, women's health is fully nursed one's health, make vital essence abundance in body, blood vessels are unimpeded, effectively improve menoxenia, body void is weak, the puzzlement of symptom and the symptoms of women's particular time such as cold caused by deficiency disease.The present invention proves through inspection body's toxicological test of State Food and Drug Administration's approval, has no side effect, and is nontoxic level product.
The specific embodiment
A kind of Chinese medicine composition with functions of removing chloasma, bowel relaxing functions of the present invention, counts by weight percentage and comprises following component:
Radix Salviae Miltiorrhizae 1.2%～25%, Poria 1.1%～20%,
Radix Angelicae Sinensis 1.2%～22%, Semen Persicae 1%～30%, Folium Sennae 1%～25%,
Semen Coicis 1%～25%, Rhizoma Alpiniae Officinarum 1%～15%, Gallus Domesticus 10%～30%,
Colla Corii Asini 5%～25%, vitamin C 1.1%～8%, vitamin e1 .1%～8%, adjuvant 0.2～25%.
Described Chinese medicine composition adjuvant comprises Fruit powder 0.5%～25%, edible essence 0.5%～25%, sweeting agent 0.5%～25%, acidic flavoring agent 0.5%～25%, lubricant 0.5%～25%, antiseptic 0.5%～25%, suspending agent 0.5%～25%, food coloring 0.5%～25%, diluent 0.5%～25%, plasticizer 0.5%～25%, makes peroral dosage form.
Fruit powder in described Chinese medicine composition adjuvant: one or more in orange powder, Fructus Citri Limoniae powder, cherry powder, apple powder, coconut palm powder form; Edible essence: one or more in orange essence, Fructus Citri Limoniae essence, cherry essence, apple essence, cocoanut flavour form; Sweeting agent: one or more in sucralose, acesulfame potassium, aspartame, mogroside, neotame form; Acidic flavoring agent: one or more in citric acid, malic acid, lactic acid, citric acid form; Filler: one or more in fructose, sugar alcohol, sucrose, starch, dextrin form; Lubricant: one or more in Pulvis Talci, magnesium stearate, silicon dioxide, stearic acid form; Antiseptic: one or more in sodium benzoate, Potassium Benzoate, sorbic acid methyl ester, ethylparaben, P-hydroxybenzoic acid phenyl ester form; Suspending agent: one or more in sodium carboxymethyl cellulose, sodium alginate, Cera Flava form; Food coloring: one or more in burnt sugar coloring, gardenia yellow, curcumin, chlorophyll form; Diluent: one or more in vegetable oil, propylene glycol, molecular weight polyethylene glycol 400～2000 form; Plasticizer: one or more in glycerol, sodium carboxymethyl cellulose, sorbitol, oleamide sodium sulfonate form, and make peroral dosage form.
In Chinese medicine composition of the present invention, described peroral dosage form comprises tablet, hard capsule, soft capsule.
Embodiment mono-:
The preparation of the hard capsule of Chinese medicine composition of the present invention
According to following percentage by weight, take each component:
Radix Salviae Miltiorrhizae 15%, Poria 11%, Rhizoma Alpiniae Officinarum 1%,
Radix Angelicae Sinensis 15%, Semen Persicae 15%, Folium Sennae 15%,
Semen Coicis 15%, Gallus Domesticus 4.8%, Colla Corii Asini 4.5%,
Vitamin C 1%, vitaminF 1%, dextrin 8%,
Preparation method: by all raw material decoction pieces after the assay was approved, standby, according to need of production, take Radix Salviae Miltiorrhizae, Poria, Radix Angelicae Sinensis, Semen Persicae, Folium Sennae, the rear water decoction of Semen Coicis mixing, be then condensed into concentrated solution, the dry powder that to obtain of spraying, standby; Gallus Domesticus water decocts, and filtrate is concentrated, and spraying is dried to obtain powder, standby; Colla Corii Asini, Rhizoma Alpiniae Officinarum pulverize and sieve respectively; Vitamin C, vitamin E are pulverized respectively, standby.Material obtained above is always mixed, with Autocapsulefillingmachine, fill, after polishing.
Through human feeding trial, prove to there is endocrine regulation, improve the function of menoxenia.Through animal function and human feeding trial, prove to there is the health care of relieving constipation.
Sample carries out Toxicological evaluation according to the check of < < health food with assessment technique standard > > (2003 editions), and result is as follows:
1, acute oral LD5t1 result: acute oral LD5t1 female, male mice is all greater than to 21500mg/kg*bw, belongs to non-poisonous material.
2, three genetic toxicity test results: three genetic toxicity tests (Salmonella reversion test, PCEMNR micronucleus test and mouse sperm deformity test) result is all negative.
3, within 30 days, feed result: the capsule with 1.33g/kgbw, 2.00g/kgbw, 2.67g/kgbw dosage is given
Rat oral gavage 30 days, experimental session, each dosage group rat body weight growth, food utilization and matched group be there was no significant difference (P > 0.05) relatively.There are no significant for testis/body ratio of female, male Mus blood biochemistry index, routine blood test index and liver/body, spleen/body, kidney/body, male Mus and matched group comparing difference (P > 0.05).Liver,spleen,kidney, Stomach duodenum, testis (ovary) tissue pathology checking are without obvious damage.Prompting submitted sample is fed the every observation index of rat is not produced to obvious toxic-side effects for 30 days.
Function:
With 0.135g/kgbw, 0.270g/kgbw, the capsule of 0.810g/kgbw dosage was to mouse stomach 14 days, 0.810g/kgbw dosage can significantly improve the small intestinal prepared Chinese ink propelling rate (P < 0.01) of enterokinesia inhibition mice, can significantly shorten the first grain melena time (P < 0.05) of mice with constipation row, significantly increase row's fecal grains and the stool weight (P < 0.01 or P < 0.05) of mice with constipation, each dosage does not make mice suffer from diarrhoea, and the body weight gain to mice has no significant effect.According to the check of < < health food and the middle criterion of assessment technique standard > > (2003 editions), think that this capsule has the function of relieving constipation to mice.
101 routine experimenters are divided into test-meal group (50 example) and matched group (51 example) immediately by menstrual symptom (menstrual cycle, menstrual blood volume, menstruation color), difference edible capsule and placebo, every day 2 times, each 2.After 15 days, result shows: test-meal group result shows that experimenter eats rear and test-meal is relatively front, and menstrual cycle is obviously tending towards normally, and menstrual blood volume and menstruation color are obviously improved (P < 0.01), and total effective rate is 90.00%; Test-meal group and matched group comparison after test-meal, menstrual cycle, menstrual blood volume, menstruation color also have clear improvement, and difference has significance (P < 0.01).Illustrate that capsule has the effect that improves menoxenia.Before and after test-meal, hemogram, the every detection index of hepatic and renal function all, within normal range, are not observed allergy and other untoward reaction yet, illustrate body health is had no adverse effects.In process of the test experimenter all occur not feel sick, flatulence, diarrhoea and the untoward reaction such as irritated.
Embodiment bis-:
The preparation of the tablet of Chinese medicine composition of the present invention
According to following percentage by weight, take each component:
Radix Salviae Miltiorrhizae 8%, Poria 8%,
Radix Angelicae Sinensis 8%, Semen Persicae 8%,
Semen Coicis 10%, Gallus Domesticus 4.5%,
Vitamin C 1.2%, vitaminF 1.2%,
Hydroxyl isomaltulose 15.9%, orange powder 3%,
Mogroside 0.02%, silicon dioxide 0.04%,
Preparation method: by all raw material decoction pieces after the assay was approved, standby, according to need of production, take Radix Salviae Miltiorrhizae, Poria, Radix Angelicae Sinensis, Semen Persicae, Folium Sennae, the rear water decoction of Semen Coicis mixing, be then condensed into concentrated solution, the dry powder that to obtain of spraying, standby; Gallus Domesticus water decocts, and filtrate is concentrated, and spraying is dried to obtain powder, standby; Colla Corii Asini, Rhizoma Alpiniae Officinarum pulverize and sieve respectively; Vitamin C, vitamin E are pulverized respectively, standby.Material obtained above is added to cherry essence, hydroxyl isomaltulose, orange powder, mogroside, silicon dioxide, the magnesium stearate upper tablet machine tabletting after Uniform that is always mixed.
Embodiment tri-:
The preparation of the soft capsule of Chinese medicine composition of the present invention:
Feed liquid: Radix Salviae Miltiorrhizae 8%, Poria 8%, Rhizoma Alpiniae Officinarum 1.2%,
Radix Angelicae Sinensis 8%, Semen Persicae 8%, Folium Sennae 8%,
Semen Coicis 10%, Gallus Domesticus 4.5%, Colla Corii Asini 4.5%,
Vitamin C 1.2%, vitaminF 1.2%, dextrin 18.4%,
Cherry essence 0.01%, soybean oil 18.5%, Cera Flava 0.5%,
Glue: gelatin 46%, glycerol 16%, purified water 37%, burnt sugar coloring 0.8%,
Ethylparaben 0.2%
Preparation method: by all raw material decoction pieces after the assay was approved, standby, according to need of production, take Radix Salviae Miltiorrhizae, Poria, Radix Angelicae Sinensis, Semen Persicae, Folium Sennae, the rear water decoction of Semen Coicis mixing, be then condensed into concentrated solution, the dry powder that to obtain of spraying, standby; Gallus Domesticus water decocts, and filtrate is concentrated, and spraying is dried to obtain powder, standby; Colla Corii Asini, Rhizoma Alpiniae Officinarum pulverize and sieve respectively; Vitamin C is pulverized, standby.Material obtained above is always mixed, according to components by weight percent, add soybean oil, Cera Flava, vitamin E to make suspended matter after mixing, with gelatin, glycerol, purified water, burnt sugar coloring, after this Ethyl formate of hydroxyl is mixed, make rubber, the fill of content suspended matter is pressed into soft capsule, wash ball, dry after and get final product.
Claims (8)
1. improve a Chinese medicine composition for menoxenia, count by weight percentage and comprise following component: Radix Salviae Miltiorrhizae 1.2%～25%, Poria 1.1%～20%, Radix Angelicae Sinensis 1.2%～22%, Semen Persicae 1%～30%, Folium Sennae 1%～25%, Semen Coicis 1%～25%, Rhizoma Alpiniae Officinarum 1%～15%, Gallus Domesticus 10%～30%, Colla Corii Asini 5%～25%, vitamin C 1.1%～8%, vitamin e1 .1%～8%, adjuvant 0.2～25%.
2. Chinese medicine composition according to claim 1, it is characterized in that: described Chinese medicine composition adjuvant comprises Fruit powder 0.5%～25%, edible essence 0.5%～25%, sweeting agent 0.5%～25%, acidic flavoring agent 0.5%～25%, lubricant 0.5%～25%, antiseptic 0.5%～25%, suspending agent 0.5%～25%, food coloring 0.5%～25%, diluent 0.5%～25%, plasticizer 0.5%～25%, makes peroral dosage form.
3. Chinese medicine composition according to claim 2, is characterized in that: described peroral dosage form comprises tablet, hard capsule, soft capsule.
4. the preparation method of Chinese medicine composition according to claim 1, is characterized in that: each component is mixed, and water decocts, and is then condensed into extractum, after being dried.
5. the preparation method of Chinese medicine composition according to claim 1, it is characterized in that: by Radix Salviae Miltiorrhizae 1.2%～25%, Poria 1.1%～20%, Radix Angelicae Sinensis 1.2%～22%, Semen Persicae 1%～30%, Folium Sennae 1%～25%, Semen Coicis 1%～25%, after mixing, water decocts, and is then condensed into concentrated solution, and spraying is dried to obtain powder; Gallus Domesticus 10%～30% water decocts, and filtrate is concentrated, and spraying is dried to obtain powder; Colla Corii Asini 5%～25%, Rhizoma Alpiniae Officinarum 1%～15%, pulverize and sieve respectively; Vitamin C 1.1%～8%, vitamin e1 .1%～8%, pulverizes respectively; After above-mentioned raw materials is mixed.
6. the preparation method of Chinese medicine composition according to claim 1, is characterized in that: directly with the extract of each component, allocate.
7. the preparation method of Chinese medicine composition according to claim 1, is characterized in that: described Chinese medicine composition is made various peroral dosage forms together with acceptable adjuvant in bromatology, as tablet, hard capsule, soft capsule.
8. the preparation method of Chinese medicine composition according to claim 1, it is characterized in that: described Chinese medicine composition is made together with acceptable composition in bromatology, make various peroral dosage forms, as powder, granule, tablet, hard capsule, soft capsule, oral liquid, soft sweet.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114027384A (en) * | 2021-11-24 | 2022-02-11 | 湖南西子电商品牌管理有限公司 | Brewed red ginseng soft sweets capable of improving dysmenorrhea and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114027384A (en) * | 2021-11-24 | 2022-02-11 | 湖南西子电商品牌管理有限公司 | Brewed red ginseng soft sweets capable of improving dysmenorrhea and preparation method thereof |
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Application publication date: 20141029 |